Article
Medicine, General & Internal
Adam G. Berman, W. Keith Tan, Maria O'Donovan, Florian Markowetz, Rebecca C. Fitzgerald
Summary: This study aimed to assess the diagnostic value of Cytosponge-TFF3 test in distinguishing clinically relevant Barrett's oesophagus from focal intestinal metaplasia pathologies, and to automate TFF3 counting using machine learning. The results showed that TFF3 counting could differentiate these two pathologies with high precision and accuracy. It could help minimize overdiagnosis of focal intestinal metaplasia pathologies with low cancer-associated risk.
Article
Biochemistry & Molecular Biology
Nikolina Kolobaric, Martina Mihalj, Natasa Kozina, Anita Matic, Zrinka Mihaljevic, Ivana Jukic, Ines Drenjancevic
Summary: High salt intake leads to hemodynamic changes and immune response, causing pro-inflammatory conditions. In this study, knock-out mice showed lower levels of inflammatory response compared to wild-type mice after salt-loading.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Hidemi Hattori, Yuma Hanai, Yuto Oshima, Hiroaki Kataoka, Nozomu Eto
Summary: Excessive consumption of HFCS drinks, such as soft drinks, without a proper diet, induces nonobese IGT due to insulin-secretion defect. This study found that excess HFCS-water intake did not lead to obesity, but impaired glucose tolerance (IGT) due to insulin-secretion defect. The intake of HFCS-water affected glucose and fructose metabolism by decreasing the expression of certain enzymes in the pancreas.
Article
Cell Biology
Seyed Amirhossein Tabatabaei Dakhili, Kunyan Yang, Cassandra A. A. Locatelli, Christina T. Saed, Amanda A. Greenwell, Jordan S. F. Chan, Jadin J. Chahade, Jared Scharff, Shahad Al-Imarah, Farah Eaton, Peter A. Crawford, Keshav Gopal, Erin E. Mulvihill, John R. Ussher
Summary: Acute elevations in circulating ketones improve glucose tolerance in obesity, independent of muscle ketone oxidation.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yasuro Furuichi, Ayana Furutani, Kotaro Tamura, Yasuko Manabe, Nobuharu L. Fujii
Summary: Skeletal muscle undergoes structural and metabolic changes in response to various conditions. The RNA-binding protein Musashi-2 (Msi2) is dominantly expressed in slow-type muscle fibers, and its knockout leads to a decrease in both fiber size and number, as well as a reduction in fast-type fibers and metabolic protein expression. These findings demonstrate the critical role of Msi2 in maintaining fiber type composition and metabolism.
Article
Endocrinology & Metabolism
Emily A. Rosenberg, Ellen W. Seely, Kaitlyn James, Marti D. Soffer, Stacey Nelson, Jacinda M. Nicklas, Camille E. Powe
Summary: The study found no association between carbohydrate intake and post-OGTT glucose levels among postpartum individuals. Therefore, dietary preparation prior to the OGTT may not be necessary in this population.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Agriculture, Dairy & Animal Science
Abigail R. Rathert-Williams, Carlee M. Salisbury, Amanda K. Lindholm-Perry, Adel Pezeshki, David L. Lalman, Andrew P. Foote
Summary: Increased propionate may decrease dry matter intake and insulin sensitivity in finishing steers.
JOURNAL OF ANIMAL SCIENCE
(2021)
Article
Plant Sciences
Pablo Albertos, Tanja Wlk, Jayne Griffiths, Maria J. Pimenta Lange, Simon J. Unterholzner, Wilfried Rozhon, Theo Lange, Alexander M. Jones, Brigitte Poppenberger
Summary: The bHLH transcription factor CESTA and its homologues BEE are involved in gibberellin catabolism and are regulated by brassinosteroids. These findings provide important insights into the regulation of plant growth and development.
Article
Microbiology
Zhe Wang, Siyuan Cui, TingTing Zhang, Wei Wang, JiaYu Li, Y. Q. Chen, Sheng Long Zhu
Summary: Disruption of blood glucose utilization can lead to diabetes mellitus, and free fatty acid receptors (FFARs) play an important role in the genetic and dietary aspects. This study found that FFAR4 has a significant effect on glucose homeostasis, and knockout of the FFAR4 gene impairs glucose tolerance in mice under high-fat feeding and chow diet conditions. Furthermore, deficiency of intestinal FFAR4 affects the composition of gut microbiota, especially at ZT12 under chow diet conditions.
Article
Microbiology
Isabel Huber-Ruano, Enrique Calvo, Jordi Mayneris-Perxachs, M-Mar Rodriguez-Pena, Victoria Ceperuelo-Mallafre, Lidia Cedo, Catalina Nunez-Roa, Joan Miro-Blanch, Maria Arnoriaga-Rodriguez, Aurelie Balvay, Claire Maudet, Pablo Garcia-Roves, Oscar Yanes, Sylvie Rabot, Ghjuvan Micaelu Grimaud, Annachiara De Prisco, Angela Amoruso, Jose Manuel Fernandez-Real, Joan Vendrell, Sonia Fernandez-Veledo
Summary: The study reveals that gut microbiota is a significant source of elevated succinate in obese individuals. Therapeutic treatments with selected bacteria can reduce circulating succinate levels in obese mice, and Odoribacter laneus shows promise as a probiotic to deplete succinate and improve glucose tolerance.
