Article
Chemistry, Applied
Lingrong Wen, Zhili Sheng, Jinping Wang, Yueming Jiang, Bao Yang
Summary: This study obtained water-soluble polysaccharides (GLSP) from Ganoderma lucidum spore through hot water extraction, revealing that GLSP is mainly composed of β-glucan and arabinogalactan. GLSP has the potential to induce cell proliferation and possess strong anti-inflammatory activity by inhibiting the overproduction of NO and pro-inflammatory cytokines induced by LPS.
Article
Fisheries
Sevdan Yilmaz, Sebahattin Ergun, Tolga Sahin, Ekrem Sanver Celik, Hany M. R. Abdel-Latif
Summary: In this study, it was found that supplementing diets with reishi mushroom powder improved growth parameters and gene expression responses related to growth, digestion, and lipid metabolism in Nile tilapia. The highest improvement in weight, weight gain, and specific growth rate was observed in the group fed with a 10.0 g/kg inclusion dose of reishi mushroom powder. These findings highlight the prebiotic effects of reishi mushroom powder in aquafeed and its potential for enhancing tilapia culture sustainability.
Review
Pharmacology & Pharmacy
Darija Cor Andrejc, Zeljko Knez, Masa Knez Marevci
Summary: Ganoderma lucidum is a medicinal mushroom with various biologically active compounds that have antioxidant, antitumor, anti-inflammatory properties.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Qi-Zhang Li, Xin Chen, Pei-Wen Mao, Meng-Yuan Jin, Qin Wu, Xuan-Wei Zhou
Summary: This study revealed that N-glycosylation can enhance the anti-inflammatory activity of FIP-glu by regulating the expression of inflammatory cytokines and inhibiting p38 MAPK phosphorylation. N-glycosylation significantly improved the functional properties of FIP-glu, providing theoretical and technical support for expanding the application of FIPs in the food and pharmaceutical industries.
Review
Food Science & Technology
Aly Farag El Sheikha
Summary: Ganoderma lucidum, with a long history of medicinal use, has potential as an antiviral medicine and is widely used in the nutraceutical and cosmetics industries. Further research on its biotherapeutic components is needed to ensure safety and effectiveness, and to promote the development of commercial functional foods.
Article
Nutrition & Dietetics
Yanfang Liu, Qingjiu Tang, Jie Feng, Jing Liu, Chuanhong Tang, Mengqiu Yan, Shuai Zhou, Liping Liu, Jing Zhou, Jingsong Zhang
Summary: The influence of molecular weight on the anti-inflammatory activity of beta-D-glucan from Ganoderma lucidum was investigated. Lowering the molecular weight of beta-D-glucan improved its anti-inflammatory activity and significantly inhibited the expression of inflammatory cytokines. In a mouse model, the lower molecular weight fraction of beta-D-glucan was able to recover inflamed tissues and more effectively inhibit the secretion of pro-inflammatory cytokines.
FRONTIERS IN NUTRITION
(2022)
Review
Integrative & Complementary Medicine
Ting Ye, Yang Ge, Xiaoying Jiang, Hang Song, Can Peng, Bin Liu
Summary: Gastrointestinal cancer is a common and deadly form of cancer, with surgical excision and chemotherapy as the main treatment methods. However, these methods often come with serious adverse reactions and drug toxicity. Ganoderma lucidum has been used medicinally and as a food source in China for a long time, and its bioactive compounds have shown potential anti-tumor activities. This review aims to compile the characteristics, anti-GI cancer mechanisms, and clinical applications of G. lucidum, providing a reference for further research on its role in the prevention and treatment of GI cancer from both traditional Chinese and western medicine perspectives.
Article
Chemistry, Applied
Da Hye Ryu, Jwa Yeong Cho, Nooruddin Bin Sadiq, Jin-Chul Kim, Bokyung Lee, Muhammad Hamayun, Taek Sung Lee, Hyoung Seok Kim, Soo Hyun Park, Chu Won Nho, Ho-Youn Kim
Summary: Optimized extraction procedures for dried Ganoderma lucidum (GL) combining ultra-sonication and heating were found to maximize pharmacological activity and bioactive components. The study suggests that extraction conditions play a crucial role in the potential effects and quality of harvested GL products.
