Article
Infectious Diseases
Gillian M. Hunt, Mukhlid Yousif, Leon Levin, Johanna Ledwaba, Kim Steegen, Tendesayi Kufa, Hloniphile Zwane, Monalisa Kalimashe, Vibha Kana, Getahun Aynalem, Jaclyn Perlman, Kassahun Ayalew, Gurpreet Kindra, Karidia Diallo, Sergio Carmona, Gayle Sherman, Elliot J. Raizes
Summary: HIV drug resistance is highly prevalent among paediatric patients failing ART in South Africa, with 90% of patients harbouring resistance to NNRTIs and/or NRTIs. Scaling up resistance testing would facilitate access to second- and third-line regimens in South Africa.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Immunology
Nadine Jaschinski, Lauren Greenberg, Bastian Neesgaard, Jose M. Miro, Katharina Grabmeier-Pfistershammer, Gilles Wandeler, Colette Smith, Stephane De Wit, Ferdinand Wit, Annegret Pelchen-Matthews, Cristina Mussini, Antonella Castagna, Christian Pradier, Antonella D'Arminio Monforte, Jorg Vehreschild, Anders Sonnerborg, Alain Anne, Andrew Carr, Loveleen Bansi-Matharu, Jens Lundgren, Harmony Garges, Felipe Rogatto, Robert Zangerle, Huldrych F. Gunthard, Line D. Rasmussen, Coca Nescoi, Marc Van der Valk, Marianna Menozzi, Camilla Muccini, Amanda Mocroft, Lars Peters, Lene Ryom
Summary: This study assessed the association between ABC and CVD in people with HIV. The results showed that recent ABC use was associated with a higher incidence of CVD. This association was not explained by the presence of pre-existing CVD or CKD risk.
Article
Microbiology
Meng-Yan Cui, Zhen-Yu Cui, Meng-Qi Zhao, Meng-Jie Zhang, Qiao-Li Jiang, Jing-Jing Wang, Lun-Gen Lu, Ying-Ying Lu
Summary: This study found that H. pylori infection led to significant changes in the diversity, composition, and functional predictions of the gut microbiota. However, these changes gradually returned to the levels of the healthy control group after eradication therapy containing minocycline and metronidazole.
Article
Chemistry, Medicinal
Ya-Li Sang, Christophe Pannecouque, Erik De Clercq, Shuai Wang, Fen-Er Chen
Summary: A series of novel biphenyl-DAPY derivatives were developed using the fragment-hopping strategy to enhance the anti-resistance efficacy of a non-nucleoside reverse transcriptase inhibitor (NNRTI). Most of the compounds exhibited improved anti-HIV-1 potency, with compound 8r showing exceptional potency against wild-type HIV-1 and mutant strains. The new DAPY analogue had lower cytotoxicity, higher selectivity index, and favorable pharmacokinetic properties, making it a potential candidate for HIV treatment.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Immunology
Anna Torun, Anna Hupalowska, Piotr Trzonkowski, Jaroslaw Kierkus, Beata Pyrzynska
Summary: The incidence and prevalence of chronic inflammatory disorders are increasing in the pediatric population, with recent research highlighting the importance of interactions between altered intestinal microbiome and the immune system in disease pathogenesis. Therapies for these disorders mainly focus on symptom management, with sustained improvement being difficult to achieve due to challenges like changing physiology and susceptibility to adverse medication effects in children. New therapeutic approaches targeting the gut microbiota and immune system hold promise for inducing long-lasting remission and improving the quality of life for pediatric patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Virology
Elena Bruzzesi, Arianna Gabrieli, Davide Bernasconi, Giulia Marchetti, Andrea Calcagno, Diego Ripamonti, Andrea Antinori, Nicola Squillace, Antonella Cingolani, Antonio Muscatello, Alessandra Bandera, Andrea Gori, Stefano Rusconi, Silvia Nozza, INACTION Study Grp
Summary: The introduction of antiretroviral therapy (ART) during primary HIV-1 infection (PHI) can restrict the establishment of HIV reservoirs. This study aimed to assess the effect of three different ART regimens on HIV-DNA load in individuals living with HIV (PLWH) who started ART in PHI. The results showed that regardless of the treatment regimen, the HIV-DNA load in PLWH decreased during the treatment period.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Medicine, General & Internal
Shahin Lockman, Sean S. Brummel, Lauren Ziemba, Lynda Stranix-Chibanda, Katie McCarthy, Anne Coletti, Patrick Jean-Philippe, Ben Johnston, Chelsea Krotje, Lee Fairlie, Risa M. Hoffman, Paul E. Sax, Sikhulile Moyo, Nahida Chakhtoura, Jeffrey S. A. Stringer, Gaerolwe Masheto, Violet Korutaro, Haseena Cassim, Blandina T. Mmbaga, Esau Joao, Sherika Hanley, Lynette Purdue, Lewis B. Holmes, Jeremiah D. Momper, Roger L. Shapiro, Navdeep K. Thoofer, James F. Rooney, Lisa M. Frenkel, K. Rivet Amico, Lameck Chinula, Judith Currier
Summary: This study compared the safety and efficacy of three antiretroviral regimens started in pregnancy. The dolutegravir-containing regimens had superior virological efficacy at delivery compared with the efavirenz-containing regimen and the dolutegravir, emtricitabine, and tenofovir disoproxil fumarate regimen. The dolutegravir, emtricitabine, and tenofovir alafenamide fumarate regimen had the lowest frequency of composite adverse pregnancy outcomes and of neonatal deaths.
