Article
Behavioral Sciences
Daiva Radzisauskiene, Monika Vitkauskaite, Karolina Zvinyte, Ruta Mameniskiene
Summary: The study described a case series of influenza A-associated neurological complications, with a low incidence rate of influenza-associated neurological complications in hospitalized patients in 2019 at 1.9%. The findings suggest that during influenza epidemics, patients with unexplained neurological symptoms resembling aseptic and septic meningitis/encephalitis should be tested for influenza virus.
BRAIN AND BEHAVIOR
(2021)
Review
Virology
Gloria Perez-Rubio, Marco Antonio Ponce-Gallegos, Bruno Andre Dominguez-Mazzocco, Jaime Ponce-Gallegos, Roman Alejandro Garcia-Ramirez, Ramces Falfan-Valencia
Summary: Research has shown that genetic susceptibility to Influenza A virus infection is influenced by multiple pathways, including innate immune response, complement activation, and variants in inflammatory response genes. Specific gene polymorphisms such as SNPs play key roles in host immune responses, affecting viral replication and host response, representing important factors in genetic susceptibility to IAV infection.
Article
Virology
Nutan Mytle, Sonja Leyrer, Jon R. Inglefield, Andrea M. Harris, Thomas E. Hickey, Jacob Minang, Hang Lu, Zhidong Ma, Hanne Andersen, Nathan D. Grubaugh, Tina Guina, Mario H. Skiadopoulos, Michael J. Lacy
Summary: Research demonstrates that utilizing combinations of conserved antigens of influenza A virus, such as NP and various forms of M2e, can generate broad immune protection in mice, reducing lung viral burden and weight loss.
Article
Immunology
Petra Mooij, Daniella Mortier, Aafke Aartse, Alexandre B. Murad, Ricardo Correia, Antonio Roldao, Paula M. Alves, Zahra Fagrouch, Dirk Eggink, Norbert Stockhofe, Othmar G. Engelhardt, Ernst J. Verschoor, Marit J. van Gils, Willy M. Bogers, Manuel J. T. Carrondo, Edmond J. Remarque, Gerrit Koopman
Summary: Influenza-naive cynomolgus macaques were immunized with virus-like particles (VLPs) displaying different hemagglutinin (HA) antigens from seasonal H1N1 strains. Subsequent infection with pandemic H1N1 (H1N1pdm09) resulted in increased immune response against intermediate antigenic variants but not against all H1N1 vaccine strains.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Virology
Denisa Bojkova, Marco Bechtel, Tamara Rothenburger, Joshua D. D. Kandler, Lauren Hayes, Ruth Olmer, Ulrich Martin, Danny Jonigk, Sandra Ciesek, Mark N. N. Wass, Martin Michaelis, Jindrich Cinatl Jr
Summary: Recent findings show that SARS-CoV-2 Omicron BA.1 induces a stronger interferon response compared to Delta. In this study, it was demonstrated that BA.1 and BA.5, but not Delta, induce an antiviral state in air-liquid interface cultures of primary human bronchial epithelial cells and primary human monocytes. Both Omicron subvariants trigger the production of biologically active interferons and protect cells from super-infection with influenza A viruses. These findings highlight the significance of Omicron in the immune response against viral infections.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Business, Finance
Di Gong, Tao Jiang, Liping Lu
Summary: This paper empirically analyzes the impact of pandemic on the contracting of bank loans. Using data on syndicated loans during the season of H1N1 Swine Flu, we find that more flu is associated with higher loan spreads and smaller loan size. The adverse impact of pandemic was alleviated by the approval of vaccines.
