Review
Infectious Diseases
Zhenwang Nie, Tao Sun, Fangcheng Zhao
Summary: The efficacy and safety of antiviral drugs in the treatment of COVID-19 were investigated. A total of 21 studies involving 2118 patients were included in the systematic review. The evaluated antiviral drugs did not show superior efficacy for treating COVID-19 in clinical trials. Lopinavir/ritonavir had gastrointestinal side effects and redsivir had serious side effects. It was found that there is no specific drug for treating COVID-19 and antiviral drugs have a greater therapeutic benefit for mild and usual patients.
INFECTION AND DRUG RESISTANCE
(2022)
Review
Pharmacology & Pharmacy
Ling Ye, Shicheng Fan, Pengfei Zhao, Chenghua Wu, Menghua Liu, Shuang Hu, Peng Wang, Hongyu Wang, Huichang Bi
Summary: COVID-19, caused by SARS-CoV-2, has led to a high demand for effective treatments. Antiviral drugs and traditional Chinese medicine formulas have been widely used. However, the potential interactions between these drugs and formulas are currently lacking information. This study aims to summarize and highlight the potential interactions between them, providing useful information for clinical medication.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Virology
Sherif Abbass, Ehab Kamal, Mohsen Salama, Tary Salman, Alyaa Sabry, Wael Abdel-Razek, Sherine Helmy, Ahmed Abdelgwad, Neamt Sakr, Mohamed Elgazzar, Mohamed Einar, Mahmoud Farouk, Mounir Saif, Ismail Shehab, Eman El-Hosieny, Mai Mansour, Doaa Mahdi, El-Sayed Tharwa, Mostafa Salah, Ola Elrouby, Imam Waked
Summary: This study demonstrated the efficacy and safety of using sofosbuvir in combination with daclatasvir as an adjunct therapy for patients with moderate to severe COVID-19 infections. The treatment resulted in reduced symptoms, improved oxygen saturation levels, and lower rates of ICU admission and mechanical ventilation.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Karthik Vivekanandhan, Poornima Shanmugam, Hamed Barabadi, Vigneshwaran Arumugam, Dharun Daniel Raj Daniel Paul Raj, Manikandan Sivasubramanian, Subbaiya Ramasamy, Krishnan Anand, Pandi Boomi, Balakumar Chandrasekaran, Selvaraj Arokiyaraj, Muthupandian Saravanan
Summary: COVID-19 has emerged rapidly and disrupted immunization services, causing fear among people worldwide. Research suggests that antiviral drugs like remdesivir, favipiravir, and peptide-based vaccines may be potential candidates for treating SARS-CoV-2, but clinical trials are crucial for validation.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Review
Medicine, General & Internal
Ningkun Xiao, Xinlin Huang, Xiaotian Kang, Wanli Zang, Bo Li, Sergey Kiselev
Summary: Background: Recent trials have shown the potential of oral antiviral VV116 in treating mild COVID-19 patients. However, the safety and efficacy of VV116 have not been comprehensively assessed. Therefore, we conducted a systematic review to evaluate the safety and efficacy of VV116. Methods: A thorough search was performed on PubMed, Scopus, and Google Scholar websites to identify relevant studies. Results: The results from the 3 included studies showed no serious adverse events in the VV116 experimental groups. These groups had a faster viral shedding time by 2.57 days compared to the control group and were non-inferior to the nirmatrelvir-ritonavir control group in alleviating major symptoms. Discussion: Available studies suggest a reliable safety and efficacy profile for VV116. However, the limited number of trials and the exclusion of elderly individuals severely affected by COVID-19 raise the need for more research to establish a more reliable safety and efficacy profile for VV116, especially in severe or critical patients.
Article
Medicine, General & Internal
Summary: The authors of the study reported the interim results of using four repurposed antiviral drugs (remdesivir, hydroxychloroquine, lopinavir, and interferon beta-1a) in hospitalized COVID-19 patients. The study showed that these drug regimens had little or no effect on overall mortality, initiation of ventilation, and duration of hospital stay.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Zhongmin Tang, Xingcai Zhang, Yiqing Shu, Ming Guo, Han Zhang, Wei Tao
Summary: In response to the COVID-19 pandemic, nanotechnology plays a significant role in antiviral research, particularly in drug and vaccine delivery, interference in the virus life cycle, and pneumonia treatment.
Review
Immunology
Bhaswati Chatterjee, Suman S. Thakur
Summary: The SARS-CoV-2 virus uses an enzyme called RNA-dependent RNA polymerase (RdRp) for replication, which can be inhibited by Remdesivir. The combination treatment of Remdesivir with Baricitinib has shown better results in treating COVID-19, reducing recovery time and mortality rate. Simultaneously targeting virus replication enzymes and host human kinases may be the future strategy for SARS-CoV-2 therapeutics.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Peter Breining, Anne Lier Frolund, Jesper Falkesgaard Hojen, Jesper Damsgaard Gunst, Nina B. Staerke, Eva Saedder, Manuel Cases-Thomas, Paul Little, Lars Peter Nielsen, Ole S. Sogaard, Mads Kjolby
Summary: Camostat mesylate is a potent inhibitor of the serine protease TMPRSS2, effectively hindering virus-cell membrane fusion and replication, reducing viral load, and potentially improving patient outcomes. Ongoing clinical trials are investigating its potential as an antiviral agent against COVID-19.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2021)
Review
Cell Biology
Monika Kumari, Ruei-Min Lu, Mu-Chun Li, Jhih-Liang Huang, Fu-Fei Hsu, Shih-Han Ko, Feng-Yi Ke, Shih-Chieh Su, Kang-Hao Liang, Joyce Pei-Yi Yuan, Hsiao-Ling Chiang, Cheng-Pu Sun, I-Jung Lee, Wen-Shan Li, Hsing-Pang Hsieh, Mi-Hua Tao, Han-Chung Wu
Summary: The COVID-19 pandemic continues to be a global health crisis, and while vaccines and therapeutics have been developed, challenges remain in addressing the effectiveness against new variants and supporting clinical trials.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Renata Esposito, Davida Mirra, Liberata Sportiello, Giuseppe Spaziano, Bruno D'Agostino
Summary: This article summarizes the importance of vaccines in fighting the COVID-19 outbreak, while also pointing out the issues with the rapid spread and drug resistance of new variants. Research also suggests that combination therapy and targeting new treatment points are crucial for enhancing vaccine efficacy and reducing drug resistance.
Review
Medicine, Research & Experimental
Roberto Barbosa Bazotte, Sandro Massao Hirabara, Tamires Afonso Duarte Serdan, Raquel Bragante Gritte, Talita Souza-Siqueira, Renata Gorjao, Laureane Nunes Masi, Marina Masetto Antunes, Vinicius Cruzat, Tania Cristina Pithon-Curi, Rui Curi
Summary: Quinine, originally extracted from the bark of Chinchona trees, has been used for treating fever since the seventeenth century. Compounds derived from quinine, such as chloroquine and hydroxychloroquine, are being studied worldwide for treating COVID-19, with some discrepancies in clinical trial outcomes. The potential underlying molecular mechanisms of how CQ and HCQ inhibit viral replication may lead to the development of novel drugs to combat COVID-19.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Infectious Diseases
Gangireddy Navitha Reddy, Akanksha Jogvanshi, Sana Naikwadi, Rajesh Sonti
Summary: The emergence of the Omicron variant in late November 2021 marked another stage in the COVID-19 pandemic. Pfizer's antiviral drug Paxlovid, a combination of nirmatrelvir and ritonavir, received FDA Emergency Use Authorization and conditional marketing by the European Medical Agency for high-risk COVID-19 patients.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2023)
Review
Pharmacology & Pharmacy
Miguel Angel Martinez
Summary: This article discusses whether drug repurposing is the best strategy for developing effective therapies to treat COVID-19 and other viral human infections.
DRUG DISCOVERY TODAY
(2022)
Article
Pharmacology & Pharmacy
Yayun Liu, Shiyong Fan, Aijing Xu, Lingling Ge, Xinyu Wang, Xu Dong, Mingxiao Xu, Wenhan Fan, Wu Zhong, Xuesong Liang
Summary: This study investigated the viral replication inhibitory effect of molnupiravir in patients with Omicron variant vaccine breakthrough COVID-19 infection. The results showed that molnupiravir can effectively shorten the viral clearance time, especially in patients who started treatment early and in those who have been vaccinated.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Plant Sciences
Hua-Jie Zhang, Xu Zhang, Jacob B. Landis, Yan-Xia Sun, Jiao Sun, Tian-Hui Kuang, Li-Juan Li, Bashir B. Tiamiyu, Tao Deng, Hang Sun, Heng-Chang Wang
Summary: In this study, we sequenced and compared plastomes of Rheum species to gain insights into their phylogenetic relationships, genome structure, and origin. Our findings provide valuable genomic resources and contribute to further research on Rheum.
