Article
Biochemistry & Molecular Biology
Sylwia Chocholska, Michal Zarobkiewicz, Agata Szymanska, Natalia Lehman, Justyna Wos, Agnieszka Bojarska-Junak
Summary: The aim of this study was to investigate the expression of miR-17 similar to 92 cluster members in CLL patients. The study provides new evidence regarding the heterogeneity of miR-17 similar to 92 cluster members' expression in CLL patients. High miR-20a expression can be considered an independent favorable prognostic factor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Kexin Li, Jiongyu Chen, Xiaoying Lou, Yiling Li, Benheng Qian, Danfei Xu, Yue Wu, Shaohui Ma, Donghong Zhang, Wei Cui
Summary: The study revealed that the dynamic changes in 25 m6A regulators were associated with the clinical features and prognosis of patients with esophageal cancer, with HNRNPA2B1 possibly affecting the prognosis of esophageal cancer patients by regulating the miR-17-92 cluster.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Myung Chan Park, Hyoji Kim, Hoyun Choi, Mee Soo Chang, Suk Kyeong Lee
Summary: The EBV-associated miRNA miR-BART1-3p plays a role in cell cycle regulation and cell growth by targeting E2F3. Moreover, miR-BART1-3p may also affect the expression of the miR-17-92 cluster by downregulating E2F3.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Fabrizio Favaloro, Annina M. DeLeo, Ana C. Delgado, Fiona Doetsch
Summary: Neural stem cells in the adult ventricular-subventricular zone play a crucial role in generating neurons and glia. MicroRNAs, specifically miR-17 and miR-92, are found to be highly upregulated in the activated stem cells and transit amplifying cells. Their deletion has stage-specific effects, affecting proliferation and differentiation of various subpopulations within the adult ventricular-subventricular zone. These findings highlight the importance of miR-17 and miR-92 in regulating neural stem cell function.
Article
Medicine, Research & Experimental
Yan Sweat, Ryan J. Ries, Mason Sweat, Dan Su, Fan Shao, Steven Eliason, Brad A. Amendt
Summary: Anaplastic thyroid cancer is a highly metastatic cancer expressing high levels of the miR-17-92 cluster. Inhibition of miR-17 unexpectedly promotes the expression of other oncogenic miRs within the cluster, leading to cancer progression. The study suggests a complex regulatory role of miR-17 in thyroid tumor growth.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Biochemistry & Molecular Biology
Madara Ratnadiwakara, Mohamed N. M. Bahrudeen, Erika Aikio, Piia Takabe, Rebekah M. Engel, Zileena Zahir, Thierry Jarde, Paul J. McMurrick, Helen E. Abud, Minna-Liisa Anko
Summary: This study reveals that Serine-arginine rich splicing factor 3 (SRSF3) plays a crucial role in the processing of miR-17-92 cluster miRNAs in pluripotent and cancer cells. SRSF3 binding to CNNC motifs downstream of Drosha cleavage sites is required for efficient processing of the cluster. The interaction between SRSF3 and miR-17-92 results in changes in RNA structure and an increase in miR-17 and miR-20a levels, promoting self-renewal and contributing to colorectal cancer pathogenesis.
Review
Genetics & Heredity
Fang Lu, Xianghong Zhao, Zhongqiu Zhang, Mengqiu Xiong, Ying Wang, Yalan Sun, Bangshun He, Junrong Zhu
Summary: This meta-analysis suggests that the miR-17-92 cluster may serve as a diagnostic and prognostic biomarker for hepatocellular carcinoma (HCC), but further large-scale, multicenter, and high-quality studies are needed for validation.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Yuka Kawaji-Kanayama, Taku Tsukamoto, Masakazu Nakano, Yuichi Tokuda, Hiroaki Nagata, Kentaro Mizuhara, Yoko Katsuragawa-Taminishi, Reiko Isa, Takahiro Fujino, Yayoi Matsumura-Kimoto, Shinsuke Mizutani, Yuji Shimura, Masafumi Taniwaki, Kei Tashiro, Junya Kuroda
Summary: The miR-17-92 cluster activates the BCR signaling pathway in MCL by regulating BTG2, resulting in cell proliferation. Silencing BTG2 leads to overactivation of the BCR signaling pathway and cell proliferation. These findings contribute to predicting therapeutic efficacy and improving outcomes in MCL.
