Article
Genetics & Heredity
Nasmah K. Bastaki, Taybha A. Albarjas, Fatma A. Almoosa, Amani M. Al-Adsani
Summary: Chronic heat stress during summer is a major challenge imposed by global warming, and chickens are more susceptible to heat stress due to the lack of sweat glands. This study investigated the expression levels of HSP27, HSP40, HSP60, HSP70, and HSP90 in the retina under chronic heat stress and revealed that HSP gene expression can be used as a biomarker for chronic heat stress in the retina.
FRONTIERS IN GENETICS
(2023)
Article
Biochemistry & Molecular Biology
V. Sudhakar Reddy, S. Pandarinath, M. Archana, G. Bhanuprakash Reddy
Summary: Chronic hyperglycemia induces differential responses of sHsps by altering their expression, solubility, interaction, and roles in apoptosis in neuronal cells, potentially contributing to cell death.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Oncology
Denise Traxler, Matthias Zimmermann, Elisabeth Simader, Elisa Einwallner, Dragan Copic, Alexandra Graf, Thomas Mueller, Cecilia Veraar, Mitja Lainscak, Robert Marcun, Mitja Kosnik, Matjaz Flezar, Ales Rozman, Peter Korosec, Walter Klepetko, Bernhard Moser, Hendrik J. Ankersmit
Summary: The study investigated the trajectory of fractional HSP27 urine excretion after acute exacerbation in COPD patients. It found that HSP27 urine excretion increased after exacerbation, especially in severe cases, and was associated with disease severity. Patients with lower HSP27 urine excretion levels showed significantly worse short-term survival outcomes.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Plant Sciences
Adity Majee, Diksha Kumari, Vidhu A. Sane, Rajesh Kumar Singh
Summary: The thermotolerant ability of heat shock factors (HSFs) and heat shock proteins (HSPs) in plants has been studied, with recent focus on their function in non-stress plant growth and development. Their involvement in flowering has been suggested, as lower levels of HSFs/HSPs affect flowering in Arabidopsis. Genetic and molecular studies of Arabidopsis mutants have identified an association between HSFs/HSPs and temperature-mediated regulation of flowering, but the underlying genetic mechanism remains unclear. This article outlines the possible integration between HSFs/HSPs and temperature-dependent pathways in plants regulating flowering, and discusses similar pathways in thermoperiodic geophytic plants.
Article
Agriculture, Dairy & Animal Science
Zhaoxin Jing, Qianyu Chen, Chaozhan Yan, Chaoyang Zhang, Zihan Xu, Xiaoli Huang, Jiayun Wu, Yunkun Li, Shiyong Yang
Summary: Chronic heat stress caused by global warming has serious implications for fish survival, affecting the kidney with inflammatory cell infiltration, increased apoptotic cell numbers, elevated plasma creatinine levels, and increased expression of heat shock protein GRP75.
Review
Agriculture, Dairy & Animal Science
Suriya Kumari Ramiah, Krishnan Nair Balakrishnan, Yashini Subramaniam, Oluwaseun Serah Iyasere, Zulkifli Idrus
Summary: Temperature manipulation during embryogenesis enhances the adaptability of chickens to heat stress and regulates the expression of heat stress response genes. Study of heat shock proteins, antioxidants, and immunological genes provides insights into the mechanisms of this adaptability.
Review
Plant Sciences
Baptiste Bourgine, Anthony Guihur
Summary: Heat stress events limit crop productivity, leading plants to accumulate heat-shock proteins (HSPs) for thermal protection. HSP chaperones play a critical role in regulating protein folding and preventing misfolded protein formation, thereby avoiding heat-induced cell death. The HSP20 family is tightly repressed at low temperatures, suggesting a costly mechanism that can become detrimental under unnecessary conditions.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
Emre Yilmaz, Mehmet Gul
Summary: This study evaluated the impact of cumin essential oil supplementation on gene expression related to antioxidant, apoptotic, detoxification, and heat shock mechanisms in heat-stressed broilers. The results showed that cumin essential oil had a dose-dependent positive effect on certain genes and downregulated these genes in the tissues of heat-stressed broilers.