JOURNAL OF SYSTEMATICS AND EVOLUTION
(2022)
Article
Environmental Sciences
Omoyemi Oluwatosin Ajayi, Abdullahi Tunde Aborode, Joshua Iseoluwa Orege, Tolulope Oyelekan Oyewumi, Amina Othmani, Mary Adeola Adegbola, Odunola Blessing Orege
Summary: This paper examines the potential health risks of heavy metal exposure from contaminated indoor dust in tertiary institutions in Ondo State, Nigeria. The results indicate that the concentrations of heavy metals in the dust samples are not carcinogenic and the calculated risk indices are below the safety limits. The implementation of strict safety regulations is recommended to protect human health.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Chemistry, Physical
Joshua Iseoluwa Orege, Jian Wei, Yu Han, Meng Yang, Xingtao Sun, Jixin Zhang, Cederick Cyril Amoo, Qingjie Ge, Jian Sun
Summary: We report a Sr and Na co-decorated Fe catalyst that can synthesize high-valued olefins in a stable manner for over 500 hours. The excellent catalytic performance is attributed to the cooperative effect of Sr and Na on different sites in the catalyst.
APPLIED CATALYSIS B-ENVIRONMENTAL
(2022)
Article
Chemistry, Applied
Emmanuel Ayodeji Ayeni, Chao Ma, Yong-Mei Zhang, Wen-Qin Fan, Xun Liao
Summary: The rhizome tuber of Sauromatum giganteum, known as 'Bai Fuzi' in China, contains various compounds that have inhibitory effects on MAO-B and protective effects on PC-12 cells. These findings suggest the potential of Sauromatum giganteum as an anti-Parkinson's disease herb.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Toluwanimi O. Akinyemi, Olatunji M. Omisore, Xingyu Chen, Wenke Duan, Wenjing Du, Guanlin Yi, Lei Wang
Summary: Robot-assisted surgery plays a crucial role in minimally invasive treatments. This study aims to achieve autonomous navigation in robot-assisted cardiac interventions and enhance motion accuracy using recurrent neural networks for control. The results show that neural-based controllers can ensure uniform motion mapping between the master-slave devices and positively contribute to patient safety concerns.
APPLIED SCIENCES-BASEL
(2022)
Article
Computer Science, Artificial Intelligence
Olatunji Mumini Omisore, Toluwanimi Oluwadara Akinyemi, Wenjing Du, Wenke Duan, Rita Orji, Thanh Nho Do, Lei Wang
Summary: This study proposes a weighting-based deep ensemble model for recognizing hand motions in intravascular catheterization. The model extracts features from electromyography data and uses machine learning methods to classify hand gestures. Results show the model achieves high recognition performances and has stable performance across different hand motion classes.
IEEE TRANSACTIONS ON HUMAN-MACHINE SYSTEMS
(2023)
Article
Green & Sustainable Science & Technology
Ming-Hui Yan, Jie-Ying Si, Nian-Ci Dong, Bin-Wen Liu, Bashir B. Tiamiyu, Heng-Chang Wang, Hong-Yu Yuan
Summary: The potential habitat of the rare tree species Perkinsiodendron macgregorii is mainly located in seven southern provinces of China, and its distribution is expected to be minimally affected by future climate change.
Article
Materials Science, Multidisciplinary
Xingyu Chen, Yinan Chen, Wenke Duan, Toluwanimi Oluwadara Akinyemi, Guanlin Yi, Jie Jiang, Wenjing Du, Olatunji Mumini Omisore
Summary: Interventional therapy is an effective method for vascular-related diseases, but the lack of precise position control and force feedback remains a challenge. This study presents a master-slave VISR system that utilizes a fuzzy-PID controller and a neural network model to enhance navigation precision, response speed, and force measurement capabilities.
