Review
Medicine, Research & Experimental
Weihua Zhan, Song Zhang
Summary: TRIM proteins play key roles in various biological processes and are closely related to tumor development; Alterations in TRIM gene and protein levels frequently emerge in tumors and affect tumor progression; TRIM proteins maintain the balance between tumor suppressive and tumor promoting genes through ubiquitylation events.
Article
Multidisciplinary Sciences
Xizhe Zhang, Chunyu Pan, Xinru Wei, Meng Yu, Shuangjie Liu, Jun An, Jieping Yang, Baojun Wei, Wenjun Hao, Yang Yao, Yuyan Zhu, Weixiong Zhang
Summary: The study focused on cancerous cells and genes that maintained abnormal cell growth, known as cancer-keeper genes (CKGs). Intervening CKGs can rectify aberrant cell growth, making them potential cancer therapeutic targets. In bladder cancer, all genes on the cell-cycle and p53 pathways were identified as CKGs, highlighting their importance in cancer.
Review
Medical Laboratory Technology
Ling-Juan Chen, Xiang Chen, Xiao-Hua Niu, Xiao-Fei Peng
Summary: Colorectal cancer (CRC) is a major cause of cancer-related deaths, and novel biomarkers are needed for timely diagnosis and management. Long noncoding RNAs (lncRNAs) have been found to have important roles in CRC progression and could potentially serve as diagnostic and prognostic biomarkers. This review summarizes the latest findings on potential lncRNAs as biomarkers in CRC samples, discusses the dysregulated lncRNAs and their molecular mechanisms, and explores the therapeutic implications and challenges for future research. It provides insights on the potential of lncRNAs as biomarkers and therapeutic targets in CRC.
CLINICA CHIMICA ACTA
(2023)
Review
Oncology
Minhong Shen, Yibin Kang
Summary: The traditional approach to cancer therapeutics targets driver oncogenes, but this method has limitations such as toxicity to normal tissue and treatment resistance. However, a new class of genes called 'cancer fitness genes' have been identified, which play crucial roles in metastasis. These genes help tumor cells adapt to changing microenvironments, facilitating tumor progression and metastasis. They have therapeutic potential as targeting them is less likely to harm noncancerous tissues.
Review
Biochemistry & Molecular Biology
Theodora A. Constantin, Kyle K. Greenland, Anabel Varela-Carver, Charlotte L. Bevan
Summary: Transcriptional deregulation is a characteristic feature of various cancer types. In metastatic castration-resistant prostate cancer, the addiction of transcriptional activity to the androgen receptor is maintained in most patients. Transcription associated cyclin-dependent kinases (tCDKs), a group of protein kinases, have shown great potential as therapeutic targets for prostate cancer and other solid tumors.
Review
Medicine, Research & Experimental
Yunhan Wang, Zongying Zhang, Weichen Sun, Jie Zhang, Qiuyun Xu, Xiaorong Zhou, Liming Mao
Summary: Colorectal cancer is a common malignant tumor with unsatisfactory prognosis. Ferroptosis, a novel form of cell death, has shown success in eliminating cancer cells resistant to other forms of cell death. Therefore, ferroptosis may become a new direction for designing therapies for colorectal cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Chemistry, Medicinal
Tingting Liu, Shubin Song, Xu Wang, Jifu Hao
Summary: Breast cancer remains a challenging health issue and a top priority in biomedical research. Researchers are increasingly interested in studying breast cancer in young women. Common treatment options for breast cancer include chemotherapy, immunotherapy, hormone therapy, surgery, and radiotherapy.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Chemistry, Medicinal
Bisant A. Labib, DeGaulle Chigbu
Summary: Allergic conjunctivitis is a common condition caused by exposure to allergens. Understanding the immune mechanisms is vital for identifying therapeutic targets. Treatment options are diverse but often require multiple agents.
Review
Cell Biology
Jia-Hao Dai, Xi-Rong Tan, Han Qiao, Na Liu
Summary: The profound influence of microbiota in cancer initiation and progression has led to extensive research on cancer microbiome and its clinical relevance. Microbiota can serve as effective diagnostic and prognostic biomarkers, and their relationship with the therapeutic efficacy, toxicity, or side effects of cancer treatments has been highlighted.
Review
Oncology
Mi Jeong Kwon
Summary: Matrix metalloproteinases (MMPs) are key proteinases in tumorigenesis, initially recognized for their role in remodeling the extracellular matrix. However, accumulating evidence suggests that some MMPs have protective roles in cancer progression, and their effects can vary depending on cell type and cancer stage. MMPs are also involved in cancer progression through cell signaling and immune regulation, independent of their proteolytic activity. This review summarizes the current understanding of tumoral or stromal MMPs in breast cancer and discusses recent advances in the development of highly selective MMP inhibitors.
