Article
Engineering, Biomedical
Mackenzie L. Wheeler, Michelle L. Oyen
Summary: Research on the complex functioning of the human placenta faces challenges due to a lack of suitable physiological in vivo models. To address this, two complementary approaches have emerged recently: computational in silico techniques and cellular in vitro methods. These approaches allow for investigations into early and later-term placental functions, highlighting the importance of taking a holistic approach to studying this temporary but critical organ.
ANNALS OF BIOMEDICAL ENGINEERING
(2021)
Article
Medicine, General & Internal
Juan Jovel, Russell Greiner
Summary: Machine learning approaches, including supervised, unsupervised, and reinforcement learning, are increasingly popular in biomedical research for various applications such as drug design, patient stratification, and medical image analysis. These methods have the potential to greatly impact basic and applied research programs in biomedicine.
FRONTIERS IN MEDICINE
(2021)
Article
Physics, Multidisciplinary
Nikos Kanakaris, Nikolaos Giarelis, Ilias Siachos, Nikos Karacapilidis
Summary: This study investigates the integration of unstructured textual data into a knowledge graph for predicting future research collaborations, proposing a three-phase pipeline for this purpose. The experimental results demonstrate a significant improvement in performance metrics for predicting future research collaborations on the new COVID-19 Open Research Dataset.
Review
Chemistry, Physical
Vladislav A. Lvov, Fedor S. Senatov, Alnis A. Veveris, Vitalina A. Skrybykina, Andres Diaz Lantada
Summary: Auxetic metamaterials with a negative Poisson ratio have the properties of lateral expansion when stretched and densification when compressed. Due to their similarity to biological tissues, auxetics have potential applications in the field of medicine. This research study provides a comprehensive overview of auxetic metamaterials in biomedical devices, including prosthetics, orthotics, ergonomic appliances, in vitro medical devices, and tissue engineering scaffolds.
Review
Chemistry, Multidisciplinary
Abdor Rahman Ahmed, Olivia C. Gauntlett, Gulden Camci-Unal
Summary: Modern biomedical applications require a combination of advanced technology and the adaptability of complex biosystems. Biomedical advancements inspired by origami have demonstrated voluminous structures, shape-shifting capabilities, and biocompatibility, offering promising potential for future discoveries. From tissue scaffolds to microfluidic devices, origami-inspired strategies have shown significant progress in various biomedical applications.
Review
Pharmacology & Pharmacy
Karen E. E. Brown, Alison E. E. Fohner, Erica L. L. Woodahl
Summary: Community-centric approaches are important for enhancing diversity and ethicality in biomedical research. Engaging communities as partners and prioritizing community health needs can make research more meaningful and respectful. Lack of consultation can alienate the very communities that these efforts aim to engage. Capacity development and changes to research processes can support collaborative partnerships and community oversight.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Mohammed Alsaqer, Salem Alelyani, Mohamed Mohana, Khalid Alreemy, Ali Alqahtani
Summary: Twitter is a popular microblogging platform with millions of active users worldwide, generating millions of posts daily. Predicting the location of tweets is crucial for various reasons, but most users don't enable geotagging and their home locations are not standardized or accurate. This study applied machine learning techniques to predict tweet locations based on their textual content and achieved 67% accuracy in experiments with Arabic tweets from Saudi Arabia.
APPLIED SCIENCES-BASEL
(2023)
Article
Thermodynamics
Mohammadali Ahmadi
Summary: This study proposes a method that combines fuzzy logic and genetic algorithm to predict the amount of wax deposition. Using different statistical indexes, the method shows high performance and integrity in determining wax deposition values. The advantages of this method include wide applicability and simple utilization.
Editorial Material
Biochemistry & Molecular Biology
David Horsfall, Jonah Cool, Simon Hettrick, Angela Oliveira Pisco, Neil Chue Hong, Muzlifah Haniffa
Summary: Research software engineering is crucial for data-driven biomedical research, yet its significance is often underestimated and misunderstood.