ANIMAL BIOTECHNOLOGY
(2022)
Article
Cell & Tissue Engineering
Ju-Fang Liu, Po-Chun Chen, Thai-Yen Ling, Chun-Han Hou
Summary: This study demonstrates that heat shock induces the expression of HSPs in hPDMCs through the activation of ROS, p38 MAPK, Akt signaling, and HSF1, which plays a protective role.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Cell Biology
Ariadni Androvitsanea, Kostas Stylianou, Eleni Drosataki, Ioannis Petrakis
Summary: Research has shown that heat-shock proteins can have varying effects on the immune system, either triggering immune responses or alleviating them, which is important for studying and treating autoimmune diseases.
Article
Environmental Sciences
Tingting Ma, Yanjuan Ding, Fengjiao Xu, Chen Zhang, Min Zhou, Ya Tang, Yanrong Chen, Yating Wen, Rufei Chen, Bin Tang, Shigui Wang
Summary: The dragonfly species Orthetrum albistylum can accumulate heavy metals, and its heat shock protein genes have the potential to serve as biomarkers for monitoring environmental pollutants.
ENVIRONMENTAL POLLUTION
(2024)
Article
Biology
Mate Mackei, Gabor Matis, Andor Molnar, Csilla Sebok, Julia Voroshazi, Laszlo Pal, Karoly Dublecz, Ferenc Husveth, Zsuzsanna Neogrady
Summary: The liver was found to be the most susceptible to heat-provoked oxidative stress, with rapid activation of protective pathways and the involvement of sHSP-s leading to an over-compensation mechanism.
JOURNAL OF THERMAL BIOLOGY
(2021)
Article
Plant Sciences
Anthony Guihur, Bruno Fauvet, Andrija Finka, Manfredo Quadroni, Pierre Goloubinoff
Summary: In the scorching summer dawn, land plants establish molecular defenses to prepare for extreme midday temperatures, inducing heat-shock proteins for acquired thermotolerance. Despite high protein crowding, heat priming did not accumulate HSP chaperones in chloroplasts, while HSP20s accumulated in the cytosol, suggesting their role in preventing heat-labile protein aggregation.
PLANT CELL AND ENVIRONMENT
(2021)
Article
Multidisciplinary Sciences
Ahmed Barakat, Even Birkeland, Melissa D. Jorstad, Magalie El Hajj, Msafiri Marijani, Anne Doskeland, Olav Mjaavatten, Frode S. Berven, Tehmina Mustafa
Summary: This study investigated the proteomic profile of PBMCs in pulmonary tuberculosis (PTB) patients to predict treatment response. Blood samples were collected from 8 adult PTB patients in Tanzania at baseline, 2 months of treatment, and treatment completion. Proteins extracted from PBMCs were quantified and analyzed using LC-MS/MS. The results identified differentially expressed proteins involved in cellular processes, metabolic processes, binding, and catalytic activity, suggesting that proteome analysis of PBMCs can be used as a novel technique to monitor anti-tuberculosis treatment response and gain insights into PTB.
Article
Ecology
A. A. Gaisina, A. A. Mekhtiev, A. N. Nurullayeva, G. M. Palatnikov, E. N. Shamilov
Summary: The suburbs of Baku, Azerbaijan have high levels of background gamma-radiation. This study investigated the impact of radiation on erythrocyte nuclear pathologies, levels of cytochrome P-450, and serotonin-modulating anticonsolidation protein (SMAP) in the tissues of hens living in settlements with different radiation levels. The results showed that higher radiation levels increased nuclear pathologies, upregulated tissue SMAP levels, and downregulated cytochrome P-450. Additionally, controlled dosage studies on rats found that SMAP administration provided significant protection to somatic cell nuclei from gamma-radiation.
