Ras and Rac1, Frequently Mutated in Melanomas, Are Activated by Superoxide Anion, Modulate Dnmt1 Level and Are Causally Related to Melanocyte Malignant Transformation

Timp1 interacts with beta-1 integrin and CD63 along melanoma genesis and confers anoikis resistance by activating PI3-K signaling pathway independently of Akt phosphorylation

(2013) Mariana Toricelli et al.   Molecular Cancer

Activation of Ras/PI3K/ERK Pathway Induces c-Myc Stabilization to Upregulate Argininosuccinate Synthetase, Leading to Arginine Deiminase Resistance in Melanoma Cells

(2012) W.-B. Tsai et al.   CANCER RESEARCH

A Landscape of Driver Mutations in Melanoma

(2012) Eran Hodis et al.   CELL

The RAS/RAF/MEK/ERK and the PI3K/AKT signalling pathways: role in cancer pathogenesis and implications for therapeutic approaches

(2012) Antonella De Luca et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

(2012) Michael Krauthammer et al.   NATURE GENETICS

Ras Stabilization Through Aberrant Activation of Wnt/ -Catenin Signaling Promotes Intestinal Tumorigenesis

(2012) W.-J. Jeong et al.   Science Signaling

Driver Mutations in Melanoma: Lessons Learned From Bench-to-Bedside Studies

(2012) Janice M. Mehnert et al.   Current Oncology Reports

Angiopoietin-like 4 Protein Elevates the Prosurvival Intracellular O2−:H2O2 Ratio and Confers Anoikis Resistance to Tumors

(2011) Pengcheng Zhu et al.   CANCER CELL

Resistance to Selective BRAF Inhibition Can Be Mediated by Modest Upstream Pathway Activation

(2011) F. Su et al.   CANCER RESEARCH

Epigenetic reprogramming as a key contributor to melanocyte malignant transformation

(2011) Fernanda Molognoni et al.   Epigenetics

Endothelial nitric oxide synthase uncoupling as a key mediator of melanocyte malignant transformation associated with sustained stress conditions

(2011) Fabiana H.M. Melo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Extending life span by increasing oxidative stress

(2011) Michael Ristow et al.   FREE RADICAL BIOLOGY AND MEDICINE

Tumor suppressor protein kinase Chk2 is a mediator of anoikis of intestinal epithelial cells

(2011) Byong Hoon Yoo et al.   INTERNATIONAL JOURNAL OF CANCER

Epigenetic mechanisms of amyloid-β production in anisomycin-treated SH-SY5Y cells

(2011) X. Guo et al.   NEUROSCIENCE

ROS-generating NADPH oxidase NOX4 is a critical mediator in oncogenic H-Ras-induced DNA damage and subsequent senescence

(2011) U Weyemi et al.   ONCOGENE

Resveratrol Inhibits Growth of Orthotopic Pancreatic Tumors through Activation of FOXO Transcription Factors

(2011) Sanjit K. Roy et al.   PLoS One

Snail-mediated regulation of reactive oxygen species in ARCaP human prostate cancer cells

(2010) Petrina Barnett et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

RETRACTED: Aberrant DNA hypermethylation patterns lead to transcriptional silencing of tumor suppressor genes in UVB-exposed skin and UVB-induced skin tumors of mice

(2010) Vijayalakshmi Nandakumar et al.   CARCINOGENESIS

EGF-induced ERK-activation downstream of FAK requires rac1-NADPH oxidase

(2010) Liv Ingrid Flinder et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Role of antioxidants in the skin: Anti-aging effects

(2010) Hitoshi Masaki   JOURNAL OF DERMATOLOGICAL SCIENCE

Oncogenic H-Ras, FK228, and exogenous H2O2 cooperatively activated the erk pathway in selective induction of human urinary bladder cancer j82 cell death

(2010) Shambhunath Choudhary et al.   MOLECULAR CARCINOGENESIS

Methylation determines fibroblast activation and fibrogenesis in the kidney

(2010) Wibke Bechtel et al.   NATURE MEDICINE

Stress and the epigenetic landscape: a link to the pathobiology of human diseases?

(2010) Sarah E. Johnstone et al.   NATURE REVIEWS GENETICS

Epigenetics in cancer

(2009) S. Sharma et al.   CARCINOGENESIS

Ras and Nox: Linked signaling networks?

(2009) Ru Feng Wu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative stress, DNA methylation and carcinogenesis

(2008) Rodrigo Franco et al.   CANCER LETTERS

Active N-Ras and B-Raf Inhibit Anoikis by Downregulating Bim Expression in Melanocytic Cells

(2008) Nathaniel B. Goldstein et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

DNMT1 as a Molecular Target in a Multimodality-Resistant Phenotype in Tumor Cells

(2008) M. V. Mishra et al.   MOLECULAR CANCER RESEARCH