Review
Biochemistry & Molecular Biology
Yuan-Tung Chu, Min-Tser Liao, Kuo-Wang Tsai, Kuo-Cheng Lu, Wan-Chung Hu
Summary: A comprehensive framework has been established to understand immunological pathways, and specific associations between immune responses and immune receptors have been identified. These findings contribute to the identification of biomarkers for immune cells and provide insights into host immunological pathways.
Review
Chemistry, Multidisciplinary
Mei Jin, Jian Fang, Jiao-jiao Wang, Xin Shao, Suo-wen Xu, Pei-qing Liu, Wen-cai Ye, Zhi-ping Liu
Summary: Atherosclerosis, a life-threatening cardiovascular disease, is associated with chronic inflammation and immune processes. Toll-like receptors (TLRs) play a vital role in the occurrence and development of atherosclerosis. Targeting TLRs and their regulated inflammatory events could be a promising new strategy for the treatment of atherosclerotic CVDs.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Medicine, Research & Experimental
Yi Zhang, Wei Wu, Yijie Wang, Lingjia Tong, Meng Hong, Qi Xia, Zhi Chen
Summary: TLR signalling pathway genes were differentially regulated in neutrophils between cirrhosis and ACLF. In ACLF patients, defective expression of TLR3 and IFN, along with enhanced CD14 and IL10 expression, was characterized by transcriptional alterations of neutrophils.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Cell Biology
Fabio Arturo Iannotti, Rosa Maria Vitale
Summary: PPARs are a family of nuclear receptors that regulate the expression of target genes involved in metabolism, immune reaction, cell differentiation, and other cellular changes. They are activated by various lipid molecules, including cannabinoids, and interact with the endocannabinoid system to modulate physiological and pathophysiological functions.
Review
Biochemistry & Molecular Biology
Ling Wei, Xue-Sen Wen, Cory J. Xian
Summary: Chemotherapy-induced intestinal mucositis is a painful condition that affects a significant number of patients undergoing chemotherapy. Recent research has highlighted the relationship between dysbiosis of intestinal microbiota and mucositis, showing that chemotherapy can shape the microbiota and worsen mucositis through TLR signaling pathways. This review aims to explore how gut microbiota affects the pathogenesis of mucositis and provide potential new strategies for treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Cassio Luiz Coutinho Almeida-da-Silva, Luiz Eduardo Baggio Savio, Robson Coutinho-Silva, David M. Ojcius
Summary: The innate immune system in vertebrates and invertebrates relies on conserved receptors and ligands, and pathways to initiate a rapid response against microbial infections and other sources of stress and danger. Research on NOD-like receptors (NLRs) has advanced in the past two decades, providing insight into the ligands and conditions that activate NLRs, as well as the outcomes of NLR activation in cells and animals. NLRs play crucial roles in diverse functions, such as transcription of MHC molecules and initiation of inflammation, and their activation can be direct or indirect depending on the ligands involved. Future discoveries will contribute to a better understanding of the molecular details and physiological consequences of NLR activation.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Valerie Lannoy, Anthony Cote-Biron, Claude Asselin, Nathalie Rivard
Summary: Phosphatases are important regulators of TLRs signaling and may represent novel therapeutic targets to control pathogenic TLRs signaling.
CELL COMMUNICATION AND SIGNALING
(2021)
Review
Oncology
Chuan Chen, Na Man, Fan Liu, Gloria Mas Martin, Hidehiro Itonaga, Jun Sun, Stephen D. Nimer
Summary: This review discusses the role of innate immune cells in cancer and the mechanisms underlying their regulation. It also explores new strategies for cancer control using innate immune cells and signaling molecules.
Review
Virology
Shaghayegh Khanmohammadi, Nima Rezaei
Summary: COVID-19 caused by SARS-CoV-2 has led to a pandemic. TLRs play a crucial role in activating the immune system in response to the virus, and could potentially be a target for controlling the infection. Understanding the mechanisms of TLR in COVID-19 may help in developing vaccines and treatments.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Review
Gastroenterology & Hepatology
Marica Cariello, Elena Piccinin, Antonio Moschetta
Summary: Nonalcoholic fatty liver disease encompasses a spectrum of liver injuries, from simple steatosis to steatohepatitis and cirrhosis. Nonalcoholic steatohepatitis (NASH) is characterized by liver steatosis, inflammation, hepatocyte damage, and fibrosis. Genetic predisposition and environmental factors such as dietary habits and obesity may contribute to the progression of NASH. The role of lipid-sensing nuclear receptors in the pathogenesis and treatment of NASH, including peroxisome proliferator-activated receptors, farnesoid X receptor, and liver X receptors, is discussed in this study.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Pharmacology & Pharmacy
Lingling Huang, Xiaoyan Ge, Yang Liu, Hui Li, Zhiyue Zhang
Summary: Toll-like receptor agonists (TLRa) as vaccine adjuvant candidates have become a hot topic in cancer immunomodulation research. However, current systemic deliveries of TLRa have limitations, and TLRa-loaded nanoparticles are considered a promising strategy to improve therapeutic outcomes.
