Epithelial Cell Mitochondrial Dysfunction and PINK1 Are Induced by Transforming Growth Factor- Beta1 in Pulmonary Fibrosis

PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis

(2014) Marta Bueno et al.   JOURNAL OF CLINICAL INVESTIGATION

Insufficient autophagy in idiopathic pulmonary fibrosis

(2012) Jun Araya et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Statins and Pulmonary Fibrosis

(2012) Jin-Fu Xu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

ROS-induced mitochondrial depolarization initiates PARK2/PARKIN-dependent mitochondrial degradation by autophagy

(2012) Yuqing Wang et al.   Autophagy

Spatial Parkin Translocation and Degradation of Damaged Mitochondria via Mitophagy in Live Cortical Neurons

(2012) Qian Cai et al.   CURRENT BIOLOGY

Role of PINK1 Binding to the TOM Complex and Alternate Intracellular Membranes in Recruitment and Activation of the E3 Ligase Parkin

(2012) Michael Lazarou et al.   DEVELOPMENTAL CELL

Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment

(2012) Andrew W Greene et al.   EMBO REPORTS

Mitochondrial Reactive Oxygen Species Regulate Transforming Growth Factor-β Signaling

(2012) Manu Jain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy in Idiopathic Pulmonary Fibrosis

(2012) Avignat S. Patel et al.   PLoS One

A Key Role for NOX4 in Epithelial Cell Death During Development of Lung Fibrosis

(2011) Stephanie Carnesecchi et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial Rac1 GTPase Import and Electron Transfer from CytochromecAre Required for Pulmonary Fibrosis

(2011) Heather L. Osborn-Heaford et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Blocking IL-17A Promotes the Resolution of Pulmonary Inflammation and Fibrosis Via TGF- 1-Dependent and -Independent Mechanisms

(2011) S. Mi et al.   JOURNAL OF IMMUNOLOGY

p53-TIGAR axis attenuates mitophagy to exacerbate cardiac damage after ischemia

(2011) Atsushi Hoshino et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking

(2011) Cathrin Meissner et al.   JOURNAL OF NEUROCHEMISTRY

The Interplay Between Mitochondrial Dynamics and Mitophagy

(2010) Gilad Twig et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondria in cell death

(2010) Melissa J. Parsons et al.   Essays in Biochemistry

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

(2010) Noriyuki Matsuda et al.   JOURNAL OF CELL BIOLOGY

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

Oxidative stress and glutathione in TGF-β-mediated fibrogenesis

(2009) R.-M. Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases

(2009) H. Chen et al.   HUMAN MOLECULAR GENETICS

Loss of PINK1 Function Promotes Mitophagy through Effects on Oxidative Stress and Mitochondrial Fission

(2009) Ruben K. Dagda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration

(2009) Suzana Gispert et al.   PLoS One

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

PINK1 Is Necessary for Long Term Survival and Mitochondrial Function in Human Dopaminergic Neurons

(2008) Alison Wood-Kaczmar et al.   PLoS One

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE