Article
Biochemistry & Molecular Biology
Laura Gonzalez-Lafuente, Jose Alberto Navarro-Garcia, Angela Valero-Almazan, Elena Rodriguez-Sanchez, Sara Vazquez-Sanchez, Elisa Mercado-Garcia, Patricia Pineros, Jonay Poveda, Maria Fernandez-Velasco, Makoto Kuro-O, Luis M. Ruilope, Gema Ruiz-Hurtado
Summary: Acute kidney injury (AKI) is associated with an elevated risk of cardiovascular major events and mortality. The presence of AKI and its evolution are significantly associated with an alteration in the anti-aging factor klotho expression. A decrease in klotho expression aggravates cardiac damage after AKI, affecting Ca2+ handling and increasing the risk of Ca2+ pro-arrhythmic events.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Jiaxin Liu, Shuang Ji, Zhaiyi Liu, Meina Guo, Guangrui Yang, Lihong Chen
Summary: Deletion of cGAS exacerbates acute immune-mediated liver injury induced by ConA, resulting in increased ALT and AST levels and amplified hepatic necrosis. The number of apoptotic hepatocytes is also significantly increased in cGAS knockout mice. Deletion of cGAS promotes leukocyte chemotaxis and migration-related genes expression, leading to infiltration of macrophages, neutrophils, and T cells in the liver.
Article
Cell Biology
Zhihui Lu, Hong Liu, Nana Song, Yiran Liang, Jiaming Zhu, Jing Chen, Yichun Ning, Jiachang Hu, Yi Fang, Jie Teng, Jianzhou Zou, Yan Dai, Xiaoqiang Ding
Summary: This study revealed that METTL14-dependent RNA m6A modification contributes to podocyte injury through posttranscriptional regulation of Sirt1 mRNA, providing a potential approach for the diagnosis and treatment of podocytopathies.
CELL DEATH & DISEASE
(2021)
Article
Urology & Nephrology
Lu Li, Xiaoxi Liu, Shasha Li, Qingyan Wang, Hongru Wang, Menglu Xu, Yanxin An
Summary: The study demonstrates that THC can prevent Sepsis-induced AKI by suppressing inflammation and oxidative stress, and activating the SIRT1 signaling pathway. THC not only increased the survival rate and improved kidney function in mice, but also inhibited inflammatory response and prevented cell apoptosis in renal tissues.
Article
Chemistry, Medicinal
Cheng Guo, Fang-Xiong Ye, Yong-Hong Jian, Chun-Hua Liu, Zhi-Hui Tu, Ding-Ping Yang
Summary: The study demonstrated the significant role of miR-214-5p in sepsis-related AKI, showing its potential as a therapeutic candidate by activating AMPK to protect the kidneys from inflammation and oxidative stress.
DRUG DEVELOPMENT RESEARCH
(2022)
Article
Cell Biology
Zhiya Deng, Maomao Sun, Jie Wu, Haihong Fang, Shumin Cai, Sheng An, Qiaobing Huang, Zhenfeng Chen, Chenglun Wu, Ziwei Zhou, Haoran Hu, Zhenhua Zeng
Summary: The study demonstrates that activation of SIRT1 can promote autophagy and attenuate sepsis-induced acute kidney injury (SAKI). SIRT1 only deacetylates Beclin1, mediating autophagy and protection against SAKI through deacetylation of Beclin1 at K430 and K437. This suggests that pharmacologic induction of autophagy via SIRT1-mediated Beclin1 deacetylation may be a promising therapeutic approach for future SAKI treatment.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Kiryeong Kim, Jaechan Leem
Summary: Hispidulin attenuates endotoxin-induced kidney injury by suppressing inflammation, oxidative stress, and tubular cell death.