Review
Genetics & Heredity
Xuefeng Pan, Xiao Cen, Xiner Xiong, Zhihe Zhao, Xinqi Huang
Summary: Osteoarthritis is a common joint disease, especially in the elderly population. It leads to joint pain and disability, reducing patients' quality of life and increasing social burden. The pathophysiology of osteoarthritis is characterized by cartilage hypertrophy or defect, subchondral bone sclerosis, and synovitis. Research suggests that certain miRNAs are closely related to the pathological processes of osteoarthritis, providing new avenues for diagnosis and treatment.
FRONTIERS IN GENETICS
(2022)
Article
Cell Biology
Yelei Cen, Jinjin Qi, Liang Chen, Caixia Xia, Min Zheng, Yanning Liu, Guohua Lou
Summary: This study revealed that aging and replicative cellular senescence reduce the therapeutic potential of mesenchymal stem cells (MSCs) on acute liver failure (ALF). The expression of miR-17-92 cluster members, especially miR-17 and miR-20a, was found to be decreased in senescent MSCs and was associated with decreased levels of the oncogene c-Myc during MSC senescence. Modifying the expression of these key miRNAs reversed senescence features of MSCs and improved their therapeutic effect on ALF.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Endocrinology & Metabolism
Hongqi Xin, Zhongwu Liu, Benjamin Buller, Yanfeng Li, William Golembieski, Xinling Gan, Fengjie Wang, Mei Lu, Meser M. Ali, Zheng G. Zhang, Michael Chopp
Summary: Exosomes enriched with the MiR-17-92 cluster derived from multipotent mesenchymal stromal cells (MSCs) can enhance functional recovery after transient stroke, potentially by promoting axonal extension and myelination. This enhancement in axon-myelin remodeling may be mediated through the activation of the PI3K/Akt/mTOR pathway induced by downregulation of PTEN.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Oncology
Yi Shen, Yi Shao, Xiaoli Ruan, Lingyan Zhu, Zhaoping Zang, Tong Wei, Rena Nakyeyune, Wenqiang Wei, Fen Liu
Summary: This study found that the rs1804506 polymorphism located in miR-17-92 cluster binding sites is associated with the susceptibility of ESCC, especially in older individuals, females, or non-smokers. The rs1804506 T allele reduces the binding of miR-19a-3p and TGFBR3, suggesting its potential role in ESCC development.
Article
Cell Biology
Jun Xie, Ying Du, Dewang Liu, Jianfeng Wu, Kang Yang, Xiaoyu He, Jiayi Zhao, Peicheng Hong, Kunyu Liao, Huanrong Zhang, Yazhen Hong, John R. Teijaro, Seung Goo Kang, Changchun Xiao, Wen-Hsien Liu
Summary: The miR-17 similar to 92 family microRNAs play a key role in T cell and plasma cell differentiation. In this study, researchers found that the miR-17 similar to 92 family also has important functions in B cell differentiation and function, regulating the key target gene Socs3 in plasma cell differentiation.
Article
Urology & Nephrology
Takuto Chiba, Debora M. Cerqueira, Yao Li, Andrew J. Bodnar, Elina Mukherjee, Katherine Pfister, Yu Leng Phua, Kai Shaikh, Brandon T. Sanders, Shelby L. Hemker, Patrick J. Pagano, Yijen L. Wu, Jacqueline Ho, Sunder Sims-Lucas
Summary: miR-17 similar to miR-92 is dynamically regulated in renal endothelial cells after renal IRI and plays a role in the pathogenesis of AKI. Endothelial-specific miR-17 similar to miR-92 knockout exacerbates renal IRI, promoting renal tubular injury, reducing renal blood flow, and increasing oxidative stress in the kidneys. miR-17 similar to miR-92 is critical in the angiogenic response after renal IRI, and treatment with miR-18a and miR-19b mimics can mitigate the damage.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Laura Diez-Ricote, Paloma Ruiz-Valderrey, Victor Mico, Ruth Blanco, Joao Tome-Carneiro, Alberto Davalos, Jose M. Ordovas, Lidia Daimiel
Summary: Atherosclerosis is strongly influenced by lifestyle and can be regulated by the miR-17/92 cluster. TMAO, a metabolite of choline, betaine, and L-carnitine, has been associated with atherosclerosis. This study found that TMAO modulates the expression of the miR-17/92 cluster and increases the expression of target genes related to inflammation and blood clotting, potentially promoting atherosclerosis and cardiovascular disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Dong Yu, Xiuying Zhou, Guowei Wang, Qianming Ding, Tianyu Li, Ya Jia
Summary: The study found that moderate chaotic activity can enhance the detection and transmission of sub-threshold signals in neuronal networks, known as chaotic resonance. In single neurons, the large amplitude and small period of sub-threshold signals have a positive effect on chaotic resonance. However, in coupled neuronal networks, chemical synapses perform better in signal transmission compared to electrical synapses.