Article
Chemistry, Physical
Nazmi Sedefoglu, Yusuf Zalaoglu, Fuat Bozok
Summary: Nanomaterials have been widely studied and applied in various technological fields in the past decade, and it is important to synthesize these materials in an eco-friendly manner. In this study, ZnO nanoparticles were synthesized using Ganoderma lucidum extract and characterized using XRD, UV-visible spectrometer, and SEM-EDS analyses. The effects of these nanoparticles as nanofertilizers on Lepidium sativum were also investigated. The results showed that the ZnO nanoparticles had a pure wurtzite phase and a consistent optical bandgap. Different hexagonal shapes of nanoparticles were observed, and the elemental composition was stoichiometric. The application of green synthesized ZnO nanoparticles significantly improved the growth of L. sativum. This study is the first to report the use of G. lucidum extract for the green synthesis of ZnO nanoparticles as a nano-nutrient.
JOURNAL OF ALLOYS AND COMPOUNDS
(2022)
Article
Polymer Science
Wei-Lun Qiu, Wei-Hung Hsu, Shu-Ming Tsao, Ai-Jung Tseng, Zhi-Hu Lin, Wei-Jyun Hua, Hsin Yeh, Tzu-En Lin, Chien-Chang Chen, Li-Sheng Chen, Tung-Yi Lin
Summary: The study investigated the effects of WSG, a polysaccharide from Ganoderma lucidum, in combination with cisplatin on lung cancer treatment. It found that WSG enhanced the inhibitory effect of cisplatin on tumor growth and metastasis in mice, as well as increased their survival rate. Additionally, WSG reduced the cytotoxic effects of cisplatin on macrophages and normal lung fibroblasts.
Article
Biochemistry & Molecular Biology
Yanna Pan, Shilin Yuan, Yilong Teng, Zeng Zhang, Yanming He, Ying Zhang, Haohui Liang, Xiao Wu, Jiaqi Li, Hongjie Yang, Ping Zhou
Summary: The proteoglycan FYGL from Ganoderma lucidum has been found to have antioxidant activity and can protect and repair pancreatic beta-cells against oxidative stress-induced injury and apoptosis. FYGL improves cell viability, insulin secretion, redox balance, and mitochondrial function by regulating apoptosis-related signaling pathways and insulin secretion-related pathways. In vivo, FYGL repairs the injured pancreas, reduces pancreatic beta-cell apoptosis, and improves blood glucose control in diabetic mice.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biotechnology & Applied Microbiology
Nur Raihan Abdullah, Mohd Hamzah Mohd Nasir, Nur Hafizah Azizan, Wan Abd Al Qadr Imad Wan-Mohtar, Faez Sharif
Summary: This study aims to investigate the inhibitory effects of EPS-BG and ENS-BG extracted from Ganoderma lucidum on the activity of alpha-glucosidase. The results showed that EPS-BG is the most potent compound with the highest inhibitory effect. Both EPS-BG and ENS-BG are non-toxic to zebrafish embryos and can reduce blood glucose levels in diabetic zebrafish.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Haoyuan Peng, Lei Zhong, Lin Cheng, Lu Chen, Rongsheng Tong, Jianyou Shi, Lan Bai
Summary: Ganoderma lucidum, also known as Lingzhi, is a widely-used herbal medicine with various pharmacological effects including antioxidant, antitumor, anti-aging, anti-liver fibrosis, and immunomodulation. Its main active components include triterpenoids, polysaccharides, sterols, peptides, and other bioactive ingredients. The triterpenoids and polysaccharides in G. lucidum have shown significant anti-liver fibrotic effects. Given the global increase in liver fibrosis cases, this review summarizes the role of G. lucidum extract in anti-liver fibrosis and its effects on fibrosis induced by different causes, providing insights for the development of G. lucidum extracts in anti-liver fibrosis treatment.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Chemistry, Medicinal
Rizwan Ahmad, Muhammad Riaz, Aslam Khan, Ahmed Aljamea, Mohammad Algheryafi, Deya Sewaket, Aljawharah Alqathama
Summary: Reishi mushroom has exceptional value in nutrition, cosmeceuticals, and medical treatments, but there is a lack of quality clinical data to support its pharmacological activities for human use. While Reishi shows promising pharmacological potential, further clinical studies are needed to validate its safety and efficacy.
