Highly Pathogenic H5N1 Influenza A Virus Strains Provoke Heterogeneous IFN-α/β Responses That Distinctively Affect Viral Propagation in Human Cells

Multifunctional Adaptive NS1 Mutations Are Selected upon Human Influenza Virus Evolution in the Mouse

(2012) Nicole E. Forbes et al.   PLoS One

Seroevidence for H5N1 Influenza Infections in Humans: Meta-Analysis

(2012) T. T. Wang et al.   SCIENCE

The influenza fingerprints: NS1 and M1 proteins contribute to specific host cell ultrastructure signatures upon infection by different influenza A viruses

(2012) Olivier Terrier et al.   VIROLOGY

PA from an H5N1 highly pathogenic avian influenza virus activates viral transcription and replication and induces apoptosis and interferon expression at an early stage of infection

(2012) Qiang Wang et al.   Virology Journal

Adaptive mutations in NEP compensate for defective H5N1 RNA replication in cultured human cells

(2012) Benjamin Mänz et al.   Nature Communications

The pathogenesis of influenza virus infections: the contributions of virus and host factors

(2011) Satoshi Fukuyama et al.   CURRENT OPINION IN IMMUNOLOGY

DDX1, DDX21, and DHX36 Helicases Form a Complex with the Adaptor Molecule TRIF to Sense dsRNA in Dendritic Cells

(2011) Zhiqiang Zhang et al.   IMMUNITY

H5N1 Influenza Virus–Induced Mediators Upregulate RIG-I in Uninfected Cells by Paracrine Effects Contributing to Amplified Cytokine Cascades

(2011) Kenrie P. Y. Hui et al.   JOURNAL OF INFECTIOUS DISEASES

Low-Dose Interferon Type I Treatment Is Effective Against H5N1 and Swine-Origin H1N1 Influenza A Viruses In Vitro and In Vivo

(2011) Emanuel Haasbach et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Viral load of the highly pathogenic avian influenza H5N1 virus in infected human tissues

(2011) Naraporn Sirinonthanawech et al.   JOURNAL OF MEDICAL VIROLOGY

Marburg Virus VP40 Antagonizes Interferon Signaling in a Species-Specific Manner

(2011) C. Valmas et al.   JOURNAL OF VIROLOGY

Avian Influenza Viruses Infect Primary Human Bronchial Epithelial Cells Unconstrained by Sialic Acid α2,3 Residues

(2011) Christine M. Oshansky et al.   PLoS One

Influenza A virus NS1 gene mutations F103L and M106I increase replication and virulence

(2011) Samar K Dankar et al.   Virology Journal

The Influenza Virus Protein PB1-F2 Inhibits the Induction of Type I Interferon at the Level of the MAVS Adaptor Protein

(2011) Zsuzsanna T. Varga et al.   PLoS Pathogens

RIG-I Detects Viral Genomic RNA during Negative-Strand RNA Virus Infection

(2010) Jan Rehwinkel et al.   CELL

Activation of host pattern recognition receptors by viruses

(2010) Kiva Brennan et al.   CURRENT OPINION IN MICROBIOLOGY

Influenza A Virus Polymerase Inhibits Type I Interferon Induction by Binding to Interferon β Promoter Stimulator 1

(2010) Atsushi Iwai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathogenicity of highly pathogenic avian H5N1 influenza A viruses isolated from humans between 2003 and 2008 in northern Vietnam

(2010) Q. M. Le et al.   JOURNAL OF GENERAL VIROLOGY

PB2 Residue 271 Plays a Key Role in Enhanced Polymerase Activity of Influenza A Viruses in Mammalian Host Cells

(2010) K. A. Bussey et al.   JOURNAL OF VIROLOGY

A Single N66S Mutation in the PB1-F2 Protein of Influenza A Virus Increases Virulence by Inhibiting the Early Interferon Response In Vivo

(2010) G. M. Conenello et al.   JOURNAL OF VIROLOGY

The PB2 Subunit of the Influenza Virus RNA Polymerase Affects Virulence by Interacting with the Mitochondrial Antiviral Signaling Protein and Inhibiting Expression of Beta Interferon