Review
Cell Biology
Zhou Fan, Janak L. Pathak, Linhu Ge
Summary: Inflammatory diseases negatively impact bone homeostasis through increased inflammation, leading to bone loss and osteoporosis. Osteoclasts, derived from hematopoietic precursors and bone marrow monocytes, play a key role in bone resorption. The Toll-like receptor (TLR) family is involved in inducing osteoclastogenic differentiation during inflammation, autoimmunity, metabolic diseases, and cancers.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Tao Zheng, Zhuo Song, Jun Qiang, Yifan Tao, Haojun Zhu, Junlei Ma, Pao Xu
Summary: This study investigated the skin responses to transport stress in hybrid yellow catfish through transcriptome and biochemical analyses. The results showed that the skin activated immune signaling pathways and regulated mucus secretion to cope with transport stress.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Rui Zhou, Guodong Wang, Qi Li, Fanxi Meng, Can Liu, Rui Gan, Dapeng Ju, Meimei Liao, Junjie Xu, Di Sang, Xue Gao, Shuang Zhou, Kejia Wu, Quanzhi Sun, Ying Guo, Chongyang Wu, Zhiyu Chen, Lin Chen, Bihan Shi, Haiyan Wang, Xia Wang, Huaiye Li, Tao Cai, Bin Li, Fengchao Wang, Hiromasa Funato, Masashi Yanagisawa, Eric Erquan Zhang, Qinghua Liu
Summary: This study characterizes a major signaling pathway for the transcriptional regulation of sleep in mice, involving the LKB1-SIK3 pathway and phosphorylation of HDAC4/HDAC5. The findings provide insights into the molecular mechanisms that regulate sleep quantity and offer new potential targets for the treatment of sleep disorders.
Article
Biology
Ivan Litvinov, Pingxing Xie, Scott Gunn, Denis Sasseville, Philippe Lefrancois
Summary: Basal cell carcinoma is the most common skin cancer, but still poses challenges in treatment. By analyzing RNA sequencing data, new therapeutic avenues and potential targets have been identified, providing new insights for treating BCC.
LIFE SCIENCE ALLIANCE
(2021)
Article
Physiology
Kirstin Bilham, Chris Newman, Christina D. Buesching, Michael J. Noonan, Amy Boyd, Adrian L. Smith, David W. Macdonald
PHYSIOLOGICAL AND BIOCHEMICAL ZOOLOGY
(2018)
Article
Multidisciplinary Sciences
Kirstin Bilham, Amy C. Boyd, Stephen G. Preston, Christina D. Buesching, Chris Newman, David W. Macdonald, Adrian L. Smith
SCIENTIFIC REPORTS
(2017)
Article
Biology
Patrik G. Flammer, Simon Dellicour, Stephen G. Preston, Dirk Rieger, Sylvia Warren, Cedric K. W. Tan, Rebecca Nicholson, Renata Prichystalova, Niels Bleicher, Joachim Wahl, Nuno R. Faria, Oliver G. Pybus, Mark Pollard, Adrian L. Smith
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2018)
Article
Multidisciplinary Sciences
Katrina J. Spensley, Paul S. Wikramaratna, Bridget S. Penman, Andrew Walker, Adrian L. Smith, Oliver G. Pybus, Letitia Jean, Sunetra Gupta, Jose Lourenco
SCIENTIFIC REPORTS
(2019)
Article
Biology
Sarah C. Hill, Rowena Hansen, Samantha Watson, Vivien Coward, Christine Russell, Jayne Cooper, Steve Essen, Holly Everest, Kris Parag, Steven Fiddaman, Scott Reid, Nicola Lewis, Sharon M. Brookes, Adrian L. Smith, Ben C. Sheldon, Christopher M. Perrins, Ian H. Brown, Oliver G. Pybus
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2019)
Article
Multidisciplinary Sciences
Frances M. Colles, Stephen G. Preston, Kenneth Klingenberg Barfod, Patrik G. Flammer, Martin C. J. Maiden, Adrian L. Smith
SCIENTIFIC REPORTS