PHYTOTHERAPY RESEARCH
(2021)
Article
Chemistry, Medicinal
Kim P. C. Kuypers
Summary: Parkinson's disease only has symptomatic treatments, while traditional pharmacological treatments do not address cognitive and emotional issues. Preclinical research suggests potential benefits of Ganoderma lucidum in neurological disorders, though there is a lack of clinical studies. A single case study showed some positive changes in affective behavior, warranting further research in this patient population.
JOURNAL OF MEDICINAL FOOD
(2021)
Article
Biology
Maud Voisin, Elina Shrestha, Claire Rollet, Cyrus A. Nikain, Tatjana Josefs, Melanie Mahe, Tessa J. Barrett, Hye Rim Chang, Rachel Ruoff, Jeffrey A. Schneider, Michela L. Garabedian, Chris Zoumadakis, Chi Yun, Bara Badwan, Emily J. Brown, Adam C. Mar, Robert J. Schneider, Ira J. Goldberg, Ines Pineda-Torra, Edward A. Fisher, Michael J. Garabedian
Summary: The study demonstrates that reducing phosphorylation at serine 196 of LXR alpha in hematopoietic cells can attenuate atherosclerosis and obesity induced by a high-fat diet in mice by reprogramming the transcriptional activity of LXR alpha in macrophages and T cells to promote an anti-inflammatory phenotype.
COMMUNICATIONS BIOLOGY
(2021)
Article
Oncology
Matthias A. Karajannis, Audrey Mauguen, Ekrem Maloku, Qingwen Xu, Erin M. Dunbar, Scott R. Plotkin, Anna Yaffee, Shiyang Wang, J. Thomas Roland, Chandranath Sen, Dimitris G. Placantonakis, John G. Golfinos, Jeffrey C. Allen, Nicholas A. Vitanza, Luis A. Chiriboga, Robert J. Schneider, Jingjing Deng, Thomas A. Neubert, Judith D. Goldberg, David Zagzag, Filippo G. Giancotti, Jaishri O. Blakeley
Summary: Inhibition of mTORC1 signaling with everolimus showed limited antitumor effect in patients with NF2, potentially due to incomplete inhibition of mTORC1 and downstream signaling. These findings provide insights for the design of future studies targeting mTORC1 in meningiomas and schwannomas.
MOLECULAR CANCER THERAPEUTICS
(2021)
Review
Chemistry, Multidisciplinary
Yamixa Delgado, Celine Casse, Yancy Ferrer-Acosta, Ivette J. Suarez-Arroyo, Jose Rodriguez-Zayas, Anamaris Torres, Zally Torres-Martinez, Daraishka Perez, Michael J. Gonzalez, Ricardo A. Velazquez-Aponte, Josue Andino, Clarissa Correa-Rodriguez, Jean C. Franco, Wandaliz Milan, Gabriela Rosario, Eddian Velazquez, Jaisy Vega, Janmary Colon, Christopher Batista
Summary: This review evaluates and summarizes recent studies on popular phytonutrients such as turmeric, garlic, cinnamon, graviola, and oregano. It provides fast, summarized information on over 250 scientific articles, highlighting the potential preventive and therapeutic effects of these phytonutrients on various diseases. Additionally, the review discusses the pharmacological properties and reported contraindications of these plant-derived products.
