Article
Biology
Chandra Sekhar Yadavalli, Sathisha Upparahalli Venkateshaiah, Sandeep Kumar, Hemanth Kumar Kandikattu, Lokanatha Oruganti, Chandra Sekhar Kathera, Anil Mishra
Summary: NLRP3-Caspase1-IL-18 pathway is activated in esophageal epithelial cells and macrophages after allergen exposure, leading to the initiation of eosinophilic esophagitis (EoE). Pharmacological inhibitors are a new treatment strategy for EoE pathogenesis.
COMMUNICATIONS BIOLOGY
(2023)
Review
Immunology
Yiming Ma, Yingjiao Long, Yan Chen
Summary: Cigarette smoke can damage a wide range of immunological functions, including innate and adaptive immune responses. The inflammasome complex is crucial in innate immune response, particularly in cigarette smoke-related diseases and physiopathological disorders. Strategies targeting the ROS/NLRP3 inflammasome axis show potential therapeutic effects in these contexts.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Marco Buscetta, Marta Cristaldi, Maura Cimino, Agnese La Mensa, Paola Dino, Fabio Bucchieri, Francesca Rappa, Santina Amato, Tommaso Silvano Aronica, Elisabetta Pace, Alessandro Bertani, Chiara Cipollina
Summary: The mechanisms and consequences of GSDMD activation in cigarette smoke-associated inflammation and lung disease are not well understood. This study shows that cigarette smoke extract (CSE) can activate caspase-1 and induce GSDMD cleavage and increased cell permeability. The activation of caspase-4 and caspase-8 by CSE further promotes GSDMD cleavage. These findings suggest that ASC-independent activation of caspase-1, -4, and -8 and subsequent GSDMD cleavage may contribute to macrophage dysfunction and chronic inflammation in the lungs of smokers.
Article
Immunology
Marko Manevski, Dinesh Devadoss, Christopher Long, Shashi P. Singh, Mohd Wasim Nasser, Glen M. Borchert, Madhavan N. Nair, Irfan Rahman, Mohan Sopori, Hitendra S. Chand
Summary: Research has found that long noncoding RNA (lncRNA) plays an important role in cigarette smoke exposure and chronic obstructive pulmonary disease. Blocking the expression of lncRNA can alleviate inflammation and excessive mucus production caused by cigarette smoke.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Sarah Huot-Marchand, Megane Nascimento, Elodie Culerier, Melissa Bourenane, Florence Savigny, Corinne Panek, Cindy Serdjebi, Marc Le Bert, Valerie F. J. Quesniaux, Bernhard Ryffel, Petr Broz, Nicolas Riteau, Aurelie Gombault, Isabelle Couillin
Summary: Chronic pulmonary inflammation and COPD are major health issues caused by air pollution and cigarette smoke exposure. Research has shown that NLRP3 and gasdermin D play important roles in CS-induced pulmonary inflammation and IL-1 beta release.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Plant Sciences
Chuang Xiao, Sha Cheng, Haochang Lin, Zhiying Weng, Peihua Peng, Deyou Zeng, Xiaohua Du, Xiujuan Zhang, Yaqing Yang, Yaping Liang, Rong Huang, Chen Chen, Lueli Wang, Hongxiang Wu, Runfeng Li, Xinhua Wang, Rongping Zhang, Zifeng Yang, Xian Li, Xue Cao, Weimin Yang
Summary: ISOF shows anti-COPD effects by improving lung function, anti-inflammation, and trachea relaxation, possibly through AC activation, mTOR signaling, and Th17/Treg balance.
Article
Immunology
Sean M. Thomas, Andrew J. Olive
Summary: Immune networks overlapping regulation and functions to ensure effective host responses against infection. Genetic interaction studies comparing host responses in single and combined knockout backgrounds are useful for identifying new mechanisms of immune control. Understanding the genetic interactions between protective immune pathways may identify new therapeutic targets for tuberculosis.
INFECTION AND IMMUNITY
(2023)
Review
Biochemistry & Molecular Biology
Georgia Bateman, Hong Guo-Parke, Aoife M. Rodgers, Dermot Linden, Melanie Bailey, Sinead Weldon, Joseph C. Kidney, Clifford C. Taggart
Summary: Cellular senescence is a state of permanent cell cycle arrest triggered by various stressors, and its accumulation has been observed in many age-related diseases. In chronic obstructive pulmonary disease (COPD), airway epithelium exhibits hallmark features of senescence, leading to cell cycle arrest and secretion of inflammatory mediators that contribute to chronic inflammation. Additionally, cellular senescence in COPD airway epithelium is associated with telomere dysfunction, DNA damage, and oxidative stress. Understanding the mechanisms and impact of cellular senescence in COPD may provide potential therapeutic targets for this disease.