Article
Virology
Marcel A. Schneider, Anton A. Buzdin, Achim Weber, Pierre-Alain Clavien, Pieter Borger
Summary: The study demonstrated that the combination of two antiretroviral drugs, zidovudine and efavirenz, significantly reduced proliferation of cancer cells and blocked tumorigenesis in mice, suggesting a potential inexpensive treatment option for colorectal tumors and liver metastasis.
Article
Clinical Neurology
Sara N. Levintow, Brian W. Pence, Kimberly A. Powers, Alexander Breskin, Teerada Sripaipan, Tran Viet Ha, Viet Anh Chu, Vu Minh Quan, Carl A. Latkin, Vivian F. Go
Summary: The study found that severe depressive symptoms decreased the cumulative incidence of ART initiation among PWID living with HIV, but had no significant impact on viral suppression. Future research should further investigate the antagonistic effect of depression on treatment uptake in order to improve HIV clinical outcomes and reduce transmission among PWID.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Editorial Material
Immunology
Laura Levi, Jean-Michel Molina
Summary: Cytomegalovirus (CMV) viremia in individuals with human immunodeficiency virus (HIV) indicates the extent of immune deficiency. In the absence of CMV end-organ disease, early initiation of effective antiretroviral therapy is the sole treatment required and is usually enough to manage CMV replication.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Medicine, General & Internal
Marc R. Larochelle, Sara Lodi, Shapei Yan, Barbara A. Clothier, Elizabeth S. Goldsmith, Amy S. B. Bohnert
Summary: This study aimed to investigate the association between opioid tapering or abrupt discontinuation and opioid overdose and suicide events among patients receiving stable long-term opioid therapy without evidence of opioid misuse. The results showed a small increase in risk of harms associated with opioid tapering compared with a stable opioid dosage. These findings suggest that mandatory dosage tapering policies for individuals receiving a stable long-term opioid dosage without evidence of opioid misuse may not reduce short-term harm via suicide and overdose.
Article
Medicine, Research & Experimental
Ruxandra-Cristina Marin, Adrian Streinu-Cercel, Lavinia Cristina Moleriu, Simona Gabriela Bungau
Summary: This study compared the long-term virological response to antiretroviral therapy in Romanian patients infected with HIV. The results showed that DRV/c was more effective in suppressing the viral load compared to DRV/r in subtype F HIV-1 infected patients. Additionally, a small number of patients exhibited resistance to therapy and developed viral mutations.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Immunology
Javier Martinez-Sanz, Raquel Ron, Elena Moreno, Matilde Sanchez-Conde, Alfonso Muriel, Luis Fernando Lopez Cortes, Jose Ramon Blanco, Juan Antonio Pineda, Alvaro Mena, Sonia Calzado Isbert, Santiago Moreno, Sergio Serrano-Villar
Summary: This study compared the impact of a 2-drug regimen with dolutegravir plus lamivudine to a 3-drug regimen based on other integrase strand transfer inhibitors (INSTIs) on the recovery of the CD4/CD8 ratio in people with HIV. The results showed no difference in the normalization rates of the CD4/CD8 ratio at 48 weeks between the two treatment strategies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Marta Celesia, Vittoria Moscatt, Alessandra Tzannis, Michele Trezzi, Emanuele Foca, Margherita Errico, Paola Cinque, Silvia Nozza, Antonella Cingolani, Manuela Ceccarelli, Benedetto M. Celesia
Summary: A multicenter cross-sectional survey-based study evaluated patients' expectations and preferences regarding long-acting antiretroviral agents. The results showed that around 90% of people living with HIV were interested in switching to long-acting drugs, and a high percentage of patients expressed a preference for receiving treatment at home, representing a significant step towards treatment simplification.
