Article
Chemistry, Multidisciplinary
Xuemei Liu, Geng Dou, Zihan Li, Xiangdong Wang, Ronghua Jin, Yao Liu, Huijuan Kuang, Xiaoyao Huang, Xiaoxue Yang, Xiaoshan Yang, Siying Liu, Meiling Wu, Hao Guo, Feng Ding, Haokun Xu, Shiyu Liu, Yan Jin, Kun Xuan
Summary: This study successfully promotes tissue regeneration in critical-sized bone defects and cutaneous wounds by manipulating the inflammatory responses, providing a new strategy for refractory wound therapy.
Article
Biochemistry & Molecular Biology
Chao Xu, Xiang-Fei Li, Liu-Ling Gao, Zhi-Rong Ding, Xiao-Ping Huang, Yuan-You Li, Di-Zhi Xie
Summary: This study characterized the full-length cDNA of thioredoxin-interacting protein (TXNIP) from Megalobrama amblycephala and investigated its roles in high glucose-induced inflammatory response. Txnip expression was found to increase in liver and white muscle under a high-carbohydrate diet, while insulin injection led to a decrease in txnip expression. In vitro studies showed that over-expression of txnip increased il-1 beta and il-6 expression in hepatocytes, while knockdown reduced il-1 beta expression. Metformin treatment increased cell viability and trx expression, and decreased ROS levels and other factors under high glucose conditions.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Je-Oh Lim, Se-Jin Lee, Woong-Il Kim, So-Won Pak, Jong-Choon Kim, Joong-Sun Kim, Young-Kwon Cho, In-Chul Lee, In-Sik Shin
Summary: The study showed that melatonin can reduce SiONPs-induced lung inflammation by downregulating the TXNIP/MAPKs/AP-1 signaling pathway, leading to decreased production of inflammatory mediators and accumulation of inflammatory cells.
Article
Biochemistry & Molecular Biology
Mengting Lin, Chengbei Bao, Lihong Chen, Shiling Geng, Haiqing Wang, Zhixun Xiao, Ting Gong, Chao Ji, Bo Cheng
Summary: The study shows that Tremella fuciformis polysaccharides (TFPS) can protect skin cells from damage caused by UV radiation and reduce oxidative stress. TFPS also regulates proteins associated with photoprotection, thereby alleviating UV-induced skin damage.
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
(2023)
Article
Medicine, Research & Experimental
Xuezhi Zhang, Cuiyu Chu, Yuankun Huang
Summary: Heart failure is the leading cause of death worldwide. Dehydrocostus lactone, an active compound in traditional Chinese medicine, has anti-inflammatory, antioxidant, and anti-cancer effects. However, its role in heart failure is still unclear.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Ryota Murata, Hiroshi Watanabe, Hiroto Nosaki, Kento Nishida, Hitoshi Maeda, Motohiro Nishida, Toru Maruyama
Summary: In this study, a long-acting Thioredoxin (Trx) was prepared by fusing human Trx with human serum albumin (HSA) and its efficacy in treating drug-induced heart failure was evaluated. The results showed that HSA-Trx administration suppressed the adverse effects of drug-induced cardiomyopathy, including heart weight decrease, myocardial fibrosis increase, and markers for myocardial damage. HSA-Trx also inhibited oxidative stress and inflammation, as well as the expression of myocardial atrophy factors. The findings suggest that HSA-Trx can improve the pathological condition associated with doxorubicin-induced cardiomyopathy.
Article
Multidisciplinary Sciences
Huan Chen, Min Li, Guang Qi, Ming Zhao, Longyu Liu, Jingyi Zhang, Gongyou Chen, Daowen Wang, Fengquan Liu, Zheng Qing Fu
Summary: The phytohormone salicylic acid (SA) plays a key role in plant defense against biotrophic and hemibiotrophic pathogens. NPR1 and EDS1 synergistically activate pathogenesis-related (PR) genes and plant defenses by forming a protein complex and recruiting Mediator. EDS1 functions as an autonomous transcriptional coactivator with intrinsic transactivation domains and physically interacts with the CDK8 subunit of Mediator.
