Article
Multidisciplinary Sciences
Ananya Agarwal, Orly Levitan, Helena Cruz de Carvalho, Paul G. Falkowski
Summary: Unlike most plants, unicellular algae can adapt to changes in irradiance within a few hours to days through an enigmatic signaling pathway that coordinates changes in plastid and nuclear gene expression. Functional studies on the model diatom, Phaeodactylum tricornutum, identified two potential signal transduction molecules responsible for photoacclimation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biotechnology & Applied Microbiology
David Fierli, Maria Elena Barone, Adam Mc Donnell, Thomas Conlon, Nicolas Touzet
Summary: This study found that applying blue light illumination and supplementing with plant hormones GA3 and ABA during the growth stage of marine diatom Phaeodactylum tricornutum can stimulate the synthesis of valuable metabolites and increase their yield. These findings are important for optimizing the timing of treatments to avoid deleterious effects on pigment and PUFA accumulation in cells.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2023)
Article
Plant Sciences
Jun Liu, Marc W. van Iersel
Summary: The study demonstrates that green light has lower photosynthetic efficiency at low light intensity, while it may have higher efficiency at high light intensity compared to red and blue light, due to its more uniform absorption throughout the leaves.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Engineering, Environmental
Zuyin Chen, Lihua Li, Lichong Hao, Yu Hong, Wencai Wang
Summary: This study assessed the effects of pristine polystyrene microplastics (pMPs) on Phaeodactylum tricornutum Bohlin. The results showed that microplastics had hormesis-like effects on microalgae growth, with the specific effects depending on the initial algae density and microplastics concentration. These findings are important for understanding the impact of microplastics on marine microalgae and aquatic ecosystems.
FRONTIERS OF ENVIRONMENTAL SCIENCE & ENGINEERING
(2022)
Article
Chemistry, Multidisciplinary
Xiaotian Han, Ting Zhao, Liyan He, Yanfen Jia, Ren-cheng Yu
Summary: Environmental factors, especially temperature and light, play a crucial role in the composition of lipid, protein, and carbohydrate in microalgae. FTIR spectrometry was used to detect biomacromolecules in Phaeodactylum tricornutum cells at different temperatures and illumination conditions. The results showed different patterns in biomacromolecule content at different temperatures, with 20°C being unique. The highest contents of biomacromolecules were observed at 2000 lx, while increasing illumination led to a decrease in content. The study demonstrated the potential of FTIR as a new technique for studying metabolic mechanisms.
Article
Biochemistry & Molecular Biology
Maofei Ren, Shanzhen Liu, Chengzhu Tang, Guiling Mao, Panpan Gai, Xiaoli Guo, Huabin Zheng, Qiyuan Tang
Summary: The purpose of this study was to investigate the effects of red and blue lights on the photomorphogenesis and photosynthetic traits of rice seedlings. The results showed that the combined application of red and blue lights could promote the growth of rice seedlings, enhance photosynthesis, and improve root characteristics and dry matter accumulation. Furthermore, the combination of red and blue lights could regulate gene expression related to photosynthesis and affect the activity of the Rubisco enzyme in rice leaves.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Shenrui Li, Xiaoyun Zheng, Qingshu Fang, Yifu Gong, Heyu Wang
Summary: By promoting photosynthetic activity in Phaeodactylum tricornutum, this study demonstrated the feasibility of increasing fucoxanthin bioaccumulation. The optimal concentration of the photosynthetic induction factor and time were determined to be 1 μg L-1 and 48 hours, respectively, leading to a significant increase in fucoxanthin content. Correlation analysis showed a positive relationship between fucoxanthin content and actual photosynthetic yield, indicating that photosynthesis plays a crucial role in fucoxanthin biosynthesis.