FINANCE RESEARCH LETTERS
(2021)
Article
Microbiology
Dennis Maletich Junqueira, Caroline Tochetto, Tavis K. Anderson, Danielle Gava, Vanessa Haach, Mauricio E. Cantao, Amy L. Vincent Baker, Rejane Schaefer
Summary: This study analyzed a large number of H1N1pdm09 gene sequences from humans and swine globally between 2009 and 2022, and found that there was rapid transmission of the virus from humans to swine in Brazil during 2009-2011, but most of the infections in swine were self-limited with limited onward transmission. After 2012, there was a reduction in human-to-swine H1N1pdm09 transmissions in Brazil. The study highlights the dynamic interplay between human-to-swine transmission, antigenic drift, and the establishment of swine-to-swine transmission in shaping the evolution and persistence of H1N1pdm09 in swine populations.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Hyesun Jang, Ted M. Ross
Summary: The study found that the humoral response to trivalent seasonal influenza virus vaccines was influenced by rapid antigenic switching of H1 HA. While successful induction of antibodies against H1N1 and H3N2 vaccine components was observed, a strong immune response against CA/09 H1N1 influenza virus negatively influenced the induction of novel humoral responses to other vaccine strains.
Article
Virology
Peter W. Cook, Thomas Stark, Joyce Jones, Rebecca Kondor, Natosha Zanders, Jeffrey Benfer, Samantha Scott, Yunho Jang, Alicia Janas-Martindale, Stephen Lindstrom, Lenee Blanton, John Schiltz, Rachel Tell, Richard Griesser, Peter Shult, Erik Reisdorf, Tonya Danz, Alicia Fry, John Barnes, Amy Vincent, David E. Wentworth, C. Todd Davis
Summary: The study discusses the transmission of seasonal influenza viruses between humans and pigs, leading to sustained circulation of human-like viruses in the U.S. swine population. Two cases of human infections with A(H1N1)pdm09 viruses originating from swine hosts are identified and classified as swine-origin variant influenza viruses. The study underscores the importance of developing techniques for distinguishing human-origin and swine-origin viruses for continued surveillance of influenza viruses.
JOURNAL OF VIROLOGY
(2021)
Article
Nanoscience & Nanotechnology
Seong Uk Son, Eun-Kyung Lim, Soojin Jang, Jaewoo Lim, Seung Beom Seo, Taejoon Kang, Juyeon Jung, Seo Yeong Oh, Sun-Woo Yoon, Dongeun Yong, Jaejong Lee
Summary: The study developed a conductive thread-based immunosensor to easily detect airborne viruses, which is important in preventing the spread of infectious diseases.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Immunology
Krista Salo-Tuominen, Tamara Teros-Jaakkola, Laura Toivonen, Helena Ollila, Paivi Rautava, Minna Aromaa, Elina Lahti, Niina Junttila, Ville Peltola
Summary: The study investigated the association between parental socioeconomic and psychosocial factors and the uptake of the 2009 pandemic influenza vaccine in children. It found that children of younger and less educated mothers had a lower rate of vaccine uptake. However, the individual or relational psychosocial well-being of parents was not associated with children's vaccination.
Article
Virology
Weixu Zhang, Hefeng Xu, Shuxuan Guan, Chengmin Wang, Guoying Dong
Summary: This study analyzed the available NA protein sequences of H1N1 influenza viruses worldwide and found that 3.76% of H1N1 viruses currently harbor oseltamivir resistance, with the most common mutation being H274Y. Oseltamivir resistance is mainly found in humans, swine, and avian, and the resistance level peaked in 2007-2008 and quickly decreased in 2009. The study highlights the importance of globally monitoring oseltamivir resistance.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Virology
Caroline Tochetto, Dennis M. M. Junqueira, Tavis K. K. Anderson, Danielle Gava, Vanessa Haach, Mauricio E. E. Cantao, Amy L. Vincent L. Baker, Rejane Schaefer
Summary: Through surveillance and analysis of swine herds in Brazil, it was found that human seasonal influenza viruses have entered the pig population at least eight different times, leading to the formation of distinct genetic subgroups. Bidirectional transmission between humans and pigs is a major contributing factor to the global genetic diversity of swine influenza viruses, highlighting the importance of surveillance.