Article
Biochemistry & Molecular Biology
Gang Nan, Shu-Hua Zhao, Ting Wang, Dong Chao, Ruo-Fei Tian, Wen-Jing Wang, Xin Fu, Peng Lin, Ting Guo, Bin Wang, Xiu-Xuan Sun, Xi Chen, Zhi-Nan Chen, Shi-Jie Wang, Hong-Yong Cui
Summary: This study investigates the role and mechanisms of CD147 in paclitaxel resistance. It demonstrates that CD147 protects cancer cells from paclitaxel-induced apoptosis and interacts with the C-terminal tail of RanBP1 to regulate microtubule stability and dynamics as well as response to paclitaxel treatment. Targeting CD147 may be a potential strategy for preventing paclitaxel resistance.
Article
Biology
Nikolai P. Jaschke, Sophie Paehlig, Anupam Sinha, Timon E. Adolph, Maria Ledesma Colunga, Maura Hofmann, Andrew Wang, Sylvia Thiele, Julian Schwaerzler, Alexander Kleymann, Marc Gentzel, Herbert Tilg, Ben Wielockx, Lorenz C. Hofbauer, Martina Rauner, Andy Goebel, Tilman D. Rachner
Summary: This study reveals the cell-autonomous function of Dickkopf1 (DKK1) in controlling inflammatory responses and maintaining the elevated inflammatory tone of cancer cells. It is found that genetic DKK1 variants are linked to elevated cytokine production in healthy populations, and genetic deletion of DKK1 can ameliorate inflammation and disease trajectories in a mouse model.
COMMUNICATIONS BIOLOGY
(2022)
Article
Cell Biology
Yang Wang, Xiang-Qian Kong, Fei Wu, Bin Xu, De-Jun Bao, Chuan-Dong Cheng, Xiang-Ping Wei, Yong-Fei Dong, Chao-Shi Niu
Summary: The SOCS1/JAK2/STAT3 axis is found to play a significant role in experimental subarachnoid hemorrhage by modulating inflammatory responses, early brain injury, and neuronal protection.
NEURAL REGENERATION RESEARCH
(2021)
Article
Multidisciplinary Sciences
Kyosuke Hattori, Nobunori Takahashi, Kenya Terabe, Yoshifumi Ohashi, Kenji Kishimoto, Yutaka Yokota, Mochihito Suzuki, Toshihisa Kojima, Shiro Imagama
Summary: This study demonstrated that TRPV4 activation has chondroprotective effects on articular cartilage stimulated with IL-1 beta by activating the CaMKK/AMPK pathway and suppressing the NF-kappa B pathway. The experimental data suggest that TRPV4 activators may offer a promising therapeutic option for preventing the progression of osteoarthritis.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Noor Hanisa Harun, Gabriele Ruth Anisah Froemming, Aletza Mohd Ismail, Hapizah Nawawi, Siti Shuhada Mokhtar, Suhaila Abd Muid
Summary: Oxidized HDL reduces the mineralization activity of human osteoblast cells by increasing the expression of inflammatory markers. Adiponectin and HDL have protective effects, increasing the expression of mineralization markers and significantly reducing the expression of inflammatory markers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Pin Gong, Dandan Cui, Yuxi Guo, Mengrao Wang, Zhineng Wang, Zihan Huang, Wenjuan Yang, Fuxin Chen, Xuefeng Chen
Summary: SGP-1-1 exhibited good inflammation-modulating activity in DN mouse models, alleviating cellular inflammation and tissue damage. Metabolomics analysis revealed potential biomarkers related to DN, and SGP-1-1 inhibited inflammation by regulating the TLR4-NF-kappa B pathway while promoting antioxidant activity.
