期刊
ACS APPLIED MATERIALS & INTERFACES
卷 14, 期 40, 页码 45178-45188出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.2c12839
关键词
low-temperature photothermal therapy; MXenes; borneol; membrane targeting; antibacterial activity
资金
- National Natural Science Foundation of China [21774035]
- Tip-top Scientific and Technical Innovative Youth Talents of Guangdong Special Support Program [2019TQ05N359]
- Science and Technology Planning Project of Guangdong Province [2020A0505100005]
- Science and Technology Program of Guangzhou [202103000069]
- Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, China [2019B030301003]
- Fundamental Research Funds for the Central Universities, SCUT [PCFM-2022A05]
- Key Laboratory of Polymeric Composite and Functional Materials of Ministry of Education [2020ZYGXZR062]
The study developed a low-temperature PTT method based on borneol-containing polymer-modified MXene nanosheets, which effectively eliminates multidrug-resistant bacteria through targeted photothermal therapy and is safe for human use.
Noninvasive photothermal therapy (PTT) is an emerging strategy for eliminating multidrug-resistant (MDR) bacteria that achieve sterilization by generating temperatures above 50 degrees C; however, such a high temperature also causes collateral damage to healthy tissues. In this study, we developed a low-temperature PTT based on borneol-containing polymer-modified MXene nanosheets (BPM) with bacteria-targeting capabilities. BPM was fabricated through the electrostatic coassembly of negatively charged two-dimensional MXene nanosheets (2DM) and positively charged quaternized alpha-(+)-borneol-poly(N, N-dimethyl ethyl methacrylate) (BPQ) polymers. Integrating BPQ with 2DM improved the stability of 2DM in physiological environments and enabled the bacterial membrane to be targeted due to the presence of a borneol group and the partially positive charge of BPQ. With the aid of near-infrared irradiation, BPM was able to effectively eliminate methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli (E. coli) through targeted photothermal hyperthermia. More importantly, BPM effectively eradicated more than 99.999% (>5 orders of magnitude) of MRSA by localized heating at a temperature that is safe for the human body (<= 40 degrees C). Together, these findings suggest that BPM has good biocompatibility and that membrane-targeting low-temperature PTT could have great therapeutic potential against MDR infections.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据