Article
Biology
Michael Lutz, Jordana Schmierer, Toru Takimoto
Summary: Avian species are the main source of pandemic influenza A viruses that can infect humans. This study found that avian influenza A virus genes, including PA, PB1, and PB2, need to undergo host-adaptive mutations in order to replicate and transmit in humans. It was discovered that the PA gene from the 2009 pH1N1 strain had host-adaptive mutations that enhanced viral replication by increasing translation efficiency. This was achieved through increased cytosolic accumulation of viral mRNA, which depended on the host RNA binding protein GRSF1. Mutations to the GRSF1 binding site and knockdown of GRSF1 reduced viral mRNA accumulation and translation efficiency. These findings reveal a previously unrecognized mechanism by which host-adaptive mutations in PA regulate viral replication and host adaptation.
COMMUNICATIONS BIOLOGY
(2022)
Article
Obstetrics & Gynecology
Nicola Vousden, Marian Knight
Summary: Influenza during pregnancy is associated with an increased risk of hospital admission, and there is variability in policies and uptake of immunization globally. Immunization is cost-effective and safe in preventing influenza in pregnant women and their infants.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2021)
Article
Crystallography
Bing Feng, Hans-Peter Martin, Alexander Michaelis
Summary: Boron carbide is a material with high thermoelectric power that can be used in thermoelectric applications. In this study, boron carbide and hafnium boride composites were prepared by pressureless sintering of B4C and HfC powders, and the effect of HfC addition on the sinterability and thermoelectric properties was investigated. The results showed that the addition of HfC decreased the Seebeck coefficient and increased the electrical conductivity, leading to a change in conduction behavior from semiconducting to metallic mechanism. The functional thermocouples based on the prepared composites showed potential for temperature measurement applications.
Article
Oncology
Anita Thomas, Kimberly Sue Slade, Roman A. Blaheta, Sascha D. Markowitsch, Philipp Stenzel, Katrin E. Tagscherer, Wilfried Roth, Mario Schindeldecker, Martin Michaelis, Florian Rothweiler, Jaroslav Cinatl, Robert Dotzauer, Olesya Vakhrusheva, Maarten Albersen, Axel Haferkamp, Eva Juengel, Jindrich Cinatl, Igor Tsaur
Summary: In metastasized penile cancer, c-MET blockade shows potential as a targeted treatment option. Elevated expression of c-MET is strongly associated with inferior tumor-related survival, and upregulation of c-MET is observed in treatment-resistant cell lines. Treating cell lines with c-MET inhibitors cabozantinib and tivantinib decreases cell growth, with different efficacy in naive and resistant cells.
Letter
Cell Biology
Denisa Bojkova, Tamara Rothenburger, Sandra Ciesek, Mark N. Wass, Martin Michaelis, Jindrich Cinatl
Article
Metallurgy & Metallurgical Engineering
Christian Berger, Johannes Poetschke, Manfred Fries, Tassilo Moritz, Alexander Michaelis
Summary: Additive Manufacturing is growing in various industries, with applications for different materials. This study introduces the use of Binder-Jetting technology to print TiCN-based cermet materials for the first time, and discusses the impact of powder morphology and composition on the printed and sintered parts.
Article
Materials Science, Ceramics
Eric Schwarzer-Fischer, Eveline Zschippang, Willy Kunz, Christof Koplin, Yannick Marian Loew, Uwe Scheithauer, Alexander Michaelis
Summary: Hardness, high mechanical strength, wear and corrosion resistance are the most important properties of silicon nitride. With the increasing demand in medical applications, additive manufacturing technologies offer the possibility to create more complex silicon nitride components with additional functionalities.
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
(2023)
Letter
Virology
Lauren J. Hayes, Hannah Uri, Denisa Bojkova, Jindrich Cinatl, Mark N. Wass, Martin Michaelis
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Chemistry, Multidisciplinary
Sahin Cangaz, Oliver Lohrberg, Thomas Abendroth, Christian Heubner, Florian Schmidt, Holger Althues, Susanne Doerfler, Alexander Michaelis, Stefan Kaskel
Summary: The study finds that using moderately thick copper current collectors can effectively reduce the mechanical failure caused by volumetric expansion of silicon anode materials, thereby increasing the energy density of lithium-ion batteries.
ADVANCED MATERIALS INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Oliver Lohrberg, Karsten Voigt, Sebastian Maletti, Henry Auer, Kristian Nikolowski, Christian Heubner, Alexander Michaelis
Summary: Zero-excess Li metal batteries (ZELMBs) have attracted much attention due to their potential to increase energy density and reduce cost. However, challenges related to non-uniform deposition of Li have limited their practical application. Promising approaches including modifications of current collector, electrolyte, and cycling protocols have been developed. These approaches improve stability but reduce energy density.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Physical
Johanna Maier, David Werner, Vinzenz Geske, Thomas Behnisch, Mathias Ahlhelm, Tassilo Moritz, Alexander Michaelis, Maik Gude
Summary: Freeze foams are cellular, ceramic structures with hierarchical pore structures that can cover a wide range of applications by tailoring their morphology and strength. The correlation between pore-forming influencing factors and resulting mechanical properties was quantified in order to manufacture foams that align with component requirements, which is an important step towards the widespread application of these promising materials. Foams with independently adjustable porosities were produced and systematically investigated, revealing different material failure characteristics.
Article
Electrochemistry
Nils Buettner, Foelke Purr, Clara Sangros Gimenez, Maria Richter, Laura Nousch, Sabrina Zellmer, Alexander Michaelis
Summary: Battery models are mathematical systems that simulate real battery cells accurately. This work presents an electrochemical and thermal model of sodium-nickel-chloride/iron-chloride battery cells. The model allows for predicting internal cell processes and has a low computational effort, making it a useful tool for battery development.
Article
Materials Science, Ceramics
Eric Schwarzer-Fischer, Uwe Scheithauer, Alexander Michaelis
Summary: Aluminum nitride (AlN) is a high-performance material used in heat sinks for various electronic applications. This study successfully developed a 3D printing process for AlN based on a commercial powder, achieving excellent thermal conductivities and densities comparable to conventionally manufactured components. The results demonstrate the potential of this technology for producing complex-shaped components with high performance.
CERAMICS-SWITZERLAND
(2023)
Article
Materials Science, Ceramics
Bing Feng, Hans-Peter Martin, Alexander Michaelis
Summary: In this study, pure B4C powders were successfully synthesized by rapid carbothermal reduction method, and the effects of heat-treating temperature and starting composition on the properties of the powders were investigated. Uniform B4C powders with an average grain size of 300 nm were synthesized under the condition of a starting powder mixture with a molar ratio of B2O3/C = 4.
CERAMICS-SWITZERLAND
(2022)
Article
Materials Science, Ceramics
Johanna Maier, Vinzenz Geske, David Werner, Thomas Behnisch, Matthias Ahlhelm, Tassilo Moritz, Alexander Michaelis, Maik Gude
Summary: Freeze foams are novel cellular structures that can be made from various materials using powder technology. The process involves complex interactions between process and material parameters, making it difficult to reproduce. By studying the foam formation process, its impacts on structure, and material parameters, tailored foam properties for specific applications can be achieved. The focus of this paper is on adjusting and tailoring the macrostructure of ceramic foams to meet specific load and application requirements.
CERAMICS-SWITZERLAND
(2022)
Review
Electrochemistry
Arnaud du Baret de Lime, Tobias Lein, Sebastian Maletti, Karoline Schmal, Sebastian Reuber, Christian Heubner, Alexander Michaelis
Summary: The rise of electric mobility has led to unprecedented demand for lithium-ion batteries. To ensure efficient production of high-quality and affordable battery cells, reasonable quality assurance criteria are needed, particularly in electrode manufacturing processes. This review highlights the importance of quantifying the electrochemical significance of defects in lithium-ion battery electrodes. It also emphasizes the need for further studies to establish knowledge-based quality assurance criteria for coating defects.
BATTERIES & SUPERCAPS
(2022)