Innate immune signaling induces expression and shedding of the heparan sulfate proteoglycan syndecan-4 in cardiac fibroblasts and myocytes, affecting inflammation in the pressure-overloaded heart

Th1 cytokine-induced syndecan-4 shedding by airway smooth muscle cells is dependent on mitogen-activated protein kinases

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Activation of CD4 + T Lymphocytes Improves Wound Healing and Survival After Experimental Myocardial Infarction in Mice

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Heparan Sulfate Chains of Syndecan-1 Regulate Ectodomain Shedding

(2012) Vishnu C. Ramani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Syndecan-4 over-expression preserves cardiac function in a rat model of myocardial infarction

(2012) Jun Xie et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Syndecan-4 signaling via NFAT regulates extracellular matrix production and cardiac myofibroblast differentiation in response to mechanical stress

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Shedding; towards a new paradigm of syndecan function in cancer

(2011) So-Joong Choi et al.   BMB Reports

Syndecan-4 signalling inhibits apoptosis and controls NFAT activity during myocardial damage and remodelling

(2011) Frank Echtermeyer et al.   CARDIOVASCULAR RESEARCH

Syndecan-4 Prevents Cardiac Rupture and Dysfunction After Myocardial Infarction

(2011) Yutaka Matsui et al.   CIRCULATION RESEARCH

Angiotensin II and norepinephrine activate specific calcineurin-dependent NFAT transcription factor isoforms in cardiomyocytes

(2011) Ida G. Lunde et al.   JOURNAL OF APPLIED PHYSIOLOGY

TNF-α and IL-1β Promote a Disintegrin-like and Metalloprotease with Thrombospondin Type I Motif-5-mediated Aggrecan Degradation through Syndecan-4 in Intervertebral Disc

(2011) Jianru Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Serum syndecan-4 is a novel biomarker for patients with chronic heart failure

(2011) Rieko Takahashi et al.   Journal of Cardiology

Methods in cardiomyocyte isolation, culture, and gene transfer

(2011) William E. Louch et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Syndecan-4 Is Essential for Development of Concentric Myocardial Hypertrophy via Stretch-Induced Activation of the Calcineurin-NFAT Pathway

(2011) Alexandra V. Finsen et al.   PLoS One

Transmembrane Signaling Proteoglycans

(2010) John R. Couchman   Annual Review of Cell and Developmental Biology

Reference gene alternatives to Gapdh in rodent and human heart failure gene expression studies

(2010) Trond Brattelid et al.   BMC MOLECULAR BIOLOGY

Proteoglycans in health and disease: novel roles for proteoglycans in malignancy and their pharmacological targeting

(2010) Achilleas D. Theocharis et al.   FEBS Journal

Proteoglycans in health and disease: the multiple roles of syndecan shedding

(2010) Tina Manon-Jensen et al.   FEBS Journal

T-lymphocytes mediate left ventricular fibrillar collagen cross-linking and diastolic dysfunction in mice

(2010) Qianli Yu et al.   MATRIX BIOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Epidemiology and risk profile of heart failure

(2010) Anh L. Bui et al.   Nature Reviews Cardiology

Inflammation as a therapeutic target in heart failure? A scientific statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology

(2009) Stephane Heymans et al.   EUROPEAN JOURNAL OF HEART FAILURE

Cleavage of syndecan-4 by ADAMTS1 provokes defects in adhesion

(2008) Juan Carlos Rodríguez-Manzaneque et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY