Article
Multidisciplinary Sciences
Francisco J. Zapatero-Belinchon, Rebecca Moeller, Lisa Lasswitz, Marco van Ham, Miriam Becker, Graham Brogden, Ebba Rosendal, Wenjie Bi, Belen Carriqui-Madronal, Koushikul Islam, Annasara Lenman, Antonia P. Gunesch, Jared Kirui, Thomas Pietschmann, Anna K. Overby, Lothar Jansch, Gisa Gerold
Summary: Clinical data suggests that statin therapy, particularly fluvastatin, may have a moderate beneficial effect on SARS-CoV-2 infection in human lung cells by downregulating proteins related to protein translation and viral replication, without affecting innate antiviral immune responses.
Article
Biochemistry & Molecular Biology
Kris Genelyn Dimasuay, Bruce Berg, Niccolette Schaunaman, Hong Wei Chu
Summary: Mitochondrial dysfunction is common in pathological conditions such as obesity, and the release of mtDNA during this dysfunction plays a role in promoting leukocyte inflammation. However, the mechanisms by which mtDNA induces inflammation and its release in an obese setting are still unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Veterinary Sciences
Tara Bocking, Laura Johnson, Amitoj Singh, Atul Desai, Gurpreet Kaur Aulakh, Baljit Singh
Summary: This study found a significant increase in the amount of CD9 protein in the lungs of 30-day-old foals, but not of SP-A and SP-D. CD9, SP-A, and SP-D were localized in the alveolar septa and vascular endothelium of the foals' lungs. Moreover, the expression of SP-A and SP-D appeared to be increased in the bronchiolar epithelium of 30-day-old foals compared to one day old foals.
BMC VETERINARY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Maria Clara Barbosa-de-Oliveira, Paolo Oliveira-Melo, Marcos Henrique Goncalves da Silva, Flavio Santos da Silva, Felipe Andrade Carvalho da Silva, Bruno Vinicios Silva de Araujo, Moacir Franco de Oliveira, Aristides Tadeu Correia, Sidnei Miyoshi Sakamoto, Samuel Santos Valenca, Manuella Lanzetti, Martina Schmidt, Emanuel Kennedy-Feitosa
Summary: This study investigates the role of eugenol (EUG) in cigarette smoke-induced acute lung injury (ALI) and how it modulates macrophage activity. The results show that EUG reduces inflammatory response and oxidative stress markers in vivo, and balances oxidative stress and cytokine release in vitro, indicating that it acts as a modulator of macrophage activity.
Article
Cell Biology
Henar Suarez, Zoraida Andreu, Carla Mazzeo, Victor Toribio, Aldo Emmanuel Perez-Rivera, Soraya Lopez-Martin, Susana Garcia-Silva, Begona Hurtado, Esperanza Morato, Laura Pelaez, Egoitz Astigarraga Arribas, Tarson Tolentino-Cortez, Gabriel Barreda-Gomez, Ana Isabel Marina, Hector Peinado, Maria Yanez-Mo
Summary: Tetraspanin CD9 plays a role in regulating early endosome numbers and is functionally connected with mitophagy, mitochondrial quality control, and cell proliferation. CD9 peptide and gene deletion result in different effects on cellular processes, with CD9 KO cells compensating for mitochondrial dysfunction by increasing total mitochondrial mass.
JOURNAL OF EXTRACELLULAR VESICLES
(2021)
Article
Biochemistry & Molecular Biology
Guendalina Lucarini, Elisa Molinelli, Caterina Licini, Giulio Rizzetto, Giulia Radi, Gaia Goteri, Monica Mattioli-Belmonte, Annamaria Offidani, Oriana Simonetti
Summary: The expression of CD9 in melanocytic nevi and cutaneous melanomas is correlated with invasiveness and metastatic potential, and it could be a valid prognostic factor for lymph node metastasis risk.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Barbara Spix, Elisabeth S. Butz, Cheng-Chang Chen, Anna Scotto Rosato, Rachel Tang, Aicha Jeridi, Veronika Kudrina, Eva Plesch, Philipp Wartenberg, Elisabeth Arlt, Daria Briukhovetska, Meshal Ansari, Gizem Gunes Gunsel, Thomas M. Conlon, Amanda Wyatt, Sandra Wetzel, Daniel Teupser, Lesca M. Holdt, Fabien Ectors, Ingrid Boekhoff, Ulrich Boehm, Jaime Garcia-Anoveros, Paul Saftig, Martin Giera, Sebastian Kobold, Herbert B. Schiller, Susanna Zierler, Thomas Gudermann, Christian Wahl-Schott, Franz Bracher, Ali Oender Yildirim, Martin Biel, Christian Grimm
Summary: The study reveals TRPML3 as a key regulator of MMP-12 clearance by alveolar macrophages, suggesting it as a therapeutic target for emphysema and chronic obstructive pulmonary disease.
