Article
Multidisciplinary Sciences
Yaarit Adamovich, Vaishnavi Dandavate, Saar Ezagouri, Gal Manella, Ziv Zwighaft, Jonathan Sobel, Yael Kuperman, Marina Golik, Asher Auerbach, Maxim Itkin, Sergey Malitsky, Gad Asher
Summary: The study showed that circadian clocks and clock proteins influence mouse exercise capacity, with effects on liver glycogen levels and muscle lipid utilization playing a key role. Training at different times of the day also showed varying effects on exercise performance.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Food Science & Technology
Chuan Qin, Shaoqin Hu, Shuangxi Zhang, Daina Zhao, Yongyao Wang, Hua Li, Yunhua Peng, Le Shi, Xiaohong Xu, Changhe Wang, Jiankang Liu, Ying Cheng, Jiangang Long
Summary: The study found that HT-ac significantly improved cognitive function in AD mice by ameliorating neuronal apoptosis and decreasing inflammatory cytokine levels in water maze tests.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Neurosciences
Jiayue Cai, Aiping Liu, Yuheng Wang, Sun Nee Tan, Taylor Chomiak, Jacqueline Burt, Richard Camicioli, Bin Hu, Martin J. McKeown, Fang Ba
Summary: Exercise can improve gait disturbances and motor function in Parkinson's disease patients. The functional connectivity of the Pedunculopontine Nucleus (PPN) is modifiable through exercise, with an increase in connectivity on the right side and a decrease on the left side correlating with motor improvement. Additionally, exercise induces a significant increase in the laterality of PPN connectivity strength, which is associated with motor improvement.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Geriatrics & Gerontology
Sujuan Liu, Chunxia Yu, Lingjian Xie, Yanmei Niu, Li Fu
Summary: Regular exercise can reverse the negative effects of sarcopenia on muscle mass and function, by regulating the Sesn2/AMPK alpha 2 pathway. This study provides new insights into the molecular mechanism by which exercise alleviates the consequences of sarcopenia.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Immunology
Arezou Khosrojerdi, Sara Soudi, Ahmad Zavaran Hosseini, Sahar Ghaffari Khaligh, Seyed Mahmoud Hashemi
Summary: The study demonstrated a dose-dependent effect of imipenem on inflammatory responses in sepsis mice. Treatment with a low dose (25 mg/kg) of imipenem resulted in decreased bacterial load, endotoxin level, and inflammatory cytokine production, improved pathology, and increased survival rate in sepsis mice compared to other groups.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ajamaluddin Malik, Abdullah Alhomida, Javed Masood Khan
Summary: This study investigated the influence of a negatively charged benzene ring containing surfactant, sodium dodecylbenzene sulphonate (SDBS), on the fibrillation of bovine liver catalase (BLC). It was found that lower concentrations of SDBS promoted the native-like alpha-helical structure of BLC, while higher concentrations led to aggregation and the formation of amyloid-like structures. At pH 2.0, higher concentrations of SDBS enabled BLC to regain its native-like alpha-helical structure.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Cell Biology
Sereen K. Nashif, Renee M. Mahr, Snehalata Jena, Seokwon Jo, Alisa B. Nelson, Danielle Sadowski, Peter A. Crawford, Patrycja Puchalska, Emilyn U. Alejandro, Micah D. Gearhart, Sarah A. Wernimont
Summary: The study found that the inhibitory effect of melanoma on the growth and invasion of skin cancer cells may be related to the regulation of proliferation and apoptosis of skin cancer cells by melanoma cells through the p38 signaling pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biology
Kepu Chen, Yuting Ye, Nikolaus F. Troje, Wen Zhou
Summary: The study provides evidence of the role of oxytocin and vasopressin in subconscious chemosignaling in humans. It shows that chemosensory communications of masculinity and femininity can be blocked by a competitive antagonist of these neuropeptides. Oxytocin modulates the decoding of sex-specific information in a manner that is dose-dependent, nonmonotonic, and contingent upon social proficiency of the recipients.
Article
Oncology
Donatella Malanga, Carmelo Laudanna, Teresa Mirante, Fabiana Colelli, Simona Migliozzi, Pietro Zoppoli, Gianluca Santamaria, Luca Roberto, Carmela De Marco, Marzia Scarfo, Donatella Montanaro, Orlando Paciello, Serenella Papparella, Chiara Mignogna, Alfonso Baldi, Giuseppe Viglietto
Summary: The gain-of-function mutation AKT1E17K is demonstrated to be a bona fide oncogene for mammary epithelium, capable of efficiently initiating breast cancer in mice. The AKT1E17K strain may serve as an appropriate model for human basal-like breast cancer and may aid in the identification of novel therapies specific to this type of tumor.
Article
Biochemistry & Molecular Biology
Zhi Li, Hai-Yan Yang, Xin-Yuan Dai, Xu Zhang, Yu-Zhou Huang, Liang Shi, Ji-Fu Wei, Qiang Ding
Summary: The newly discovered circMETTL3 in breast cancer is significantly upregulated and may play a crucial role in promoting cell proliferation, migration, and invasion. It functions as a ceRNA of miR-31-5p, potentially upregulating CDK1, and its m6A modification could influence its expression, suggesting a new therapeutic target for breast cancer.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Mingjie Zheng, Shannon Erhardt, Di Ai, Jun Wang
Summary: The Bmp signaling pathway and Hand1 play crucial roles in cardiac development. Bmp2 and Bmp4 can regulate Hand1 expression and directly activate and bind to Hand1. The results suggest that the Bmp signaling pathway directly regulates Hand1 expression in a dose-dependent manner during heart development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Ying Fei, Abukar Ali, Majd Mohammad, Tao Jin
Summary: This study found that human commensal bacteria can augment Staphylococcus aureus-induced septic arthritis. This augmentation effect is dose-dependent and can lead to worsened clinical symptoms and pathological changes.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Kirsty Brown, Carolyn A. Thomson, Soren Wacker, Marija Drikic, Ryan Groves, Vina Fan, Ian A. Lewis, Kathy D. McCoy
Summary: Commensal bacteria play a significant role in mammalian metabolism. This study investigates the impact of microbiota, age, and sex on metabolite profiles in various body sites of mice. The microbiota has the highest influence on the gastrointestinal tract, while age and microbiota similarly contribute to urine, serum, and peritoneal fluid metabolome variations. Moreover, age mainly drives metabolome variations in the liver and spleen, while sex has a significant impact on all sites except the ileum.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Milena Schonke, Zhixiong Ying, Artemiy Kovynev, Wietse In Het Panhuis, Anne Binnendijk, Sabine van Der Poel, Amanda C. M. Pronk, Trea C. M. Streefland, Menno Hoekstra, Sander Kooijman, Patrick C. N. Rensen
Summary: The timing of exercise training plays a critical role in reducing fat mass and early-stage atherosclerotic lesions, as well as affecting the composition of gut microbiota.
Article
Biochemistry & Molecular Biology
Mengmeng Zhang, Beibei Feng, Yun Chen, Mingxi Geng, Ming Li, Xianbo Zheng, Haipeng Zhang, Langlang Zhang, Bin Tan, Xia Ye, Wei Wang, Jidong Li, Jun Cheng, Jiancan Feng
Summary: Annual shoots of peach trees grow quickly, limiting the lighting and ventilation of orchards. Three PpIBH1s proteins were found to play important roles in regulating cell elongation and plant stature. The expression of these genes correlated with internode length and were highly expressed in dwarf peach cultivars, suggesting that they prevent the elongation of peach shoots.
Review
Medicine, Research & Experimental
Colin Harper, Venkatesh Gopalan, Jorming Goh
Summary: This review examines the cellular and molecular changes in skeletal muscle mitochondria during aging, particularly focusing on the efficiency of mitochondrial coupling and its impact on muscle function decline. It also discusses how different exercise modalities can potentially reverse these changes and delay the onset of sarcopenia. Additional concepts such as mitophagy and the implications of muscle fiber type changes with sarcopenia on mitochondrial function are also integrated in this review.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Jorming Goh, Esther Wong, Janjira Soh, Andrea Britta Maier, Brian Keith Kennedy
Summary: Biological aging is the main driver of age-related chronic diseases. A meeting sponsored by the United States National Institute of Aging (NIA) identified seven biological pillars of aging, providing a useful framework for studying human aging. This review examines these pillars from the perspective of exercise and discusses how regular physical exercise can modulate them to prevent age-related chronic diseases and maintain functional capacity.
Review
Endocrinology & Metabolism
Bibek Gyanwali, Zi Xiang Lim, Janjira Soh, Clarissa Lim, Shou Ping Guan, Jorming Goh, Andrea B. Maier, Brian K. Kennedy
Summary: Alpha-ketoglutarate (AKG) is an intermediate in the Krebs cycle with various metabolic and cellular functions. Recent studies suggest its potential in extending human healthspan, but further clinical research is needed to understand its role in treating aging and age-related diseases.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Yuan Wen, Taylor Valentino, Lauren Depa, Jensen Goh, Alexander Alimov, Ivan Vechetti, Charlotte A. Peterson, John J. McCarthy
Review
Geriatrics & Gerontology
Zi Xiang Lim, Jorming Goh
Summary: Aging leads to loss of muscle mass and strength, and strength training at 70% 1RM or higher intensity is recommended for older adults. However, many older adults may not be able to perform at such intensity. A training program combining low intensity resistance exercise with blood flow restriction can provide similar muscle benefits for older adults. Safety considerations need to be taken when using BFR in older adults.