Article
Cell Biology
Qing Chen, Kingsley Okechukwu Nwozor, Maarten van den Berge, Dirk-Jan Slebos, Alen Faiz, Marnix R. Jonker, H. Marike Boezen, Irene H. Heijink, Maaike de Vries
Summary: In this study, it was found that smoking leads to decreased DNA methylation of the AHRR gene in COPD patients, and the functional role of AHRR was investigated in vitro. The results suggest that increased airway epithelial AHRR expression may contribute to smoking-induced mitochondrial dysfunction and cell death, potentially promoting unprogrammed/immunogenic cell death.
Article
Medicine, Research & Experimental
Yingmin Liang, Ruixuan Du, Rui Chen, Pak Hin Chu, Mary Sau Man Ip, Kalin Yan Bo Zhang, Judith Choi Wo Mak
Summary: DOPs extracted from Dendrobium officinale showed therapeutic effects in reducing cigarette smoke-induced airway inflammation by decreasing oxidative stress and inflammatory cell infiltration, as well as inhibiting the activation of MAPK and NF-kappa B signaling pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Chemistry, Multidisciplinary
Xuan Ma, Jinzhao Zhang, Shengyu Wang, Yaming Li, Ibrahim Abdel Aziz Ibrahim, Xin Diao
Summary: In this study, the ameliorative effect of paclobutrazol against chronic cigarette smoke-induced COPD in rats was assessed. Results showed that paclobutrazol increased body weight, improved respiratory function, and decreased inflammation in rats exposed to secondhand smoke.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Respiratory System
Xiaofeng Mei, Ruilong Lu, Lili Cui, Yange Tian, Peng Zhao, Jiansheng Li
Summary: This study aimed to investigate the effects and mechanisms of Poly I:C on pathological changes in CS-induced COPD mice, such as airway inflammation and remodeling.
Article
Biochemistry & Molecular Biology
Pritam Saha, Sneha Durugkar, Siddhi Jain, P. A. Shantanu, Samir R. Panda, Aishwarya Jala, Sharad Gokhale, Pawan Sharma, V. G. M. Naidu
Summary: The study found that PIP treatment can protect cells from CSE-induced lung epithelial cell death. PIP treatment can restore epithelial markers and reduce mesenchymal and inflammatory markers in both in vitro and in vivo models. PIP treatment can improve altered lung function in mice induced by CS exposure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Physiology
Baishakhi Ghosh, Pratulya Pragadaraju Chengala, Sonya Shah, Daniel Chen, Vaishnavi Karnam, Kai Wilmsen, Bonnie Yeung-Luk, Venkataramana K. Sidhaye
Summary: The airway epithelial barrier plays a crucial role in defending against respiratory diseases, and this study reveals sex-specific differences in the baseline characteristics and response to chronic cigarette smoke exposure in murine tracheal epithelial cells. The findings suggest potential protective roles of planar cell polarity and highlight the importance of recognizing sex-based differences in disease susceptibility and treatment response in respiratory diseases.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Article
Cell Biology
Mahyar Aghapour, Christy B. M. Tulen, Mohsen Abdi Sarabi, Soenke Weinert, Mathias Muesken, Borna Relja, Frederik-Jan Van Schooten, Andreas Jeron, Ruediger Braun-Dullaeus, Alexander H. Remels, Dunja Bruder
Summary: Cigarette smoke exposure impairs mitochondrial function in airway epithelial cells, leading to impaired immune responses to Streptococcus pneumoniae.