NATURE COMMUNICATIONS
(2022)
Article
Environmental Sciences
Hua Qin, Jiao Chen, Yang Li, Lifang Gao, Ji Wang, Guangbo Qu, Man Yang, Xianqing Zhou, Zhiwei Sun
Summary: Black phosphorus nanosheets have diverse potential in nanomedical applications but their potential toxic effects on physiological systems have not been well studied. Research showed that black phosphorus induced a reversible inflammatory response in mice and led to significant changes in cell survival, apoptosis, and inflammatory cytokines. Evaluations of molecular levels in treated cells indicated an expansion of inflammatory reactions, suggesting inhibition of anti-inflammatory effects and worsening of inflammation.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Chemistry, Analytical
Wei Zhang, Jin Li, Na Zhao, Ping Li, Wen Zhang, Hui Wang, Bo Tang
Summary: Atherosclerosis is an important disease threatening human health. In this study, a fluorescence nanosensor was successfully prepared and applied for ratiometric fluorescence imaging analysis of protein phosphorylation level in AS mice model, showing a lower level compared to normal mice.
ANALYTICA CHIMICA ACTA
(2022)
Article
Pharmacology & Pharmacy
Rama Malaviya, Carol R. Gardner, Raymond C. Rancourt, Ley Cody Smith, Elena Abramova, Kinal N. Vayas, Andrew J. Gow, Jeffrey D. Laskin, Debra L. Laskin
Summary: This study investigated the impact of chlorine gas-induced injury and oxidative stress on lung macrophage phenotype and function. Chlorine gas exposure resulted in alveolar epithelial barrier dysfunction and inflammation. Inflammatory proteins in bronchoalveolar lavage fluid were increased, and DNA damage and oxidative stress proteins were upregulated. Chlorine gas exposure also resulted in proinflammatory activation of lung macrophages. These findings contribute to the mechanistic understanding of chlorine gas injury and the development of effective treatments.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Marco Orecchioni, Dennis Wolf, Vasantika Suryawanshi, Holger Winkels, Kouji Kobiyama, Jeffrey Makings, William B. Kiosses, Klaus Ley
Summary: Atherosclerosis is caused by the retention of lipoproteins and cholesterol in the subendothelial layer, leading to an inflammatory process and plaque formation. Macrophages are found to be the main producers of the anti-inflammatory cytokine IL-10 in atherosclerotic plaques. IL-10 secretion by macrophages is critical for limiting atherosclerosis progression.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Review
Immunology
Li Ning, Shishi Zou, Wang Bo, Huiqing Lin
Summary: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are life-threatening conditions with complex molecular mechanisms and high mortality rates. In recent years, the field of immunometabolism has made significant progress in understanding the interaction between intracellular metabolism and immune function. Evidence has shown the important roles of immunometabolism in inflammatory response and ALI. Different immune cells undergo metabolic reprogramming and epigenetic changes during ALI, which not only provide energy and biosynthetic precursors, but also regulate inflammation and immunity. However, there are variations in the features and roles of metabolic reprogramming in different immune cells. This article outlines the impact of adverse factors on immunometabolism in different immune cell types during ALI, highlights key proteins associated with energy expenditure and metabolic reprogramming, and discusses potential therapeutic targets and challenges in immunometabolism against ALI.