Article
Infectious Diseases
Amanuel Amare
Summary: This study in Ethiopia focused on assessing the clinical presentation, cause, and treatment outcome of patients with HIV infection presenting with seizures. The majority of patients had late-stage HIV infection with low CD4 counts, recent onset seizures, and high case-fatality rates. The common causes of seizures were central nervous system opportunistic infections, highlighting the importance of early diagnosis and treatment to improve outcomes for HIV-infected patients presenting with seizures.
BMC INFECTIOUS DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Joe Miantezila Basilua, Olivier Sawoo, Irene Mangin, Flore Dossou-Yovo, Aline Boussard, Lucie Chevillard, Gaston T. Lutete, Bruno Eto, Gilles Peytavin, Philippe Pochart
CURRENT DRUG METABOLISM
(2019)
Article
Immunology
Fatma Tannich, Asma Tlili, Coralie Pintard, Amina Chniguir, Bruno Eto, Pham My-Chan Dang, Ouajdi Souilem, Jamel El-Benna
INFLAMMOPHARMACOLOGY
(2020)
Article
Food Science & Technology
Mohamed-Amine Jabri, Nicolas Limas-Nzouzi, Bruno Eto, Hichem Sebai
Correction
Immunology
Fatma Tannich, Asma Tlili, Coralie Pintard, Amina Chniguir, Bruno Eto, Pham My-Chan Dang, Ouajdi Souilem, Jamel El-Benna
Summary: The same mouse brain extracts were used in both figures to ensure accuracy in the study results.
INFLAMMOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mohamed Bouhrim, Hayat Ouassou, Salima Boutahiri, Nour Elhouda Daoudi, Hamza Mechchate, Bernard Gressier, Bruno Eto, Hamada Imtara, Amal A. Alotaibi, Mohammed Al-zharani, Abderrahim Ziyyat, Hassane Mekhfi, Abdelkhaleq Legssyer, Mohammed Aziz, Mohamed Bnouham
Summary: The study found that Opuntia dillenii seed oil (ODSO) has a significant antihyperglycemic effect in both normal and diabetic rats, without causing a risk of hypoglycemia. ODSO regulates intestinal absorption and digestive enzymes in vitro, and no toxic effects were observed in acute toxicity tests.
Article
Biochemistry & Molecular Biology
Mohamed Bouhrim, Salima Boutahiri, Loubna Kharchoufa, Hamza Mechchate, Omkulthom Mohamed Al Kamaly, Ali Berraaouan, Bruno Eto, Abderrahim Ziyyat, Hassane Mekhfi, Abdelkhaleq Legssyer, Mohammed Aziz, Mohamed Bnouham
Summary: This study confirms the safety and efficacy of Opuntia dillenii (Ker-Gawl) haw. seed oil (ODSO), demonstrating no toxicity in mice and an improvement in glucose absorption activity in isolated rat hemidiaphragm, especially when combined with insulin. These findings suggest the potential use of ODSO as a supplement for treating diabetes.
Article
Biochemistry & Molecular Biology
Noureddine Bencheikh, Mohamed Bouhrim, Loubna Kharchoufa, Omkulthom Mohamed Al Kamaly, Hamza Mechchate, Imane Es-safi, Ahmed Dahmani, Sabir Ouahhoud, Soufiane El Assri, Bruno Eto, Mohamed Bnouham, Mohammed Choukri, Mostafa Elachouri
Summary: The extract of Zizyphus lotus L. (Desf.) Fruit has shown protective effects against renal damage induced by gentamicin in rats, significantly improving biochemical parameters, kidney function, and oxidative balance. Chemical analysis revealed its richness in beneficial phenolic compounds.
Article
Chemistry, Multidisciplinary
Noureddine Bencheikh, Mohamed Bouhrim, Ilyass Alami Merrouni, Salima Boutahiri, Loubna Kharchoufa, Mohamed Addi, Duangjai Tungmunnithum, Christophe Hano, Bruno Eto, Abdelkhaleq Legssyer, Mostafa Elachouri
Summary: This study evaluated the anti-hyperlipidemic and antioxidant activities of a flavonoid-rich aqueous extract of Ziziphus lotus fruits. The extract showed significant antioxidant power against DPPH radicals and beta-carotene oxidation. Additionally, it exhibited a considerable anti-hyperlipidemic effect by improving abnormal lipid profile and blood glucose levels in mice on a chronic high-fat diet.
