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Biochemistry & Molecular Biology
Da-Yeon Lee, Su-Jeong Lee, Prabha Chandrasekaran, Gopal Lamichhane, Jennifer F. O'Connell, Josephine M. Egan, Yoo Kim
Summary: This study investigated the effects of dietary curcumin (CUR) as an antioxidant on hepatic cellular senescence in aged mice. The results showed that CUR supplementation downregulated senescence-associated hepatic gene expressions, enhanced antioxidant properties, suppressed MAPK signaling cascades, and inhibited proinflammatory cytokines and SASPs expression, suggesting that CUR may be a nutritional strategy to prevent hepatic cellular senescence.
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Environmental Sciences
Xinwen Dong, Lvfei Deng, Yaguang Su, Xiaofeng Han, Sanqiao Yao, Weidong Wu, Jia Cao, Linqiang Tian, Yichun Bai, Guizhi Wang, Wenjie Ren
Summary: Gas explosions are a common cause of traumatic brain injury in coal miners. This study investigated the effects of curcumin on gas explosion-induced brain injury in rats. The results showed that curcumin treatment improved histological abnormalities, mitochondrial structure, and neuroinflammatory signaling molecules in the brain tissue. Curcumin also reshaped the gut microbiota and reduced serum lipopolysaccharide levels, showing potential therapeutic effects.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
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Immunology
Bo Wu, Lihua Qiang, Yong Zhang, Yesheng Fu, Mengyuan Zhao, Zehui Lei, Zhe Lu, Yan-Ge Wei, Hongmiao Dai, Yingwei Ge, Mingqiu Liu, Xuemei Zhou, Zhiqiang Peng, Hongchang Li, Chun-Ping Cui, Jing Wang, Hui Zheng, Cui Hua Liu, Lingqiang Zhang
Summary: The E3 ubiquitin ligase (E3)-mediated ubiquitination and deubiquitinase (DUB)-mediated deubiquitination play crucial roles in colonic inflammation. Ovarian tumor deubiquitinase 1 (OTUD1) inhibits RIPK1-mediated NF-kappa B activation to alleviate inflammation, with lower expression in UC patients. OTUD1 is a potential target for treating IBD due to its regulatory role in intestinal inflammation.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
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Pharmacology & Pharmacy
Yarong Du, Cong Jia, Yan Liu, Yehua Li, Jufang Wang, Kun Sun
Summary: Isorhamnetin (ISO) pretreatment enhances radiosensitivity of A549 cells by inducing apoptosis, disrupting mitochondrial membrane potential, and modulating NF-kappa B activity. The expression of anti-inflammatory cytokine IL-13 is positively correlated with ISO-mediated radiosensitization. Knockdown of IL-13 decreases ISO-induced radiosensitivity, suggesting a potential mechanism for ISO's effects on radiotherapy responsiveness.
FRONTIERS IN PHARMACOLOGY
(2021)
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Microbiology
Caijiao Dai, Li Yu, Zhiwen Wang, Peng Deng, Lijuan Li, Zemao Gu, Xugang He, Jianghua Wang, Junfa Yuan
Summary: The emergence or reemergence of viruses poses a significant threat and challenge to the world population, livestock, and wildlife. However, the development of antiviral agents for viral diseases in humans and animals is still lacking. This study focused on the pathophysiology of M. salmoides rhabdovirus (MSRV) and identified inflammation and oxidative stress as major factors. Mangiferin or taurine showed potential as antiviral agents by suppressing NF-kappa B signaling and reducing inflammation and oxidative stress.
MICROBIOLOGY SPECTRUM
(2023)
Article
Biochemistry & Molecular Biology
Seung Yong Kim, Dong-Uk Shin, Ji-Eun Eom, Sun Young Jung, Hyeon-Ji Song, Kyung Min Lim, Gun-Dong Kim, Soon-Il Yun, Mi-Yeon Kim, Hee Soon Shin, So-Young Lee
Summary: This study found that Artemisia gmelinii has a protective effect against lung inflammation caused by cigarette smoke. The mechanism of action may involve inhibiting the MAPK and NF-kappa B signaling pathways. This research provides a potential solution for improving respiratory and lung health.