EUROPEAN REVIEW OF AGING AND PHYSICAL ACTIVITY
(2022)
Review
Geriatrics & Gerontology
Susanne Janette Oudbier, Jorming Goh, Stephanie Marcella Leonie Maria Looijaard, Esmee Marielle Reijnierse, Carolus Gerardus Maria Meskers, Andrea Britta Maier
Summary: Low skeletal muscle mass is associated with cognitive impairment and dementia in older adults. Possible underlying mechanisms include systemic inflammation, insulin metabolism, protein metabolism, and mitochondrial function. The dysfunctional secretion of myokines, resulting from minimal physical activity, may play a central role in this pathophysiology. Restoring myokine balance through physical activity could be a targeted approach in the pathophysiology of low muscle mass and cognition.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Medicine, General & Internal
Adrian Matysek, Aneta Studnicka, Wade Menpes Smith, Michal Hutny, Pawel Gajewski, Krzysztof J. J. Filipiak, Jorming Goh, Guang Yang
Summary: Since the outbreak of COVID-19, there have been individual differences in the course of the disease, influenced by various factors. By using machine learning to analyze the clinical characteristics of affected populations, we can assess the significance and create a tool to evaluate individual risk of SARS-CoV-2 infection.
FRONTIERS IN MEDICINE
(2022)
Article
Oncology
Janjira Soh, Zi Xiang Lim, Elaine Hsuen Lim, Brian K. Kennedy, Jorming Goh
Summary: Regular exercise may have significant implications for tumor and stromal cells in the tumor microenvironment by modulating iron bioavailability, transport, and metabolism, affecting multiple tumor-autonomous and stromal cell responses.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Physiology
H. L. Notbohm, F. Moser, J. Goh, J. F. Feuerbacher, W. Bloch, M. Schumann
Summary: The immune system's role in exercise responses and adaptations is important, but the impact of fluctuating hormone concentrations across the menstrual cycle on these processes is unknown. This systematic review with meta-analysis compared immune and inflammatory parameters between menstrual cycle phases. The findings suggest that certain parameters of innate immunity, such as leukocytes, monocytes, granulocytes, neutrophils, and leptin concentrations, are higher in the luteal phase compared to the follicular phase at rest. The exercise-induced response of these parameters also indicate a higher pro-inflammatory response in the luteal phase. However, more research is needed to understand the exercise responses in different hormonal profiles.
Review
Rehabilitation
Zi Xiang Lim, Bibek Gyanwali, Janjira Soh, Angela S. Koh, Jorming Goh
Summary: Cardiopulmonary exercise testing (CPET) is widely used to assess the fitness of both healthy and clinical populations. While most studies focus on physiological responses during exercise, this review highlights the importance of studying post-CPET recovery responses, especially in middle-aged and older adults. The authors propose examining the aerobic and anaerobic recovery threshold post-CPET as potential diagnostic and prognostic tools.
BMC SPORTS SCIENCE MEDICINE AND REHABILITATION
(2023)
Article
Geriatrics & Gerontology
Elena Sandalova, Jorming Goh, Zi Xiang Lim, Zhi Meng Lim, Diogo Barardo, Rajkumar Dorajoo, Brian K. Kennedy, Andrea B. Maier
Summary: Targeting molecular processes of aging can help prevent age-related diseases and extend people's healthy lifespan. Geroprotectors have the potential to increase healthspan and lifespan, but their translation to humans is limited. Alpha-Ketoglutarate (AKG) has been extensively studied in animal models, but there are few studies on its geroprotective properties in humans.
Article
Biochemistry & Molecular Biology
Venkatesh Gopalan, Jadegoud Yaligar, Navin Michael, Kavita Kaur, Rengaraj Anantharaj, Sanjay Kumar Verma, Suresh Anand Sadananthan, Giang Thi Thu Le, Jorming Goh, S. Sendhil Velan
Summary: Investigations on obese rodent models have shown that 12 weeks of aerobic exercise training can effectively improve metabolic health, fat depots, ectopic fat, and inflammation.
BIOSCIENCE REPORTS
(2021)
Article
Geriatrics & Gerontology
Reshma A. Merchant, J. Goh, Y. H. Chan, J. Y. Lim, B. Vellas
Summary: MCR and SG-A are associated with global cognitive decline, particularly in non-memory domains, and lower functional scores. The prevalence of MCR increases with age, especially among elderly females. The SG prevalence is highest in the Malay ethnic group.
JOURNAL OF NUTRITION HEALTH & AGING
(2021)
Meeting Abstract
Sport Sciences
Jorming Goh, Lina Lim, Brian Kennedy, Soo Chin Lee
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2020)
Article
Pathology
Lida Zhu, Juan Wang, Christina Pettan-Brewer, Warren Ladiges, Jorming Goh
PATHOBIOLOGY OF AGING AND AGE-RELATED DISEASES
(2019)