Article
Immunology
Samira Mansouri, Seema Patel, Divya S. Katikaneni, Steven M. Blaauboer, Wei Wang, Stefan Schattgen, Katherine Fitzgerald, Lei Jin
MUCOSAL IMMUNOLOGY
(2019)
Article
Immunology
Michael Carty, Jay Kearney, Katharine A. Shanahan, Emily Hams, Ryoichi Sugisawa, Dympna Connolly, Ciara G. Doran, Natalia Munoz-Wolf, Claudia Gurtler, Katherine A. Fitzgerald, Ed C. Lavelle, Padraic G. Fallon, Andrew G. Bowie
Article
Biochemical Research Methods
Maxwell R. Mumbach, Jeffrey M. Granja, Ryan A. Flynn, Caitlin M. Roake, Ansuman T. Satpathy, Adam J. Rubin, Yanyan Qi, Zhaozhao Jiang, Shadi Shams, Bryan H. Louie, Jimmy K. Guo, David G. Gennert, M. Ryan Corces, Paul A. Khavari, Maninjay K. Atianand, Steven E. Artandi, Katherine A. Fitzgerald, William J. Greenleaf, Howard Y. Chang
Article
Multidisciplinary Sciences
Mona Motwani, Sudesh Pawaria, Jennifer Bernier, Stephanie Moses, Kate Henry, Terry Fang, Linda Burkly, Ann Marshak-Rothstein, Katherine A. Fitzgerald
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Multidisciplinary Sciences
Shigao Yang, Alfred T. Harding, Catherine Sweeney, David Miao, Gregory Swan, Connie Zhou, Zhaozhao Jiang, Katherine A. Fitzgerald, Gianna Hammer, Martin O. Bergo, Heather K. Kroh, D. Borden Lacy, Chunxiang Sun, Michael Glogauer, Loretta G. Que, Nicholas S. Heaton, Donghai Wang
Review
Genetics & Heredity
Mona Motwani, Scott Pesiridis, Katherine A. Fitzgerald
NATURE REVIEWS GENETICS
(2019)
Editorial Material
Immunology
Fiachra Humphries, Katherine A. Fitzgerald
JOURNAL OF IMMUNOLOGY
(2019)
Editorial Material
Biochemistry & Molecular Biology
Fiachra Humphries, Katherine A. Fitzgerald
News Item
Genetics & Heredity
Fiachra Humphries, Katherine A. Fitzgerald
Article
Multidisciplinary Sciences
Shiuli Agarwal, Tim Vierbuchen, Sreya Ghosh, Jennie Chan, Zhaozhao Jiang, Richard K. Kandasamy, Emiliano Ricci, Katherine A. Fitzgerald
NATURE COMMUNICATIONS
(2020)
Review
Rheumatology
Susan MacLauchlan, Katherine A. Fitzgerald, Ellen M. Gravallese
Summary: Evidence has shown that DNA plays a unique role in distinguishing between endogenous and foreign DNA, posing a challenge in disease discrimination. Autoinflammatory diseases resulting from gene mutations or DNA sensing pathway activation provide insight into the role of DNA in inflammation. This review discusses the current understanding of intracellular DNA sensing and its relevance to various diseases, as well as the development of therapies targeting these pathways.
ARTHRITIS & RHEUMATOLOGY
(2022)
Review
Cell Biology
John S. S. Mattick, Paulo P. P. Amaral, Piero Carninci, Susan Carpenter, Howard Y. Y. Chang, Ling-Ling Chen, Runsheng Chen, Caroline Dean, Marcel E. E. Dinger, Katherine A. A. Fitzgerald, Thomas R. R. Gingeras, Mitchell Guttman, Tetsuro Hirose, Maite Huarte, Rory Johnson, Chandrasekhar Kanduri, Philipp Kapranov, Jeanne B. B. Lawrence, Jeannie T. T. Lee, Joshua T. T. Mendell, Timothy R. R. Mercer, Kathryn J. J. Moore, Shinichi Nakagawa, John L. L. Rinn, David L. L. Spector, Igor Ulitsky, Yue Wan, Jeremy E. E. Wilusz, Mian Wu
Summary: Genes encoding lncRNAs are abundant in complex organisms and are transcribed by RNA polymerase I, II, and III, as well as processed introns. The classification and annotation of lncRNAs are challenging due to their various functions, isoforms, and interactions with other genes. These lncRNAs evolve rapidly, are cell type-specific, and regulate multiple cellular processes, including gene expression and translation control.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2023)
Editorial Material
Immunology
Michelle A. Kelliher, Katherine A. Fitzgerald
Summary: Resistance mechanisms have hindered the effectiveness of immune checkpoint blockade therapies, but inhibition of TBK1 can restore their efficacy by sensitizing tumors to RIPK1 kinase-dependent cell death.
TRENDS IN IMMUNOLOGY
(2023)
Editorial Material
Cell Biology
Kevin MingJie Gao, Katherine A. Fitzgerald
Summary: Endoplasmic-reticulum-associated degradation of the adaptor STING by SEL1L-HRD1 regulates steady-state STING levels to limit STING-driven inflammation, according to the study by Jie et al.
NATURE CELL BIOLOGY
(2023)
Article
Rheumatology
Jonathan J. J. Miner, Katherine A. A. Fitzgerald
Summary: Next-generation sequencing has revolutionized the field of genetics and has allowed for the discovery of rare autoinflammatory diseases and their corresponding mutations. This has opened up opportunities for personalized medicine and has shed light on more common forms of autoimmunity and autoinflammation. The rapid and cost-effective sequencing of individual genomes is changing the practice of rheumatology.
NATURE REVIEWS RHEUMATOLOGY
(2023)