Article
Entomology
Wen-Feng Chen, Ying Wang, Wei-Xing Zhang, Zhen-Guo Liu, Bao-Hua Xu, Hong-Fang Wang
Summary: The study indicated that methionine plays a regulatory role in caste differentiation of honey bees. It affects the development of worker bee larvae and may direct female larvae towards becoming worker bees. By promoting DNA methylation, methionine may regulate caste differentiation through influencing gene expression.
Article
Biochemistry & Molecular Biology
Robert Lowe, Marek Wojciechowski, Nancy Ellis, Paul J. Hurd
Summary: This study provides the first comprehensive genome-wide maps of the regulatory landscape in all three phenotypes of honey bees, identifying thousands of regulatory regions and elucidating key gene regulatory networks associated with distinct polyphenisms.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Leila Gharehdaghi, Mohammad Reza Bakhtiarizadeh, Kang He, Taher Harkinezhad, Gholamhosein Tahmasbi, Fei Li
Summary: The study found evidence of cross-species regulation function of miRNA between honeybees and flowering host plants by demonstrating the transmission of plant miRNAs into the midgut of honey bees feeding on sunflower and sedr pollen. Specifically, 11 plant miRNAs were identified in the midgut, with 9 miRNAs shared between sunflower- and sedr-fed honeybees, indicating potential essential roles in plant-insect interactions. Furthermore, the study predicted 121 honeybee mRNAs as targets of these plant-derived miRNAs, with implications in various biological pathways such as hippo signaling and Wnt signaling.
Article
Biochemistry & Molecular Biology
Kaixin Qin, Fuping Cheng, Luxia Pan, Zilong Wang
Summary: This study investigated the expression profiles of miRNAs in the hypopharyngeal gland of honey bees and found significant expression differences of multiple miRNAs between different development stages. Many of the differentially expressed miRNAs and target genes are related to growth and development or apoptosis in honey bees.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Susie Cho, Si Hyeock Lee, Sanghyeon Kim
Summary: This paper compares the responses of honey bees to pesticides at different maturation temperatures and evaluates the appropriate maturation temperature. The results showed that honey bees matured at 30 degrees C had the best body weight and gland development. The transcription profiles of detoxification-related genes in field bees were closest to those of bees matured at 30 degrees C. Considering all the biological and toxicological aspects examined, it was confirmed that 30 degrees C is the recommended maturation temperature for adult honey bee toxicity testing.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2022)
Review
Entomology
Thomas D. Seeley
Summary: Thomas Seeley's research focuses on collective intelligence and natural lives of honey bees. By studying their behavior and social life, he reveals how a honey bee colony functions as a single decision-making unit in the wild.
ANNUAL REVIEW OF ENTOMOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yong Zhang, Zhen Li, Xujiang He, Zilong Wang, Zhijiang Zeng
Summary: Honey bees are an important species for studying epigenetics. Previous research has shown that DNA methylation and histone modification can lead to distinct gene expression patterns, resulting in caste differentiation. This study investigates the role of histone methylation modification H3K4me1 in caste differentiation in honey bees. The results suggest that H3K4me1 may act as an important regulatory factor in the establishment and maintenance of caste-specific transcriptional programs in honey bees.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Environmental Sciences
Karoline Wueppenhorst, Jakob H. Eckert, Michael Steinert, Silvio Erler
Summary: The loss of honey bee colonies is attributed to factors such as habitat degradation, parasites, pathogens, and exposure to pesticides. Bee products like honey, wax, and pollen can be contaminated by pesticides, potentially affecting colony health. Understanding pesticide residues in larval food jelly and factors influencing contaminant concentration is important for risk assessment and protecting honey bee brood.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Multidisciplinary Sciences
Yu-Han Huang, Yu-Hsin Chen, Jui-Hung Chen, Pei-Shou Hsu, Tzu-Hsien Wu, Chuen-Fu Lin, Chi-Chung Peng, Ming-Cheng Wu
Summary: The isolated bacterium TBE-8, identified as Leuconostoc mesenteroides, exhibited probiotic properties and potential benefits for bee health by enhancing the expression of immunity and nutrition-related genes in bees. The findings suggest that TBE-8 has high potential as a bee probiotic to improve bee colony health.
SCIENTIFIC REPORTS
(2021)
Article
Entomology
Xiaoxue Fan, Wende Zhang, Sijia Guo, Leran Zhu, Yiqiong Zhang, Haodong Zhao, Xuze Gao, Haibin Jiang, Tianze Zhang, Dafu Chen, Rui Guo, Qingsheng Niu
Summary: This study investigated the role of miRNAs in the developmental process of Asian honey bee guts. Through transcriptome-wide identification and analysis, differentially expressed miRNAs were found to target genes associated with growth and development. The results highlight the importance of miRNAs in gene regulation and their involvement in various life activities.
Article
Ecology
Maxime Eeraerts, Emma Rogers, Bob Gillespie, Lincoln Best, Olivia M. Smith, Lisa W. DeVetter
Summary: This study investigated the factors influencing honey bee and wild bee visitation in highbush blueberry fields. The results showed that honey bee visitation was mainly determined by the number of honey bee hives in the surrounding landscape. Semi-natural habitat and blueberry planting area within a radius of 1000 m had different impacts on wild bee visitation. Honey bee visitation had a positive effect on blueberry seed set.
Review
Chemistry, Applied
Jorge Ederson G. Santana, Henrique Douglas M. Coutinho, Jose Galberto M. da Costa, Jorge Marcell C. Menezes, Raimundo Nonato Pereira Teixeira
Summary: Eligible articles were collected from various databases and searches were conducted using specific terms. The systematic review emphasizes the importance of identifying compounds using fluorescence techniques and suggests the use of cheaper and more accessible techniques. Limited research has been done on Apis mellifera honey in the last 12 years, with some studies focusing on viability rather than quantifying compounds, and others using more costly techniques for fluorescent aspects.
Article
Environmental Sciences
Ge Zhang, Miranda Kersten, Amy Owen, Amanda Skidmore
Summary: The negative impacts of industrial farming on honey bee health, such as pesticide use and habitat loss, are well-known. Evaluating the suitability of urban farms for honey bee health is crucial for sustainable agriculture and apiculture in urban settings. Organic urban farms with restrictions on synthetic pesticides and conservation of natural habitat can provide an environment that mitigates these stressors. This experiment found that honey bees on organic urban farms in New Mexico were not stressed by pesticides, had diverse forage resources, and thrived with certain hive equipment. Overall, organic urban farms are important for honey bee health and food safety in desert climates, and hive equipment selection plays a role in mitigating environmental stress.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Multidisciplinary Sciences
Myra Dickey, Elizabeth M. M. Walsh, Tonya F. F. Shepherd, Raul F. F. Medina, Aaron Tarone, Juliana Rangel
Summary: Honey bees are crucial for global agricultural production due to their role in pollination services. However, their health is continuously threatened by factors such as mites, poor queen quality, and pesticide exposure. This study examines the sublethal effects of pesticides commonly found in wax on the queen's brain transcriptome, identifying differentially expressed genes. Further research should explore the relationship between these molecular findings and the queen's behavior and physiology.
Article
Entomology
Francis A. Drummond, Jennifer Lund, Brian Eitzer
Summary: A two-year study in Maine wild blueberry fields monitored the health of migratory honey bee colonies in 2014 and 2015. Varroa mite infestations and pesticide residues on pollen were significant predictors of colony health, explaining 71% of the variance in colony health over the two years. Pathogen prevalence and incidence varied between the two years, with high levels of recently discovered pathogens and parasites detected.
Article
Gastroenterology & Hepatology
Qiang Wang, Yang An, Fengling Wang, Guosen Zhang, Lu Zhang, Huan Dong, Junfang Xin, Yongqiang Li, Shaoping Ji, Xiangqian Guo
Summary: This study established an online prognostic analysis web server named OSchol to evaluate the correlation between candidate genes and survival for cholangiocarcinoma (CHOL). It validated the prognostic values of known biomarkers like ITIH4, PTEN and DACH1, and identified E2F1 as a potential novel prognostic biomarker for CHOL. The study provides a platform for researchers and clinicians to screen, develop and validate genes of interest as potential prognostic biomarkers for CHOL.
Letter
Geriatrics & Gerontology
Longxiang Xie, Xiangqian Guo
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Chemistry, Multidisciplinary
Jian Shu, Jun Ma, Xiameng Ren, Jian Wang, Yan Wang, Kun Zhang, Hanjie Yu, Xiangqian Guo, Zheng Li
Summary: This study investigated the altered salivary glycopatterns between ESCC patients and healthy volunteers, and found significant differences in the glycopatterns of ESCC patients' saliva. The study suggests that GlcNAc or Gal β 1-4GlcNAc-containing N-glycans recognized by lectins like DSA may serve as potential biomarkers for the diagnosis of ESCC.
FRONTIERS IN CHEMISTRY
(2021)
Review
Pharmacology & Pharmacy
Guo Zhao, Chuan Liu, Xin Wen, Gan Luan, Longxiang Xie, Xiangqian Guo
Summary: This article discusses the significance of TRIM proteins in regulating the biological behaviors of cancer cells, highlighting the potential of certain TRIM family members as molecular biomarkers for cancer diagnosis and therapy.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Endocrinology & Metabolism
Na Qiu, Hongmei He, Ling Qiao, Yong Ding, Shaoping Ji, Xiangqian Guo, Jiajia Luo, Zengyou Luo, Yuan Li, Huishen Pang, Yingsa Huang, Lu Zhang
Summary: This study of 445 Chinese school-aged children found that during the COVID-19 quarantine, boys were more likely to experience an increase in BMI, while both boys and girls showed an increase in blood pressure. The study also identified environmental factors, dietary habits like consuming chili, parents' perception of their child's size, and family dynamics as potential predictors of overweight, obesity, and elevated blood pressure.