BIOPROCESS AND BIOSYSTEMS ENGINEERING
(2021)
Article
Biotechnology & Applied Microbiology
Liv Celin Kraemer, Daniel Wasser, Fabian Haitz, Bjoern Sabel, Claudia Buechel
Summary: This study demonstrates the potential of Phaeodactylum tricornutum as an efficient biofactory under mixotrophic conditions, by expressing the HUP1 protein to enable glucose uptake and increase biomass. The study also provides insights into the targeting pathway of plasma membrane transporters.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2022)
Article
Microbiology
Jian Liu, Weihua Yin, Xinya Zhang, Xuan Xie, Guanghui Dong, Yao Lu, Baoxiang Tao, Qiangbin Gong, Xinyan Chen, Chao Shi, Yuan Qin, Rensen Zeng, Dawei Li, Hongye Li, Chao Zhao, Huiying Zhang
Summary: This study investigated the effect of CHES-induced intracellular alkalization on lipid production in Phaeodactylum tricornutum. The results showed that CHES treatment significantly induced lipid accumulation by up-regulating genes involved in various metabolic pathways and enhancing enzyme activity. Furthermore, CHES treatment activated chloroplast-specific biological processes, redirecting carbon flux into lipid biosynthesis and stimulating de novo fatty acid biosynthesis.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Plant Sciences
Gabor Bernat, Tomas Zavrel, Eva Kotabova, Laszlo Kovacs, Gabor Steinbach, Lajos Voros, Ondrej Prasil, Boglarka Somogyi, Viktor R. Toth
Summary: The study found that Cyanobium gracile has different adaptive strategies under different light wavelengths to optimize its photosynthetic performance. Growth under blue and near far-red light leads to slower growth rates, while growth under orange or red light results in reduced cell volumes and lower electron transport rates.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Biotechnology & Applied Microbiology
Megumu Takahashi, Koji Mikami
Summary: Phycobilisomes in cyanobacteria, red algae and glaucophyte algae can absorb various light wavelengths to optimize photosynthesis. Research on the red alga Pyropia yezoensis showed that changes in light wavelength, specifically blue and red light, can modify the composition of phycobilisomes, resulting in reversible color changes in the algae. This blue-red chromatic acclimation in Pyropia yezoensis provides new insights into regulatory mechanisms for adjusting photosynthetic pigment contents in phycobilisomes of photosynthetic organisms.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2021)
Article
Plant Sciences
Yahan Su, Huan Yang, Yushan Wu, Wanzhuo Gong, Hina Gul, Yanhong Yan, Wenyu Yang
Summary: The ability of soybean to acclimate to changing light environments in relay intercropping is crucial for its growth and yield formation. This study compared the photosynthetic acclimation of two soybean varieties with contrasting shade tolerance and found that the shade-tolerant variety displayed better adaptation to variations in light conditions and had higher growth and yield potential.
Article
Environmental Sciences
Xiufen Wang, Yun Li, Shouxiang Wei, Luqing Pan, Jingjing Miao, Yufei Lin, Jiangyue Wu
Summary: The study showed that butyl acrylate had toxic effects on the photosynthetic systems of two marine microalgae, with Fv/Fm being a suitable indicator for evaluating its toxicity. The data obtained in this study could be used as a reference for assessing the impact of butyl acrylate on the photosynthetic capacity of marine microalgae when it enters the marine ecosystem.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Multidisciplinary Sciences
Osamu Kutomi, Ryosuke Yamamoto, Keiko Hirose, Katsutoshi Mizuno, Yuuhei Nakagiri, Hiroshi Imai, Akira Noga, Jagan Mohan Obbineni, Noemi Zimmermann, Masako Nakajima, Daisuke Shibata, Misa Shibata, Kogiku Shiba, Masaki Kita, Hideo Kigoshi, Yui Tanaka, Yuya Yamasaki, Yuma Asahina, Chihong Song, Mami Nomura, Mamoru Nomura, Ayako Nakajima, Mia Nakachi, Lixy Yamada, Shiori Nakazawa, Hitoshi Sawada, Kazuyoshi Murata, Kaoru Mitsuoka, Takashi Ishikawa, Ken-ichi Wakabayashi, Takahide Kon, Kazuo Inaba
Summary: A novel subunit named DYBLUP has been discovered to modulate dynein activity in animal spermatozoa and a unicellular green alga through connecting the f/I1 motor domain and the tether complex. Chlamydomonas lacking the DYBLUP ortholog showed both positive and negative phototaxis, but became acclimated and attracted to high-intensity blue light, suggesting a mechanism to avoid toxic strong light via direct photoregulation of dyneins.
Article
Biology
Sofie E. Voerman, Arvydas Ruseckas, Graham A. Turnbull, Ifor D. W. Samuel, Heidi L. Burdett
Summary: This study investigates the light harvesting mechanism and acclimatory response of the red coralline alga in the mesophotic zone. The results demonstrate that responsive light harvesting and functional acclimation are key to the success of red algae in this low light environment.
