Mitochondrial respiration and redox coupling in articular chondrocytes

Life-long caloric restriction does not alter the severity of age-related osteoarthritis

(2014) Jenna N. McNeill et al.   AGE

Emerging regulators of the inflammatory process in osteoarthritis

(2014) Ru Liu-Bryan et al.   Nature Reviews Rheumatology

Disruption of Sirt1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice

(2013) Tokio Matsuzaki et al.   ANNALS OF THE RHEUMATIC DISEASES

Hypoxia Promotes the Production and Inhibits the Destruction of Human Articular Cartilage

(2013) Brendan L. Thoms et al.   ARTHRITIS AND RHEUMATISM

Strain-dependent oxidant release in articular cartilage originates from mitochondria

(2013) M. J. Brouillette et al.   Biomechanics and Modeling in Mechanobiology

Metabolism of inflammation limited by AMPK and pseudo-starvation

(2013) Luke A. J. O'Neill et al.   NATURE

Proinflammatory Cytokines Stimulate Mitochondrial Superoxide Flashes in Articular Chondrocytes In Vitro and In Situ

(2013) Yongxing Cao et al.   PLoS One

Linked decreases in liver kinase B1 and AMP-activated protein kinase activity modulate matrix catabolic responses to biomechanical injury in chondrocytes

(2013) Freyr Petursson et al.   ARTHRITIS RESEARCH & THERAPY

Mitochondrial dysfunction in osteoarthritis is associated with down-regulation of superoxide dismutase 2

(2012) Christos Gavriilidis et al.   ARTHRITIS AND RHEUMATISM

Metabolic Plasticity in Stem Cell Homeostasis and Differentiation

(2012) Clifford D.L. Folmes et al.   Cell Stem Cell

High Dietary Fat Selectively Increases Catalase Expression within Cardiac Mitochondria

(2012) Paul M. Rindler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sirtuins mediate mammalian metabolic responses to nutrient availability

(2012) Angeliki Chalkiadaki et al.   Nature Reviews Endocrinology

Mitochondrial electron transport and glycolysis are coupled in articular cartilage

(2012) J.A. Martin et al.   OSTEOARTHRITIS AND CARTILAGE

SIRT1, a class III histone deacetylase, regulates TNF-α-induced inflammation in human chondrocytes

(2012) M.-H. Moon et al.   OSTEOARTHRITIS AND CARTILAGE

Chondrocyte AMP-activated protein kinase activity suppresses matrix degradation responses to proinflammatory cytokines interleukin-1β and tumor necrosis factor α

(2011) Robert Terkeltaub et al.   ARTHRITIS AND RHEUMATISM

The role of mitochondria in osteoarthritis

(2011) Francisco J. Blanco et al.   Nature Reviews Rheumatology

AMPK Is a Direct Adenylate Charge-Regulated Protein Kinase

(2011) J. S. Oakhill et al.   SCIENCE

Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease

(2010) J. L. Scott et al.   ANNALS OF THE RHEUMATIC DISEASES

EPR detection of cellular and mitochondrial superoxide using cyclic hydroxylamines

(2010) Sergey I. Dikalov et al.   FREE RADICAL RESEARCH

Inhibition of Hypoxia-inducible Factor-targeting Prolyl Hydroxylase Domain-containing Protein 2 (PHD2) Enhances Matrix Synthesis by Human Chondrocytes

(2010) Brendan L. Thoms et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptional regulation of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis development

(2010) Taku Saito et al.   NATURE MEDICINE

Hypoxia-inducible factor-2α is a catabolic regulator of osteoarthritic cartilage destruction

(2010) Siyoung Yang et al.   NATURE MEDICINE

Mechanical impact induces cartilage degradation via mitogen activated protein kinases

(2010) L. Ding et al.   OSTEOARTHRITIS AND CARTILAGE

Lipid metabolism and osteoarthritis: Lessons from atherosclerosis

(2010) Vasiliki Gkretsi et al.   PROGRESS IN LIPID RESEARCH

Regulation of autophagy in human and murine cartilage: Hypoxia-inducible factor 2 suppresses chondrocyte autophagy

(2009) Jolene Bohensky et al.   ARTHRITIS AND RHEUMATISM

Knee osteoarthritis in obese women with cardiometabolic clustering

(2009) Maryfran Sowers et al.   ARTHRITIS AND RHEUMATISM

Regulation of superoxide dismutase genes: Implications in disease

(2009) Lu Miao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Regulation of Hypoxia-Inducible Factor 2  Signaling by the Stress-Responsive Deacetylase Sirtuin 1

(2009) E. M. Dioum et al.   SCIENCE

Impaired glucose transporter-1 degradation and increased glucose transport and oxidative stress in response to high glucose in chondrocytes from osteoarthritic versus normal human cartilage

(2009) Susana C Rosa et al.   ARTHRITIS RESEARCH & THERAPY

Mitochondrial DNA haplogroups: Role in the prevalence and severity of knee osteoarthritis

(2008) Ignacio Rego-Pérez et al.   ARTHRITIS AND RHEUMATISM

Mitochondrial Dysregulation of Osteoarthritic Human Articular Chondrocytes Analyzed by Proteomics

(2008) Cristina Ruiz-Romero et al.   MOLECULAR & CELLULAR PROTEOMICS

Interleukin-1β and interleukin-6 disturb the antioxidant enzyme system in bovine chondrocytes: a possible explanation for oxidative stress generation

(2008) M. Mathy-Hartert et al.   OSTEOARTHRITIS AND CARTILAGE

Proteomic analysis of human osteoarthritic chondrocytes reveals protein changes in stress and glycolysis

(2008) Cristina Ruiz-Romero et al.   PROTEOMICS

Metabolic Flexibility Permits Mesenchymal Stem Cell Survival in an Ischemic Environment

(2008) Louise A. Mylotte et al.   STEM CELLS