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Immunology
LuLu Qian, Jun-Zhao Li, XueMei Sun, Jie-Bin Chen, Ying Dai, Qiu-Xiang Huang, Ying-Ji Jin, Qing-Ning Duan
Summary: The study demonstrates that safinamide can inhibit the production of pro-inflammatory cytokines by macrophages, reduce the release of inflammatory mediators, prevent leukocyte migration, and decrease the generation of related enzymes. These effects are mainly achieved through safinamide's inhibition of the TLR4/NF-kappa B signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Chenghong Hu, Yue Chen, Lingxi Zhang, Min Liu, Jie Yang, Fang Huang, Yi Wang, Lijiang Huang
Summary: This study found that C66 can exhibit its anti-inflammatory effect by inhibiting the activation of the JNK/NF-kappa B signaling pathways, thereby reducing the pathological damage of inflammatory bowel disease, increasing epithelial cell proliferation, and reducing apoptosis.
INFLAMMOPHARMACOLOGY
(2022)
Article
Environmental Sciences
Ali S. Alshehri, Attalla F. El-kott, Mohamed S. A. El-Gerbed, Ayman E. El-Kenawy, Ghadeer M. Albadrani, Heba S. Khalifa
Summary: The study evaluated the protective effect of kaempferol against cadmium chloride-induced liver damage through antioxidant and anti-inflammatory mechanisms, involving the upregulation of Nr12/HO-1 axis and suppression of NF-kappa B p65 and keap1.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Plant Sciences
Bin Li, Baoke Zhang, Zhenyu Li, Shasha Li, Jun Li, Aiwu Wang, Jinling Hou, Jiping Xu, Rui Zhang
Summary: The study aimed to investigate the potential of ginkgolide C (GC), an active ingredient in Ginkgo biloba leaves, to attenuate cerebral ischemia/reperfusion injury (CI/RI) and its anti-inflammatory effect through suppression of the CD40/NF-kappa B pathway. The results showed that GC reduced neurological scores, cerebral infarct rate, and brain edema, while improving microvessel ultrastructure and blood-brain barrier integrity. GC also inhibited the release of inflammatory mediators and enhanced cell viability. These effects were mediated through the suppression of the CD40/NF-kappa B pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
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Biochemistry & Molecular Biology
Zahra Eskandari, Fatemeh Bahadori, Vildan Betul Yenigun, Mutlu Demiray, Mehmet Sayip Eroglu, Abdurrahim Kocyigit, Ebru Toksoy Oner
Summary: The study aimed to increase the bioavailability of curcumin by loading it into nano-micelles made of PLGA and levan, showing reduced NF-kappa B levels and anti-tumor effects both in vitro and in vivo.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Xiaojing Wang, Liangjing Wang, Lin Geng, Naoki Tanaka, Bin Ye
Summary: Resmetirom, an orally active agonist of THR-beta that targets the liver, shows promise in treating NASH, but its underlying mechanism is not well understood. This study established a NASH cell model to test the preventive effect of resmetirom and used RNA-seq for screening. They also conducted rescue experiments to validate the drug's target gene. A NASH mouse model was used to further investigate the role and mechanism of resmetirom. The findings showed that resmetirom effectively reduced lipid accumulation and triglyceride levels and recovered the expression of RGS5, which is repressed in the NASH model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Correction
Multidisciplinary Sciences
Jia Sun, Chao Niu, Weijian Ye, Ning An, Gen Chen, Xiaozhong Huang, Jianan Wang, Xixi Chen, Yingjie Shen, Shuai Huang, Ying Wang, Xu Wang, Yang Wang, Litai Jin, Weitao Cong, L. Xiaokun
Summary: During the final preparation, the authors mistakenly assembled some panels in Figure S2I and S9A. The images for AAV9-Scramblecontrol in Figure S2I actually represent AAV9-LacZcontrol. The images for Ad-FGF13 OE+Ad-IKB OE in Figure S9A actually represent Ad-FGF13 NLS-OE. These errors do not affect the results or the conclusions of the paper. The authors apologize for any inconvenience caused to the readers.
