Article
Multidisciplinary Sciences
Kaela M. Varberg, Khursheed Iqbal, Masanaga Muto, Mikaela E. Simon, Regan L. Scott, Keisuke Kozai, Ruhul H. Choudhury, John D. Aplin, Rebecca Biswell, Margaret Gibson, Hiroaki Okae, Takahiro Arima, Jay L. Vivian, Elin Grundberg, Michael J. Soares
Summary: Invasive trophoblast cells play a crucial role in placental development and pregnancy outcomes. ASCL2 is identified as a key regulator of invasive trophoblast cell lineage development in humans and rats. ASCL2 deficiency impairs EVT cell differentiation and impacts placental morphogenesis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Developmental Biology
Andreanna Burman, Rolando Garcia-Milian, Madeleine Wood, Natalie A. DeWitt, Vasilis Vasiliou, Seth Guller, Vikki M. Abrahams, Shannon Whirledge
Summary: The use of acetaminophen may interfere with critical trophoblast functions, potentially impacting fetal development.
Article
Cell Biology
Violeta Stojanovska, Susanne Arnold, Mario Bauer, Hermann Voss, Stefan Fest, Ana Claudia Zenclussen
Summary: This study characterized three different 3D cultures derived from trophoblast cell lines and compared them to primary fetal trophoblasts and placental tissue. The results showed that these 3D cell culture models exhibit similar functionality and gene expression profiles to primary placental tissue, making them ideal models for studying the placenta.
Review
Endocrinology & Metabolism
Yongdan Ma, Yongyan Hu, Jingmei Ma
Summary: Placenta accreta spectrum disorder (PAS) is a disease characterized by abnormal invasion of the placenta into the myometrium and uterus. The understanding of its mechanisms and signaling pathways is limited due to the lack of suitable animal models. Mouse models, particularly those induced by uterine surgery, have been used to simulate different phenotypes of PAS and investigate its pathogenesis. This review summarizes the approaches of PAS modeling in mice and provides insight into the strengths, limitations, and future perspectives of each strategy.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cell Biology
Qian Yang, Yeling Ma, Yanlei Liu, Xuan Shao, Wentong Jia, Xin Yu, Yu-xia Li, Long Yang, Wenwen Gu, Haibin Wang, Jian Wang, Yan-Ling Wang
Summary: The study demonstrated the crucial role of MNSF beta in regulating trophoblast invasion and fetal development. Lack of MNSF beta led to restricted embryonic growth and fetal loss, primarily due to limited trophoblast invasion. Conjugation with IGF2BP2 stabilized the protein and promoted trophoblast invasion.
CELL PROLIFERATION
(2021)
Article
Obstetrics & Gynecology
Zhirui Chen, Mengying Wu, Haixia Huang, Hui Tao, Li Zou, Qingqing Luo
Summary: The expression of miR-199a-5p is significantly increased in plasma exosomes and placenta tissue from patients with severe preeclampsia (sPE). Exosomal miR-199a-5p impairs endothelial cell function by targeting SIRT1, contributing to the development of preeclampsia.
REPRODUCTIVE SCIENCES
(2022)
Article
Endocrinology & Metabolism
Jose M. Murrieta-Coxca, Emanuel Barth, Paulina Fuentes-Zacarias, Ruby N. Gutierrez-Samudio, Tanja Groten, Alexandra Gellhaus, Angela Koeninger, Manja Marz, Udo R. Markert, Diana M. Morales-Prieto
Summary: Placenta accreta spectrum (PAS) is a group of pathological conditions characterized by abnormal attachment of the placenta to the uterus wall, and it is a major cause of maternal morbidity and mortality worldwide. In this study, altered miRNA expression, particularly in placenta-specific miRNA clusters, was identified in placenta accreta tissue compared to normal placental tissues. Dysregulated pathways associated with cell cycle regulation, inflammation, and invasion were also observed. The study provides miRNA:mRNA associations that could contribute to our understanding of PAS development.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cell Biology
Danai Georgiadou, Souad Boussata, Remco Keijser, Dianta A. M. Janssen, Gijs B. Afink, Marie van Dijk
Summary: Mutations in the LINC-HELLP non-coding RNA (HELLPAR) are associated with familial forms of the pregnancy-specific HELLP syndrome, impacting EVT differentiation and the binding of RNA splicing complex proteins PCBP1, PCBP2, and YBX1 to LINC-HELLP. Knockdown of PCBP2, and to a lesser extent YBX1 and PCBP1, leads to failure of EVTs to differentiate towards an invasive phenotype. PCBP2 silencing alters splicing for genes related to cellular assembly, organization, function, maintenance, growth, proliferation, and the cell cycle, indicating its crucial role in EVT differentiation mechanisms.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Developmental Biology
Juan F. Mejia, Parker Hall, Kelsey M. Hirschi, Paul R. Reynolds, Juan A. Arroyo
Summary: The PKM2 protein is associated with IUGR in placenta, and its activation can protect placental and fetal weights from decreasing. The expression and localization of PKM2 in trophoblast cells change under different oxygen levels.
