Article
Food Science & Technology
Limei Yang, Le Hu, Hongyu Tang, Xuemei Chen, Xueqing Liu, Yue Zhang, Yixian Wen, Yongxiu Yang, Yanqing Geng
Summary: Ti3C2 MXene exposure impairs villus explant extension ability and trophoblast cell functions by inhibiting cell migration and invasion abilities, and enhancing autophagy. Inhibition of autophagy may be a potential therapeutic strategy for alleviating nanoparticle-induced placental toxicity.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xuan Feng, Zhi Wei, Sai Zhang, Jiayi Zhou, Jing Wu, Baoxin Luan, Yan Du, Hongbo Zhao
Summary: The expression of Laeverin (LVRN) is elevated in patients with preeclampsia. Overexpression of LVRN inhibits trophoblast invasion and may affect epithelial-mesenchymal transition. Furthermore, upregulation of long noncoding RNA NONSTAT103348 (lnc10-7) may lead to increased expression of LVRN.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Article
Biochemistry & Molecular Biology
Nan Chu, Yao Tang, Cheng-Jie Wang, Jiang-Nan Pei, Shou-Ling Luo, Yi Yu, Zhen-Zhen Liu, Hai-Yan Liu, Xue-Min Qiu, Ling Wang, Da-Jin Li, Wei-Rong Gu
Summary: Preeclampsia is associated with a lack of active ANP, and ANP can promote trophoblast invasion by inhibiting autophagy. The study also found that NFYA is one of the transcription factors for PKN3 and ANP can regulate PKN3 expression through NFYA. These findings suggest that ANP can enhance trophoblast invasion by inhibiting autophagy through the AMPK/mTORC1 signaling pathway.
Article
Food Science & Technology
Zhilong Chen, Chen Li, Anwen Yuan, Ting Gu, Feng Zhang, Xiujun Fan, Xiaosong Wu, Xingyao Xiong, Qing Yang
Summary: The study found that alpha-solanine can impair the functions of human trophoblast cells by activating cell apoptosis and autophagy, including inhibiting cell viability, migration, invasion, and tube formation.
Article
Cell Biology
Jin Seok, Sujin Jun, Jinki Cho, Sohea Park, Jung Ok Lee, Gi Jin Kim
Summary: The study reveals that PD-MSCs regulate the balance between survival and death of trophoblast cells, protect damaged mitochondria, and enhance trophoblast invasion. These findings suggest that PD-MSCs modulate trophoblast invasion through dynamic effects on mitochondrial energy metabolism.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Cell Biology
Rujie Lai, Lulu Ji, Xiaoli Zhang, Yating Xu, Yu Zhong, Liying Chen, Hanyang Hu, Lin Wang
Summary: Maternal pregnancy hyperglycemia is often accompanied by placental dysfunction. This study found that the upregulation of Stanniocalcin2 (STC2) expression in gestational diabetes mellitus (GDM) placentas was associated with autophagy activation and EMT suppression, leading to decreased invasiveness of extravillous trophoblasts (EVTs).
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Article
Oncology
Wuguang Liu, Xiaolong Liu, Ying Liu, Ting Ling, Di Chen, Wuxiyar Otkur, Hailong Zhao, Ming Ma, Kexin Ma, Bing Dong, Zexuan Yang, Hai-long Piao, Rui Liang, Chengyong Dong
Summary: PLIN2 has been found to be upregulated in hepatocellular carcinoma (HCC) and its overexpression promotes cancer progression by inhibiting HIF1 alpha expression and stabilizing HIF1 alpha.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Cell Biology
Lanlan Fang, Yibo Gao, Zhen Wang, Yuxi Li, Yang Yan, Ze Wu, Jung-Chien Cheng, Ying-Pu Sun
Summary: This study reveals that downregulation of EGF can lead to poor trophoblast cell invasion by increasing KISS1 expression, which subsequently contributes to the pathogenesis of preeclampsia.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Biochemistry & Molecular Biology
Seungmin Shin, Seungyeon Yang, Minjoong Kim, Eun Kyung Lee, Soojung Claire Hur, Seung Min Jeong
Summary: Metastasis is a malignant characteristic of cancer cells. Melanoma cells undergo metabolic reprogramming during metastasis, specifically upregulation of fatty acid oxidation (FAO). Inhibition of FAO impairs migration of melanoma cells by regulating autophagosome formation. FAO inhibition increases autophagosome formation and suppresses migration and invasion properties of melanoma cells. Modulating cellular acetyl-CoA levels may be a potential therapeutic strategy for inhibiting cancer metastasis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biotechnology & Applied Microbiology
Wen-Ying Long, Guo-Hua Zhao, Yao Wu
Summary: Hesperetin induces apoptotic cell death in BCBL-1 cells in a dose-dependent manner. It also inhibits KSHV reactivation and reduces the production of progeny virus from KSHV-harbouring cells by suppressing HIF1 alpha expression. These findings suggest that hesperetin may be a novel strategy for treating KSHV infection and KSHV-associated lymphomas.