Article
Biochemistry & Molecular Biology
Guangjin Chen, Qingming Tang, Shaoling Yu, Yufeng Shen, Jiwei Sun, Jinfeng Peng, Ying Yin, Guangxia Feng, Xiaofeng Lu, Gang Mei, Yifan Zhang, Qian Wan, Luoying Zhang, Lili Chen
Summary: Excessive exposure to artificial light at night (LAN) can damage the formation of cartilage and impair bone growth. This is due to downregulation of the core circadian clock protein BMAL1, which leads to collagen buildup in the endoplasmic reticulum (ER). Restoring BMAL1 signaling can rescue the dysregulation of cartilage formation caused by LAN exposure, suggesting a potential therapeutic approach for promoting bone growth.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Multidisciplinary Sciences
Kota Kokubo, Kiyoshi Hirahara, Masahiro Kiuchi, Kaori Tsuji, Yuki Shimada, Yuri Sonobe, Rie Shinmi, Takahisa Hishiya, Chiaki Iwamura, Atsushi Onodera, Toshinori Nakayama
Summary: CD4(+) memory T cells play a vital role in long-lasting protective immunity and the pathophysiology of chronic inflammation. However, the mechanisms controlling redox metabolism in memory T cell formation are still unclear. This study reveals that Thioredoxin-interacting protein (Txnip) regulates apoptosis and scavenges reactive oxygen species (ROS) through the Nrf2-Biliverdin reductase B pathway, thereby influencing chronic airway inflammation in the lung. The Txnip-Nrf2-Blvrb axis could be a potential therapeutic target for chronic inflammatory diseases.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Zoology
Masato Mori, Maria Narahashi, Tetsutaro Hayashi, Miyuki Ishida, Nobuyoshi Kumagai, Yuki Sato, Reza Bagherzadeh, Kiyokazu Agata, Takeshi Inoue
ZOOLOGICAL LETTERS
(2019)
Article
Cell Biology
Yuki Sato, Norito Shibata, Chikara Hashimoto, Kiyokazu Agata
Summary: Research on the migration of adult stem cells in vivo is hindered by the complexity of tissue structures and limited accessibility of the cells. In this study, two planarian homologous genes (MTA-A and MTA-B) were identified as being involved in neoblast migration. Knockdown of MTA-A disrupted homeostasis and regeneration, while knockdown of MTA-B inhibited neoblast migration. This study highlights the importance of MTA-A and MTA-B in maintaining tissue homeostasis and regeneration through neoblast migration.
DEVELOPMENT GROWTH & DIFFERENTIATION
(2022)
Article
Developmental Biology
Yuki Sato, Yoshihiko Umesono, Yoshihito Kuroki, Kiyokazu Agata, Chikara Hashimoto
Summary: The relationship between cell cycle exit and differentiation has been widely observed in stem cells and organisms, but the causal relationship is still unclear due to the complex regulation of the cell cycle. In this study, the planarian Dugesia japonica was used to investigate this relationship, and it was found that the cell cycle regulator Cdh1 plays a role in cell cycle exit and differentiation in this organism.
DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Yuki Sato, Izumi Narasaki, Takuya Kunimoto, Yuki Moriyama, Chikara Hashimoto
Summary: The subduction and zippering (S&Z) model is a novel amphibian gastrulation model, which explains the movement of embryonic regions during gastrulation. By conducting experiments on Xenopus laevis embryos, it was confirmed that the dorsal one-third of the marginal zone is sufficient to form the complete dorsal structure, supporting the S&Z model. Furthermore, by comparing amphibian gastrulation with that of protochordates and amniotes, evolutionary conservation of gastrulation movement among chordates was identified.
DEVELOPMENT GENES AND EVOLUTION
(2023)
Article
Genetics & Heredity
Shinichi Hayashi, Ryohei Seki-Omura, Shintaro Yamada, Taito Kamata, Yuki Sato, Souichi Oe, Taro Koike, Yousuke Nakano, Hikaru Iwashita, Yukie Hirahara, Susumu Tanaka, Tsuneo Sekijima, Takeshi Ito, Yoshiki Yasukochi, Koichiro Higasa, Masaaki Kitada