Article
Hematology
Xiamin Wang, Guangyu Wei, Yangyang Ding, Xiang Gui, Huan Tong, Xiaoqi Xu, Sixuan Zhang, Zengtian Sun, Wen Ju, Yue Li, Ruosi Yao, Qingyu Wu, Zhihao Lu, Chunling Fu, Zhenyu Li, Si Zhang, Elizabeth E. Gardiner, Robert K. Andrews, Hu Hu, Lingyu Zeng, Jianlin Qiao, Kailin Xu
Summary: This study reveals a novel role of protein tyrosine phosphatase nonreceptor type 22 (PTPN22) in platelet function and arterial thrombosis, identifying new potential targets for future prevention of thrombotic or cardiovascular diseases.
Article
Medicine, Research & Experimental
Wan-Jung Lu, Chung-Hsin Tsai, Ray-Jade Chen, Li-Ting Huang, Ting-Yu Chen, Lih-Chyang Chen, Hsueh-Hsiao Wang, Hsien-Yu Peng, Yu-Yo Sun, Kuan-Hung Lin
Summary: Artesunate acts as a GPVI antagonist and effectively prevents platelet activation and thrombus formation with minimal risk of bleeding.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Cardiac & Cardiovascular Systems
Jianfeng Shi, Renyang Tong, Meng Zhou, Yu Gao, Yichao Zhao, Yifan Chen, Wenhua Liu, Gaoxiang Li, Dong Lu, Guofeng Meng, Liuhua Hu, Ancai Yuan, Xiyuan Lu, Jun Pu
Summary: The study revealed that the circadian protein Rev-erb alpha is functionally expressed in platelets and enhances platelet activation and thrombus formation. This suggests that Rev-erb alpha could be a promising therapeutic target for managing thrombosis-related cardiovascular diseases.
EUROPEAN HEART JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Dan Shu, Ying Zhu, Meng Lu, Ao-Di He, Jiang-Bin Chen, Ding-Song Ye, Yue Liu, Xiang-Bin Zeng, Rong Ma, Zhang-Yin Ming
Summary: Sanguinarine demonstrates antiplatelet activity by inhibiting thrombus formation and platelet activation through multiple molecular mechanisms. This indicates its potential clinical value in treating cardiovascular diseases involving excessive platelet activation.
Article
Hematology
Ilaria De Simone, Constance C. F. M. J. Baaten, Jonathan M. Gibbins, Hugo Ten Cate, Johan W. M. Heemskerk, Chris I. Jones, Paola E. J. van der Meijden
Summary: This study found that previously activated platelets can be reactivated through different receptors and contribute to thrombus formation. Reactivated platelets can regain their ability to participate in thrombus formation under flow conditions.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Hematology
Christopher W. Smith, Maan H. Harbi, Lourdes Garcia-Quintanilla, Kieran Rookes, Helena Brown, Natalie S. Poulter, Steve P. Watson, Phillip L. R. Nicolson, Mark R. Thomas
Summary: LH34 potently inhibits atherosclerotic plaque-induced thrombus formation and procoagulant platelet activity in vitro with less off-target inhibition of Src than ibrutinib, suggesting it is a promising antiplatelet therapy with the potential for reduced bleeding side effects.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Cell Biology
Tzenge-Lien Shih, Kuan-Hung Lin, Ray-Jade Chen, Ting-Yu Chen, Wei-Ting Kao, Jen-Wei Liu, Hsueh-Hsiao Wang, Hsien-Yu Peng, Yu-Yo Sun, Wan-Jung Lu
Summary: The naphthalimide derivative compound 5 exhibits antiplatelet and antithrombotic effects, preventing thrombus formation while potentially increasing bleeding risk. Development of more potent and efficient antiplatelet agents from compound 5 while minimizing bleeding risk may offer therapeutic potential for cardiovascular diseases.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Nutrition & Dietetics
Na Xiao, Tengfei Zhang, Mingli Han, Dan Tian, Jiawei Liu, Shan Li, Lele Yang, Guojun Pan
Summary: Chlorogenic acid (CGA) has been found to regulate glucose and lipid metabolism. In this study, the protective effects of CGA on glucagon-induced hepatic glucose production were investigated. CGA treatment lowered the levels of glucose production in mice and also prevented glucose and ceramide accumulation in high-fat diet (HFD)-fed mice. CGA inhibited the inflammation response and prevented hepatic gluconeogenesis by inhibiting ceramide accumulation and p38 MAPK expression.