Article
Biochemistry & Molecular Biology
Nikkhil Velingkaar, Volha Mezhnina, Allan Poe, Roman Kondratov
Summary: Reducing caloric intake is essential for metabolic reprogramming and improving glucose metabolism, rather than meal frequency and duration of fasting.
Article
Multidisciplinary Sciences
Mai Kanno, Shun Hiramatsu, Shu Kondo, Hiromu Tanimoto, Toshiharu Ichinose
Summary: The study found that fruit flies showed acute preference for ethanol and methamphetamine but not for cocaine, caffeine, or morphine. Over time, flies developed a long-term preference for ethanol, and dopamine signaling and its plastic changes played a crucial role in controlling voluntary drug intake.
SCIENTIFIC REPORTS
(2021)
Article
Agriculture, Dairy & Animal Science
Abigail R. Rathert-Williams, Hunter L. McConnell, Carlee M. Salisbury, Amanda K. Lindholm-Perry, David L. Lalman, Adel Pezeshki, Andrew P. Foote
Summary: The objective of this study was to investigate the effects of providing additional propionate to the rumen on various parameters in steers fed a finishing diet. The results showed that the high propionate treatment resulted in decreased meal size, meal frequency, and dry matter intake. There were also changes in glucose metabolism and rumen fluid metabolites observed among the different treatments. However, the supply of exogenous propionate did not have a significant impact on insulin and glucose levels. These findings suggest that mechanisms other than hepatic oxidation of propionate may be involved in regulating DMI.
JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Plant Sciences
Natalia Repkina, Anna Ignatenko, Ekaterina Holoptseva, Zbigniew MiszalskI, Pawel Kaszycki, Vera Talanova
Summary: Exogenous Methyl Jasmonate (MJ) can enhance cold tolerance in wheat by promoting the recovery of photosynthesis, increasing antioxidant enzyme activity, and promoting proline accumulation, thus increasing wheat cold tolerance.
Article
Nutrition & Dietetics
Gil Zandani, Sarit Anavi-Cohen, Tamar Yudelevich, Abraham Nyska, Nativ Dudai, Zecharia Madar, Jonathan Gorelick
Summary: This study found that supplementing high-fat diet with C. iphionoides can improve metabolic effects in a NAFLD model. Consumption of C. iphionoides can reduce weight gain, liver and adipose tissue weights, and improve liver function and lipid metabolism.
Article
Biochemistry & Molecular Biology
Ingrid C. Rulifson, Patrick Collins, Li Miao, Dana Nojima, Ki Jeong Lee, Miki Hardy, Jamila Gupte, Kelly Hensley, Kim Samayoa, Cynthia Cam, James B. Rottman, Mike Ollmann, William G. Richards, Yang Li
JOURNAL OF BIOLOGICAL CHEMISTRY
(2017)
Article
Biochemistry & Molecular Biology
Sally Yu Shi, Ya-Wen Lu, Zhi Liu, Jennitte Stevens, Christopher M. Murawsky, Vicki Wilson, Zhonghua Hu, William G. Richards, Mark Leo Michaels, Jun Zhang, Wei Yan, Yang Li
JOURNAL OF BIOLOGICAL CHEMISTRY
(2018)
Article
Multidisciplinary Sciences
Sally Yu Shi, Ya-Wen Lu, Jason Richardson, Xiaoshan Min, Jennifer Weiszmann, William G. Richards, Zhulun Wang, Zhongqi Zhang, Jun Zhang, Yang Li
SCIENTIFIC REPORTS
(2018)
Article
Biochemistry & Molecular Biology
Xiaoshan Min, Jennifer Weiszmann, Sheree Johnstone, Wei Wang, Xinchao Yu, William Romanow, Stephen Thibault, Yang Li, Zhulun Wang
JOURNAL OF BIOLOGICAL CHEMISTRY
(2018)
Article
Multidisciplinary Sciences
Zhengjian Zhang, Caroline Broderick, Marni Nishimoto, Teppei Yamaguchi, Sung-Jin Lee, Haili Zhang, Hui Chen, Mehaben Patel, Jay Ye, Alberto Ponce, Jennifer Brady, Helene Baribault, Yang Li, Wen-Chen Yeh
SCIENTIFIC REPORTS
(2020)
Article
Medicine, Research & Experimental
Huiren Zhao, Ki-Jeong Lee, Mark Daris, Yun Lin, Thomas Wolfe, Jackie Sheng, Cherylene Plewa, Songli Wang, W. Hans Meisen
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT
(2020)
Article
Multidisciplinary Sciences
Tristan W. Fowler, Troy L. Mitchell, Claudia Y. Janda, Liqin Xie, Shengjiang Tu, Hui Chen, Haili Zhang, Jingjing Ye, Brian Ouyang, Tom Z. Yuan, Sung-Jin Lee, Maureen Newman, Nikita Tripuraneni, Erica S. Rego, Devin Mutha, Archana Dilip, Meghah Vuppalapaty, Helene Baribault, Wen-Chen Yeh, Yang Li
