Roles of ceramide synthase and ceramide clearence genes in nilotinib-induced cell death in chronic myeloidleukemia cells

Activation of Sphingosine Kinase-1 in Cancer: Implications for Therapeutic Targeting

(2012) Olivier Cuvillier et al.   Current Molecular Pharmacology

Ceramide promotes apoptosis in chronic myelogenous leukemia-derived K562 cells by a mechanism involving caspase-8 and JNK

(2010) Alina Felicia Nica et al.   CELL CYCLE

Targeting sphingolipid metabolism in head and neck cancer: rational therapeutic potentials

(2010) Thomas H Beckham et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Nilotinib significantly induces apoptosis in imatinib resistant K562 cells with wild-type BCR–ABL, as effectively as in parental sensitive counterparts

(2010) Huseyin Atakan Ekiz et al.   Hematology

The roles of bioactive sphingolipids in resveratrol-induced apoptosis in HL60 acute myeloid leukemia cells

(2010) Zeynep Cakir et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

First-line therapy for chronic myeloid leukemia: Past, present, and future

(2009) Carolina Pavlovsky et al.   AMERICAN JOURNAL OF HEMATOLOGY

Failure to achieve a complete hematologic response at the time of a major cytogenetic response with second-generation tyrosine kinase inhibitors is associated with a poor prognosis among patients with chronic myeloid leukemia in accelerated or blast phase

(2009) C. Fava et al.   BLOOD

Nilotinib

(2008) M. W. Deininger   CLINICAL CANCER RESEARCH

Nilotinib: A second-generation tyrosine kinase inhibitor for the treatment of chronic myelogenous leukemia

(2008) David L. DeRemer et al.   CLINICAL THERAPEUTICS

Nilotinib

(2008) Greg L Plosker et al.   DRUGS

Sphingosine kinase-1 is a downstream regulator of imatinib-induced apoptosis in chronic myeloid leukemia cells

(2008) E Bonhoure et al.   LEUKEMIA

Chemosensitizing effects of sphingosine kinase-1 inhibition in prostate cancer cell and animal models

(2008) D. Pchejetski et al.   MOLECULAR CANCER THERAPEUTICS

"Inside-Out" Signaling of Sphingosine-1-Phosphate: Therapeutic Targets

(2008) K. Takabe et al.   PHARMACOLOGICAL REVIEWS

Overexpression of glucosylceramide synthase in associated with multidrug resistance of leukemia cells

(2007) Ping Xie et al.   LEUKEMIA RESEARCH