Article
Nutrition & Dietetics
Alon Kaplan, Hila Zelicha, Anat Yaskolka Meir, Ehud Rinott, Gal Tsaban, Gidon Levakov, Ofer Prager, Moti Salti, Yoram Yovell, Jonathan Ofer, Sebastian Huhn, Frauke Beyer, Veronica Witte, Arno Villringer, Nachshon Meiran, Tamar B. Emesh, Peter Kovacs, Martin von Bergen, Uta Ceglarek, Matthias Bluher, Michael Stumvoll, Frank B. Hu, Meir J. Stampfer, Alon Friedman, Ilan Shelef, Galia Avidan, Iris Shai
Summary: The study found that following a high-polyphenol, low red/processed meat (Green-MED) diet can slow down age-related brain atrophy, with more significant effects in participants over 50 years old. Results suggest that improving insulin sensitivity, increasing intake of Mankai, green tea, and walnuts, and reducing intake of red and processed meat are beneficial for reducing brain atrophy rate.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Environmental Sciences
J. L. Krause, B. Engelmann, U. Nunes da Rocha, A. Pierzchalski, H. D. Chang, A. C. Zenclussen, M. von Bergen, U. Rolle-Kampczyk, G. Herberth
Summary: This study compared the effects of BPA, BPF, and BPS on intestinal microbiota and immune cells. Results showed that BPA and BPF directly modulated MAIT cell responses at low concentrations, while high concentrations affected microbiota-mediated effects.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Environmental Sciences
Stefan Scholz, John W. Nichols, Beate Escher, Gerald T. Ankley, Rolf Altenburger, Brett Blackwell, Werner Brack, Lawrence Burkhard, Timothy W. Collette, Jon A. Doering, Drew Ekman, Kellie Fay, Fabian Fischer, Joerg Hackermueller, Joel C. Hoffman, Chih Lai, David Leuthold, Dalma Martinovic-Weigelt, Thorsten Reemtsma, Nathan Pollesch, Anthony Schroeder, Gerrit Schueuermann, Martin von Bergen
Summary: The concept of the eco-exposome, analogous to the human exposome, aims to describe the totality of internal exposure over the lifetime of ecologically relevant organisms and explore linking exposure to adverse effects. The study discusses methods and technologies using targeted and nontargeted chemical analyses and bioassays to characterize eco-exposome exposure.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2022)
Article
Gastroenterology & Hepatology
Laura Krieg, Konrad Didt, Isabel Karkossa, Stephan H. Bernhart, Stephanie Kehr, Narmadha Subramanian, Andreas Lindhorst, Alexander Schaudinn, Shirin Tabei, Maria Keller, Michael Stumvoll, Arne Dietrich, Martin von Bergen, Peter F. Stadler, Jurga Laurencikiene, Martin Krueger, Matthias Blueher, Martin Gericke, Kristin Schubert, Peter Kovacs, Rima Chakaroun, Lucas Massier
Summary: The study compared different fat depots in 70 obese patients undergoing Roux-en-Y gastric bypass surgery, revealing significant differences in metabolism and inflammatory pathways, with epiploic fat tissue showing the highest gene expression levels.
Article
Microbiology
Priyadarshini Dey, Anushree Malik, Dileep Kumar Singh, Sven-Bastiaan Haange, Martin von Bergen, Nico Jehmlich
Summary: This study investigated the cellular response of the fungus Aspergillus fumigatus PD-18 to multimetal stress using proteomics, revealing the inherent intracellular and extracellular metal resistance mechanisms of the fungus. The study identified a large number of proteins exclusively expressed in response to multimetal stress, providing insights into metal microbe interactions in the presence of multiple metals.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Melanie Brede, Sven-Bastiaan Haange, Susanne Riede, Beatrice Engelmann, Nico Jehmlich, Ulrike Rolle-Kampzczyk, Karl Rohn, Dirk von Soosten, Martin von Bergen, Gerhard Breves
Summary: The study evaluated the effects of glyphosate and its formulations on the fermentation pattern, community composition, and metabolic activity of the rumen microbiota. The results showed that the compounds did not have a significant impact on the rumen bacterial communities.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Charlotte M. Fries, Sven-Bastiaan Haange, Ulrike Rolle-Kampczyk, Andreas Till, Mathis Lammert, Linda Grasser, Evelyn Medawar, Arne Dietrich, Annette Horstmann, Martin von Bergen, Wiebke K. Fenske
Summary: Extreme weight responders to Roux-en-Y gastric bypass (RYGB) surgery exhibit differences in their metabolic outcomes and gut microbiota composition. Differences in weight loss did not reflect in metabolic outcome after RYGB. Fecal and circulating metabolite analyses showed variations in metabolite levels between different weight responders.
