Inhibition of Ceramide Metabolism Sensitizes Human Leukemia Cells to Inhibition of BCL2-Like Proteins

Bax and Bcl-xL exert their regulation on different sites of the ceramide channel

(2012) Meenu N. Perera et al.   BIOCHEMICAL JOURNAL

Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1

(2012) Mark E. Schnute et al.   BIOCHEMICAL JOURNAL

Resveratrol dimers are novel sphingosine kinase 1 inhibitors and affect sphingosine kinase 1 expression and cancer cell growth and survival

(2012) Keng Gat Lim et al.   BRITISH JOURNAL OF PHARMACOLOGY

Sphingolipid Metabolism Cooperates with BAK and BAX to Promote the Mitochondrial Pathway of Apoptosis

(2012) Jerry E. Chipuk et al.   CELL

Targeting glucosylceramide synthase sensitizes imatinib-resistant chronic myeloid leukemia cells via endogenous ceramide accumulation

(2011) Yusuf Baran et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Roles of ceramide synthase and ceramide clearence genes in nilotinib-induced cell death in chronic myeloidleukemia cells

(2011) Aylin Camgoz et al.   LEUKEMIA & LYMPHOMA

Resveratrol Triggers Apoptosis Through Regulating Ceramide Metabolizing Genes in Human K562 Chronic Myeloid Leukemia Cells

(2011) Melis Kartal et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Ceramide and activated Bax act synergistically to permeabilize the mitochondrial outer membrane

(2010) Vidyaramanan Ganesan et al.   APOPTOSIS

Ceramide channels and their role in mitochondria-mediated apoptosis

(2010) Marco Colombini   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Regulation of ceramide channels by Bcl-2 family proteins

(2010) Vidyaramanan Ganesan et al.   FEBS LETTERS

Increased radiation sensitivity of head and neck squamous cell carcinoma with sphingosine kinase 1 inhibition

(2010) Uttam K. Sinha et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

The BCL-2 Protein BAK Is Required for Long-chain Ceramide Generation during Apoptosis

(2010) Leah J. Siskind et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity

(2010) Wyndham H Wilson et al.   LANCET ONCOLOGY

Resveratrol attenuates C5a-induced inflammatory responses in vitro and in vivo by inhibiting phospholipase D and sphingosine kinase activities

(2009) Priya D. A. Issuree et al.   FASEB JOURNAL

Real-world clinical experience with long-term miglustat maintenance therapy in type 1 Gaucher disease: the ZAGAL project

(2009) P. Giraldo et al.   HAEMATOLOGICA

ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor

(2008) C. Tse et al.   CANCER RESEARCH

Implications of sphingosine kinase 1 expression level for the cellular sphingolipid rheostat: relevance as a marker for daunorubicin sensitivity of leukemia cells

(2008) S. Sobue et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY