Article
Geriatrics & Gerontology
Roxana Coras, Brian Pedersen, Rekha Narasimhan, Anahy Brandy, Lourdes Mateo, Agueda Prior-Espanol, Arthur Kavanaugh, Aaron M. Armando, Mohit Jain, Oswald Quehenberger, Melania Martinez-Morillo, Monica Guma
Summary: The study revealed that arthritis symptoms in older adults were related to disturbances in serum oxylipins, suggesting that certain oxylipins may be key effectors in arthritis in this population.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Nutrition & Dietetics
Masayuki Okuda, Aya Fujiwara, Satoshi Sasaki
Summary: The study found that in Japanese youths, high intake of omega-6 polyunsaturated fatty acids was associated with low levels of low-density-lipoprotein cholesterol, while high intake of saturated fatty acids was associated with high levels of gamma-glutamyl transpeptidase, indicating a close relationship between dietary fatty acid composition and cardiometabolic risk.
Article
Environmental Sciences
Virak Visudtiphole, Jutatip Khudet, Panomkorn Chaitongsakul, Siwat Plaisen, Jittima Siriwattano, Seansook Laiphrom, Anupong Klaysuban, Thaninthorn Raweeratanapong, Kanchana Sittikankaew, Nakul Rattanaphan, Looksorn Koichai, Panida Unagul, Umaporn Uawisetwathana
Summary: Long-chain polyunsaturated fatty acids (LC-PUFAs) are crucial for the growth and health of larval marine animals, but marine animals have limited capacity to synthesize LC-PUFAs. The protist Aurantiochytrium limacinum (AL) has high levels of LC-PUFAs and can be used as a source of these essential fatty acids in feed. In this study, Penaeus monodon larvae fed with AL showed increased accumulation of key fatty acids such as DHA and DPA, indicating the importance of LC-PUFAs in their diet.
FRONTIERS IN MARINE SCIENCE
(2021)
Article
Oncology
Iman Moussa, Rena S. Day, Ruosha Li, Ahmed Kaseb, Prasun K. Jalal, Carrie Daniel-MacDougall, Rikita I. Hatia, Ahmed Abdelhakeem, Asif Rashid, Yun Shin Chun, Donghui Li, Manal M. Hassan
Summary: This study found an inverse association between monounsaturated fatty acid intake and hepatocellular carcinoma (HCC) risk, and a direct association between total polyunsaturated fatty acid intake and HCC risk. Omega-6 PUFA intake was directly associated with HCC risk, while long-chain omega-3 PUFA intake was inversely associated with HCC risk. No significant association was observed for saturated fat and HCC risk.
Article
Geriatrics & Gerontology
Jolan Dupont, Eva Wauters, Lenore Dedeyne, Laura Vercauteren, Nadjia Amini, Laurence Lapauw, Christophe Matthys, Sabine Verschueren, Jos Tournoy, Katrien Koppo, Evelien Gielen
Summary: This study aims to explore the relationship between dietary polyunsaturated fatty acids (PUFAs) intake, nutritional PUFAs status and sarcopenia outcomes in sarcopenic older adults. The results showed no correlation between dietary PUFAs intake and status. However, some markers of PUFAs intake and status were positively associated with sarcopenia outcomes.
Article
Biochemistry & Molecular Biology
Ritchie Ly, Brittany C. Macintyre, Stuart M. Philips, Chris Mcglory, David M. Mutch, Philip Britz-McKibbin
Summary: An alternative biomarker for omega-3 index (O3I) was identified using a high-throughput lipidomics method, which revealed that circulating phosphatidylcholines (PCs) can serve as surrogate biomarkers. The study also found that DHA was more effective than EPA in improving the O3I, particularly in young adults with poor nutritional status.
JOURNAL OF LIPID RESEARCH
(2023)
Review
Biotechnology & Applied Microbiology
Abu Bakr Ahmad Fazili, Aabid Manzoor Shah, Xinyi Zan, Tahira Naz, Shaista Nosheen, Yusuf Nazir, Samee Ullah, Huaiyuan Zhang, Yuanda Song
Summary: Microbial oils, especially those produced by the fungus Mucor circinelloides, have gained significant attention for their potential use in various industrial applications. The high efficiency of M. circinelloides in synthesizing and accumulating lipids, combined with its ability to be genetically engineered for increased yields, makes it a promising alternative source of fatty acids. In addition to its potential as a biodiesel raw material, M. circinelloides has shown promise in fields such as antioxidants, nutraceuticals, bioremediation, and carotenoid production.
MICROBIAL CELL FACTORIES
(2022)
Article
Food Science & Technology
Shengyang Ji, Feiran Xu, Na Zhang, Ying Wu, Xingrong Ju, Lifeng Wang
Summary: This study investigated the effects of a novel structured lipid prepared from soybean oil and coconut oil on fatty acid metabolism in mice. The results showed that structured lipids can help increase the conversion of essential fatty acids and fatty acid oxidation, while reducing the expression of lipogenesis genes. Prepared structured lipids may serve as a functional oil to resist obesity.