Article
Endocrinology & Metabolism
Huaiyun Tang, Linqing Pan, Yun Xiong, Leilei Wang, Yugui Cui, Jiayin Liu, Lisha Tang
Summary: The study revealed that increased levels of microRNA-4497 in placental villus tissues of recurrent miscarriage patients may down-regulate SP1 protein expression, leading to trophoblast apoptosis and potentially contributing to the pathogenesis of recurrent miscarriage.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Immunology
Yingshi Ouyang, Jean-Francois Mouillet, Alexander Sorkin, Yoel Sadovsky
Summary: Cells produce cytoplasmic vesicles to facilitate the processing and transport of molecules, while releasing extracellular vesicles for intercellular communication. Understanding the biological functions and potential diagnostic/therapeutic applications of EVs, especially exosomes, is a current focus. EVs and viruses share similarities in biogenesis, size distribution, cargo, and cell-targeting mechanisms, with potential impacts on viral replication and infectivity revealed by research.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Orsolya Oravecz, Andrea Balogh, Roberto Romero, Yi Xu, Kata Juhasz, Zsolt Gelencser, Zhonghui Xu, Gaurav Bhatti, Roger Pique-Regi, Balint Peterfia, Petronella Hupuczi, Ilona Kovalszky, Padma Murthi, Adi L. Tarca, Zoltan Papp, Janos Matko, Nandor Gabor Than
Summary: Proteoglycan macromolecules, specifically syndecan-1, play crucial roles in various physiological processes during placenta development and healthy pregnancy. Dysregulated expression of proteoglycans, including syndecan-1, has been observed in pregnancy complications such as pre-eclampsia and fetal growth restriction. Further research is needed to explore the potential diagnostic and therapeutic applications of proteoglycans in complicated pregnancies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Jin Seok, Sujin Jun, Jinki Cho, Sohea Park, Jung Ok Lee, Gi Jin Kim
Summary: The study reveals that PD-MSCs regulate the balance between survival and death of trophoblast cells, protect damaged mitochondria, and enhance trophoblast invasion. These findings suggest that PD-MSCs modulate trophoblast invasion through dynamic effects on mitochondrial energy metabolism.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Developmental Biology
Tomoaki Yoshida, Kazuhide Takada, Shihoko Komine-Aizawa, Yoshimasa Kamei, Osamu Ishihara, Satoshi Hayakawa
Summary: Recent studies indicate that Lactobacillus crispatus can promote trophoblast invasion by increasing the activation of MMP-1 and MMP-2, without affecting migration. This suggests that the dominance of Lactobacillus in the endometrium may be beneficial for implantation, but further research is needed to determine if it is favorable for successful placentation at the early stage of pregnancy.
Article
Chemistry, Analytical
Gun Ko, Tae-Joon Jeon, Sun Min Kim
Summary: This study investigates the role of hypoxic environment in trophoblast cell invasion and migration. It shows that under hypoxic conditions, the mobility of trophoblast cells is upregulated, suggesting the importance of hypoxic environment in the endometrium for cell migration. This has implications for the understanding and management of preeclampsia, a pregnancy complication caused by incomplete placental formation.