CLINICAL IMMUNOLOGY
(2023)
Review
Immunology
Amelia Kulle, Ajitha Thanabalasuriar, Taylor S. Cohen, Marta Szydlowska
Summary: Resident macrophages play a crucial role in tissue maintenance by defending against pathogens and regulating inflammatory tone and tissue structure. This review focuses on the developmental origin of liver and lung resident macrophages, their contribution to host defense, and the mechanisms they use to regulate tissue homeostasis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Qi Zhao, Lei He, Junwu Zhang, Hong Li, Wanying Li, Zhihui Zhou, Yuanyuan Li
Summary: In this study, it was found that miR-598 expression was significantly increased in the lung tissues of mice with LPS-induced acute lung injury. Inhibition of miR-598 attenuated the inflammatory response, oxidative stress, and lung injury, while overexpression of miR-598 exacerbated the LPS-induced acute lung injury. Ebf1 was identified as a downstream target of miR-598, and overexpression of Ebf1 ameliorated LPS-induced inflammation and oxidative stress, promoted proliferation and inhibited apoptosis in lung epithelial cells.
HISTOCHEMISTRY AND CELL BIOLOGY
(2023)
Article
Cell Biology
Yanna Lei, Qingsong Cui, Guang Yang, Limei Piao, Aiko Inoue, Hongxian Wu, Xiang Li, Masafumi Kuzuya, Xian Wu Cheng
Summary: The study demonstrates that pitavastatin can prevent vascular senescence and atherogenesis induced by chronic stress and high fat diet in mice, potentially by increasing GLP-1 and APN levels and suppressing plaque inflammation and oxidative stress.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Yuji Otsuki, Juntaro Yamasaki, Kentaro Suina, Shogo Okazaki, Naoyoshi Koike, Hideyuki Saya, Osamu Nagano
Article
Genetics & Heredity
Yuji Otsuki, Yuki Okuda, Kiyoshi Naruse, Hideyuki Saya
G3-GENES GENOMES GENETICS
(2020)
Article
Cell Biology
Haruko Kunitomi, Yoshinao Oki, Nobuyuki Onishi, Koichiro Kano, Kouji Banno, Daisuke Aoki, Hideyuki Saya, Hiroyuki Nobusue
Article
Biochemistry & Molecular Biology
Yosui Nojima, Yoshito Takeda, Yohei Maeda, Takeshi Bamba, Eiichiro Fukusaki, Mari N. Itoh, Kenji Mizuguchi, Atsushi Kumanogoh
Article
Biochemistry & Molecular Biology
Yasuhiro Teranishi, Hiroshi Kuwahara, Masaru Ueda, Tadashi Takemura, Masanori Kusumoto, Keiji Nakamura, Jun Sakai, Toru Kimura, Yasuji Furutani, Makoto Kawashima, Genji Imokawa, Mari Nogami-Itoh
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Genetics & Heredity
Lokesh P. Tripathi, Mari N. Itoh, Yoshito Takeda, Kazuyuki Tsujino, Yasushi Kondo, Atsushi Kumanogoh, Kenji Mizuguchi
FRONTIERS IN GENETICS
(2020)
Article
Medicine, General & Internal
Kaori Nakanishi, Makoto Nishida, Manabu Taneike, Ryohei Yamamoto, Toshiki Moriyama, Keiko Yamauchi-Takihara
Summary: The study showed that serum levels of alpha Klotho are associated with the progression of various pre-clinical disorders, particularly with the progression of hyperglycemia. Low alpha Klotho levels may be related to disease progression.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Virology
Masaru Takeshita, Naoshi Nishina, Saya Moriyama, Yoshimasa Takahashi, Yoshifumi Uwamino, Mika Nagata, Wataru Aoki, Katsunori Masaki, Makoto Ishii, Hideyuki Saya, Yasushi Kondo, Yuko Kaneko, Katsuya Suzuki, Koichi Fukunaga, Tsutomu Takeuchi
Summary: The study found that asymptomatic and mild COVID-19 patients had inadequate humoral immune responses, with most antibodies being correlated with disease severity, symptoms such as pneumonia, lymphopenia, and certain serological markers, and some patients failing to develop antibodies against the virus.
Article
Biochemistry & Molecular Biology
Toshikatsu Tsuji, Yusuke Maeda, Kenji Kita, Kazuhiro Murakami, Hideyuki Saya, Hirofumi Takemura, Noriyuki Inaki, Masanobu Oshima, Hiroko Oshima
Summary: The study found that FOXO3 displays different expression patterns in different subtypes of gastric cancer: in FOXO3-Cyt gastric cancer cells, activation of mutant FOXO3 leads to nuclear accumulation and growth inhibition, while inhibition of the PI3K-AKT pathway also suppresses proliferation in this type of gastric cancer cells.
