Article
Neurosciences
David Alcantara-Gonzalez, Elissavet Chartampila, Chiara Criscuolo, Helen E. Scharfman
Summary: The granule cells (GCs) in the Tg2576 mouse exhibit early electrophysiological alterations including increased synaptic excitation, reduced inhibition, and dysregulation of the muscarinic cholinergic system, consistent with hyperexcitability.
NEUROBIOLOGY OF DISEASE
(2021)
Review
Neurosciences
Matthew R. Hudson, Nigel C. Jones
Summary: Neural oscillatory activity in the gamma frequency range is important for sensory and cognitive processing. However, the interpretation and generalization of studies on gamma oscillations are limited by diverse and questionable methodologies. This article provides an overview of different measures of gamma oscillatory activity, discusses the limitations of current techniques, and makes recommendations for future studies to optimize analysis, presentation, and interpretation of gamma frequency oscillations.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Mathematics, Applied
Songting Li, David W. McLaughlin, Douglas Zhou
Summary: This article investigates neuronal dendritic integration using theoretical and computational approaches. A cable neuron model and a point-neuron model are introduced to describe the changes in membrane potential when dendrites receive multiple synaptic inputs. The results provide a comprehensive computational framework for the study of spatial neuron dynamics and are validated through numerical simulations.
COMMUNICATIONS ON PURE AND APPLIED MATHEMATICS
(2023)
Article
Multidisciplinary Sciences
Wladyslaw Sredniawa, Jacek Wrobel, Ewa Kublik, Daniel Krzysztof Wojcik, Miles Adrian Whittington, Mark Jeremy Hunt
Summary: This study reveals that ketamine-xylazine (KX) anesthesia in rats is associated with a prominent 80-130 Hz rhythm in the olfactory bulb, while gamma power in the range of 30-65 Hz is diminished. The 80-130 Hz rhythm is dependent on nasal respiration and excitatory-inhibitory synaptic activity, and is conserved in higher mammals like cats.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Francisco Garcia-Rosales, Luciana Lopez-Jury, Eugenia Gonzalez-Palomares, Yuranny Cabral-Calderin, Manfred Koessl, Julio C. Hechavarria
Summary: Neural oscillations play a central role in important computations in the mammalian brain. The interaction between oscillatory activities in different frequency bands is a powerful mechanism for binding different spatiotemporal scales in neural processing. Phase-amplitude coupling (PAC) is a well-known interaction, but its contribution to sensory representations is still not fully understood. This study investigates PAC dynamics in the frontal-auditory field (FAF) and the auditory cortex (AC) of bats, and reveals distinct PAC profiles in these areas. The findings suggest that different PAC profiles may represent different mechanisms for neuronal processing in frontal and auditory cortices.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Immunology
Gursel Caliskan, Timothy French, Sara Enrile Lacalle, Miguel del Angel, Johannes Steffen, Markus M. Heimesaat, Ildiko Rita Dunay, Oliver Stork
Summary: Long-term use of antibiotics may lead to gut microbiota dysbiosis, affecting synaptic transmission and behavioral network activities in the hippocampus. Our study demonstrates that antibiotic-induced dysbiosis of the gut microbiome and alteration of immune cell function are associated with reduced synaptic transmission and gamma oscillations in the hippocampus.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Acoustics
Jason Mulsow, James J. Finneran, Dorian S. Houser, Robert F. Burkard, Madelyn G. Strahan, Ryan Jones
Summary: Studies on dolphin auditory brainstem response (ABR) have shown that the response to sound offset includes contributions from at least two distinct responses, with one possibly arising from activation of neural units shifted basally relative to stimulus frequency, and the other representing a true offset response from afferent centers further up the auditory pathway.
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
(2021)
Article
Cell Biology
Jie Zheng, Ivan Skelin, Jack J. Lin
Summary: Our perception of facial expressions is influenced by the context of social interactions. The context provides specific framing and resolves ambiguity in interpreting facial expressions, guiding our behavior. This modulation of facial expression may involve the amygdala, hippocampus, and orbitofrontal cortex, but the neural mechanisms are still unknown.
Article
Biochemistry & Molecular Biology
Salomon Z. Muller, L. F. Abbott, Nathaniel B. Sawtell
Summary: In weakly electric mormyrid fish, sensory input selectively modulates the rate of dendritic spiking by adjusting the amplitude of backpropagating axonal action potentials. This mechanism does not require spatially segregated synaptic inputs or dendritic compartmentalization but relies instead on an electrotonically distant spike initiation site in the axon.
Article
Neurosciences
Anusha Mohan, Alison Luckey, Nathan Weisz, Sven Vanneste
Summary: Tinnitus may result from predictive coding issues, with patients potentially being more sensitive to auditory stimuli unrelated to tinnitus characteristics. In individuals with minimal or no hearing loss, a more top-down subtype of tinnitus driven by maladaptive changes in the auditory predictive coding network may exist. Empirical evidence suggests the presence of maladaptive changes in hierarchical predictive coding network in a subgroup of tinnitus patients with minimal to no hearing loss.
Review
Neurosciences
Ines Ibarra-Lecue, Saskia Haegens, Alexander Z. Harris
Summary: This review discusses the application of optogenetics and related techniques in studying brain oscillations and their functional roles. By studying brain rhythms associated with behavior, insights can be gained at different levels, providing a better understanding of the complex behavioral regulation involving brain oscillations.
FRONTIERS IN NEURAL CIRCUITS
(2022)
Article
Multidisciplinary Sciences
Naho Konoike, Haruhiko Iwaoki, Miki Miwa, Honami Sakata, Kosuke Itoh, Katsuki Nakamura
Summary: This study compared the characteristics of auditory steady-state responses (ASSRs) among humans, rhesus monkeys, and marmosets. The results showed that although the optimal frequency for synchronization differed, monkeys and marmosets also exhibited auditory event-related potentials and phase-locking activity in gamma-frequency trains. This suggests that ASSR could be a useful cross-species translational biomarker.
SCIENTIFIC REPORTS
(2022)
Article
Physics, Fluids & Plasmas
F. M. Trukhachev, N. V. Gerasimenko, M. M. Vasiliev, O. F. Petrov
Summary: New features of motion of background plasma ions in the presence of ion-acoustic solitons are analyzed using a hydrodynamic model. Ion velocity distribution functions are obtained analytically for the first time based on the ergodic hypothesis. The study reveals that the initial Maxwellian distribution of ions transforms into a beam-like form in the region occupied by solitons, and the main parameters of the distribution functions are determined for solitons of different amplitudes. Motion of soliton trains, commonly observed in experiments, and other experimental aspects are also considered.
PHYSICS OF PLASMAS
(2023)
Article
Biochemical Research Methods
David Reyner-Parra, Gemma Huguet
Summary: This study explores the synchronization between neuronal circuits connected with unidirectional projections and finds that inputs with high coherence can entrain the network for a wider range of frequencies, leading to more effective communication. It also shows that faster oscillatory inputs are more effective in communication than inputs with similar frequency. Additionally, it demonstrates that pulsatile inputs can switch between attended inputs in selective attention.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Article
Biochemical Research Methods
Kathleen Jacquerie, Guillaume Drion
Summary: The time scale separation between the activation of sodium and T-type calcium channels is crucial for robust switches in brain states in thalamic neurons. Conductance-based models show that this difference in kinetics is essential for studying the interaction between switches in brain states, synaptic plasticity, and neuromodulation.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Jose Antonio Villacorta-Atienza, Carlos Calvo Tapia, Sergio Diez-Hermano, Abel Sanchez-Jimenez, Sergey Lobov, Nadia Krilova, Antonio Murciano, Gabriela E. Lopez-Tolsa, Ricardo Pellon, Valeri A. Makarov
Summary: The human brain processes static and dynamic situations as purely static maps to efficiently deal with time-changing environments. Experimental evidence supports the theory of time compaction as a cognitive strategy adopted by the human brain, with mathematical modeling validating the findings. Men are shown to be more prone to exploiting time compaction as a cognitive basis for survival.
JOURNAL OF ADVANCED RESEARCH
(2021)
Article
Chemistry, Analytical
Sergey A. Lobov, Alexey I. Zharinov, Valeri A. Makarov, Victor B. Kazantsev
Summary: The study introduces a spiking neural network capable of generating an internal representation of the external environment and implementing spatial memory, with the network's function explored through its embodiment in a robot moving in an arena with safe and dangerous zones.
Article
Critical Care Medicine
R. David Andrew, Eszter Farkas, Jed A. Hartings, K. C. Brennan, Oscar Herreras, Michael Mueller, Sergei. A. Kirov, Cenk Ayata, Nikita Ollen-Bittle, Clemens Reiffurth, Omer Revah, R. Meldrum Robertson, Ken D. Dawson-Scully, Ghanim Ullah, Jens P. Dreier
Summary: The spreading depolarizations (SD) theory provides a better explanation for acute neuronal injury caused by brain ischemia than the theory of excessive glutamate release. The challenges in developing therapeutic strategies based on more informed basic science are highlighted, calling for a shift in focus towards understanding the molecular biology of SD initiation and propagation.