Article
Pharmacology & Pharmacy
Saki Noguchi, Moeko Okochi, Hayumi Atsuta, Rika Kimura, Ayaka Fukumoto, Kyoko Takahashi, Tomohiro Nishimura, Masatoshi Tomi
Summary: OAT4 may play a role in the excretion of azilsartan, candesartan, carboxylosartan, and valsartan, as well as olmesartan. Only OAT4-mediated dianion transport is Cl- sensitive.
DRUG METABOLISM AND PHARMACOKINETICS
(2021)
Article
Pharmacology & Pharmacy
Saki Noguchi, Akinori Takagi, Takahiro Tanaka, Yu Takahashi, Xiaole Pan, Yuka Kibayashi, Ryo Mizokami, Tomohiro Nishimura, Masatoshi Tomi
Summary: The study revealed that ENT1 expression was higher than ENT2 in triple-negative breast cancer cell lines, but both transporters had minimal contribution to fluorouracil uptake and showed no correlation with fluorouracil sensitivity. It suggests that neither ENT1 nor ENT2 significantly affects the sensitivity of TNBC cell lines to fluorouracil.
BIOPHARMACEUTICS & DRUG DISPOSITION
(2021)
Article
Chemistry, Medicinal
Valentina M. Fokina, Svetlana Patrikeeva, Xiao-Ming Wang, Saki Noguchi, Masatoshi Tomi, Jorg Konig, Mahmoud S. Ahmed, Tatiana Nanovskaya
Summary: This study aimed to identify the uptake transporters responsible for the placental disposition of pravastatin. The results showed that OATP1A2 and OATP2A1 are responsible for the uptake of pravastatin from the maternal circulation into the placenta, while OAT4 mediates the transport of the drug across the placental basolateral membrane in the fetal-to-maternal direction.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Arimi Fujita, Saki Noguchi, Rika Hamada, Satoko Inoue, Tsutomu Shimada, Satomi Katakura, Tetsuo Maruyama, Yoshimichi Sai, Tomohiro Nishimura, Masatoshi Tomi
Summary: The functional impact of a single MDR1 molecule at the placental barrier and blood-brain barrier in mice is compared in this study. The findings suggest that murine placental MDR1 has minimal influence on fetal drug concentration, possibly due to bypass transfer via connexin26 gap junctions.
PHARMACEUTICAL RESEARCH
(2022)
Article
Chemistry, Medicinal
Tomoya Akashi, Saki Noguchi, Yu Takahashi, Tomohiro Nishimura, Masatoshi Tomi
Summary: The study aimed to investigate the transport mechanism of pregabalin at the blood-spinal cord barrier (BSCB) using in vivo experiments and in vitro studies. The results showed that the uptake of pregabalin by rat spinal cord endothelial cells was sodium-independent and inhibited by L-leucine, 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid, and JPH203. In addition, pre-administration of branched chain amino acids (BCAAs) significantly decreased the transfer of pregabalin to the rat spinal cord and brain. These findings suggest that pregabalin transport across the BSCB is mediated at least in part by LAT1 and is inhibited by plasma BCAAs.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Environmental Sciences
Di Liu, Shaofeng Xu, Yunchao Lang, Shengjie Hou, Lianfang Wei, Xiaole Pan, Yele Sun, Zifa Wang, Kimitaka Kawamura, Pingqing Fu
Summary: This study investigated the source, formation, and seasonality of biogenic secondary organic aerosol (BSOA) in Beijing, China from April 2017 to January 2018. BSOA tracers derived from isoprene, monoterpene, and sesquiterpene were measured and showed significant seasonal variations. Isoprene SOA tracers correlated with biomass burning and long-range transport, while sesquiterpene SOA tracer was associated with local biomass burning. These results suggest that BSOA tracers are promising for understanding the source, formation, and seasonality of BSOA.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Ping Du, Xiaoling Nie, Hongtao Liu, Zhiru Hou, Xiaole Pan, Hang Liu, Xinghui Liu, Xinfeng Wang, Xiaomin Sun, Yan Wang
Summary: Cloud and fog droplets play a crucial role in atmospheric chemistry by impacting the distribution and chemical transformation of pollutants. The design of a cloud/fog sampler must prioritize accurate fog event identification and high collection efficiency. The automatic cloud/fog collector (ACFC) was developed, tested, and found to collect cloud/fog water samples reliably. ACFC utilizes a control box, standard sensors, and airflow measurement to ensure automation, stability of airspeed, and efficient sampling.