Article
Multidisciplinary Sciences
Joo-Han Gwak, Samuel Imisi Awala, Ngoc-Loi Nguyen, Woon-Jong Yu, Hae-Young Yang, Martin von Bergen, Nico Jehmlich, K. Dimitri Kits, Alexander Loy, Peter F. Dunfield, Christiane Dahl, Jung-Ho Hyun, Sung-Keun Rhee
Summary: This study reports the isolation of a new aerobic methanotrophic bacterium capable of oxidizing both methane and reduced sulfur compounds for growth. Genomic and proteomic analyses revealed its metabolic pathways for methane and sulfur oxidation. The discovery of this versatile bacterium highlights the intimate interactions of methane and sulfur cycles in the oxic-anoxic interface environments.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Marcus Nagel, Rocco Moretti, Ralf Paschke, Martin von Bergen, Jens Meiler, Stefan Kalkhof
Summary: This study reveals the role of the hinge region in hormone binding and signal transduction of the follicle-stimulating hormone receptor through experimentally driven full-length models. Important information such as the interface, side-chain interactions, and activation mechanism is obtained by molecular modeling and chemical crosslinking.
Article
Microbiology
Julia Muenzker, Nadine Haase, Andreas Till, Robert Sucher, Sven-Bastiaan Haange, Linda Nemetschke, Thorsten Gnad, Elisabeth Jaeger, Jiesi Chen, Sjaak J. Riede, Rima Chakaroun, Lucas Massier, Peter Kovacs, Mario Ost, Ulrike Rolle-Kampczyk, Nico Jehmlich, Juliane Weiner, John T. Heiker, Nora Kloeting, Gudrun Seeger, Markus Morawski, Verena Keitel, Alexander Pfeifer, Martin von Bergen, Joerg Heeren, Ute Kruegel, Wiebke K. Fenske
Summary: This study demonstrates the significant role of the gut microbiome in the energy and metabolic improvements achieved through gastric bypass surgery. By eliminating and transplanting the gut microbiota, the study identifies a signaling cascade involving altered bile acid receptor signaling that readjusts energy imbalance and metabolic diseases in obese hosts.
Article
Biochemistry & Molecular Biology
Lei Zhang, Marina Toplak, Raspudin Saleem-Batcha, Lars Hoeing, Roman Jakob, Nico Jehmlich, Martin von Bergen, Timm Maier, Robin Teufel
Summary: Antimicrobial resistance is a serious threat to human health, and understanding the underlying mechanisms is crucial. This study discovered and characterized oxidoreductases that inactivate the broad-spectrum antibiotic chloramphenicol through dual oxidation of the C3-hydroxyl group. These enzymes also enable the inactivation of related compounds but not the fluorinated derivative. Phylogenetic analyses suggest that distinct isofunctional enzymes evolved independently in Gram-positive and Gram-negative bacteria. Mechanistic and structural studies provide insights into the catalytic mechanisms of these enzymes, which have both negative and positive impacts on antibiotic resistance and chloramphenicol bioremediation.
Article
Ecology
Nelson Khan, Edward Muge, Francis J. Mulaa, Benson Wamalwa, Martin von Bergen, Nico Jehmlich, Lukas Y. Wick
Summary: Fungi play a crucial role in the biodegradation of soil organochlorine pesticides by facilitating bacterial dispersal and nutrient release. Experimental results indicate that the transfer of nutrients from fungi to bacteria can enhance the degradation of organic pollutants, highlighting the importance of fungal-bacterial interactions.
Article
Biochemical Research Methods
Lisa Hoefert, Susen Becker, Jan Dressler, Sven Baumann
Summary: The semisynthetic cannabinoid hexahydrocannabinol (HHC) is gaining attention due to its unclear legal status in many countries. This study developed a GC-MS method to quantify THC, 11-OH-THC, and THC-COOH, and extended it to (9R) and (9S)-HHC. The method was proven effective in analyzing serum/plasma samples from drivers suspected of cannabis consumption. HHC diastereomers were detected in a small percentage of traffic control samples, and cross-reactivity with other compounds was evaluated in different screening tests.
DRUG TESTING AND ANALYSIS
(2023)
Article
Ecology
Markus Krueger, Narendrakumar Chaudhari, Bo Thamdrup, Will A. Overholt, Laura A. Bristow, Martin Taubert, Kirsten Kuesel, Nico Jehmlich, Martin von Bergen, Martina Herrmann
Summary: The study reveals that complete ammonia-oxidizing bacteria (CMX) of the genus Nitrospira have a competitive advantage over ammonia-oxidizing bacteria (AOB) and archaea (AOA) in oligotrophic carbonate rock aquifers, due to their ecophysiological characteristics and wide occurrence in groundwater. However, their specific contribution to nitrification processes has been unclear. The research aimed to unravel the contribution of CMX, AOA, and AOB to nitrification and identify the environmental drivers of their niche differentiation in oligotrophic carbonate rock aquifers.
Letter
Critical Care Medicine
Silke Leonhardt, Sven Baumann, Christian Juergensen, Lars Hueter, Julia Leonhardt, Ketamine Cast Res Grp
INTENSIVE CARE MEDICINE
(2023)