JOURNAL OF GENERAL VIROLOGY
(2021)
Article
Cell Biology
Jiaye Chen, Tinglin Song, Sizhu Yang, Qingxue Meng, Xiaoyu Han, Ze Wu, Jung-Chien Cheng, Lanlan Fang
Summary: This study aimed to investigate the effect of GDF-8 on invasion and MMP2 expression in human EVT cells, and found that Snail is a key factor in GDF-8-induced MMP2 expression and cell invasion.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Biochemistry & Molecular Biology
Xiaole Pan, Saki Noguchi, Misuzu Ando, Tomohiro Nishimura, Masatoshi Tomi
Summary: The study found that overexpression of miR-126 can inhibit the invasive ability of JEG-3 cells by targeting LIN28A, without affecting proliferation and migration. In addition, miR-126-mediated downregulation of LIN28A may contribute to the onset/deterioration of preeclampsia.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Immunology
Jinli Ding, Chaogang Yang, Yanxiang Cheng, Jiayu Wang, Sainan Zhang, Sisi Yan, Fan He, Tailang Yin, Jing Yang
Summary: The study demonstrates that trophoblasts induce M2 macrophages polarization via the IL-6/Stat3 signaling pathway, thereby promoting trophoblast invasion and migration. These results reveal the interaction between macrophages and trophoblasts in the maternal-fetal microenvironment during normal pregnancy.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Mei-Tsz Su, Ching-Wei Tsai, Pei-Yin Tsai, Chia-Yih Wang, Hui-Ling Tsai
Summary: This study demonstrates that elevated cellular FN expression in the placenta of preeclamptic patients is associated with the disease, while aspirin inhibits FN expression and reverses FN-mediated trophoblast functions, providing a drug mechanism for disease prevention and a target for preeclampsia intervention.
Article
Cell Biology
Ze Wu, Lanlan Fang, Sizhu Yang, Yibo Gao, Zhen Wang, Qingxue Meng, Xuan Dang, Ying-Pu Sun, Jung-Chien Cheng
Summary: This study discovers a new biological function and underlying molecular mechanisms of GDF-11 in the regulation of human extravillous trophoblast cell invasion.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Biochemistry & Molecular Biology
Chunmei Chang, Lindsey N. Young, Kyle L. Morris, Soeren von Buelow, Johannes Schoeneberg, Hitomi Yamamoto-Imoto, Yukako Oe, Kentaro Yamamoto, Shuhei Nakamura, Goran Stjepanovic, Gerhard Hummer, Tamotsu Yoshimori, James H. Hurley
Article
Cell Biology
Aif Hakon Lystad, Sven R. Carlsson, Laura R. de la Ballina, Karlina J. Kauffman, Shanta Nag, Tamotsu Yoshimori, Thomas J. Melia, Anne Simonsen
NATURE CELL BIOLOGY
(2019)
Article
Cell Biology
Akitoshi Nakashima, Shi-Bin Cheng, Masahito Ikawa, Tamotsu Yoshimori, Warren J. Huber, Ramkumar Menon, Zheping Huang, Jamie Fierce, James F. Padbury, Yoel Sadovsky, Shigeru Saito, Surendra Sharma
Article
Multidisciplinary Sciences
Sumiko Ikari, Shiou-Ling Lu, Feike Hao, Kenta Imai, Yasuhiro Araki, Yo-hei Yamamoto, Chao-Yuan Tsai, Yumi Nishiyama, Nobukazu Shitan, Tamotsu Yoshimori, Takanobu Otomo, Takeshi Noda
Article
Cell Biology
Tadayoshi Murakawa, Amy A. Kiger, Yuriko Sakamaki, Mitsunori Fukuda, Naonobu Fujita
JOURNAL OF CELL SCIENCE
(2020)
Article
Cell Biology
Narumi Suzuki, Yoshikazu Johmura, Teh-Wei Wang, Toshiro Migita, Wenwen Wu, Rei Noguchi, Kiyoshi Yamaguchi, Yoichi Furukawa, Shuhei Nakamura, Ichiro Miyoshi, Tamotsu Yoshimori, Tomohiko Ohta, Makoto Nakanishi
Summary: The study demonstrates that TP53 upregulates basal autophagy through the FBXO22-TFEB axis, governing the hormetic effect in chemotherapy.
