Structures of Coxsackievirus, Rhinovirus, and Poliovirus Polymerase Elongation Complexes Solved by Engineering RNA Mediated Crystal Contacts

A Polymerase Mechanism-based Strategy for Viral Attenuation and Vaccine Development

(2012) Spencer A. Weeks et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Assembly, Purification, and Pre-steady-state Kinetic Analysis of Active RNA-dependent RNA Polymerase Elongation Complex

(2012) Zhinan Jin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Template RNA Entry Channel in the Fingers Domain of the Poliovirus Polymerase

(2012) Matthew G. Kortus et al.   JOURNAL OF MOLECULAR BIOLOGY

Coxsackievirus B3 mutator strains are attenuated in vivo

(2012) N. F. Gnadig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Motif D of Viral RNA-Dependent RNA Polymerases Determines Efficiency and Fidelity of Nucleotide Addition

(2012) Xiaorong Yang et al.   STRUCTURE

What Is the Role of Motif D in the Nucleotide Incorporation Catalyzed by the RNA-dependent RNA Polymerase from Poliovirus?

(2012) Hujun Shen et al.   PLoS Computational Biology

Molecular Dynamics Simulations of Viral RNA Polymerases Link Conserved and Correlated Motions of Functional Elements to Fidelity

(2011) Ibrahim M. Moustafa et al.   JOURNAL OF MOLECULAR BIOLOGY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Long-Range Interaction Networks in the Function and Fidelity of Poliovirus RNA-Dependent RNA Polymerase Studied by Nuclear Magnetic Resonance

(2010) Xiaorong Yang et al.   BIOCHEMISTRY

Poliovirus Polymerase Residue 5 Plays a Critical Role in Elongation Complex Stability

(2010) S. E. Hobdey et al.   JOURNAL OF VIROLOGY

Host Alternation of Chikungunya Virus Increases Fitness while Restricting Population Diversity and Adaptability to Novel Selective Pressures

(2010) L. L. Coffey et al.   JOURNAL OF VIROLOGY

Structural basis for active site closure by the poliovirus RNA-dependent RNA polymerase

(2010) P. Gong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Machines and Targeted Molecular Dynamics: DNA in Motion

(2010) Janice D. Pata et al.   STRUCTURE

The Mechanism of the Translocation Step in DNA Replication by DNA Polymerase I: A Computer Simulation Analysis

(2010) Andrei A. Golosov et al.   STRUCTURE

A Multi-Step Process of Viral Adaptation to a Mutagenic Nucleoside Analogue by Modulation of Transition Types Leads to Extinction-Escape

(2010) Rubén Agudo et al.   PLoS Pathogens

Fidelity Variants of RNA Dependent RNA Polymerases Uncover an Indirect, Mutagenic Activity of Amiloride Compounds

(2010) Laura I. Levi et al.   PLoS Pathogens

A quantitative stopped-flow fluorescence assay for measuring polymerase elongation rates

(2009) Peng Gong et al.   ANALYTICAL BIOCHEMISTRY

Conformational analysis of nucleic acids revisited: Curves+

(2009) R. Lavery et al.   NUCLEIC ACIDS RESEARCH

Structural Insights into Mechanisms of Catalysis and Inhibition in Norwalk Virus Polymerase

(2008) Dmitry F. Zamyatkin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of Coxsackievirus B3 3Dpol Highlights the Functional Importance of Residue 5 in Picornavirus Polymerases

(2008) G. Campagnola et al.   JOURNAL OF VIROLOGY

Determinants of RNA-Dependent RNA Polymerase (In)fidelity Revealed by Kinetic Analysis of the Polymerase Encoded by a Foot-and-Mouth Disease Virus Mutant with Reduced Sensitivity to Ribavirin

(2008) A. Arias et al.   JOURNAL OF VIROLOGY

Accurate Structural Correlations from Maximum Likelihood Superpositions

(2008) Douglas L. Theobald et al.   PLoS Computational Biology