Review
Biochemistry & Molecular Biology
Nazanin Sabet, Zahra Soltani, Mohammad Khaksari
Summary: Exercise has a renoprotective effect on kidney injury patients by increasing the expression and activity of SIRT1. However, further research is needed to determine the role of SIRT1 in different types and severities of kidney injury following exercise.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Critical Care Medicine
Matthias Wolfgang Heinzl, Michael Resl, Carmen Klammer, Paul Fellinger, Lukas Schinagl, Florian Obendorf, Roland Feldbauer, Johannes Pohlhammer, Thomas Wagner, Margot Egger, Benjamin Dieplinger, Martin Clodi
Summary: This study found that even a relatively small inflammatory stimulus is sufficient to cause subclinical structural kidney injury in healthy volunteers, highlighting the insufficiency of current diagnostic approaches for AKI and the urgency to develop new diagnostic algorithms.
Article
Pharmacology & Pharmacy
Zhen Wang, Menglin Liu, Di Ye, Jing Ye, Menglong Wang, Jianfang Liu, Yao Xu, Jishou Zhang, Mengmeng Zhao, Yongqi Feng, Shuwan Xu, Wei Pan, Zhen Luo, Dan Li, Jun Wan
Summary: The study revealed an upregulation of Il12a in septic patients, while Il12a deletion exacerbated sepsis-induced cardiac dysfunction and injury mainly by affecting macrophage activity and the NF-κB signaling pathway. The findings suggest Il12a as a potential target for treating sepsis-induced cardiac dysfunction.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Hidekazu Sugiura, Jun Tsunezumi, Hiromi Yanagisawa, Mayuko Futaya, Kosaku Nitta, Ken Tsuchiya
Summary: Fbln7, a matricellular protein localized on the cell surface of renal tubular epithelium, has been found to play a harmful role in calcium crystal-induced kidney injuries. Releasing Fbln7 from the cell surface through heparin treatment may provide a general strategy to mitigate such injuries.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Immunology
Chao Zhou, Ping Sun, Milton H. Hamblin, Ke-Jie Yin
Summary: Genetic deletion of KLF11 exacerbates sensorimotor and cognitive deficits, brain tissue loss and neuronal death, accelerates post-trauma astrocytic activation, promotes microglial polarization to a pro-inflammatory phenotype, and increases the infiltration of peripheral neutrophils and macrophages into the brain parenchyma in mice with traumatic brain injury. Loss-of-KLF11 function also directly increases the expression of pro-inflammatory cytokines in the brains of TBI mice.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Biochemistry & Molecular Biology
Meiling Yu, Hongyu Li, Boying Wang, Zhenxiang Wu, Sheng Wu, Guojun Jiang, Huaxue Wang, Yingying Huang
Summary: The polypeptide antibiotic Polymyxin B (PMB) can cause acute kidney injury (AKI), and ferroptosis is found to be one of the main mechanisms of renal injury caused by PMB. Baicalein, known to inhibit ferroptosis, is found to attenuate PMB-induced renal injury in vivo and in vitro studies. These findings suggest that baicalein decreases p53 acetylation level by elevating SIRT1, which can then inhibit PMB-induced ferroptosis and ultimately attenuates AKI.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Immunology
Jing Yang, Hanh Chi Do-Umehara, Qiao Zhang, Huashan Wang, Changchun Hou, Huali Dong, Edith A. Perez, Marc A. Sala, Kishore R. Anekalla, James M. Walter, Shuwen Liu, Richard G. Wunderink, G. R. Scott Budinger, Jing Liu
Summary: JNK2 plays a crucial role in regulating lung inflammation and injury during sepsis and acute lung injury. The upregulation of miR-221-5p targets JNK2 mRNA leading to downregulation of JNK2, thereby exacerbating lung inflammation and injury during sepsis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Ayman M. Mahmoud, Omnia A. M. Abd El-Ghafar, Mohammed A. Alzoghaibi, Emad H. M. Hassanein
Summary: This study demonstrated that the melatonergic agonist agomelatine is protective against gentamicin-induced kidney injury in rats by reducing oxidative stress and inflammation. AGM suppressed TLR-4 signaling, increased antioxidants, and upregulated SIRT1 and PPAR gamma in the kidney of GM-intoxicated rats.