INTERNATIONAL JOURNAL OF OBESITY
(2021)
Editorial Material
Genetics & Heredity
Lin Chen, Huimin Li, Longxiang Xie, Zhanjie Zuo, Liqing Tian, Changning Liu, Xiangqian Guo
FRONTIERS IN GENETICS
(2021)
Article
Genetics & Heredity
Jia Lei, Shuping Yan, Xiangqian Guo, Fengling Wang, Guosen Zhang, Quancheng Kan, Ruixia Guo
Summary: This study identified two distinct molecular subtypes of Endometrioid adenocarcinoma (EAC), with subtype I associated with a more favorable prognosis and subtype II representing high-grade EAC. The up-regulated genes in each subtype were associated with different pathways, and potential subtype-specific biomarkers were also identified.
FRONTIERS IN GENETICS
(2021)
Article
Endocrinology & Metabolism
Umair Ali Khan Saddozai, Fengling Wang, Muhammad Usman Akbar, Lu Zhang, Yang An, Wan Zhu, Longxiang Xie, Yongqiang Li, Xinying Ji, Xiangqian Guo
Summary: Pheochromocytoma (PCC) is a rare neuroendocrine tumor of the adrenal gland with distinct subtypes identified through gene expression profiling. Specific genes enriched in each subtype may serve as potential therapeutic targets and provide insights into the mechanisms of tumorigenesis.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Pediatrics
Hongmei He, Shujun Yang, Na Qiu, Ling Qiao, Yong Ding, Jiajia Luo, Yuan Li, Zengyou Luo, Yingsa Huang, Huishen Pang, Shaoping Ji, Lu Zhang, Xiangqian Guo
Summary: This study aimed to explore the impact of obesity on elevated blood pressure, elevated pulse pressure, and elevated mean arterial pressure in Chinese school-age children, with a focus on gender differences. The results showed that obesity had a greater influence on blood pressure and mean arterial pressure than on pulse pressure, especially among boys. The interaction between obesity and related blood pressure indicators was more prominent in boys, suggesting a gender disparity in the effects of obesity on cardiovascular health in children.
FRONTIERS IN PEDIATRICS
(2021)
Article
Biology
Xitong Yao, Xinlei Qi, Yao Wang, Baokun Zhang, Tianshuai He, Taoning Yan, Lu Zhang, Yange Wang, Hong Zheng, Guosen Zhang, Xiangqian Guo
Summary: Identification of new prognostic biomarkers and therapeutic targets is crucial for improving outcomes of bladder cancer patients. This study comprehensively analyzed the mRNA expression and prognosis of Annexin family members in bladder cancer, constructed an Annexin-related prognostic signature, and validated it in four independent cohorts, providing potential insights into the molecular mechanisms of bladder cancer development and suggesting therapeutic targets.
Article
Biology
Zhongyi Yan, Qiang Wang, Susu Zhao, Longxiang Xie, Lu Zhang, Yali Han, Baokun Zhang, Huimin Li, Xiangqian Guo
Summary: The study aims to build a free prognostic web server for ovarian cancer by integrating gene expression profiles and clinical follow-up information. The constructed web server provides various analysis tools and validates a significant number of prognostic biomarkers. It is a valuable and free web server for prognostic assessment of ovarian cancer.
Letter
Biochemistry & Molecular Biology
Guosen Zhang, Qiang Wang, Xinlei Qi, Huimin Yang, Xiaodong Su, Manman Yang, Chao Jiang, Yang An, Hong Zheng, Lu Zhang, Wan Zhu, Jiancheng Guo, Xiangqian Guo
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2022)
Review
Pharmacology & Pharmacy
Yali Han, Guo Zhao, Xinhang Shi, Yushan Wang, Xin Wen, Lu Zhang, Xiangqian Guo
Summary: Esophageal cancer is a common malignancy with poor prognosis. Understanding the molecular mechanisms, identifying effective biomarkers, and developing early diagnosis and treatment strategies are crucial for improving patient survival. Long non-coding RNAs (lncRNAs) play important roles in the regulation of esophageal cancer, influencing the expression of oncogenes and tumor suppressors. Targeting lncRNAs through genome editing, RNA interference, and molecular drugs holds great potential for future esophageal cancer treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Longxiang Xie, Qiang Wang, Zhongyi Yan, Yali Han, Xiaoyu Ma, Huimin Li, Lu Zhang, Xianzhe Li, Xiangqian Guo
Summary: In this study, a web-based portal called OSgc was developed to facilitate the evaluation of prognostic value of known and novel biomarker candidates in gastric cancer (GC). OSgc includes gene expression data and clinical follow-up information of 1,824 GC cases, and provides evaluation results for multiple survival endpoints.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Umair Ali Khan Saddozai, Fengling Wang, Saadullah Khattak, Muhammad Usman Akbar, Muhammad Badar, Nazeer Hussain Khan, Lu Zhang, Wan Zhu, Longxiang Xie, Yongqiang Li, Xinying Ji, Xiangqian Guo
Summary: This study identified two distinct epithelioid malignant pleural mesothelioma subtypes with different gene expression patterns. Each subtype has different clinicopathological characteristics and molecular pathways, providing insights for the clinical applications and advanced mechanisms of eMPM.
