Review
Clinical Neurology
Sara E. Gombash, Priscilla W. Lee, Elizabeth Sawdai, Amy E. Lovett-Racke
Summary: Vitamin D insufficiency during childhood is associated with the development of multiple sclerosis (MS), possibly due to abnormal immune responses and vulnerability of the central nervous system.
FRONTIERS IN NEUROLOGY
(2022)
Article
Nutrition & Dietetics
Dohyup Kim, Emily E. Witt, Simone Schubert, Elias Sotirchos, Pavan Bhargava, Ellen M. Mowry, Karen Sachs, Biter Bilen, Lawrence Steinman, Avni Awani, Zihuai He, Peter A. Calabresi, Keith Van Haren
Summary: The gene expression profile of vitamin D in the immune system may vary by cell type. Future clinical studies should consider techniques that allow for cell-type resolution.
Article
Clinical Neurology
Maurizio Grassano, Umberto Manera, Fabiola De Marchi, Paolo Cugnasco, Enrico Matteoni, Margherita Daviddi, Luca Solero, Alessandro Bombaci, Francesca Palumbo, Rosario Vasta, Antonio Canosa, Paolina Salamone, Giuseppe Fuda, Federico Casale, Letizia Mazzini, Andrea Calvo, Cristina Moglia, Adriano Chio
Summary: This study investigated the impact of immune responses on the clinical phenotype of ALS patients. Results revealed that immune responses were associated with disease progression, survival, and pulmonary function. Understanding the significance of immune dysregulation in ALS and further research may contribute to clinical practice and treatments.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Gastroenterology & Hepatology
Francesca M. Trovato, Rabiya Zia, Florent Artru, Salma Mujib, Ellen Jerome, Anna Cavazza, Muireann Coen, Ian Wilson, Elaine Holmes, Phillip Morgan, Arjuna Singanayagam, Christine Bernsmeier, Salvatore Napoli, William Bernal, Julia Wendon, Rosa Miquel, Krishna Menon, Vishal C. Patel, John Smith, Stephen R. Atkinson, Evangelos Triantafyllou, Mark J. W. McPhail
Summary: A metabolome study found that ALF patients have dysregulated metabolism and immune responses, potentially mediated by the LPC-ATX-LPA pathway.
JOURNAL OF HEPATOLOGY
(2023)
Review
Nutrition & Dietetics
Mattia Perazzi, Enrico Gallina, Giulia Francesca Manfredi, Filippo Patrucco, Antonio Acquaviva, Donato Colangelo, Mario Pirisi, Mattia Bellan
Summary: This paper reviews the potential role of vitamin D in the pathogenesis and management of systemic sclerosis (SSc). Pre-clinical data suggest that vitamin D and its analogs may suppress fibrogenesis, while clinical data show a high prevalence of hypovitaminosis D and osteoporosis in SSc patients, but inconsistent findings regarding the association with clinical manifestations and phenotypes of SSc.
Article
Clinical Neurology
Jiaxin Liu, Ning Li, Zhiyuan Zhu, Karrie Mei-Yee Kiang, Anson Cho Kiu Ng, Celia M. Dong, Gilberto Ka-Kit Leung
Summary: This study found that vitamin D promotes the differentiation of reparative macrophages, facilitates hematoma clearance, and improves neurological function after intracerebral hemorrhage. These findings suggest that vitamin D could be a potentially promising treatment for intracerebral hemorrhage.
Article
Neurosciences
G. Sferruzza, F. Clarelli, E. Mascia, L. Ferre, L. Ottoboni, M. Sorosina, S. Santoro, L. Moiola, V. Martinelli, G. Comi, F. Martinelli Boneschi, M. Filippi, P. Provero, Federica Esposito
Summary: The study investigated the gene transcriptional changes induced by FTY in monocytes of multiple sclerosis patients, revealing its major impact on genes associated with cell trafficking and immune cell activation.