Article
Cell Biology
Shintaro Kira, Masafumi Noguchi, Yasuhiro Araki, Yu Oikawa, Tamotsu Yoshimori, Aiko Miyahara, Takeshi Noda
Summary: Under starvation conditions, cells degrade their own components via autophagy for survival, but there exists a termination mechanism that involves re-phosphorylation of Atg13 by Atg1 protein kinase and the involvement of the Tag1 protein in yeast.
JOURNAL OF CELL SCIENCE
(2021)
Review
Immunology
Prashanta Silwal, Seungwha Paik, Jin Kyung Kim, Tamotsu Yoshimori, Eun-Kyeong Jo
Summary: This review discusses the role of autophagy in restricting the growth of Mycobacterium tuberculosis and the potential of autophagy-modulating agents as host-directed therapeutics. Molecular mechanisms involved include various signaling pathways and factors, and a further understanding of these mechanisms will aid in the development of host-directed therapies against tuberculosis and other intracellular bacterial infections targeted by autophagic degradation.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Shuhei Nakamura, Shiori Akayama, Tamotsu Yoshimori
Summary: This article introduces the canonical and non-canonical roles of ATG8 in autophagy, and highlights the novel discovery of ATG8 activating Transcriptional Factor EB (TFEB) during lysosomal damage.
BIOCHEMICAL SOCIETY TRANSACTIONS
(2022)
Article
Cell Biology
Tadashi Yamamuro, Shuhei Nakamura, Kyosuke Yanagawa, Ayaka Tokumura, Tsuyoshi Kawabata, Atsunori Fukuhara, Hirofumi Teranishi, Maho Hamasaki, Iichiro Shimomura, Tamotsu Yoshimori
Summary: Fasting decreases RUBCN levels and increases autophagy in adipocytes. Loss of RUBCN promotes a metabolic response to fasting via increasing autophagic activity.
Article
Developmental Biology
Tadayoshi Murakawa, Tsuyoshi Nakamura, Kohei Kawaguchi, Futoshi Murayama, Ning Zhao, Timothy J. Stasevich, Hiroshi Kimura, Naonobu Fujita
Summary: The research team has developed a versatile toolkit for Drosophila, using a genetically encoded single-chain variable fragment, to analyze the function of a protein of interest (POI) in live tissues. By crossing different tagged flies, various analyses of the tagged POI in vivo can be conducted. The study reveals that downregulated lysosomal function in the fat body plays a crucial role in the metamorphosis of Drosophila.
Article
Cell Biology
Xiaotong Jia, Anastasia Knyazeva, Yu Zhang, Sergio Castro-Gonzalez, Shuhei Nakamura, Lars-Anders Carlson, Tamotsu Yoshimori, Dale P. Corkery, Yao-Wen Wu
Summary: Jia et al. have identified cholesterol as the primary lipid responsible for the interaction between Vibrio cholerae toxin MakA and host membranes. They have also characterized a sophisticated mechanism of recurrent membrane damage regulated by pH-dependent pore formation, leading to V-ATPase-dependent unconventional LC3 lipidation on damaged endolysosomal membranes.
JOURNAL OF CELL BIOLOGY
(2022)
Editorial Material
Cell Biology
Keisuke Tabata, Marika Saeki, Tamotsu Yoshimori, Maho Hamasaki
Summary: Macroautophagy, or autophagy, is a highly conserved cellular degradation system that maintains cellular homeostasis. This study identified a new E3 ligase complex, involving CUL4A, as a regulatory complex in lysophagy, the process of targeting damaged lysosomes through autophagy. The complex was found to mediate a critical protein modification on LAMP2 during lysosomal damage, leading to the clearance of damaged lysosomes.
Article
Cell Biology
Takayuki Shima, Monami Ogura, Ruriko Matsuda, Shuhei Nakamura, Natsuko Jin, Tamotsu Yoshimori, Akiko Kuma
Summary: Shima et al. developed a new probe, TMEM192-mKeima, to monitor lysophagy more specifically than conventional probes. They re-evaluated factors involved in the lysosomal damage response and identified factors involved in lysophagy via screenings using the probe. This study highlights the importance of TMEM192-mKeima probe in investigating lysophagy.
JOURNAL OF CELL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Tatsuya Shioda, Ittetsu Takahashi, Kensuke Ikenaka, Naonobu Fujita, Tomotake Kanki, Toshihiko Oka, Hideki Mochizuki, Adam Antebi, Tamotsu Yoshimori, Shuhei Nakamura
Summary: Accumulating evidence suggests that the molecular network involving neuronal MML-1 function is crucial for regulating systemic aging. This study demonstrates that MML-1 and its heterodimer partners play a primary role in neurons to extend longevity in germlineless animals, acting via downstream cascades that are distinct from HLH-30. The MML-1-GLT-5 axis in neurons is critical for maintaining proteostasis and reducing oxidative stress in long-lived animals through autophagy and peroxidase MLT-7, respectively.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)