Summary: The study introduces a novel antibody-based platform for generating potent Wnt mimetics to address conditions like osteoporosis. The synthetic Wnt agonists demonstrate rapid bone building effects in murine models, indicating potential for therapeutic use in bone-related disorders.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Jiamiao Lu, Patrick Collins, Ki Jeong Lee, Chi-Ming Li, Songli Wang
Summary: Researchers have developed a novel tBID-based safety switch system to control undesired toxicity or ablate engineered cells by regulating a small molecule inducer TMP. With optimization, significant killing potency in vitro has been achieved.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Liqin Xie, Russell B. Fletcher, Diksha Bhatia, Darshini Shah, Jacqueline Phipps, Shalaka Deshmukh, Haili Zhang, Jingjing Ye, Sungjin Lee, Lucas Le, Maureen Newman, Hui Chen, Asmiti Sura, Suhani Gupta, Laura E. Sanman, Fan Yang, Weixu Meng, Helene Baribault, Geertrui F. Vanhove, Wen -Chen Yeh, Yang Li, Chenggang Lu
Summary: The study demonstrates that modulation of Wnt signaling is a potential approach to treating epithelial damage in inflammatory bowel disease. Exogenous R-spondin and Wnt mimetics can repair damaged intestinal epithelium, reduce disease activity and inflammation. Among them, the Wnt mimetic SZN-1326-p, specific to receptors FZD5/8 and LRP6, shows robust repair effects.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Ophthalmology
Huy Nguyen, Hui Chen, Meghah Vuppalapaty, Elizabeth Whisler, Kelsey Ronarda Logas, Parthasarathy Sampathkumar, Russell Byron Fletcher, Asmiti Sura, Nicholas Suen, Suhani Gupta, Tom Lopez, Jay Ye, Shengjiang Tu, Menaka Bolaki, Wen-Chen Yeh, Yang Li, Sung-Jin Lee
Summary: This study developed a Norrin mimetic targeting FZD4 and LRP5, named SZN-413-p, and demonstrated its ability to promote the regeneration of functional blood vessels in animal models. After humanization, SZN-413 showed significant efficacy in reducing neovascularization and avascular areas in a mouse model. Moreover, it effectively reduced retinal vascular leakage in a rabbit model. These findings suggest that SZN-413 can offer a new therapeutic strategy for diabetic retinopathy.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Huy Nguyen, Sung-Jin Lee, Yang Li
Summary: Retinal ischemia is a major cause of visual impairment and blindness worldwide, often associated with various disorders. Diabetic retinopathy is a common cause, and its exact pathogenesis remains unclear, but vascular leakage plays a significant role in visual impairment. Current treatments have limitations, therefore there is a need for new therapies to address vessel regeneration and reperfusion in ischemic retinal areas. The Wnt signaling pathway in the retina could provide a novel disease modifying therapy.
Article
Multidisciplinary Sciences
Jie Ding, Sung-Jin Lee, Lukas Vlahos, Kanako Yuki, Cara C. Rada, Vincent van Unen, Meghah Vuppalapaty, Hui Chen, Asmiti Sura, Aaron K. McCormick, Madeline Tomaske, Samira Alwahabi, Huy Nguyen, William Nowatzke, Lily Kim, Lisa Kelly, Douglas Vollrath, Andrea Califano, Wen-Chen Yeh, Yang Li, Calvin J. Kuo
Summary: Derangements of the blood-brain barrier (BBB) or blood-retinal barrier (BRB) occur in various disorders. A non-lipidated, FZD(4)-specific surrogate called L6-F4-2 has been developed and shown to improve BBB and BRB function. It also demonstrates systemic efficacy during ischemic stroke BBB dysfunction.
NATURE COMMUNICATIONS
(2023)
Article
Biochemical Research Methods
Hui Chen, Chenggang Lu, Sung-Jin Lee, Yang Li
Article
Biochemistry & Molecular Biology
Hui Chen, Chenggang Lu, Brian Ouyang, Haili Zhang, Zhong Huang, Diksha Bhatia, Sung-Jin Lee, Darshini Shah, Asmiti Sura, Wen-Chen Yeh, Yang Li
CELL CHEMICAL BIOLOGY
(2020)
Article
Biology
Maia Azubel, Stephen D. Carter, Jennifer Weiszmann, Jun Zhang, Grant J. Jensen, Yang Li, Roger D. Kornberg