Article
Computer Science, Artificial Intelligence
Xiahan Chen, Weishen Wang, Yu Jiang, Xiaohua Qian
Summary: This paper proposes a deep learning model to predict lymph node metastasis in pancreatic cancer using multiphase CT. It overcomes the challenges of insufficient data and difficulty in feature extraction in fine-grained prediction with small sample sizes by employing a dual-transformation with contrastive learning framework.
MEDICAL IMAGE ANALYSIS
(2023)
Article
Urology & Nephrology
Kai Yao, Yue Chen, Yunlin Ye, Zhiming Wu, Dong Chen, Hui Han, Zaishang Li, Zhuowei Liu, Yanjun Wang, Zike Qin, Yonghong Li, Zhiyong Li, Fangjian Zhou
Summary: The study provides a detailed map of pelvic lymph node metastasis in patients with penile carcinoma, showing that the external iliac and obturator packages are most commonly involved. Pelvic lymph node metastasis is associated with advanced T-stage. Some patients have crossover metastasis.
JOURNAL OF UROLOGY
(2021)
Article
Oncology
Hao Cheng, Jin-Hong Xu, Xiao-Hong Kang, Xiao-Mei Liu, Hai-Feng Wang, Zhi-Xia Wang, Hao-Qi Pan, Qing-Qin Zhang, Xue-Lian Xu
Summary: The study aimed to develop a clinical model to accurately predict the risk of lymph node metastasis (LNM) in resectable pancreatic cancer (PC) patients. Six independent risk factors were identified and included in the nomogram, which showed good predictive performance in the internal and external validation groups.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Surgery
Shingo Seo, Kenichiro Uemura, Tatsuaki Sumiyoshi, Naru Kondo, Kenjiro Okada, Hiroyuki Otsuka, Yoshiaki Murakami, Shinya Takahashi
Summary: The optimal range of lymph-node dissection for pancreatic tail cancer remains uncertain. This study investigated the location and frequency of lymph-node metastases to determine the correct range of lymph-node dissection for pancreatic tail cancer. The results suggest that lymph-node dissection at stations 7, 8, and 9 may not be necessary for resectable pancreatic cancer confined to the tail.
Article
Oncology
Wenna Jiang, Weiwei Bai, Jianhua Li, Jing Liu, Kaili Zhao, Li Ren
Summary: LIF overexpression in pancreatic tumor tissues is associated with poorer overall survival and recurrence-free survival. Higher serum LIF levels in pancreatic cancer patients are more effective in predicting lymph node and distant metastasis compared to other biomarkers.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Multidisciplinary Sciences
Xiaodong Wang, Ying Chen, Yunshu Gao, Huiqing Zhang, Zehui Guan, Zhou Dong, Yuxuan Zheng, Jiarui Jiang, Haoqing Yang, Liming Wang, Xianming Huang, Lirong Ai, Wenlong Yu, Hongwei Li, Changsheng Dong, Zhou Zhou, Xiyang Liu, Guanzhen Yu
Summary: The study proposes a deep-learning framework to analyze lymph node whole-slide images, identifying lymph nodes and tumor regions, and revealing the importance of the tumor-area-to-MLN-area ratio (T/MLN) in predicting the prognosis of gastric cancer patients.
NATURE COMMUNICATIONS
(2021)
Review
Oncology
Yuhang Li, Yinghui Song, Yujing Zhang, Sulai Liu
Summary: This article discusses the lymph node pathways, metastatic directions, and treatment methods for gallbladder cancer, emphasizing the importance of developing individualized treatments for predicting the prognosis of patients with different lymph node conditions.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Ho-Kyoung Lee, Yoo-Seok Yoon, Ho-Seong Han, Jun Suh Lee, Hee Young Na, Soomin Ahn, Jaewoo Park, Kwangrok Jung, Jae Hyup Jung, Jaihwan Kim, Jin-Hyeonk Hwang, Jong-chan Lee
Summary: Unexpected para-aortic lymph node metastasis in pancreatic cancer surgery has a negative prognostic impact comparable to radiological PALN metastasis. Prompt pathologic evaluation and modification of surgical strategy is crucial for patients with unexpected PALN metastasis. Multivariable analysis showed positive PALN as a negative prognostic factor, emphasizing the importance of detecting and managing unexpected PALN enlargement during surgery.
