Article
Medicine, Research & Experimental
Negin Farzamikia, Behzad Baradaran, Soroush Mostafavi, Elham Ahmadian, Seyed Mahdi Hosseiniyan Khatibi, Sepideh Zununi Vahed, Mohammadreza Ardalan
Summary: Microparticles are vesicles released into the extracellular environment derived from cell plasma membranes, facilitating intercellular communication through the transfer of various lipids, cytosolic proteins, RNA, and microRNAs. The progression of diseases can affect the composition and function of these cell-derived particles, with podocyte injury playing a significant role in the pathophysiology of various glomerular diseases including IgA nephropathy.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Medicine, Research & Experimental
Xuanli Tang, Yuan Yuan, Xiaoli Liang, Xue Jiang
Summary: This study aimed to investigate the potential of Mfn2 as a biomarker to evaluate the degree of podocyte injury in IgA nephropathy. The findings suggest that the absence of Mfn2 indicates severe podocyte injury and a high degree of podocyte effacement in IgA nephropathy.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Stuart E. Dryer, Eun Young Kim
Summary: Diseases that cause a loss of renal function are common and can range in severity. The TRPC6 channel has shown potential as a therapeutic target for kidney diseases, but its efficacy varies depending on the specific condition. This research is important for the development of new drugs.
Article
Immunology
Baowei Ji, Junchao Liu, Yanli Ma, Ye Yin, Hong Xu, Qian Shen, Jian Yu
Summary: Minimal change disease (MCD) is the common type of nephrotic syndrome in children. Current treatments for MCD have many drawbacks and cause significant side effects, highlighting the need for new treatment methods. This study found that combining minnelide with Angptl3 knockout completely protected mice with adriamycin nephropathy (AN) by inhibiting the TGF-beta 1-smad2 and p53 pathways, reducing proteinuria and restoring foot processes. These findings suggest that minnelide combined with Angptl3 knockout could be a promising therapeutic approach for AN.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Medicine, General & Internal
Haidong Zhang, Zhenling Deng, Yue Wang
Summary: Immunoglobulin A nephropathy (IgAN) is the leading cause of kidney failure in the world and is characterized by intrarenal inflammation. The pathogenesis involves various types of cells in the nephrons, including mesangial cells, endothelial cells, podocytes, and tubular epithelial cells (TECs). Immune complex deposition and complement activation trigger an inflammatory response in mesangial cells, leading to cellular proliferation and tissue damage. This cascade of events also results in endothelial dysfunction, podocyte damage, and tubular injury, ultimately leading to kidney failure.
FRONTIERS IN MEDICINE
(2023)
Article
Genetics & Heredity
Takahiro Ishikawa, Minoru Takemoto, Yoshihiro Akimoto, Aki Takada-Watanabe, Kunimasa Yan, Kenichi Sakamoto, Yoshiro Maezawa, Miyuki Suguro, Liqun He, Karl Tryggvason, Christer Betsholtz, Koutaro Yokote
Summary: A novel podocyte-expressed protein R3h domain containing-like (R3hdml) was identified, which inhibits podocyte apoptosis by suppressing TGF-beta-mediated p38 MAPK signaling. Overexpression of R3hdml ameliorated albuminuria in STZ-induced diabetes mice, suggesting it may be a potential therapeutic strategy for diabetic nephropathy.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Physiology
Sha Jia, Xiaofeng Peng, Ludan Liang, Ying Zhang, Meng Li, Qin Zhou, Xiujin Shen, Yucheng Wang, Cuili Wang, Shi Feng, Jianghua Chen, Pingping Ren, Hong Jiang
Summary: Differential gene expression related to podocytes and Angptl4 was found between IgA nephropathy patients and healthy controls. Plasma and urine levels of Angptl4 were closely associated with podocyte damage and urine protein, suggesting a potential tool for assessing the severity of IgAN.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Cell Biology
Mateus Justi Luvizotto, Luisa Menezes-Silva, Viktoria Woronik, Renato C. Monteiro, Niels Olsen Saraiva Camara
Summary: IgA Nephropathy is a common primary glomerular disease characterized by the deposition of IgA-immune complexes and mesangial expansion. The disease's clinical manifestations and development are closely related to mucosal immunity, microbiota, and nutritional status.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, General & Internal
Xia Tan, Yexin Liu, Di Liu, Xiaofang Tang, Ming Xia, Guochun Chen, Liyu He, Xuejing Zhu, Hong Liu
Summary: This study reveals that the expression of protein SUMO1 is upregulated in IgA nephropathy and is associated with inhibition of autophagy. In a stimulated mesangial cell model, inhibiting SUMOylation or silencing SUMO1 can promote autophagy and decrease cell proliferation.
FRONTIERS IN MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Wencheng Xu, Wanci Song, Shuhe Chen, Shanshan Jin, Xue Xue, Jinwen Min, Xiaoqin Wang, Pengtao You
Summary: This study found that tetrandrine inhibited the proliferation of mesangial cells induced by enzymatically deglycosylated human IgA1 via the IgA receptor/MAPK/NF-kappa B signaling pathway, indicating that tetrandrine could be an appealing therapeutic option for IgAN.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Oncology
Jung Eun Baik, Hyeung Ju Park, Raghu P. Kataru, Ira L. Savetsky, Catherine L. Ly, Jinyeon Shin, Elizabeth M. Encarnacion, Michele R. Cavali, Mark G. Klang, Elyn Riedel, Michelle Coriddi, Joseph H. Dayan, Babak J. Mehrara
Summary: TGF-beta 1 is an essential regulator of extracellular matrix deposition in secondary lymphedema, and inhibition of this response is a promising means of treating lymphedema.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Medicine, General & Internal
Ming Xia, Di Liu, Haiyang Liu, Liang Peng, Danyi Yang, Chengyuan Tang, Guochun Chen, Yu Liu, Hong Liu
Summary: This study identified DEGs in the kidney transcriptome of IgAN patients, revealing interesting pathological changes in glomerular compartments. Hub genes (ITGB2, FCER1G, CSF1R) were significantly upregulated in IgAN and related to the severity of renal lesions. Computational drug repurposing suggested tetrandrine as a potential treatment for IgAN, which was validated to reverse mesangial cell proliferation and cell cycle transition.
FRONTIERS IN MEDICINE
(2022)
Article
Physiology
Junjun Zhang, Ruwen Zhou, Yiming Mi, Zhangsuo Liu, Bo Huang, Ruxue Guo, Panfei Wang, Songxia Quan, Yali Zhou
Summary: This study found that approximately one-third of IgAN patients had SIgA deposition in the mesangium, but SIgA was rarely detected in the tubulointerstitium. The binding rate of SIgA to human renal mesangial cells was significantly higher than to human proximal tubule epithelial cells. Inflammatory factors released from the mesangium via mesangial-tubular crosstalk may mediate tubulointerstitial damage in IgAN.
KIDNEY & BLOOD PRESSURE RESEARCH
(2021)
Article
Immunology
Zhixin Lan, Lu Zhao, Liang Peng, Lili Wan, Di Liu, Chengyuan Tang, Guochun Chen, Yu Liu, Hong Liu
Summary: IgA nephropathy is a major cause of kidney failure, and this study revealed that endoplasmic reticulum (ER) stress plays a role in promoting mesangial cell proliferation in IgA nephropathy. In addition, the expression of certain ER stress-related proteins in the glomerulus negatively correlated with the clinical remission of IgA nephropathy patients.
CLINICAL IMMUNOLOGY
(2023)
Article
Plant Sciences
Mingming Zhao, Bin Yang, Liusheng Li, Yuan Si, Meiying Chang, Sijia Ma, Ronghai Li, Yuejun Wang, Yu Zhang
Summary: This study demonstrates that MHCD can alleviate renal fibrosis in rats with IgA nephropathy by reducing the expression levels of fibronectin, laminin, and collagen IV in renal tissues.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