Editorial Material
Cell Biology
Dan Wang, Jack Odle, Yulan Liu
Summary: The balance between self-renewal and differentiation of intestinal stem cells is crucial for intestinal epithelial homeostasis, regulated by dietary cues. Recent evidence suggests that metabolic pathways sense changes in nutritional status to control stem cell fate, potentially offering new insights for preventing intestinal diseases.
TRENDS IN CELL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Hao-Wei Chang, Nathan P. McNulty, Matthew C. Hibberd, David O'Donnell, Jiye Cheng, Vincent Lombard, Bernard Henrissat, Olga Ilkayeva, Michael J. Muehlbauer, Christopher B. Newgard, Michael J. Barratt, Xi Lin, Jack Odle, Jeffrey Gordon
Summary: The study found that microbiomes associated with diet restriction have specific features in amino acid metabolism, which affect ponderal growth and health. Experimental colonization of gnotobiotic mice further confirmed the impact of microbiomes on host energy metabolism and the selection of energy substrates.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Nutrition & Dietetics
John D. Sorkin, Mark Manary, Paul A. M. Smeets, Amanda J. MacFarlane, Arne Astrup, Ronald L. Prigeon, Beth B. Hogans, Jack Odle, Teresa A. Davis, Katherine L. Tucker, Christopher P. Duggan, Deirdre K. Tobias
Summary: This article discusses the appropriate use of P values in accordance with the scientific method, as well as increasing transparency and reproducibility in nutrition research. The proper use of P values and research transparency are crucial for building trust and ensuring the replicability of study results.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Review
Biochemistry & Molecular Biology
Elizabeth C. Rose, Jack Odle, Anthony T. Blikslager, Amanda L. Ziegler
Summary: This review summarizes the effects of probiotics and prebiotics on the intestinal epithelial barrier and non-epithelial barrier constituents, such as the enteric glial cell network, and investigates their potential therapeutic benefits in preventing and treating gastrointestinal diseases associated with impaired intestinal barrier function and dysbiosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Nutrition & Dietetics
Dan Wang, Pei Li, Jack Odle, Xi Lin, Jiangchao Zhao, Kan Xiao, Yulan Liu
Summary: Intestinal stem cells play a crucial role in maintaining intestinal epithelial homeostasis and disease development. Diet and nutrient-sensing pathways impact intestinal health by regulating the self-renewal and differentiation of intestinal stem cells.
NUTRITION RESEARCH REVIEWS
(2022)
Letter
Nutrition & Dietetics
John D. Sorkin, Mark Manary, Paul A. M. Smeets, Amanda J. MacFarlane, Arne Astrup, Ronald L. Prigeon, Beth B. Hogans, Jack Odle, Teresa A. Davis, Katherine L. Tucker, Christopher P. Duggan, Deirdre K. Tobias
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Review
Agriculture, Dairy & Animal Science
Brittany M. Pecoraro, Diego F. Leal, Alba Frias-De-Diego, Matthew Browning, Jack Odle, Elisa Crisci
Summary: Selenium is an essential trace mineral with strong antioxidant, anti-inflammatory, and potential antimicrobial capacities. It is primarily present in selenoproteins as selenocysteine, playing a crucial role in maintaining homeostasis. Dietary selenium supplementation, in both organic and inorganic forms, improves growth performance, immune function, and meat quality in food animals like pigs. Additionally, selenium exhibits antiviral activity by protecting immune cells and inhibiting viral replication. However, further in vivo and in vitro studies are needed to explore the full potential of selenium as an antiviral agent.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Timothy E. Boston, Feng Wang, Xi Lin, Suzanne Leonard, Sung Woo Kim, Denny McKilligan, Vivek Fellner, Jack Odle
Summary: The study examined the effects of supplementing piglets with a gruel feed before weaning. The results showed that piglets fed gruel had higher feed intake and body weight, and these effects were sustained after weaning. Additionally, the gruel feed had an impact on the intestinal health of the piglets.