Article
Chemistry, Physical
Kingsley I. John, Aderemi T. Adeleye, Adewale G. Adeniyi, Luqman A. Sani, Solomon Abesa, Iseoluwa J. Orege, Abraham A. Adenle, Mohammed Elawad, Martins O. Omorogie
Summary: The choice of a suitable Zeolite template for photocatalyst composites is a major challenge. In this study, H-beta, H-MOR, and H-ZSM-5 Zeolites were investigated as potential templates, with H-MOR showing the highest performance in the removal of tetracycline molecules.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Applied
Joshua Iseoluwa Orege, Na Liu, Cederick Cyril Amoo, Jian Wei, Qingjie Ge, Jian Sun
Summary: A selective Ba and Na co-modified Fe catalyst enriched with Fe5C2 and Fe3C active sites exhibited high selectivity and stability for the synthesis of high-value olefins from CO2 hydrogenation. The combined effect of Ba and Na additives suppressed catalyst deactivation and stabilized FeCx sites. This study provides a strategy for the design of scalable Fe-based catalysts for the stable synthesis of high-value olefins.
JOURNAL OF ENERGY CHEMISTRY
(2023)
Review
Plant Sciences
Dwaipayan Sinha, Soumi Datta, Reema Mishra, Preeti Agarwal, Tripti Kumari, Sherif Babatunde Adeyemi, Arun Kumar Maurya, Sharmistha Ganguly, Usman Atique, Sanchita Seal, Laxmi Kumari Gupta, Shahana Chowdhury, Jen-Tsung Chen
Summary: Arsenic, a metalloid, is mainly found in soil and water. Excessive levels of arsenic are toxic to living organisms, making it a global concern. Humans can absorb arsenic through polluted water and contaminated food, while plants are more susceptible to arsenic poisoning due to their inability to move and their reliance on roots for nutrients. Arsenic competes with phosphorus and disrupts physiological processes in plants, leading to decreased yield and biomass. Various mitigation strategies, including agronomic practices and genetic manipulation, can help reduce arsenic absorption by plants and address the negative effects.
Article
Plant Sciences
Emmanuel Ayodeji Ayeni, Chao Ma, Yikao Hu, Xiaolin Bai, Yongmei Zhang, Xun Liao
Summary: This study found that the seeds of Nigella glandulifera contain Tauroside E and thymoquinone, which can inhibit monoamine oxidase B (MAO-B) and have therapeutic effects on Parkinson's disease.
Review
Multidisciplinary Sciences
Sherif Babatunde Adeyemi, Aishat Mojisola Akere, Joshua Iseoluwa Orege, Onome Ejeromeghene, Odunola Blessing Orege, Jubril Olayinka Akolade
Summary: Essential oils, which are volatile constituents found in aromatic plants, have been widely studied for their applications in food, agriculture, pharmaceutics, and cosmetics. Aromatherapy, using essential oils to treat various diseases, has been practiced for centuries. These oils possess pharmacological properties such as anticancer, antimicrobial, and anti-inflammatory activities, and can be used as nutraceuticals, green preservatives, and functional additives in foods. However, due to their physicochemical properties, delivering essential oils as chemotherapeutics is challenging. Nanotechnology provides a unique approach for formulating essential oils into polymeric nanoparticles for controlled and sustained release, enhancing their bioactivity and therapeutic efficacy.
Article
Engineering, Electrical & Electronic
Toluwanimi Oluwadara Akinyemi, Olatunji Mumini Omisore, Wenjing Du, Wenke Duan, Xing-Yu Chen, Guanlin Yi, Lei Wang
Summary: This study proposes a deep learning-based model for identifying operators' actions in robot-assisted percutaneous coronary intervention (R-PCI) trials. The model achieves a 92%-96% accuracy in identifying five actions across four clusters compared with a recognition performance of 83% when recognizing all six actions.
IEEE SENSORS JOURNAL
(2023)
Review
Cardiac & Cardiovascular Systems
Dimitrios Tsiachris, Christos-Konstantinos Antoniou, Ioannis Doundoulakis, Panagiota Manolakou, Demetrios Sougiannis, Athanasios Kordalis, Konstantinos A. Gatzoulis, Gian-Battista Chierchia, Carlo de Asmundis, Christodoulos Stefanadis, Konstantinos Tsioufis
Summary: Nowadays, cryoballoon (CB) has become an established alternative to radio frequency (RF) ablation for pulmonary vein isolation (PVI), with the ability to isolate PVs in a single application. In a study on over 1000 consecutive patients, our center optimized the CB PVI procedure. It is expected that future guidelines will recommend CB as the first-line PVI for patients with paroxysmal AF and a class I indication. In a long-term follow-up of the EARLY-AF trial, CB showed a lower incidence of persistent atrial fibrillation compared to anti-arrhythmic drugs.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)