Article
Hematology
Xiang Gui, Xiang Chu, Yuwei Du, Yuhan Wang, Sixuan Zhang, Yangyang Ding, Huan Tong, Mengdi Xu, Yue Li, Wen Ju, Zengtian Sun, Zhenyu Li, Lingyu Zeng, Kailin Xu, Jianlin Qiao
Summary: PDE5A deficiency prolongs bleeding time and delays arterial and venous thrombus formation. It inhibits platelet aggregation and activation, reduces phosphatidylserine exposure, calcium mobilization, and reactive oxygen species production, increases intracellular cGMP level, and modulates platelet function and thrombus formation.
THROMBOSIS AND HAEMOSTASIS
(2023)
Review
Plant Sciences
Yuan Yee Lee, Sung Dae Kim, Seung-Chun Park, Man Hee Rhee
Summary: This article summarizes the therapeutic effects of ginseng on cardiovascular diseases, focusing on its influence on platelet aggregation, plaque formation, and thrombus formation.
JOURNAL OF GINSENG RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yanfei Jiang, Hao Nan, Na Shi, Wenfang Hao, Juane Dong, Hongying Chen
Summary: Chlorogenic acid (CGA), a compound derived from Eucommia ulmoides, has exhibited potent cytotoxic and anti-proliferative activities against various human cancers, particularly hepatocellular carcinoma (HCC). Through modulation of multiple pharmacological signaling pathways, CGA effectively inhibits hepatoma cell activity and promotes mitochondrial apoptosis in HCC.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Hematology
Adriana Yamaguchi, Livia Stanger, Cody J. Freedman, Melissa Standley, Timothy Hoang, Reheman Adili, Wan-Chen Tsai, Christopher van Hoorebeke, Theodore R. Holman, Michael Holinstat
Summary: DHA and its 12-LOX oxylipins, 11-HDHA and 14-HDHA, attenuate platelet aggregation, inhibit IIb β3 activation, decrease α-granule secretion, impair platelet adhesion and accumulation, and inhibit thrombus formation. The protective mechanism of DHA oxylipins is mediated via activation of protein kinase A, supporting their use as therapeutic intervention in atherothrombotic diseases.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Cell Biology
Kahdr A. Alatawi, Divyashree Ravishankar, Pabitra H. Patra, Alexander P. Bye, Alexander R. Stainer, Ketan Patel, Darius Widera, Sakthivel Vaiyapuri
Summary: 1,8-cineole has shown inhibitory effects on platelet activation, thrombus formation, and hemostasis, affecting platelet signaling pathways, granule secretion, and intracellular calcium mobilization. It may act as a potential therapeutic agent to control unwarranted platelet reactivity under various pathophysiological settings.
Article
Nutrition & Dietetics
Lisard Iglesias-Carres, Lauren A. Essenmacher, Kathryn C. Racine, Andrew P. Neilson
Summary: The study aimed to develop a method to inhibit choline metabolism into TMA by gut microbiota using phenolic compounds. Results showed that DMB, gallic acid, and chlorogenic acid were effective TMA inhibitors that could significantly reduce TMA production, potentially through altering TMA-lyase activity or expression.