Review
Biochemistry & Molecular Biology
Andrey A. Buglak, Marina A. Kapitonova, Yulia L. Vechtomova, Taisiya A. Telegina
Summary: This review focuses on the quantum chemistry and photonics of pterins, providing a comprehensive overview of their electronic structure and potential applications in biomedicine. The study suggests that UV irradiation of pterins can affect enzymatic reactions and that the emission properties of pterins can be used in fluorescence diagnostics. The use of two-photon absorption and metal nanostructures is also proposed for pterin-related infrared therapy and spectroscopy detection of biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Kana Fuji, Sakurako Tanida, Masaki Sano, Makiko Nonomura, Daniel Riveline, Hisao Honda, Tetsuya Hiraiwa
Summary: This review discusses the elementary units of liquid-filled cavities called lumens. Theoretical modeling and computations are important tools to understand the biophysics of cell assembly and lumen formation. However, the appropriate computational approaches for this purpose have not been well-documented. The review provides an overview of typical lumen morphologies and development mechanisms, while discussing the pros and cons of current computational strategies and providing guidance on experimental measurements for comparison with model assumptions and predictions.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Rika Kobayashi
Summary: Sustainable scientific software relies on a strong collaboration framework, including elements such as education, tools, and community building. The COVID-19 pandemic has accelerated the development of remote platforms and tools, facilitating wider collaborations within the global community.
TOPICS IN CURRENT CHEMISTRY
(2021)
Review
Biotechnology & Applied Microbiology
Qisong Liu, Jianghong Huang, Jiang Xia, Yujie Liang, Guangheng Li
Summary: Imaging of extracellular vesicles (EVs) plays a crucial role in understanding their biological functions and potential as therapeutics and drug delivery vehicles. Various labeling and imaging methods, such as fluorescent imaging, bioluminescent imaging, nuclear imaging, and nanoparticle-assisted imaging, have been developed to track the communication and bio-distribution of EVs. These techniques contribute to a better understanding of EV uptake mechanisms, biological functions, and pharmacokinetic properties, which are essential for their clinical application.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Editorial Material
Biotechnology & Applied Microbiology
Stuart J. Smyth, Trevor C. Charles
Summary: Digital sequence information (DSI), defined as nonphysical genetic resources like genetic sequence data, lacks a clear definition and is not consistent among countries. Restricting the free sharing of DSI may conflict with core principles in fields like microbiology and molecular genetics, potentially impacting international research collaborations.
TRENDS IN BIOTECHNOLOGY
(2021)
Review
Biochemical Research Methods
Mohamed Nadif, Francois Role
Summary: Biomedical scientific literature is growing rapidly, making it challenging to identify relevant results; automated information extraction tools based on text mining techniques are essential; deep neural networks have significantly advanced this research field.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Dermatology
Theodosios Bisdas, Nikolaos Patelis, Georgia Argyrakopoulou, Dimitrios Tsiachris, Aristotelis Kurtis, Panagiotis Gargalianos-Kakoliris, Christodoulos Stefanadis
Summary: The complexity of critical limb ischemia (CLI) requires a dedicated multidisciplinary team for treatment. This study aimed to assess the effectiveness of referring CLI patients scheduled for major amputation elsewhere to a dedicated CLI center. The analysis showed that patients in severe stages of CLI who received a second opinion from a dedicated multidisciplinary team had high limb salvage and survival rates after major amputation.
INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
(2022)
Letter
Cardiac & Cardiovascular Systems
Georgios Zakynthinos, Gerasimos Siasos, Evangelos Oikonomou, Maria Gazouli, Konstantinos Mourouzis, Marina Zaromitidou, Vasiliki Tsigkou, Evanthia Bletsa, Panagiota Stampouloglou, Stamatis Tsouroulas, Georgios Marinos, Konstantinos Vlasis, Manolis Vavuranakis, Christodoulos Stefanadis, Dimitris Tousoulis
HELLENIC JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Erika Rimondi, Annalisa Marcuzzi, Fabio Casciano, Gianluca Tornese, Agnese Pellati, Barbara Toffoli, Paola Secchiero, Elisabetta Melloni
Summary: This study demonstrates that vitamin D deficiency may contribute to the formation and instability of atheromatous plaques in mice, suggesting a potential role for vitamin D in preventing or delaying atheromatous disease in cardiovascular disorders. Further research is needed to fully understand the impact of vitamin D in cardiovascular diseases.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Review
Cardiac & Cardiovascular Systems
Dimitris Tsiachris, Ioannis Doundoulakis, Eirini Pagkalidou, Athanasios Kordalis, Spyridon Deftereos, Konstantinos A. Gatzoulis, Konstantinos Tsioufis, Christodoulos Stefanadis
Summary: Our network meta-analysis identified the most effective antiarrhythmics for pharmacologic cardioversion over different time settings, with intravenous vernakalant and flecainide showing the highest conversion rate within 4 hours. Flecainide, especially when compared to propafenone, demonstrated superiority for conversion rates within 12 hours, while amiodarone exhibited efficacy within 24 hours, particularly if ranolazine was added.
CARDIOVASCULAR DRUGS AND THERAPY
(2021)
Article
Gastroenterology & Hepatology
Corey J. Ketchem, Craig C. Reed, Zoe Stefanadis, Evan S. Dellon
Summary: The study evaluated the efficacy of a compounded fluticasone suspension for treating eosinophilic esophagitis, showing significant improvements in symptoms and endoscopic findings, with over a third of patients achieving histologic response.
DISEASES OF THE ESOPHAGUS
(2021)
Letter
Cardiac & Cardiovascular Systems
Dimitrios A. Vrachatis, George V. Giannopoulos, Sotiria G. Giotaki, Konstantinos Raisakis, Charalampos Kossyvakis, Konstantinos E. Iliodromitis, Bernhard Reimers, Dimitrios Tousoulis, Michael Cleman, Christodoulos Stefanadis, Alexandra Lansky, Spyridon G. Deftereos
HELLENIC JOURNAL OF CARDIOLOGY
(2021)
Review
Immunology
Joshua Adedeji Bolarin, Mercy Adaramodu Oluwatoyosi, Joshua Iseoluwa Orege, Emmanuel Ayodeji Ayeni, Yusuf Ajibola Ibrahim, Sherif Babatunde Adeyemi, Bashir Bolaji Tiamiyu, Lanre Anthony Gbadegesin, Toluwanimi Oluwadara Akinyemi, Chuks Kenneth Odoh, Happiness Ijeoma Umeobi, Adenike Bernice-Eloise Adeoye
Summary: This review outlines the usage of antiviral drugs, antibiotics, and immune-stimulants in managing SARS-CoV-2, as well as discussing potential drug interactions and monitoring methods.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Panagiota Pietri, Christodoulos Stefanadis
Summary: Cardiovascular aging and longevity are interconnected through various pathophysiological mechanisms, with factors like cardiometabolic disorders and genetic modulators playing significant roles. Understanding the genetic, molecular, and biochemical pathways of aging may lead to interventions that delay cardiovascular aging, potentially contributing to achieving longevity goals. Research on long-living populations helps translate these mechanisms into clinical data for further study.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Dimitris Tsiachris, Ioannis Doundoulakis, Panagiotis Tsioufis, Eirini Pagkalidou, Christos-Konstantinos Antoniou, Stefanos M. Zafeiropoulos, Konstantinos A. Gatzoulis, Konstantinos Tsioufis, Christodoulos Stefanadis
Summary: This systematic review compares the effectiveness and safety of class Ic agents for cardioversion of paroxysmal AF and finds that intravenous flecainide is the most effective option. Class Ic agents appear to be safe for pharmacologic cardioversion of AF regardless of the presence of SHD.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Economics
Jay Pil Choi, Christodoulos Stefanadis
Summary: This article examines tippy network markets that allow price discrimination and finds that under certain conditions, network competition may lead to a unique subgame-perfect equilibrium where the winner's identity is fully determined by its product features. The concept of the dominant value margin is introduced as a metric for the effectiveness of divide-and-conquer strategies. However, the outcome of a market where suppliers with larger dominant value margins can sell to all customers does not necessarily result in social efficiency.