FRONTIERS IN ONCOLOGY
(2023)
Article
Health Care Sciences & Services
Chin-Chou Wang, Wan-Jou Shen, Gangga Anuraga, Hoang Dang Khoa Ta, Do Thi Minh Xuan, Sih-Tong Chen, Chiu-Fan Shen, Jia-Zhen Jiang, Zhengda Sun, Chih-Yang Wang, Wei-Jan Wang
Summary: This study identified PTPN family members as significant prognostic biomarkers for lung cancer progression and promising clinical therapeutic targets through the use of big data analysis methods. These findings provide new targets for treating LUAD patients.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Cell Biology
Fajuan Cheng, Bin Zheng, Shubin Si, Jianwei Wang, Guiting Zhao, Zhongshun Yao, Zhihong Niu, Wei He
Summary: Bladder cancer (BCa) is the most common malignancy of the urinary system. CircRNAs, a subtype of non-coding RNAs, play a crucial role in physiological and developmental processes. Dysregulated circRNAs associated with BCa contribute to abnormalities in biological, genetic, and epigenetic information.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Wan-Hsiang Hu, Ting-Ting Liu, Pei-Feng Liu, Paul Morgan, I-Ling Lin, Wei-Lun Tsai, Yi-Yun Cheng, Ang-Tsen Hsieh, Tsung-Hui Hu, Chih-Wen Shu
Summary: ATG4B and its phosphorylated form (pS383/392-ATG4B) are associated with clinical outcomes in colorectal cancer (CRC). High levels of ATG4B are correlated with poor survival, while high levels of pS383/392-ATG4B are associated with poor survival in male and elderly patients, but not in female and younger patients. Furthermore, silencing ATG4B weakens migration and invasion of CRC cells and enhances the cytotoxic effects of chemotherapy drugs.
CANCER CELL INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Cangang Zhang, Yueji Zou, Yanan Zhu, Yi Liu, Hui Feng, Fan Niu, Pengcheng He, Haibo Liu
Summary: This study developed an immune-related 21-gene signature for predicting the prognosis of pancreatic cancer patients. MET, OAS1, and OASL mRNAs were found to be up-regulated in pancreatic cancer, associated with unfavorable prognosis, and closely related to tumor progression and immune infiltrates.
FRONTIERS IN MEDICINE
(2021)
Review
Oncology
Philipp Wolf
Summary: Evasion from cell death is a characteristic of cancer, which is promoted by IAPs through suppressing the induction of cell death. Overexpression of IAPs in cancerous tissues contributes to therapeutic resistance.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
H. J. Li, Y. L. Wang, L. Ming, X. Q. Guo, Y. L. Li, J. C. Wang, Y. Q. Zhang, L. Cheng
Summary: Traditional screening and therapeutic programs for colorectal cancer are insufficient, but advances in immunogenomics show promise. By identifying survival-related IRGs and establishing a prognostic model, it offers a new approach in determining risk for CRC patients.
Review
Medicine, General & Internal
Chuan Liu, Guo Zhao, Danni Qiao, Lintao Wang, Yeling He, Mingge Zhao, Yuanyuan Fan, Enshe Jiang
Summary: This review summarizes the historical hypotheses of the pathogenesis of nausea and vomiting of pregnancy (NVP) and hyperemesis gravidarum (HG), and introduces various treatment approaches. Future research on NVP and HG may reduce adverse outcomes and improve the quality of life for pregnant women.
FRONTIERS IN MEDICINE
(2022)
Article
Biology
Xitong Yao, Xinlei Qi, Yao Wang, Baokun Zhang, Tianshuai He, Taoning Yan, Lu Zhang, Yange Wang, Hong Zheng, Guosen Zhang, Xiangqian Guo
Summary: Identification of new prognostic biomarkers and therapeutic targets is crucial for improving outcomes of bladder cancer patients. This study comprehensively analyzed the mRNA expression and prognosis of Annexin family members in bladder cancer, constructed an Annexin-related prognostic signature, and validated it in four independent cohorts, providing potential insights into the molecular mechanisms of bladder cancer development and suggesting therapeutic targets.
Article
Biology
Zhongyi Yan, Qiang Wang, Susu Zhao, Longxiang Xie, Lu Zhang, Yali Han, Baokun Zhang, Huimin Li, Xiangqian Guo
Summary: The study aims to build a free prognostic web server for ovarian cancer by integrating gene expression profiles and clinical follow-up information. The constructed web server provides various analysis tools and validates a significant number of prognostic biomarkers. It is a valuable and free web server for prognostic assessment of ovarian cancer.
Letter
Biochemistry & Molecular Biology
Guosen Zhang, Qiang Wang, Xinlei Qi, Huimin Yang, Xiaodong Su, Manman Yang, Chao Jiang, Yang An, Hong Zheng, Lu Zhang, Wan Zhu, Jiancheng Guo, Xiangqian Guo
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2022)
Review
Pharmacology & Pharmacy
Yali Han, Guo Zhao, Xinhang Shi, Yushan Wang, Xin Wen, Lu Zhang, Xiangqian Guo
Summary: Esophageal cancer is a common malignancy with poor prognosis. Understanding the molecular mechanisms, identifying effective biomarkers, and developing early diagnosis and treatment strategies are crucial for improving patient survival. Long non-coding RNAs (lncRNAs) play important roles in the regulation of esophageal cancer, influencing the expression of oncogenes and tumor suppressors. Targeting lncRNAs through genome editing, RNA interference, and molecular drugs holds great potential for future esophageal cancer treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Longxiang Xie, Qiang Wang, Zhongyi Yan, Yali Han, Xiaoyu Ma, Huimin Li, Lu Zhang, Xianzhe Li, Xiangqian Guo
Summary: In this study, a web-based portal called OSgc was developed to facilitate the evaluation of prognostic value of known and novel biomarker candidates in gastric cancer (GC). OSgc includes gene expression data and clinical follow-up information of 1,824 GC cases, and provides evaluation results for multiple survival endpoints.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Umair Ali Khan Saddozai, Fengling Wang, Saadullah Khattak, Muhammad Usman Akbar, Muhammad Badar, Nazeer Hussain Khan, Lu Zhang, Wan Zhu, Longxiang Xie, Yongqiang Li, Xinying Ji, Xiangqian Guo
Summary: This study identified two distinct epithelioid malignant pleural mesothelioma subtypes with different gene expression patterns. Each subtype has different clinicopathological characteristics and molecular pathways, providing insights for the clinical applications and advanced mechanisms of eMPM.
Review
Pharmacology & Pharmacy
Shuhang Wang, Kun Chen, Yale Jiang, Guo Zhao, Caie Wang, Hong Fang, Qiyu Tang, Chao Sun, Liang Zhang, Haiyang Wu, Li-Feng Zhang, Ning Li
Summary: Natural killer (NK) cell therapy is emerging as a promising cancer treatment that utilizes innate cytotoxic lymphocytes with germline-encoded receptors to kill cancer cells, virus-infected cells, and other stressed cells. NK cells have the advantage of being safe for allogeneic applications and can be used as off-the-shelf cells, overcoming the limitations of autologous cell therapy. However, NK cells have a shorter in vivo persistence compared to T cells, but they have a reservoir of innate immune receptors and can utilize antibody guidance for target recognition.
DRUG DISCOVERY TODAY
(2023)
Letter
Oncology
Guo Zhao, Yale Jiang, Peiwen Ma, Shuhang Wang, Guangjun Nie, Ning Li
EUROPEAN JOURNAL OF CANCER
(2023)
Editorial Material
Medicine, General & Internal
G. Zhao, Y. Jiang, P. Ma, S. Wang, G. Nie, N. Li
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2023)
Editorial Material
Oncology
Guo Zhao, Shuhang Wang, Ning Li
MOLECULAR THERAPY-ONCOLYTICS
(2023)
Article
Immunology
Caie Wang, Guo Zhao, Zhen Zhang, Lukui Yang, Shihao Liu, Guifang Li, Hongxia Wang, Jiaxin Huang, Shuhang Wang, Ning Li
Summary: This study conducted a systematic analysis of case reports on ICI-associated myocarditis and found that myocarditis is a highly life-threatening disease, with more than half of the cases requiring glucocorticoid treatment. The best response to ICI, glucocorticoid administration, and discontinuation of ICI were associated with higher rates of improvement.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Guo Zhao, Junfeng Zhen, Xinyuan Liu, Jinshuai Guo, Duanduan Li, Jianping Xie, Longxiang Xie
Summary: Lysine succinylation (Ksuc) is a novel protein post-translational modification that has significant impacts on protein structure and function. Recent studies have highlighted its importance in physiological processes and diseases such as tumorigenesis and metabolic diseases. This review provides an overview of the current research on Ksuc in eukaryotes and prokaryotes and discusses the potential applications of inhibitors or activators associated with Ksuc in proteomic studies and clinical practice. A deeper understanding of Ksuc could have profound implications for life science and the development of novel therapeutic strategies.