NEUROCRITICAL CARE
(2022)
Article
Critical Care Medicine
R. David Andrew, Jed A. Hartings, Cenk Ayata, K. C. Brennan, Ken D. Dawson-Scully, Eszter Farkas, Oscar Herreras, Sergei A. Kirov, Michael Muller, Nikita Ollen-Bittle, Clemens Reiffurth, Omer Revah, R. Meldrum Robertson, C. William Shuttleworth, Ghanim Ullah, Jens P. Dreier
Summary: In this review, the mechanism and impact of spreading depolarization (SD) in the gray matter following blood flow loss are discussed. The initiation and propagation of SD are explored, along with the challenges and pitfalls in studying SD. The review concludes with a summary of the research direction and ongoing debates regarding SD.
NEUROCRITICAL CARE
(2022)
Article
Neurosciences
Oscar Herreras, Daniel Torres, Gonzalo Martin-Vazquez, Sara Hernandez-Recio, Victor J. Lopez-Madrona, Nuria Benito, Valeri A. Makarov, Julia Makarova
Summary: Field potentials generated by neuron populations have a multisource origin and exhibit site-dependent blending. When assessing whether waveforms and temporal motifs arise from a single source, it is important to consider the spatial reach and the realistic structure of neuron aggregates.
Review
Mathematical & Computational Biology
Valeri A. Makarov, Sergey A. Lobov, Sergey Shchanikov, Alexey Mikhaylov, Viktor B. Kazantsev
Summary: The design of modern convolutional artificial neural networks (ANNs) imitates the architecture of the visual cortex, while spiking neural networks (SNNs) have the potential for a qualitative leap in cognitive computations. However, the training of SNNs remains challenging, and the concept of a high-dimensional brain provides new insights and possibilities for the development of neural networks.
FRONTIERS IN COMPUTATIONAL NEUROSCIENCE
(2022)
Article
Mathematics
Sergey A. Lobov, Alexey N. Mikhaylov, Ekaterina S. Berdnikova, Valeri A. Makarov, Victor B. Kazantsev
Summary: One challenge in modern neuroscience is creating a brain-on-a-chip, a device that can interact with the environment when integrated into a robot. This study proposes a mathematical model of a modular spiking neural network (SNN) to understand learning mechanisms in this context. The model shows that spike-timing-dependent plasticity, synaptic competition, and neuronal competition are all crucial for successful learning. The proposed solution has been tested in neuronal cultures and demonstrated the ability to establish associations between touch and ultrasonic sensors, allowing the robot to avoid obstacles.
Review
Neurosciences
Oscar Herreras, Daniel Torres, Valeriy A. Makarov, Julia Makarova
Summary: Field potential (FP) recording, as an accessible means to capture the shifts in the activity of neuron populations, has largely overlooked the spatial and composite nature of these signals until recently. By prioritizing the spatial geometry and density of sources, rather than the distance to the recording site, the amplitudes and spatial reach of FPs can be better defined. Considering the role of geometry and regional activation in shaping FP oscillations can explain counterintuitive observations and reduce the risk of misassignments based solely on FP amplitude or temporal pattern.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Neurosciences
Marta Montero-Atalaya, Sara Exposito, Ricardo Munoz-Arnaiz, Julia Makarova, Begona Bartolome, Eduardo Martin, Maria Victoria Moreno-Arribas, Oscar Herreras
Summary: Dietary polyphenols have beneficial effects on impaired cognition in acute neurodegeneration models. The study showed that protocatechuic acid (PCA) has direct electrophysiological action on CA1 pyramidal cells and network activity. This is the first report demonstrating the neuromodulatory role of a dietary polyphenol at both the cellular and network levels.
Article
Neurosciences
Sara Hernandez-Recio, Ricardo Munoz-Arnaiz, Victor Lopez-Madrona, Julia Makarova, Oscar Herreras
Summary: This study investigated the role of interhemispheric connections in the cortico-hippocampal circuits in anesthetized rats. The results showed varying bilateral correlation and coherence in different frequency bands and time scales. The CA1 region and the Schafer segment exhibited high bilateral coherence, while the Dentate Gyrus showed low coherence. Granger causality testing revealed strong bidirectional relationships between most homonymous bilateral generators.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Quantum Science & Technology
G. Martin-Vazquez, G. Aarts, M. Mueller, A. Bermudez
Summary: In this work, we study the generating functional of a self-interacting scalar quantum field theory and map it onto a collection of multipartite-entangled two-level sensors via an interferometric protocol. We show that using always-on harmonic sources can simplify the sensing protocol and allow for the extraction of relevant information about the renormalization of the quantum field theory.