APPLIED SCIENCES-BASEL
(2021)
Article
Plant Sciences
Noureddine Bencheikh, Amine Elbouzidi, Loubna Kharchoufa, Hayat Ouassou, Ilyass Alami Merrouni, Hamza Mechchate, Imane Es-safi, Christophe Hano, Mohamed Addi, Mohamed Bouhrim, Bruno Eto, Mostafa Elachouri
Summary: In this study, an ethnobotanical survey was conducted in a remote area of North-Eastern Morocco to investigate traditional medicinal plants used to treat kidney diseases. A total of 121 plant species from 57 botanical families were identified, with Asteraceae, Lamiaceae, and Apiaceae being the most represented families. The study found correlations between traditional plant use and well-studied pharmacological evidence, providing valuable insights for potential biologically active compound research.
Article
Pharmacology & Pharmacy
Salima Boutahiri, Mohamed Bouhrim, Chayma Abidi, Hamza Mechchate, Ali S. Alqahtani, Omar M. Noman, Ferdinand Kouoh Elombo, Bernard Gressier, Sevser Sahpaz, Mohamed Bnouham, Jehan-Francois Desjeux, Touriya Zair, Bruno Eto
Summary: The aqueous extract of Lavandula pedunculata shows significant antihyperglycemic effects by inhibiting digestive enzymes and glucose absorption, while its combination with Punica granatum and Trigonella foenum-graecum enhances oral glucose tolerance in rats. These findings support the traditional use of Lavandula pedunculata in treating type 2 diabetes and the effectiveness of alternative and combinative poly-phytotherapy.
Article
Biology
Salima Boutahiri, Bruno Eto, Mohamed Bouhrim, Hamza Mechchate, Asmaa Saleh, Omkulthom Al Kamaly, Aziz Drioiche, Firdaous Remok, Jennifer Samaillie, Christel Neut, Bernard Gressier, Ferdinand Kouoh Elombo, Laila Nassiri, Touriya Zair, Sevser Sahpaz
Summary: Lavender aqueous extracts from Morocco have been used in traditional medicine for their antibacterial properties. This study evaluated the antibacterial activity of the Moroccan Lavandula pedunculata (Mill.) Cav. aqueous extract alone and in combination with extracts of other plants known for their antibacterial activity. The results showed that the extracts had a wide spectrum of antibacterial activity, especially against staphylococci, streptococci, Mycobacterium smegmatis, and Proteus mirabilis. The combination of the extracts showed synergistic effects, and the extracts were rich in polyphenols and tannins, with high levels of rosmarinic acid. This is the first study to demonstrate the enhanced antibacterial activity of L. pedunculata aqueous extract combined with other plant extracts.
Article
Biology
Jamila El Karkouri, Amale Kchibale, Mounia Chroho, Brahim Eddamsyry, Hanane Touijer, Fadoua El Makhoukhi, Nadia Handaq, Bruno Eto, Ahmad Mohammad Salamatullah, Mohammed Bourhia, Touriya Zair
Summary: The present study aimed to investigate the chemical composition, antioxidant, anti-hyperglycemic effect, and toxicity assessment of Ridolfia segetum (L.) Moris extract. The extract was found to have high levels of phenolic compounds and exhibited potent antioxidant and antihyperglycemic effects.
Article
Biochemistry & Molecular Biology
Ahlam Outman, Barbara Deracinois, Christophe Flahaut, Mira Abou Diab, Jihen Dhaouefi, Bernard Gressier, Bruno Eto, Naima Nedjar
Summary: This study focuses on the enzymatic hydrolysis of hemoglobin and compares the antibacterial and antioxidant potentials of human and bovine hemoglobin hydrolysates. The results show strong antimicrobial and antioxidant activities of the peptide hydrolysates, independent of the initial substrate concentration level. The presence of bioactive peptides in human hemoglobin suggests its potential as a valuable source for the food or pharmaceutical industries.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Chaima Abidi, Kais Rtibi, Salima Boutahiri, Haifa Tounsi, Afifa Abdellaoui, Soumaya Wahabi, Bernard Gressier, Bruno Eto, Hichem Sebai
Summary: The aqueous extract of ginger has been found to have a regulatory effect on gastrointestinal motility, reducing constipation symptoms and restoring oxidative balance.
Article
Plant Sciences
Aziz Drioiche, Sanae Amine, Salima Boutahiri, Soukaina Saidi, Atika Ailli, Rachid Rhafouri, Malika Mahjoubi, Fatima El Hilali, Aicha Mouradi, Bruno Eto, Touriya Zair
JOURNAL OF ESSENTIAL OIL BEARING PLANTS
(2020)