COGNITIVE NEURODYNAMICS
(2022)
Article
Engineering, Mechanical
Guowei Wang, Lijian Yang, Xuan Zhan, Anbang Li, Ya Jia
Summary: This study investigates the influence of electromagnetic induction on chaotic resonance phenomenon in neuronal network motifs. The results show that electromagnetic induction can enhance the detection ability of neurons for weak signals, and there exists an optimal chaotic current intensity for achieving the best weak signal detection. Additionally, adjusting the parameters of electromagnetic induction can lead to more pronounced chaotic resonance phenomenon in certain network motifs compared to others.
NONLINEAR DYNAMICS
(2022)
Article
Physics, Applied
Zhiqiu Ye, Yumei Yang, Ya Jia
Summary: This paper investigates the inhibitory effect of noise on neural discharge activity and its mechanism, and discovers the phenomenon of inverse stochastic resonance. The findings are of great importance for understanding complex physiological phenomena of the nervous systems.
INTERNATIONAL JOURNAL OF MODERN PHYSICS B
(2023)
Article
Engineering, Mechanical
Yong Wu, Qianming Ding, Tianyu Li, Dong Yu, Ya Jia
Summary: The ambient temperature and the time delay of signal transmission have important influences on the synchronization behavior of neuronal networks. Both electrical and chemical synapses contribute to the synchronization of scale-free networks, with different effects at different temperatures. The presence of time delay leads to multiple synchronization transitions in both types of synapses. Surprisingly, there is a temperature threshold for synchronization in networks connected by chemical synapses. The generality of the results and mechanisms is verified by investigating the effects of different network scales on synchronization.
NONLINEAR DYNAMICS
(2023)
Review
Genetics & Heredity
Bingbing Ren, Min-Xin Guan, Tianhua Zhou, Xiujun Cai, Ge Shan
Summary: Mitochondria, organelles with circular genomes, play critical roles in energy production and homeostasis maintenance in eukaryotic cells. Recent studies have identified various mitochondria-encoded noncoding RNAs (mt-ncRNAs), including novel types such as mecciRNAs and mt-dsRNAs. This review discusses the expression patterns, biogenesis, metabolism, regulatory roles, and functional mechanisms of mt-ncRNAs, highlighting their importance in cellular physiology and potential involvement in human diseases. Additionally, advancements in technologies and methodologies, as well as future perspectives and challenges in studying these noncoding RNAs and their biomedical applications, are also addressed.
TRENDS IN GENETICS
(2023)
Article
Mathematics, Applied
Dong Yu, Guowei Wang, Tianyu Li, Qianming Ding, Ya Jia
Summary: This paper investigates the frequency selection and filtering properties of neurons in response to band-pass filtered signals. It is found that the filtering property of neurons depends on the locking relationship between the signal frequency and the neuronal natural frequency. Neurons respond better to low-frequency signals due to the reduction in the amplitude of harmonic components. Additionally, the filtering ability of neurons can be modulated by the excitation level.
COMMUNICATIONS IN NONLINEAR SCIENCE AND NUMERICAL SIMULATION
(2023)
Article
Engineering, Mechanical
Dong Yu, Lijian Yang, Xuan Zhan, Ziying Fu, Ya Jia
Summary: In this work, a new method for designing logic circuits by mapping the output of a stochastic Hodgkin-Huxley neuron system to logic gate operations is reported. Logical stochastic resonance is achieved and low energy consumption is observed, indicating that HH neurons are excellent building blocks for logic circuits. The mechanisms underlying these findings are interpreted using bifurcation and phase plane diagrams. A neuronal network is constructed to improve the reliability of logic gates, where synaptic currents modulate the performance by regulating the switching time between steady states. Possible schemes for enhancing the reliability of logic gates are also discussed.