MOLECULAR NEUROBIOLOGY
(2021)
Review
Immunology
Barbara Rossi, Bruno Santos-Lima, Eleonora Terrabuio, Elena Zenaro, Gabriela Constantin
Summary: Neurodegenerative diseases are closely linked to inflammatory and autoimmune processes, with immune system dysregulation playing a key role in their pathology. Both multiple sclerosis and Alzheimer's disease share common features such as infiltrating immune cells and activated neutrophils. Regulatory T cells are beneficial in the early stages of MS and AD, helping to control neuroinflammation and potentially influencing disease progression.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
James A. A. DeVoti, Mohd Israr, Fung Lam, Christopher Papayannakos, Douglas K. K. Frank, Dev P. P. Kamdar, Lucio M. M. Pereira, Allan Abramson, Bettie M. M. Steinberg, Vincent R. R. Bonagura
Summary: This study found that elevated plasma levels of PGE(2) are expressed in half of patients with OPC secondary to overexpression of COX-2 by peripheral blood monocytes, and this expression is driven by IL-1 alpha secreted by the tumors. Monocytes from patients are much more sensitive to the stimulation than monocytes from controls, suggesting the possibility of enhanced immune-modulating feed-back loops. Furthermore, control monocytes pre-exposed to PGE(2) overexpress COX-2 in response to IL-1 alpha, simulating responses made by monocytes from some OPC patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Nutrition & Dietetics
Weronika Galus, Tomasz Chmiela, Anna Walawska-Hrycek, Ewa Krzystanek
Summary: Current data highlight the importance of vitamin D in boosting the anti-inflammatory response, especially in patients with multiple sclerosis. While vitamin D deficiency is a known risk factor for developing multiple sclerosis, the benefits of vitamin D supplementation in this disease remain inconclusive. However, maintaining optimal or higher levels of vitamin D throughout the observation period was associated with a lower number of new lesions in patients with multiple sclerosis, suggesting the potential implementation and improvement of vitamin D in these patients.
Article
Medicine, General & Internal
Weronika Galus, Anna Walawska-Hrycek, Michalina Rzepka, Ewa Krzystanek
Summary: This study assessed the vitamin D status and practices among MS patients and professionals in the clinical setting. Results showed that while most patients confirmed vitamin D supplementation, only a small percentage achieved optimal vitamin D levels. Lack of doctor's recommendation was the most common reason for the absence of supplementation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Nutrition & Dietetics
Julie Langlois, Damien Denimal
Summary: This systematic review examined the effects of vitamin D supplementation on clinical and imaging outcomes in patients with multiple sclerosis (MS). The results showed no significant impact of vitamin D supplementation on relapse events, disability progression, and magnetic resonance imaging (MRI) lesions. However, recent studies found a significant reduction in new MRI lesions in the central nervous system of MS patients during supplementation with vitamin D3.
Article
Immunology
Dirk Lemke, Rainer Johannes Klement, Felix Schweiger, Beatrix Schweiger, Jorg Spitz
Summary: Vitamin D-3 plays an important role in treating autoimmune diseases, and high-dose vitamin D-3 therapy can improve treatment outcomes. Acquired vitamin D resistance may be a plausible pathomechanism for the development of autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Hao Li, Xiaokun Li, Shouming Lv, Xuefang Peng, Ning Cui, Tong Yang, Zhendong Yang, Chun Yuan, Yang Yuan, Jiaying Yao, Zan Yuan, Jiachen Li, Xiaolei Ye, Xiaoai Zhang, Shu Zhu, Ke Peng, Wei Liu
Summary: The single-cell landscape of peripheral immune responses in SFTS patients is reprogrammed, with potential targets including intermediate monocytes and IFN-I-inducible plasmablasts. A retrospective clinical study showed no efficiency of IFN-α in treating SFTS, indicating the pivotal role of the IFN-I response in exacerbating hyperinflammation and lethal SFTS.
Article
Clinical Neurology
Ashvin Kuri, Nicola Vickaryous, Amine Awad, Benjamin Meir Jacobs, Ruth Dobson
Summary: This study demonstrates that vD supplementation is the major determinant of vD levels in people with MS, with genetic factors playing a smaller role.
JOURNAL OF NEUROLOGY
(2023)
Letter
Medicine, General & Internal
Anne-Katrin Proebstel, Jens Kuhle, Anne-Catherine Lecourt, Isabelle Vock, Nicholas S. R. Sanderson, Ludwig Kappos, Tobias Derfuss