Article
Oncology
Ryo Sato, Kosuke Imamura, Takashi Semba, Yusuke Tomita, Sho Saeki, Koei Ikeda, Yoshihiro Komohara, Makoto Suzuki, Takuro Sakagami, Hideyuki Saya, Yoshimi Arima
Summary: CAF secrete TGF beta to induce a solid-to-acinar transition in lung cancer cells, demonstrating how the tumor microenvironment influences histological patterns and tumor heterogeneity in lung adenocarcinoma.
Review
Cell & Tissue Engineering
Go J. Yoshida, Hideyuki Saya
Summary: Intratumoral heterogeneity is closely linked to treatment failure in cancer, with cancer stem cells (CSCs) playing a key role in this process. CSCs, located at the top of the tumor cell hierarchy, possess self-renewal and therapeutic resistance capabilities, contributing to the challenges in cancer therapy.
REGENERATIVE THERAPY
(2021)
Article
Biology
Sayaka Ueno, Tamotsu Sudo, Hideyuki Saya, Eiji Sugihara
Summary: This study reveals that pigment epithelium-derived factor (PEDF) promotes the dissemination of ovarian cancer by inducing IL-10 expression in macrophages. High PEDF gene expression is associated with poor prognosis in ovarian cancer patients, and elevated PEDF levels are correlated with early recurrence. BET inhibitors reduce PEDF expression and limit both cancer cell survival and macrophage induction.
COMMUNICATIONS BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Haruki Inoue, Eriko Aimono, Akiyoshi Kasuga, Haruto Tanaka, Aika Iwasaki, Hideyuki Saya, Yoshimi Arima
Summary: Our mouse BTC models are suitable for studying BTC carcinogenesis and may contribute to the development of new therapeutic strategies. Analysis of images of mouse and human tumor tissues reveals similarities in tissue structure between the two, suggesting similarities in tumor characteristics independent of animal species. Additionally, our pixel-level clustering model can serve as a new diagnostic tool for BTC.
Article
Medicine, Research & Experimental
Tomofumi Ando, Ikue Tai-Nagara, Yuki Sugiura, Dai Kusumoto, Koji Okabayashi, Yasuaki Kido, Kohji Sato, Hideyuki Saya, Sutip Navankasattusas, Dean Y. Li, Makoto Suematsu, Yuko Kitagawa, Elena Seiradake, Satoru Yamagishi, Yoshiaki Kubota
Summary: Blood vessel abnormalities in cancer can be targeted therapeutically to suppress cancer progression, according to a study. Researchers found that a molecule called fibronectin leucine-rich transmembrane protein 2 (FLRT2) is expressed in abnormal blood vessels of advanced colorectal cancers in humans. Deleting FLRT2 in endothelial cells selectively pruned abnormal blood vessels and suppressed tumor metastasis. Additionally, FLRT2 deletion increased the number of mature vessels, enhancing the antitumor effects of immune checkpoint blockers. The study suggests that targeting tumor-specific interendothelial adhesions could be a safe and effective therapeutic option.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Respiratory System
Taro Koba, Yoshito Takeda, Ryohei Narumi, Takashi Shiromizu, Yosui Nojima, Mari Ito, Muneyoshi Kuroyama, Yu Futami, Takayuki Takimoto, Takanori Matsuki, Ryuya Edahiro, Satoshi Nojima, Yoshitomo Hayama, Kiyoharu Fukushima, Haruhiko Hirata, Shohei Koyama, Kota Iwahori, Izumi Nagatomo, Mayumi Suzuki, Yuya Shirai, Teruaki Murakami, Kaori Nakanishi, Takeshi Nakatani, Yasuhiko Suga, Kotaro Miyake, Takayuki Shiroyama, Hiroshi Kida, Takako Sasaki, Koji Ueda, Kenji Mizuguchi, Jun Adachi, Takeshi Tomonaga, Atsushi Kumanogoh
Summary: Novel COPD biomarkers were discovered using next-generation proteomics of EVs, revealing potential pathogenic biomarkers for COPD. This strategy represents a novel approach for biomarker discovery and precision medicine.