Article
Biochemistry & Molecular Biology
Pasquale Pignatelli, Francesco Baratta, Raffaella Buzzetti, Alessandra D'Amico, Valentina Castellani, Simona Bartimoccia, Antonio Siena, Luca D'Onofrio, Ernesto Maddaloni, Annachiara Pingitore, Giovanni Alfonso Chiariello, Francesca Santilli, Daniele Pastori, Nicholas Cocomello, Francesco Violi, Maria Del Ben, Vittoria Cammisotto, Roberto Carnevale
Summary: This study demonstrates that gliflozins have antiplatelet and antithrombic effects in patients with T2D, potentially through the modulation of oxidative stress, platelet activation, and thrombus formation.
Review
Biochemistry & Molecular Biology
Angela Inzulza-Tapia, Marcelo Alarcon
Summary: Cardiovascular diseases are the leading cause of death worldwide. Platelet-secreted non-coding RNA (ncRNA) play a crucial regulatory role in the occurrence and development of these diseases, and have potential value in identifying and treating cardiovascular diseases.
CURRENT MEDICINAL CHEMISTRY
(2022)
Editorial Material
Microbiology
Ileana Gonzalez, Cristian Lindner, Ivan Schneider, Miguel A. Morales, Armando Rojas
FUTURE MICROBIOLOGY
(2022)
Article
Oncology
Alice Blandino, Dominique Scherer, Trine B. Rounge, Sinan U. Umu, Felix Boekstegers, Carol Barahona Ponce, Katherine Marcelain, Valentina Garate-Calderon, Melanie Waldenberger, Erik Morales, Armando Rojas, Cesar Munoz, Javier Retamales, Gonzalo de Toro, Olga Barajas, Maria Teresa Rivera, Analia Cortes, Denisse Loader, Javiera Saavedra, Lorena Gutierrez, Alejandro Ortega, Maria Enriqueta Bertran, Fernando Gabler, Monica Campos, Juan Alvarado, Fabrizio Moisan, Loreto Spencer, Bruno Nervi, Daniel E. Carvajal-Hausdorf, Hector Losada, Mauricio Almau, Plinio Fernandez, Ivan Gallegos, Jordi Olloquequi, Macarena Fuentes-Guajardo, Rolando Gonzalez-Jose, Maria Catira Bortolini, Carla Gallo, Andres Ruiz Linares, Francisco Rothhammer, Justo Lorenzo Bermejo
Summary: This study investigates the relationship between genotype-based expression of circulating lncRNAs and the risk of gallbladder cancer (GBC). The results suggest that preselection of lncRNAs and utilization of cis-lncRNA-eQTLs can facilitate the identification of circulating noncoding RNAs linked to cancer risk.
Review
Cell Biology
Armando Rojas, Ivan Schneider, Cristian Lindner, Ileana Gonzalez, Miguel A. Morales
Summary: Compelling research has shown that diabetes mellitus is a major risk factor for increased cancer incidence and mortality. Classic factors like hyperglycemia, hyperinsulinemia, metabolic inflammation, and dyslipidemia contribute to this association. New emerging factors including the microbiome, epigenetic changes, endoplasmic reticulum stress, and increased glycolytic influx also play important roles in cancer development. The impact of different glucose-lowering therapeutic agents on this association remains controversial.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Chemistry, Physical
Jose Luis Velazquez-Libera, Julio Caballero, Jans Alzate-Morales, J. Javier Ruiz-Pernia, Inaki Tunon
Summary: We conducted a computational study on the reaction mechanism of USP7 with Ubiquitin-Rhodamine 110-G substrate using a robust methodology. Our findings provide insights into the dynamic nature of USP7 enzyme-substrate complexes and describe the conformational changes observed in our simulations. The protein-protein interactions and geometric states identified in this study could be utilized for designing potent and selective inhibitors for USP7's activity.