Review
Food Science & Technology
Yi Wang, Ke Liu, Tingting Long, Jieyi Long, Ying Li, Jiaoyuan Li, Liming Cheng
Summary: Through a meta-analysis of observational studies, we found that dietary fish and marine omega-3 PUFA consumption are associated with improved cancer prognosis and reduced mortality in patients.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Suresh K. Nagumalli, Rose A. Willett, Aline de Conti, Volodymyr P. Tryndyak, Mark I. Avigan, Goncalo Gamboa da Costa, Frederick A. Beland, Ivan Rusyn, Igor P. Pogribny
Summary: Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease characterized by excessive accumulation of lipids in hepatocytes. Recent studies have shown that changes in lipid composition, particularly in PUFA/MUFA ratios, play a crucial role in the development and severity of NAFLD. This research analyzed the fatty acid composition in various mouse models and demonstrated that alterations in PUFA/MUFA ratios can serve as a diagnostic marker for NAFLD severity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Chemistry, Analytical
Linxiu Peng, Weichen Xu, Jingying Wang, Yan Liu, Wenjuan Qian, Shaodong Wang, Tong Xie, Jinjun Shan
Summary: Bronchoalveolar lavage (BAL) is a minimally invasive and well-tolerated procedure widely used for diagnosing pulmonary diseases. Lipid analysis of BAL fluid provides comprehensive information about lipid phenotypes, potential biomarkers, and biological mechanisms of respiratory diseases. However, the diverse concentration of lipids in BAL fluid poses a challenge in obtaining high-quality lipidomic data. This study investigated the optimal concentration multiple of BAL fluid for lipidomic analysis and found that freeze-drying/ reconstitution prior to lipid extraction increased the richness and abundance of lipids. The altered phospholipids in the BAL fluid of H1N1 infected mice were found, indicating disrupted inflammatory homeostasis in the lungs.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Oncology
Theodore M. Brasky, Erinn M. Hade, David E. Cohn, Alison M. Newton, Stacey Petruzella, Kelli O'Connell, Kimberly A. Bertrand, Linda S. Cook, Immaculata De Vivo, Mengmeng Du, Jo L. Freudenheim, Christine M. Friedenreich, Marc T. Goodman, Jessica Gorzelitz, Torukiri I. Ibiebele, Vittorio Krogh, Linda M. Liao, Loren Lipworth, Lingeng Lu, Susan McCann, Tracy A. O'Mara, Julie R. Palmer, Jeanette Ponte, Anna Prizment, Harvey Risch, Sven Sandin, Leo J. Schouten, Veronica Wendy Setiawan, Xiao-ou Shu, Britton Trabert, Piet A. van den Brandt, Penelope M. Webb, Nicolas Wentzensen, Lynne R. Wilkens, Alicja Wolk, Herbert Yu, Marian L. Neuhouser
Summary: This study analyzed data from 12 prospective cohort studies and found that higher dietary intake of long-chain omega-3 polyunsaturated fatty acids (LCn3PUFA) may increase the risk of endometrial cancer, especially among specific subgroups characterized by body weight and tumor pathology.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Nutrition & Dietetics
Alfonso M. Duran, W. Lawrence Beeson, Anthony Firek, Zaida Cordero-MacIntyre, Marino De Leon
Summary: This study aims to identify the cellular pathways stimulated by dietary omega-3 polyunsaturated fatty acid (PUFA) supplementation in patients with type 2 diabetes mellitus (T2DM) affected by painful diabetic neuropathy (pDN). The results show that supplementation leads to a shift towards an anti-inflammatory state and improved membrane fluidity, which may be responsible for the reduction in adverse symptoms associated with neuroinflammatory diseases and painful neuropathy.
Article
Agriculture, Dairy & Animal Science
Chaiwat Arjin, Chanmany Souphannavong, Rakkiat Norkeaw, Niraporn Chaiwang, Supamit Mekchay, Apinya Sartsook, Maninphan Thongkham, Thanchanok Yosen, Warintorn Ruksiriwanich, Sarana Rose Sommano, Korawan Sringarm
Summary: The supplementation of perilla cake improved pig performance, increased PUFA fatty acids, and decreased the proportion of saturated and unsaturated fatty acids in pork, while not affecting carcass traits and meat quality. This alternative source of raw material can be considered for functional feed additives in livestock production.
Article
Chemistry, Medicinal
Diego Valdebenito, Sebastian Urrutia, Allison Leyton, Yusuf Chisti, Juan A. Asenjo, Carolina Shene
Summary: This study investigates the effects of different amino acids in the culture medium on the growth and lipid synthesis of Thraustochytrium sp. RT2316-16. The results show that lysine, alanine, or serine can increase the content of omega-3 polyunsaturated fatty acids (PUFA) in the lipids. The use of organic ammonium and glucose in the culture medium also affects lipid accumulation and mobilization. The findings suggest a possible relationship between carotenoid and lipid metabolism, and provide guidance for enhancing omega-3 PUFA in the biomass.