(2010) K. M. Graef et al.   JOURNAL OF VIROLOGY

Comparison of pro-inflammatory cytokine expression and cellular signal transduction in human macrophages infected with different influenza A viruses

(2010) Janina Geiler et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Identifying genetic markers of adaptation for surveillance of viral host jumps

(2010) Kim M. Pepin et al.   NATURE REVIEWS MICROBIOLOGY

Influenza Virus Non-Structural Protein 1 (NS1) Disrupts Interferon Signaling

(2010) Danlin Jia et al.   PLoS One

A Systematic Molecular Pathology Study of a Laboratory Confirmed H5N1 Human Case

(2010) Rongbao Gao et al.   PLoS One

Preference of RIG-I for short viral RNA molecules in infected cells revealed by next-generation sequencing

(2010) A. Baum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The HA and NS Genes of Human H5N1 Influenza A Virus Contribute to High Virulence in Ferrets

(2010) Hirotaka Imai et al.   PLoS Pathogens

NS2/NEP protein regulates transcription and replication of the influenza virus RNA genome

(2009) Nicole C. Robb et al.   JOURNAL OF GENERAL VIROLOGY

Influenza Viruses Control the Vertebrate Type I Interferon System: Factors, Mechanisms, and Consequences

(2009) Thorsten Wolff et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Intranasal Administration of Alpha Interferon Reduces Seasonal Influenza A Virus Morbidity in Ferrets

(2009) D. Kugel et al.   JOURNAL OF VIROLOGY

Detection of Mammalian Virulence Determinants in Highly Pathogenic Avian Influenza H5N1 Viruses: Multivariate Analysis of Published Data

(2009) S. J. Lycett et al.   JOURNAL OF VIROLOGY

Pathogenesis of 1918 Pandemic and H5N1 Influenza Virus Infections in a Guinea Pig Model: Antiviral Potential of Exogenous Alpha Interferon To Reduce Virus Shedding

(2009) N. Van Hoeven et al.   JOURNAL OF VIROLOGY

Hemagglutinin-Dependent Tropism of H5N1 Avian Influenza Virus for Human Endothelial Cells

(2009) M. Ocana-Macchi et al.   JOURNAL OF VIROLOGY

Early Control of H5N1 Influenza Virus Replication by the Type I Interferon Response in Mice

(2009) K. J. Szretter et al.   JOURNAL OF VIROLOGY

Selection of H5N1 Influenza Virus PB2 during Replication in Humans

(2009) Q. M. Le et al.   JOURNAL OF VIROLOGY

Emergence and pandemic potential of swine-origin H1N1 influenza virus

(2009) Gabriele Neumann et al.   NATURE

(Highly pathogenic) avian influenza as a zoonotic agent

(2009) Donata Kalthoff et al.   VETERINARY MICROBIOLOGY

Sabotage of antiviral signaling and effectors by influenza viruses

(2008) Thorsten Wolff et al.   BIOLOGICAL CHEMISTRY

An Inhibitory Activity in Human Cells Restricts the Function of an Avian-like Influenza Virus Polymerase

(2008) Andrew Mehle et al.   Cell Host & Microbe

Pathogenesis of emerging avian influenza viruses in mammals and the host innate immune response

(2008) Taronna R. Maines et al.   IMMUNOLOGICAL REVIEWS

Recent Avian H5N1 Viruses Exhibit Increased Propensity for Acquiring Human Receptor Specificity

(2008) James Stevens et al.   JOURNAL OF MOLECULAR BIOLOGY

Distinctly different expression of cytokines and chemokines in the lungs of two H5N1 avian influenza patients

(2008) R Deng et al.   JOURNAL OF PATHOLOGY

Crystal structure of the polymerase PAC–PB1N complex from an avian influenza H5N1 virus

(2008) Xiaojing He et al.   NATURE

Update on Avian Influenza A (H5N1) Virus Infection in Humans

(2008)   NEW ENGLAND JOURNAL OF MEDICINE

Virulence of H5N1 avian influenza virus enhanced by a 15-nucleotide deletion in the viral nonstructural gene

(2008) Jin-Xue Long et al.   VIRUS GENES

Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures

(2007) R. E. Randall et al.   JOURNAL OF GENERAL VIROLOGY