(2019)
Article
Microbiology
Tara Patricia Hurst, Amr Aswad, Timokratis Karamitros, Aris Katzourakis, Adrian L. Smith, Gkikas Magiorkinis
FRONTIERS IN MICROBIOLOGY
(2019)
Review
Psychology, Biological
Narjis Kraimi, Marian Dawkins, Sabine G. Gebhardt-Henrich, Philippe Velge, Ivan Rychlik, Jiri Volf, Pauline Creach, Adrian Smith, Frances Colles, Christine Leterrier
PHYSIOLOGY & BEHAVIOR
(2019)
Article
Virology
Emilia C. Skirmuntt, Marina Escalera-Zamudio, Emma C. Teeling, Adrian Smith, Aris Katzourakis
ANNUAL REVIEW OF VIROLOGY, VOL 7, 2020
(2020)
Article
Virology
Hila Levy, Steven R. Fiddaman, Anni Djurhuus, Caitlin E. Black, Simona Kraberger, Adrian L. Smith, Tom Hart, Arvind Varsani
Review
Marine & Freshwater Biology
Graeme C. Hays, Heather J. Koldewey, Samantha Andrzejaczek, Martin J. Attrill, Shanta Barley, Daniel T. I. Bayley, Cassandra E. Benkwitt, Barbara Block, Robert J. Schallert, Aaron B. Carlisle, Pete Carr, Taylor K. Chapple, Claire Collins, Clara Diaz, Nicholas Dunn, Robert B. Dunbar, Dannielle S. Eager, Julian Engel, Clare B. Embling, Nicole Esteban, Francesco Ferretti, Nicola L. Foster, Robin Freeman, Matthew Gollock, Nicholas A. J. Graham, Joanna L. Harris, Catherine E. I. Head, Phil Hosegood, Kerry L. Howell, Nigel E. Hussey, David M. P. Jacoby, Rachel Jones, Sivajyodee Sannassy Pilly, Ines D. Lange, Tom B. Letessier, Emma Levy, Mathilde Lindhart, Jamie M. McDevitt-Irwin, Mark Meekan, Jessica J. Meeuwig, Fiorenza Micheli, Andrew O. M. Mogg, Jeanne A. Mortimer, David A. Mucciarone, Malcolm A. Nicoll, Ana Nuno, Chris T. Perry, Stephen G. Preston, Alex J. Rattray, Edward Robinson, Ronan C. Roche, Melissa Schiele, Emma V. Sheehan, Anne Sheppard, Charles Sheppard, Adrian L. Smith, Bradley Soule, Mark Spalding, Guy M. W. Stevens, Margaux Steyaert, Sarah Stiffel, Brett M. Taylor, David Tickler, Alice M. Trevail, Pablo Trueba, John Turner, Stephen Votier, Bry Wilson, Gareth J. Williams, Benjamin J. Williamson, Michael J. Williamson, Hannah Wood, David J. Curnick
Article
Virology
Hila Levy, Rafaela S. Fontenele, Ciara Harding, Crystal Suazo, Simona Kraberger, Kara Schmidlin, Anni Djurhuus, Caitlin E. Black, Tom Hart, Adrian L. Smith, Arvind Varsani
Article
Infectious Diseases
Patrik G. Flammer, Hannah Ryan, Stephen G. Preston, Sylvia Warren, Renata Prichystalova, Rainer Weiss, Valerie Palmowski, Sonja Boschert, Katarina Fellgiebel, Isabelle Jasch-Boley, Madita-Sophie Kairies, Ernst Ruemmele, Dirk Rieger, Beate Schmid, Ben Reeves, Rebecca Nicholson, Louise Loe, Christopher Guy, Tony Waldron, Jiri Machacek, Joachim Wahl, Mark Pollard, Greger Larson, Adrian L. Smith
PLOS NEGLECTED TROPICAL DISEASES
(2020)
Article
Multidisciplinary Sciences
Theresa L. Cole, Ludovic Dutoita, Nicolas Dussex, Tom Hart, Alana Alexander, Jane L. Younger, Gemma V. Clucas, Maria Jose Frugonei, Yves Cherel, Richard Cuthbert, Ursula Ellenberg, Steven R. Fiddaman, Johanna Hiscock, David Houston, Pierre Jouventin, Thomas Mattern, Gary Miller, Colin Miskelly, Paul Nolan, Michael J. Polito, Petra Quillfeldt, Peter G. Ryan, Adrian Smith, Alan J. D. Tennyson, David Thompson, Barbara Wienecke, Juliana A. Vianna, Jonathan M. Waters
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Fisheries
Nick A. Ciccone, Lorraine P. Smith, William Mwangi, Amy Boyd, Andrew J. Broadbent, Adrian L. Smith, Venugopal Nair
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2017)