Chronic Treatment with Novel Small Molecule Hsp90 Inhibitors Rescues Striatal Dopamine Levels but Not α-Synuclein-Induced Neuronal Cell Loss
出版年份 2014 全文链接
标题
Chronic Treatment with Novel Small Molecule Hsp90 Inhibitors Rescues Striatal Dopamine Levels but Not α-Synuclein-Induced Neuronal Cell Loss
作者
关键词
Toxicity, Parkinson disease, Dopamine, Small molecules, Dopaminergics, Neostriatum, Cytotoxicity, Drug therapy
出版物
PLoS One
Volume 9, Issue 1, Pages e86048
出版商
Public Library of Science (PLoS)
发表日期
2014-01-21
DOI
10.1371/journal.pone.0086048
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Hsp90 Molecular Chaperone Inhibitors: Are We There Yet?
- (2012) L. Neckers et al. CLINICAL CANCER RESEARCH
- Molecular Chaperones as Rational Drug Targets for Parkinsons Disease Therapeutics
- (2012) S. K. Kalia et al. CNS & Neurological Disorders-Drug Targets
- Heat shock protein 90 in neurodegenerative diseases
- (2012) Wenjie Luo et al. Molecular Neurodegeneration
- Molecular Chaperones and Co-Chaperones in Parkinson Disease
- (2012) Hemi Dimant et al. NEUROSCIENTIST
- Impaired neurotransmission caused by overexpression of -synuclein in nigral dopamine neurons
- (2012) M. Lundblad et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Disrupted and transgenic urate oxidase alter urate and dopaminergic neurodegeneration
- (2012) X. Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A phase II study of 17-allylamino-17-demethoxygeldanamycin in metastatic or locally advanced, unresectable breast cancer
- (2011) Elaina M. Gartner et al. BREAST CANCER RESEARCH AND TREATMENT
- Distinct Roles In Vivo for the Ubiquitin-Proteasome System and the Autophagy-Lysosomal Pathway in the Degradation of -Synuclein
- (2011) D. Ebrahimi-Fakhari et al. JOURNAL OF NEUROSCIENCE
- Molecular chaperones in protein folding and proteostasis
- (2011) F. Ulrich Hartl et al. NATURE
- Phase I Evaluation of STA-1474, a Prodrug of the Novel HSP90 Inhibitor Ganetespib, in Dogs with Spontaneous Cancer
- (2011) Cheryl A. London et al. PLoS One
- Targeting Heat Shock Proteins in Tauopathies
- (2010) M. DeTure et al. Current Alzheimer Research
- Heat-shock protein 70 modulates toxic extracellular α-synuclein oligomers and rescues trans-synaptic toxicity
- (2010) Karin M. Danzer et al. FASEB JOURNAL
- Expression of human A53T alpha-synuclein in the rat substantia nigra using a novel AAV1/2 vector produces a rapidly evolving pathology with protein aggregation, dystrophic neurite architecture and nigrostriatal degeneration with potential to model the pathology of Parkinson's disease
- (2010) James B Koprich et al. Molecular Neurodegeneration
- The HSP70 Molecular Chaperone Is Not Beneficial in a Mouse Model of α-synucleinopathy
- (2010) Derya R. Shimshek et al. PLoS One
- Chaperone-mediated autophagy in health and disease
- (2009) Maria Kon et al. FEBS LETTERS
- α-Synuclein S129 Phosphorylation Mutants Do Not Alter Nigrostriatal Toxicity in a Rat Model of Parkinson Disease
- (2009) Nikolaus R. McFarland et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Brain-Permeable Small-Molecule Inhibitors of Hsp90 Prevent -Synuclein Oligomer Formation and Rescue -Synuclein-Induced Toxicity
- (2009) P. Putcha et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- SNX-2112, a selective Hsp90 inhibitor, potently inhibits tumor cell growth, angiogenesis, and osteoclastogenesis in multiple myeloma and other hematologic tumors by abrogating signaling via Akt and ERK
- (2008) Y. Okawa et al. BLOOD
- SNX2112, a Synthetic Heat Shock Protein 90 Inhibitor, Has Potent Antitumor Activity against HER Kinase Dependent Cancers
- (2008) S. Chandarlapaty et al. CLINICAL CANCER RESEARCH
- Heat Shock Transcription Factor 1-activating Compounds Suppress Polyglutamine-induced Neurodegeneration through Induction of Multiple Molecular Chaperones
- (2008) Nobuhiro Fujikake et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Hsp104 antagonizes α-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease
- (2008) Christophe Lo Bianco et al. JOURNAL OF CLINICAL INVESTIGATION
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started