Article
Oncology
Felix Boekstegers, Dominique Scherer, Carol Barahona Ponce, Katherine Marcelain, Valentina Garate-Calderon, Melanie Waldenberger, Erik Morales, Armando Rojas, Cesar Munoz, Javier Retamales, Gonzalo de Toro, Olga Barajas, Maria Teresa Rivera, Analia Cortes, Denisse Loader, Javiera Saavedra, Lorena Gutierrez, Alejandro Ortega, Maria Enriqueta Bertran, Leonardo Bartolotti, Fernando Gabler, Monica Campos, Juan Alvarado, Fabricio Moisan, Loreto Spencer, Bruno Nervi, Daniel Carvajal-Hausdorf, Hector Losada, Mauricio Almau, Plinio Fernandez, Jordi Olloquequi, Macarena Fuentes-Guajardo, Rolando Gonzalez-Jose, Maria Catira Bortolini, Victor Acuna-Alonzo, Carla Gallo, Andres Ruiz Linares, Francisco Rothhammer, Justo Lorenzo Bermejo
Summary: Chile has implemented a gallbladder cancer prevention program since 2006. In this study, three risk prediction models were developed and validated using retrospective data from Chilean GBC patients and population-based controls. The models considered genetic and non-genetic risk factors, such as age, sex, gallstones, body mass index, educational level, and family history of GBC. Including these factors improved the prediction of GBC risk and may help allocate resources and surgical capacity more efficiently.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Review
Gastroenterology & Hepatology
Armando Rojas, Cristian Lindner, Ivan Schneider, Ileana Gonzalez, Miguel Angel Morales
Summary: Compelling evidence from clinical and experimental research shows that activation of the receptor for advanced glycation end products (RAGE) axis is crucial in the development of neoplasms, including gastric cancer (GC). RAGE plays a significant role in establishing an inflammatory environment that supports tumor growth and dissemination, and acts as a pattern-recognition receptor in the inflammatory response to Helicobacter pylori infection. This review highlights the contribution of RAGE axis overexpression and activation to the proliferation, survival, and invasive phenotypes of GC cells, as well as the potential role of RAGE gene polymorphisms in susceptibility and prognosis.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Chemistry, Multidisciplinary
S. Monroy-Moya, J. Caballero, F. Gonzalez-Norambuena, M. Simirgiotis, E. Sanchez, C. Areche, D. Fuentealba, A. Cornejo
Summary: Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder worldwide, and the treatment focuses on delivering L-DOPA. In this study, multiple compounds including flavonols, isoflavone, flavone, and compounds with alpha, beta unsaturated carbonyl moieties were found to inhibit alpha-synuclein fibrillization and promote cell proliferation and differentiation.
Article
Biochemistry & Molecular Biology
Andres Trostchansky, Marcelo Alarcon
Summary: Oxidative stress is involved in various non-communicable diseases, such as cardiovascular diseases. Excessive reactive oxygen species (ROS) formation can lead to the undesirable effects of oxidative stress. Platelets play a crucial role in arterial thrombosis, and excessive ROS formation stimulates platelet activation and aggregation. The proteins Protein Disulphide Isomerase (PDI) and NADPH oxidase (NOX) isoforms are involved in these processes. A bioinformatic analysis of their roles and interactions in platelets, as well as the signaling pathways involved, was performed. The data support the potential use of specific enzyme inhibitors or dual inhibition of these enzymes for treating diseases involving platelet dysfunction.
Article
Biochemistry & Molecular Biology
Luis Castillo-Campos, Jose Luis Velazquez-Libera, Julio Caballero
Summary: This study investigates 67 naphthalene-derived compounds as noncovalent PLpro inhibitors using molecular modeling methods. The structural characteristics and interactions of these inhibitors with the SARS-CoV-1 PLpro binding site are reported in detail, considering the flexibility of protein residues. A flexible docking protocol and Gaussian Accelerated Molecular Dynamics (GaMD) simulations were used to find the highest correlation between docking energies and activities, providing candidates for potential drug development against viral respiratory diseases caused by coronaviruses.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Diana Elizabeth Gonzalez-Guerrero, Maria-Luisa Lazo-de-la-Vega-Monroy, Armando Gomez-Ojeda, Claudia Luevano-Contreras, Armando Rojas-Rubio, Ma. Eugenia Garay-Sevilla
Summary: This study aimed to investigate whether the -374 T/A and -429 T/C polymorphisms were associated with metabolic syndrome (MS). The results showed that these two polymorphisms were not associated with MS in the Mexican population and had no influence on serum sRAGE levels.