NEW ENGLAND JOURNAL OF MEDICINE
(2016)
Article
Multidisciplinary Sciences
Nicholas S. R. Sanderson, Maria Zimmermann, Luca Eilinger, Celine Gubser, Nicole Schaeren-Wiemers, Raija L. P. Lindberg, Stephanie K. Dougan, Hidde L. Ploegh, Ludwig Kappos, Tobias Derfuss
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Immunology
Martin Diebold, Claudia Sievers, Glenn Bantug, Nicholas Sanderson, Ludwig Kappos, Jens Kuhle, Raija L. P. Lindberg, Tobias Derfuss
JOURNAL OF AUTOIMMUNITY
(2018)
Article
Biochemistry & Molecular Biology
Edoardo Galli, Felix J. Hartmann, Bettina Schreiner, Florian Ingelfinger, Eirini Arvaniti, Martin Diebold, Dunja Mrdjen, Franziska van der Meer, Carsten Krieg, Faiez Al Nimer, Nicholas Sanderson, Christine Stadelmann, Mohsen Khademi, Fredrik Piehl, Manfred Claassen, Tobias Derfuss, Tomas Olsson, Burkhard Becher
Article
Immunology
Maria Zimmermann, Natalie Rose, John M. Lindner, Hyein Kim, Ana Rita Goncalves, Ilaria Callegari, Mohammedyaseen Syedbasha, Lukas Kaufmann, Adrian Egli, Raija L. P. Lindberg, Ludwig Kappos, Elisabetta Traggiai, Nicholas S. R. Sanderson, Tobias Derfuss
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Clinical Neurology
David Johansson, Celine Rauld, Julien Roux, Camille Regairaz, Edoardo Galli, Ilaria Callegari, Layla Raad, Annick Waldt, Rachel Cuttat, Guglielmo Roma, Martin Diebold, Burkhard Becher, Jens Kuhle, Tobias Derfuss, Jose M. Carballido, Nicholas S. R. Sanderson
Summary: Deep immune phenotyping identified a B-cell population associated with multiple sclerosis, with increased levels of B cell-related factors in early disease stages. Soluble signaling molecules related to B cells, including FCRL2 and BAFF, were altered in multiple sclerosis.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2021)
Article
Clinical Neurology
Martin Diebold, Edoardo Galli, Andreas Kopf, Nicholas Sanderson, Ilaria Callegari, Florian Ingelfinger, Nicolas Gonzalo Nunez, Pascal Benkert, Ludwig Kappos, Jens Kuhle, Burkhard Becher, Manfred Claassen, Tobias Derfuss
Summary: This study utilized single-cell mass cytometry to evaluate immune markers in multiple sclerosis patients treated with dimethyl fumarate. The research identified a negative correlation between CCR4-expressing T helper cells and relevant lymphopenia, suggesting CCR4-expressing T helper cells as a potential prognostic biomarker for lymphopenia development during DMF treatment.
ANNALS OF NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ilaria Callegari, Mika Schneider, Giuliano Berloffa, Tobias Muhlethaler, Sebastian Holdermann, Edoardo Galli, Tim Roloff, Renate Boss, Laura Infanti, Nina Khanna, Adrian Egli, Andreas Buser, Gert Zimmer, Tobias Derfuss, Nicholas S. R. Sanderson
Summary: In this study, we isolated spike-protein-specific B cells and produced recombinant antibodies of IgM, IgG, and IgA classes. Two IgM antibodies demonstrated potent virus neutralization at picomolar concentrations, but this potency was lost when switched to IgG. Decreased avidity alone cannot explain the loss of potency.
Meeting Abstract
Clinical Neurology
V. Epple, L. Hauss, A. Orleth, P. Benkert, D. Jorganxhi, N. Sanderson, K. Ivanek, L. Kappos, L. Achtnichts, J. Saxer, C. Pot, P. L. Dubois-Ferriere, P. H. Lalive, G. Breville, C. Bridel, C. Gobbi, C. Zecca, S. Mueller, F. Gruenenfelder, T. Derfuss, C. T. Berger, R. Pedotti, C. Raposo, K. Leuzinger, H. H. Hirsch, J. Kuhle, M. Mehling
MULTIPLE SCLEROSIS JOURNAL
(2021)
Meeting Abstract
Clinical Neurology
M. Diebold, E. Galli, A. Kopf, N. Sanderson, R. L. Lindberg, M. Claassen, B. Becher, T. Derfuss
MULTIPLE SCLEROSIS JOURNAL
(2019)
Meeting Abstract
Clinical Neurology
N. Sanderson, D. Johansson, C. Rauld, L. Raad, L. Kappos, J. Kuhle, J. Carballido, T. Derfuss
MULTIPLE SCLEROSIS JOURNAL
(2017)
Meeting Abstract
Clinical Neurology
M. Diebold, C. Sievers, N. Sanderson, L. Kappos, R. L. P. Lindberg, T. Derfuss
MULTIPLE SCLEROSIS JOURNAL
(2017)
Meeting Abstract
Clinical Neurology
M. Diebold, C. Sievers, N. Sanderson, M. Meira, L. Kappos, R. L. P. Lindberg, T. Derfuss
MULTIPLE SCLEROSIS JOURNAL
(2016)
Meeting Abstract
Clinical Neurology
N. Sanderson, M. Zimmermann, L. Eilinger, R. Lindberg, L. Kappos, T. Derfuss
MULTIPLE SCLEROSIS JOURNAL
(2016)
Meeting Abstract
Clinical Neurology
Y. Naegelin, M. Rasenack, C. Blatti, C. Sievers, M. Meira, N. Sanderson, M. Mehling, B. Fischer-Barnicol, M. Andelova, M. Amann, C. Stippich, E. W. Radue, B. Engelhardt, R. L. Lindberg, L. Kappos, T. Sprenger, T. Derfuss
MULTIPLE SCLEROSIS JOURNAL
(2015)