NONLINEAR DYNAMICS
(2023)
Article
Physics, Multidisciplinary
Dong Yu, Yong Wu, Lijian Yang, Yunjie Zhao, Ya Jia
Summary: This paper investigates the influence of topology on the phenomenon of delay-induced multiple resonances in locally driven systems. The results show that the maximum value of the Fourier coefficient occurs at an integer multiple of T/N, where T is the external signal period or the neuronal intrinsic oscillation period, and N is determined by the network's topology. The obtained results are briefly discussed in terms of the network's topology. The emergence of delay-induced multiple resonances depends on the interaction of the delay enhancement effect and the delay inhibition effect. In the case of weak coupling, the signal response performance is enhanced over a wider range of delay windows, dominated by delay enhancement effects. These findings may provide new insights into weak signal response and transmission in delay-coupled neural networks.
PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS
(2023)
Article
Neurosciences
Xuening Li, Dong Yu, Lijian Yang, Ziying Fu, Ya Jia
Summary: This paper investigates the synchronization mode transition and energy dependence in a delay-coupled FitzHugh-Nagumo neuronal system. The research findings suggest that the synchronization mode and the Hamiltonian energy can be modulated by adjusting the chaotic current intensity, coupling strength, and time delay.
COGNITIVE NEURODYNAMICS
(2023)
Article
Physics, Multidisciplinary
Xueqin Wang, Dong Yu, Tianyu Li, Ya Jia
Summary: This paper investigates the phenomenon of logical stochastic resonance in Hodgkin-Huxley neurons under electromagnetic effects. It is found that appropriately reducing the magnitude of the external bias current allows Hodgkin-Huxley neurons to perform reliable logic operations while consuming less energy. Additionally, an appropriate increase in coupling strength in neuronal networks has a favorable impact on system logic operations. Small-world networks outperform scale-free networks for logical operations.
PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS
(2023)
Article
Physics, Multidisciplinary
Qianming Ding, Yong Wu, Dong Yu, Tianyu Li, Ya Jia
Summary: This paper investigates the effect of magnetic flux on spiral waves and draws some conclusions, which are important for the recovery of cardiac tissue.
Article
Physics, Fluids & Plasmas
Dong Yu, Xuan Zhan, Li-jian Yang, Ya Jia
Summary: In the past decade, dynamic schemes using bistable systems for logic device design have been proposed. These bistable systems can function as reliable logic gates in the presence of moderate noise, known as logical stochastic resonance (LSR). This paper explores the emergence and underlying mechanisms of LSR in general bistable systems. The timescale relationship between measured time and mean first-pass time of state transitions plays a crucial role in determining system reliability. Moreover, utilizing appropriate filtering methods can significantly enhance the stability of logic operations.
Article
Engineering, Multidisciplinary
Xueqing Wang, Dong Yu, Yong Wu, Qianming Ding, Tianyu Li, Ya Jia
Summary: Inverse stochastic resonance (ISR), where the firing of a neuron is inhibited at a certain noise level, is studied in this paper. The effects of potassium channel blockage on ISR in single Hodgkin-Huxley neurons and small-world networks are investigated. The study shows that the ISR phenomenon in single neurons occurs within a specific range of potassium channel blockage, and for small-world networks, the duration of ISR decreases with an increase in network blockage ratio at small coupling strengths.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE A
(2023)
Letter
Cell Biology
Cai-Rong Sun, Da Xu, Fengrui Yang, Zhuanghao Hou, Yuyao Luo, Chen-Yu Zhang, Ge Shan, Guangming Huang, Xuebiao Yao, Yuxing Chen, Qiong Li, Cong-Zhao Zhou
Article
Chemistry, Multidisciplinary
Jingxin Li, Xiaolin Wang, Liang Shi, Boqiang Liu, Zhiyong Sheng, Shuhui Chang, Xiujun Cai, Ge Shan
Summary: This study identifies a mammalian conserved circRNA, circLARP1B, as playing critical roles in hepatocellular carcinoma (HCC). It promotes HCC metastasis and lipid accumulation by affecting LKB1 mRNA stability and protein levels through the HNRNPD-LKB1-AMPK pathway.