Review
Medicine, Research & Experimental
Jiajing Sun, Sikai Wu, Zixian Jin, Sijia Ren, William C. Cho, Chengchu Zhu, Jianfei Shen
Summary: Lung cancer has high morbidity and mortality rates, with tumor metastasis being a significant risk factor for death. Even after complete removal of a tumor at an early stage, there is still a risk of recurrence. Lymph node micrometastasis has been found to be associated with poor prognosis, but predicting prognosis and choosing the appropriate surgical and postoperative adjuvant chemotherapy options remain challenging for clinicians.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Endocrinology & Metabolism
Yubo Sun, Wei Sun, Jingzhe Xiang, Hao Zhang
Summary: This study aimed to construct a nomogram that predicts central lymph node metastasis (CLNM) in T1-T2 papillary thyroid carcinoma (PTC) patients without lateral lymph node metastases (LLNM). The nomogram showed good accuracy and applicability in predicting CLNM in both internal and external validation.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Wanyao Duan, Wei Wang, Chiyi He
Summary: The study investigates the predictive significance of PALR for lymph node metastasis in patients with clinically node-negative colon cancer. Data from 800 patients who underwent surgery were reviewed and analyzed. PALR was identified as an independent predictor of LNM in patients with cN0 CC, and a nomogram incorporating PALR and other independent predictors showed good performance ability.
FRONTIERS IN ONCOLOGY
(2023)
Article
Immunology
Chao Yang, Fengyu Cao, Shuoyang Huang, Yongbin Zheng
Summary: This study identified crucial ECM-related genes responsible for LNM in CRC through multi-omics analysis, highlighting the impact of FSTL3 on LNM and prognosis in CRC, as well as its potential role in promoting an inhibitory immune microenvironment leading to chemoresistance but immunotherapy sensitivity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
HuiFang Lei, ShuXia Xu, XiaoDan Mao, XiaoYing Chen, YaoJia Chen, XiaoQi Sun, PengMing Sun
Summary: This study found that a high SII in EC patients was associated with LNM, and in combination with CA125, CA153, and LVSI could be used for diagnosing LNM. Additionally, SII was identified as a predictor for MI and higher pathological grade in young premenopausal EC patients.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Oncology
Keiichiro Kumamoto, Takashi Tasaki, Koji Ohnishi, Michihiko Shibata, Shohei Shimajiri, Masaru Harada, Yoshihiro Komohara, Toshiyuki Nakayama
Summary: The activation of immune cells in regional lymph nodes is associated with lymphocyte infiltration in primary cancer tissues, impacting cancer-specific survival in patients with gastric cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Nannan Lu, Changfang Fu, Lei Zhang, Yangyang You, Xiang Li, Qian Zhang, Pin Wang, Xinghua Han
Summary: A prognostic biomarker called LNPRS was developed for breast cancer patients with lymph node metastasis. It was found to be able to predict the overall survival of patients and guide the therapeutic decisions. The LNPRS was also associated with immune cell infiltration and had predictive value for chemotherapy and immunotherapy.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Carolyn Nessim, Chandrajit P. Raut, Dario Callegaro, Francesco Barretta, Rosalba Miceli, Mark Fairweather, Piotr Rutkowski, Jean-Yves Blay, Dirk Strauss, Ricardo Gonzalez, Nita Ahuja, Giovanni Grignani, Vittorio Quagliuolo, Eberhard Stoeckle, Antonino De Paoli, Venu G. Pillarisetty, Carol J. Swallow, Sanjay P. Bagaria, Robert J. Canter, John T. Mullen, Yvonne Schrage, Elisabetta Pennacchioli, Winan van Houdt, Kenneth Cardona, Marco Fiore, Alessandro Gronchi, Guy Lahat
Summary: This study evaluated perioperative morbidity after surgery for first locally recurrent retroperitoneal sarcoma, showing that a surgical approach to recurrent RPS is relatively safe and resection of recurrent RPS is a reasonable option. Efforts should be made to minimize the need for blood transfusions.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Karan Kohli, Venu G. Pillarisetty, Teresa S. Kim
Summary: Immune cell infiltration into solid tumors and their interactions with chemokine receptors play a crucial role in tumor growth and the balance between effector and immunosuppressive cells. This review discusses the implications of dysregulated chemokine signaling in the tumor microenvironment and the potential for targeting chemokine signaling in cancer immunotherapy.
CANCER GENE THERAPY
(2022)
Review
Surgery
Kevin P. Labadie, David J. Droullard, Alex W. Lois, Sara K. Daniel, Kathryn E. McNevin, Jaqueline Valdez Gonzalez, Yongwoo D. Seo, Kevin M. Sullivan, Kyle S. Bilodeau, Lindsay K. Dickerson, Alan F. Utria, John Calhoun, Venu G. Pillarisetty, Jonathan G. Sham, Raymond S. Yeung, James O. Park
Summary: Robotic hepatectomy (RH) is increasingly utilized for minor and major liver resections, with the IWATE criteria being developed to classify minimally invasive liver resections by difficulty. This study applied the IWATE criteria in RH and described perioperative and oncologic outcomes. Results showed a close association between the IWATE criteria and surgical outcomes of RH, with the majority of resections being parenchymal-sparing approaches.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Gastroenterology & Hepatology
Venu G. Pillarisetty, Arezou Abbasi, James O. Park, Jonathan G. Sham
Summary: A phase II single-arm trial of preoperative lanreotide (120 mg) in patients undergoing pancreatectomy showed significantly lower rates of CR-POPF compared to historical controls or published literature, supporting the need for a randomized controlled trial.