Article
Biochemistry & Molecular Biology
Hector Montecino-Garrido, Magdalena Sepulveda, Diego Mendez, Matias Monroy-Cardenas, Sergio Alfaro, Mariela Gonzalez-Avendano, Julio Caballero, Felix A. Urra, Ramiro Araya-Maturana, Eduardo Fuentes
Summary: In this study, the effects of triphenylphosphonium-linked acyl hydroquinone derivatives with different alkyl chain lengths on the metabolism and function of human platelets were evaluated. It was found that longer alkyl chain lengths were associated with increased cytotoxicity and decreased mitochondrial membrane potential. Molecular dynamics simulations indicated that the permeability of the mitochondrial membrane may be involved in the cytotoxicity of phosphonium salts. These findings are important for the design of new TPP+-based drugs with a safe cardiovascular profile.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Carolina Anazco, Janin Riedelsberger, Lorenzo Vega-Montoto, Armando Rojas
Summary: Collagen is a vital structural protein in mammals and is strengthened by complex enzymatic and non-enzymatic reactions, such as covalent cross-linking and glycation. This review article explores the amine oxidase-like activity of plant polyphenols and their potential as antiglycation agents. It also discusses the molecular mechanisms by which specific flavonoids impact or protect the normal collagen cross-linking process, with the aim of promoting the stabilization of highly organized collagen fibrils.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Ricelia Gonzalez, Juliana Murillo-Lopez, Walter Rabanal-Leon, Luis Prent-Penaloza, Odette Concepcion, Pedro Olivares, Yorley Duarte, Alexander F. de la Torre, Margarita Gutierrez, Julio Caballero
Summary: Novel alpha, beta-unsaturated carbonyl depsipeptides and peptoids incorporating various chromophores were synthesized using multicomponent reactions. UV/Vis spectroscopy was used to study the photophysical properties of the compounds, and the differences in electron delocalization caused by different chromophores were captured in the spectra. A photostability study for one compound showed that its molecular structure remained unchanged after exposure to UV radiation. Fluorescence analysis revealed incipient emission and blue fluorescence for specific compounds under UV radiation. The photophysical properties and electronic structure were also studied theoretically.
FRONTIERS IN CHEMISTRY
(2023)
Article
Oncology
Linda Zollner, Felix Boekstegers, Carol Barahona Ponce, Dominique Scherer, Katherine Marcelain, Valentina Garate-Calderon, Melanie Waldenberger, Erik Morales, Armando Rojas, Cesar Munoz, Javier Retamales, Gonzalo De Toro, Allan Vera Kortmann, Olga Barajas, Maria Teresa Rivera, Analia Cortes, Denisse Loader, Javiera Saavedra, Lorena Gutierrez, Alejandro Ortega, Maria Enriqueta Bertran, Leonardo Bartolotti, Fernando Gabler, Monica Campos, Juan Alvarado, Fabricio Moisan, Loreto Spencer, Bruno Nervi, Daniel Carvajal, Hector Losada, Mauricio Almau, Plinio Fernandez, Jordi Olloquequi, Alice R. Carter, Juan Francisco Miquel Poblete, Bernabe Ignacio Bustos, Macarena Fuentes Guajardo, Rolando Gonzalez-Jose, Maria Catira Bortolini, Victor Acuna-Alonzo, Carla Gallo, Andres Ruiz Linares, Francisco Rothhammer, Justo Lorenzo Bermejo
Summary: There is a strong association between the proportion of Mapuche ancestry and the risk of gallbladder cancer (GBC). Mapuche ancestry has a putatively causal effect on GBC risk and gallstone disease, while showing a negative effect on BMI. These findings have significant implications for GBC prevention and future admixture mapping studies.