Article
Environmental Sciences
Hang Liu, Xiaole Pan, Shandong Lei, Yuting Zhang, Aodong Du, Yu Tian, Weijie Yao, Jinyuan Xin, Jie Li, Yele Sun, Junji Cao, Zifa Wang
Summary: The study investigates the microphysical properties of fresh black carbon aerosol (BC) emitted from traffic sources and aged BC emitted from solid fuel burning sources. Differences in size distribution and coating thickness of BC from these sources cause variations in light absorption and hygroscopicity. The study emphasizes the importance of considering the microphysical properties of BC in climate models to better understand its concentrations and optical properties.
ATMOSPHERIC ENVIRONMENT
(2023)
Article
Environmental Sciences
Mingming Zhu, Qi Liao, Lin Wu, Si Zhang, Zifa Wang, Xiaole Pan, Qizhong Wu, Yangang Wang, Debin Su
Summary: Radar reflectivity data can accurately represent atmospheric variations, but cannot predict fine-grained changes that numerical weather prediction models or satellites cannot capture. We reconstructed radar echoes from the WRF model simulations and Himawari-8 satellite products using deep networks, producing reconstructions that matched well in terms of patterns, locations, and intensities. We discovered stratified features in the multiscale representation, with smaller-scale patterns influenced by WRF-simulated variables and larger-scale information captured from satellite images. These results could inspire innovative model-data fusion methods to improve nowcasting.
Article
Meteorology & Atmospheric Sciences
Ning Yang, Qiaorong Xie, Xinxing Zhang, Shujun Zhong, Wei Hu, Junjun Deng, Libin Wu, Ming Sheng, Mutong Niu, Dandan Liu, Jialei Zhu, Yong Chen, Jing Duan, Xiaole Pan, Yele Sun, Zifa Wang, Pingqing Fu
Summary: This study investigates the photochemical processes between organic coatings and aqueous samples such as fogwater, which contain light absorbing brown carbon (BrC). Through laboratory studies and field observations, it is found that unsaturated fatty acids can interact with aqueous samples, forming organic peroxy radicals and undergoing oxidation pathways. The results also suggest that the interaction between organic acids and hydroxyl radicals (OH) has a higher oxidative capacity than OH alone. In addition, oleic acid is shown to enhance the aqueous oxidation ability by producing oxygen-containing radicals.
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES
(2023)
Article
Environmental Sciences
Hang Liu, Xiaole Pan, Shandong Lei, Yuting Zhang, Aodong Du, Weijie Yao, Guiqian Tang, Tao Wang, Jinyuan Xin, Jie Li, Yele Sun, Junji Cao, Zifa Wang
Summary: In this study, vertical measurements of black carbon (BC) and other pollutants were conducted in the Beijing urban area. The vertical profiles showed different types of BC distribution, with uniform distribution during the day and gradual or sharp decrease at night. The study also found variations in the ozone concentration and the coating thickness of BC particles along the vertical direction. This research provides insights into the regional environmental effects of BC.
ATMOSPHERIC CHEMISTRY AND PHYSICS
(2023)
Article
Environmental Sciences
Lei Kong, Xiao Tang, Jiang Zhu, Zifa Wang, Yele Sun, Pingqing Fu, Meng Gao, Huangjian Wu, Miaomiao Lu, Qian Wu, Shuyuan Huang, Wenxuan Sui, Jie Li, Xiaole Pan, Lin Wu, Hajime Akimoto, Gregory R. Carmichael
Summary: The lockdown measures during the COVID-19 pandemic in China had limited impact on air pollution, and traffic control alone cannot effectively address O-3 and PM2.5 pollution.
ATMOSPHERIC CHEMISTRY AND PHYSICS
(2023)
Meeting Abstract
Developmental Biology
Saki Noguchi, Xiaole Pan, Misuzu Ando, Tomohiro Nishimura, Masatoshi Tomi
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)