Article
Gastroenterology & Hepatology
Montse Pauta, Noemi Rotllan, Ana Fernandez-Hernando, Cedric Langhi, Jordi Ribera, Mingjian Lu, Loreto Boix, Jordi Bruix, Wladimiro Jimenez, Yajaira Suarez, David A. Ford, Angel Baldan, Morris J. Birnbaum, Manuel Morales-Ruiz, Carlos Fernandez-Hernando
Article
Cell Biology
Bo Wang, Xin Rong, Mark A. Duerr, Daniel J. Hermanson, Per Niklas Hedde, Jinny S. Wong, Thomas Q. de Aguiar Vallim, Benjamin F. Cravatt, Enrico Gratton, David A. Ford, Peter Tontonoz
Editorial Material
Cardiac & Cardiovascular Systems
Narmadaa Thyagarajan, Alexander M. Brannan, Robert J. Brown
Article
Biochemistry & Molecular Biology
Elisa N. D. Palladino, Wen-yi Wang, Carolyn J. Albert, Cedric Langhi, Angel Baldan, David A. Ford
JOURNAL OF LIPID RESEARCH
(2017)
Article
Biochemistry & Molecular Biology
David A. Ford, Jaideep Honavar, Carolyn J. Albert, Mark A. Duerr, Joo Yeun Oh, Stephen Doran, Sadis Matalon, Rakesh P. Patel
JOURNAL OF LIPID RESEARCH
(2016)
Article
Biochemistry & Molecular Biology
Thomas Q. de Aguiar Vallim, Elinor Lee, David J. Merriott, Christopher N. Goulbourne, Joan Cheng, Angela Cheng, Ayelet Gonen, Ryan M. Allen, Elisa N. D. Palladino, David A. Ford, Tisha Wang, Angel Baldan, Elizabeth J. Tarling
JOURNAL OF LIPID RESEARCH
(2017)
Article
Biochemistry & Molecular Biology
Narmadaa Thyagarajan, Jenika D. Marshall, Arthur T. Pickett, Clemens Schumacher, Yanbo Yang, Sherri L. Christian, Robert J. Brown
Article
Multidisciplinary Sciences
Sherri L. Christian, Nikitha K. Pallegar, Robert J. Brown, Alicia M. Viloria-Petit
Article
Biochemistry & Molecular Biology
Breanne M. Coady, Jenika D. Marshall, Luke E. Hattie, Alexander M. Brannan, Madeline N. Fitzpatrick, Kala E. Hickey, Stefan Wallin, Valerie Booth, Robert J. Brown
JOURNAL OF PEPTIDE SCIENCE
(2018)
Article
Multidisciplinary Sciences
Jenika D. Marshall, Emily R. Courage, Ryan F. Elliott, Madeline N. Fitzpatrick, Anne D. Kim, Andrea F. Lopez-Clavijo, Bronwyn A. Woolfrey, Mireille Ouimet, Michael J. O. Wakelam, Robert J. Brown
Editorial Material
Biochemistry & Molecular Biology
David A. Ford
JOURNAL OF LIPID RESEARCH
(2021)
Article
Biology
Alexandria J. Tobin, Nicholas P. Noel, Sherri L. Christian, Robert J. Brown
Summary: The study found that lipoprotein hydrolysis products can increase secretion of multiple cytokines in breast cancer cells, with different responses observed in different cell lines. The changes in cytokine secretion profiles were independent of increased cell metabolic activity, providing insight into how these products may affect breast cancer cell viability and progression in the tumor microenvironment.
BMC RESEARCH NOTES
(2021)
Article
Biochemistry & Molecular Biology
Kaushalya Amunugama, Matthew J. Jellinek, Megan P. Kilroy, Carolyn J. Albert, Valerio Rasi, Daniel F. Hoft, Michael G. S. Shashaty, Nuala J. Meyer, David A. Ford
Summary: This study identified novel very long carbon chain plasmalogens in human neutrophils, which undergo oxidation during activation to produce chlorolipid products. Elevated levels of these chlorolipids were found in septic patients, indicating their potential role in the pathophysiology of sepsis.
Article
Biochemistry & Molecular Biology
Makayla M. Bavis, Allison M. Nicholas, Alexandria J. Tobin, Sherri L. Christian, Robert J. Brown
Summary: The energy demand of breast cancers is partly met by the oxidation of exogenous fatty acids. Fatty acids also play a role in cell signaling and membrane construction for tumor cells. Lipoprotein lipase (LPL) hydrolyzes lipoprotein triacylglycerols and phospholipids to provide fatty acids, which may promote breast tumor growth in the tumor microenvironment.
Article
Biochemistry & Molecular Biology
Shubha Shakya, Kelly D. Pyles, Carolyn J. Albert, Rakesh P. Patel, Kyle S. McCommis, David A. Ford
Summary: This study reveals a novel distribution of plasmalogen molecular species in airway epithelial cells that are targeted by myeloperoxidase-derived hypochlorous acid, resulting in the formation of electrophilic 2-ClFALD. Furthermore, the proteomics analysis shows distinct protein enrichments in metabolic pathways, particularly in pyruvate metabolism, in epithelial cells compared to endothelial cells modified by 2-ClFALD.