Article
Oncology
Harrison K. Chinn, Jennifer L. Gardell, Lisa R. Matsumoto, Kevin P. Labadie, Tara N. Mihailovic, Nicole A. P. Lieberman, Amira Davis, Venu G. Pillarisetty, Courtney A. Crane
Summary: This study demonstrates the engineering of human macrophages to conditionally express genes under hypoxic conditions, allowing for localized gene delivery in cancer. The engineered macrophages were able to express therapeutic proteins in a controlled manner, making them ideal vehicles for delivering payloads in hypoxic tissues.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Editorial Material
Surgery
Kristin E. Goodsell, Jeremy M. Sharib, Venu G. Pillarisetty, Jonathan G. Sham
AMERICAN JOURNAL OF SURGERY
(2023)
Article
Gastroenterology & Hepatology
Lindsay Kathleen Dickerson, Jason A. Carter, Karan Kohli, Venu G. Pillarisetty
Summary: The efficacy of antitumour immunity relies on complex cytokine networks, particularly the role of interleukins (ILs) in regulating tumour-infiltrating lymphocytes and shaping the tumour microenvironment. Understanding the specific effects of IL signalling provides opportunities to optimize IL networks and develop targeted immunotherapies. This review highlights the potential of IL-based treatments, with a focus on IL-2, IL-10, IL-12, and IL-15 in gastrointestinal malignancies.
Article
Biochemical Research Methods
Heidi L. Kenerson, Kevin M. Sullivan, Kevin P. Labadie, Venu G. Pillarisetty, Raymond S. Yeung
Summary: The protocol outlines steps for establishing slice cultures to investigate the response to chemotherapies, immunotherapies, or adoptive cell therapies in a variety of gastrointestinal malignancies. The culture conditions and treatment parameters can be modified for specific experiments, making the platform highly flexible and easy to manipulate. For more details, please refer to the mentioned studies.
Article
Cell Biology
Neda Jabbari, Heidi L. Kenerson, Christopher Lausted, Xiaowei Yan, Changting Meng, Kevin M. Sullivan, Priyanka Baloni, Dani Bergey, Venu G. Pillarisetty, Leroy E. Hood, Raymond S. Yeung, Qiang Tian
CELL REPORTS MEDICINE
(2020)
Meeting Abstract
Oncology
Kevin P. Labadie, Shannon A. Kreuser, Katherine J. Brempelis, Xiuyun Jiang, Sara K. Daniel, Courtney A. Crane, Venu G. Pillarisetty
Article
Oncology
Arezou Abbasi, Kristina M. Wakeman, Venu G. Pillarisetty
Meeting Abstract
Immunology
Shannon A. Kreuser, Katherine J. Brempelis, Kevin P. Ladabie, Courtney M. Cowan, Harrison K. Chinn, Amira Davis, Venu G. Pillarisetty, Courtney A. Crane
JOURNAL OF IMMUNOLOGY
(2020)
Correction
Biochemistry & Molecular Biology
Donnele Daley, Constantinos Pantelis Zambirinis, Lena Seifert, Neha Akkad, Navyatha Mohan, Gregor Werba, Rocky Barilla, Alejandro Torres-Hernandez, Mautin Hundeyin, Vishnu Raj Kumar Mani, Antonina Avanzi, Daniel Tippens, Rajkishen Narayanan, Jung-Eun Jang, Elliot Newman, Venu Gopal Pillarisetty, Michael Loran Dustin, Dafna Bar-Sagi, Cristina Hajdu, George Miller
Article
Oncology
Katherine J. Brempelis, Courtney M. Cowan, Shannon A. Kreuser, Kevin P. Labadie, Brooke M. Prieskorn, Nicole A. P. Lieberman, Chibawanye Ene, Kara W. Moyes, Harrison Chinn, Kole R. DeGolier, Lisa R. Matsumoto, Sara K. Daniel, Jason K. Yokoyama, Amira D. Davis, Virginia J. Hoglund, Kimberly S. Smythe, Stephanie D. Balcaitis, Michael C. Jensen, Richard G. Ellenbogen, Jean S. Campbell, Robert H. Pierce, Eric C. Holland, Venu G. Pillarisetty, Courtney A. Crane
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2020)
Meeting Abstract
Surgery
Sara Daniel, Kevin Michael Sullivan, Xiuyun Jiang, Heidi L. Kenerson, Alan Fremder Utria, Kevin Paul Labadie, Kimberly J. Riehle, Teresa S. Kim, Venu Gopal Pillarisetty, Raymond S. W. Yeung
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2020)