Article
Immunology
Binzhen Chen, Jia Han, Shaoheng Chen, Rufeng Xie, Jie Yang, Tongming Zhou, Qi Zhang, Rong Xia
Summary: In this study, the regulatory pathway of miR-let-7b/TLR4/NF-kappa B in neutrophils was investigated. Overexpression of miR-let-7b down-regulated TLR4 expression and decreased proinflammatory factors while increasing anti-inflammatory factor in vitro. Treatment with miR-let-7b agomir in septic mice improved survival, reduced organ injuries, and inhibited neutrophil recruitment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Yanyan Li, Huifang Sun, Xin Liu, Zhihui Hu, Henghua Jiang, Huilin Guo, Xing Long
Summary: This study aimed to explore the ability of TG2 inhibitors to suppress TMJ-OA progression. The results showed that TG2 inhibitors suppressed inflammation and cartilage degradation by inhibiting NF-kappa B activation, leading to significant reversal of structural damage in TMJ-OA. These findings suggest the potential therapeutic efficacy of TG2 inhibitors in the treatment of TMJ-OA.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
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Biochemistry & Molecular Biology
J. Niu, A. Xue, Y. Chi, J. Xue, W. Wang, Z. Zhao, M. Fan, C. H. Yang, Z-M Shao, L. M. Pfeffer, J. Wu, Z-H Wu
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Biochemistry & Molecular Biology
J. Xue, Y. Chi, Y. Chen, S. Huang, X. Ye, J. Niu, W. Wang, L. M. Pfeffer, Z-m Shao, Z-H Wu, J. Wu
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Oncology
Chuan He Yang, Yinan Wang, Michelle Sims, Chun Cai, Ping He, Junming Yue, Jinjun Cheng, Frederick A. Boop, Susan R. Pfeffer, Lawrence M. Pfeffer
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Oncology
Cezary Skobowiat, Allen S. W. Oak, Tae-Kang Kim, Chuan He Yang, Lawrence M. Pfeffer, Robert C. Tuckey, Andrzej T. Slominski
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Biochemistry & Molecular Biology
Suriyan Ponnusamy, Ryan D. Sullivan, Dahui You, Nadeem Zafar, Chuan He Yang, Thirumagal Thiyagarajan, Daniel L. Johnson, Maron L. Barrett, Nikki J. Koehler, Mayra Star, Erin J. Stephenson, Dave Bridges, Stephania A. Cormier, Lawrence M. Pfeffer, Ramesh Narayanan
HUMAN MOLECULAR GENETICS
(2017)
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Oncology
Chuan He Yang, Yinan Wang, Michelle Sims, Chun Cai, Ping He, Hans Hacker, Junming Yue, Jinjun Cheng, Frederick A. Boop, Lawrence M. Pfeffer
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Oncology
Wenying Huo, Guannan Zhao, Jinggang Yin, Xuan Ouyang, Yinan Wang, Chuanhe Yang, Baojing Wang, Peixin Dong, Zhixiang Wang, Hidemichi Watari, Edward Chaum, Lawrence M. Pfeffer, Junming Yue
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Oncology
Tao Zhang, Guannan Zhao, Chuanhe Yang, Peixin Dong, Hidemichi Watari, Lin Zeng, Lawrence M. Pfeffer, Junming Yue
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Chemistry, Medicinal
Chuanhe Yang, Yinan Wang, Michelle M. Sims, Yali He, Duane D. Miller, Lawrence M. Pfeffer
Summary: The study showed that PFI-3 can bind to BRDs in GBM cells, enhance the antiproliferative and cell death-inducing effects of TMZ in sensitive GBM cells, overcome chemoresistance in highly resistant GBM cells, and alter gene expression in GBM. Additionally, PFI-3 enhanced the anticancer effect of TMZ in an intracranial GBM animal model, leading to increased survival in animals with GBM tumors.
Review
Chemistry, Medicinal
Ronald Nicholas Laribee, Andrew B. Boucher, Saivikram Madireddy, Lawrence M. Pfeffer
Summary: This article explores the association between over-activation of autophagy and cell death in glioblastoma, as well as the inherent resistance of cancer stem cells to therapy. It suggests that autophagy promotes and maintains the stem-like state of cancer stem cells and contributes to their resistance to treatment.
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Chemistry, Medicinal
Debolina Ganguly, Chun Cai, Michelle M. Sims, Chuan He Yang, Matthew Thomas, Jinjun Cheng, Ali G. Saad, Lawrence M. Pfeffer
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Biochemistry & Molecular Biology
Ziyun Du, Chun Cai, Michelle Sims, Frederick A. Boop, Andrew M. Davidoff, Lawrence M. Pfeffer
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2017)
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Biochemistry & Molecular Biology
Susan R. Pfeffer, Meiyun Fan, Ziyun Du, Chuan He Yang, Lawrence M. Pfeffer
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2017)
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Biochemistry & Molecular Biology
Baojin Wang, Airong Shen, Xuan Ouyang, Guannan Zhao, Ziyun Du, Wenying Huo, Tao Zhang, Yinan Wang, Chuanhe Yang, Peixin Dong, Hidemichi Watari, Lawrence M. Pfeffer, Junming Yue
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2017)
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Oncology
Aarti Sethuraman, Martin Brown, Tiffany N. Seagroves, Zhao-Hui Wu, Lawrence M. Pfeffer, Meiyun Fan
BREAST CANCER RESEARCH
(2016)