INTERNATIONAL ECONOMIC REVIEW
(2022)
Letter
Cardiac & Cardiovascular Systems
Christodoulos Stefanadis, Christina Chrysohoou, Dimitrios Tsiachris, Christos-Konstantinos Antoniou, Panagiota Manolakou, Gerasimos Siasos, Konstantinos Tsioufis, George Panagiotakopoulos, Theoklis Zaoutis, Demosthenes Panagiotakos
HELLENIC JOURNAL OF CARDIOLOGY
(2022)
Letter
Cardiac & Cardiovascular Systems
Dimitrios Tsiachris, Grigorios Chatzantonis, Christos-Konstantinos Antoniou, Haris Lalos, Gregory C. Bogdanis, Pantelis Nikolaou, Anastasios Spanos, Stefanos Karagiannis, Costas Tsiou, Ali Yilmaz, Christodoulos Stefanadis
HELLENIC JOURNAL OF CARDIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Dimitris Tsiachris, Ioannis Doundoulakis, Christos-Konstantinos Antoniou, Eirini Pagkalidou, Stefanos Zafeiropoulos, Athanasios Kordalis, Konstantinos A. Gatzoulis, Gian-Battista Chierchia, Carlo de Asmundis, Konstantinos Tsioufis, Christodoulos Stefanadis
Summary: This study conducted a systematic review and meta-analysis to evaluate the effectiveness and safety of a time to isolation (TTI)-based strategy of cryoballoon ablation (CBA) in the treatment of atrial fibrillation. The results suggest that an individualized CBA dosing strategy based on TTI and extended duration of CBA can reduce recurrence post-AF ablation and decrease procedure time and incidence of phrenic nerve palsy.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Dimitrios Tsiachris, Christos-Konstantinos Antoniou, Ioannis Doundoulakis, Panagiota Manolakou, Athanasios Kordalis, Dimitrios Konstantinou, Konstantinos Gatzoulis, Konstantinos Tsioufis, Christodoulos Stefanadis
Summary: This study compared the clinical outcomes of a three-dimensional electroanatomical mapping (3D-EAM)-based strategy targeting slow pathway (SP) elimination with the conventional fluoroscopic approach in atrioventricular node reentrant tachycardia (AVNRT) ablation. The results showed that 3D-EAM improved procedural parameters, reduced fluoroscopy time and dose, and increased SP elimination frequency. Follow-up results demonstrated lower recurrence rates and redo procedure rates in the 3D-EAM-based group.
JOURNAL OF ARRHYTHMIA
(2022)
Review
Cardiac & Cardiovascular Systems
Dimitrios Tsiachris, Christos-Konstantinos Antoniou, Ioannis Doundoulakis, Panagiota Manolakou, Demetrios Sougiannis, Athanasios Kordalis, Konstantinos A. Gatzoulis, Gian-Battista Chierchia, Carlo de Asmundis, Christodoulos Stefanadis, Konstantinos Tsioufis
Summary: Nowadays, cryoballoon (CB) has become an established alternative to radio frequency (RF) ablation for pulmonary vein isolation (PVI), with the ability to isolate PVs in a single application. In a study on over 1000 consecutive patients, our center optimized the CB PVI procedure. It is expected that future guidelines will recommend CB as the first-line PVI for patients with paroxysmal AF and a class I indication. In a long-term follow-up of the EARLY-AF trial, CB showed a lower incidence of persistent atrial fibrillation compared to anti-arrhythmic drugs.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)