Article
Biochemistry & Molecular Biology
Brandon Pike, Jinan Zhao, Julie A. Hicks, Feng Wang, Rachel Hagen, Hsiao-Ching Liu, Jack Odle, Xi Lin
Summary: This study investigated the effects of peroxisome proliferator-activated receptor alpha (PPARα) on carnitine status and intestinal fatty acid oxidation in neonates. Suckled newborn piglets were fed different diets with or without clofibrate, succinate+glycerol, tri-valerate, tri-hexanoate, or tri-2-methylpentanoate. Clofibrate increased carnitine concentrations in the liver and plasma, but had no effect in the intestine. TC5 and TMPA stimulated fatty acid oxidation, while TC6 had no effect. These results suggest that clofibrate improves carnitine status and increases fatty acid oxidation in neonates.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Brandon J. Eudy, Jack Odle, Xi Lin, Christian Maltecca, Kathleen R. Walter, Nathan P. McNulty, Vivek Fellner, Sheila K. Jacobi
Summary: This study evaluated the effects of arachidonate (ARA) and/or prebiotic oligosaccharide (PRE) supplementation in formula on the development of the microbial ecosystem and colonic health parameters. The results showed that PRE supplementation increased the abundance of specific bacterial genera and concentrations of short-chain fatty acids (SCFA), benefiting intestinal development. ARA supplementation increased the ARA content in the colonic mucosa and increased the unsaturation of fatty acids.
JOURNAL OF NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Feng Wang, Chaolai Man, Xiaoqiu Wang, Jack Odle, Christian Maltecca, Xi Lin
Summary: Maternal undernutrition during pregnancy can lead to severe fetal impairments, but the exact mechanisms are not fully understood. This study investigated the potential impacts of restricted nutrition on metabolic pathways in fetal pigs. The results revealed differential expression of mRNA and miRNA, as well as alterations in metabolic and signaling pathways. These findings provide valuable insights into the negative effects of maternal malnutrition on hepatic metabolism in full-term fetal pigs via miRNA-mRNA interactions.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Meeting Abstract
Agriculture, Dairy & Animal Science
Timothy E. Boston, Feng Wang, Lin Xi, Sung Woo Kim, Vivek Fellner, Mark F. Scott, Amanda L. Ziegler, Laurianne Van Landeghem, Anthony T. Blikslager, Jack Odle
JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
Jinan Zhao, Brandon Pike, Jin Huang, Zhihua Feng, Jack Odle, Xi Lin
Summary: Supporting the anaplerotic and ketogenic fatty acids (FA) could potentially impact FA oxidation and modify the metabolism of acetyl-CoA via alteration of tricarboxylic acid (TCA) cycle activity. However, it has no significant effect on the hepatic FA oxidative capacity induced by peroxisome proliferator-activated receptor-alpha (PPARa). The availability of carnitine is crucial for maintaining FA oxidation during the neonatal period.
Meeting Abstract
Agriculture, Dairy & Animal Science
Lin Xi, Feng Wang, Daisy Cagle, Yue Zhu, Jack Odle, Deyu Xie
JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Allergy
Lizette M. Cortes, David Brodsky, Celine Chen, Tiffany Pridgen, Jack Odle, Douglas B. Snider, Glenn Cruse, Arina Putikova, Mia Y. Masuda, Alfred D. Doyle, Benjamin L. Wright, Harry D. Dawson, Anthony Blikslager, Evan S. Dellon, Scott M. Laster, Tobias Kaser
Summary: This study aimed to establish swine as a large animal model for EoE and demonstrated that swine can develop immunological and pathological markers similar to human EoE after sensitization and challenge treatment.
FRONTIERS IN ALLERGY
(2022)