APPLIED SCIENCES-BASEL
(2021)
Article
Multidisciplinary Sciences
Viviana Volta, Sandra Perez-Baos, Columba de la Parra, Olga Katsara, Amanda Ernlund, Sophie Dornbaum, Robert J. Schneider
Summary: The differentiation of Treg cells requires non-canonical mRNA translation mechanism involving DAP5 and eIF3d, facilitated by TGF-beta-1 and downregulation of mTORC1 activity.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Astrid Zayas-Santiago, Michelle M. Martinez-Montemayor, Jadier Colon-Vazquez, Gabriela Ortiz-Soto, Jose G. Cirino-Simonet, Mikhail Inyushin
Summary: The study found that Aβ peptides are present in breast cancer tumors, distributed in gradients with concentration near blood vessels. Significant presence of amyloid precursor protein (APP) was also detected in tumor samples.
Editorial Material
Cell Biology
Chandan Kumar-Sinha, Arul M. Chinnaiyan
Summary: In breast cancer, the leucyl-tRNA synthetase LARS suppresses transformation and tumour development by increasing tRNA-Leu(CAG) translation of certain tumour suppressor mRNAs.
NATURE CELL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Preeyam S. Patel, Sandra Perez-Baos, Beth Walters, Margo Orlen, Angelina Volkova, Kelly Ruggles, Christopher Y. Park, Robert J. Schneider
Summary: This article explores the translational regulation of T cells and discovers a previously unknown mechanism of selective mRNA translation in T follicular helper cells (TFH cells). The study demonstrates that this translation mechanism is essential for TFH cell fate-specification and their role in autoimmune pathogenesis.
Article
Oncology
Ariana Acevedo-Diaz, Beatriz M. Morales-Caban, Astrid Zayas-Santiago, Michelle M. Martinez-Montemayor, Ivette J. Suarez-Arroyo
Summary: Triple-negative breast cancer (TNBC) is the most aggressive subtype, and this study found that SCAMP3 plays an important role in TNBC development through the regulation of multiple pathways, potentially serving as a target for breast cancer therapy.
Article
Biochemistry & Molecular Biology
Mohammad Sadic, William M. Schneider, Olga Katsara, Gisselle N. Medina, Ashley Fisher, Aishwarya Mogulothu, Yingpu Yu, Meigang Gu, Teresa de Los Santos, Robert J. Schneider, Meike Dittmann
Summary: DDX60, an interferon-stimulated helicase, selectively reduces translation from certain viral IRESs to inhibit viral replication.
Article
Biochemistry & Molecular Biology
Gabriela Ortiz-Soto, Natalia S. Babilonia-Diaz, Mercedes Y. Lacourt-Ventura, Delmarie M. Rivera-Rodriguez, Jailenne I. Quinones-Rodriguez, Monica Colon-Vargas, Israel Almodovar-Rivera, Luis E. Ferrer-Torres, Ivette J. Suarez-Arroyo, Michelle M. Martinez-Montemayor
Summary: Inflammatory breast cancer (IBC) is a lethal subtype of breast cancer, comprising 1-5% of all cases. This study confirms the overexpression of metadherin (MTDH) in IBC cells and reveals its crucial role in IBC progression, including signaling pathway regulation and tumor growth promotion. CRISPR/Cas9 editing of IBC cells shows that the absence of MTDH significantly reduces cell migration, proliferation, and tumor spheroid formation, as well as the expression of key signaling molecules in IBC. Additionally, IBC xenografts exhibit distinct tumor growth patterns and phenotypes in lung tissue. These findings highlight MTDH as a potential therapeutic target for IBC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Amandine Alard, Olga Katsara, Tiffany Rios-Fuller, Columba de la Parra, Ugur Ozerdem, Amanda Ernlund, Robert J. Schneider
Summary: Cancer cell plasticity enables cell survival and fate transitions, such as epithelial-to-mesenchymal transition (EMT), which are essential for invasion and metastasis. The DAP5/eIF3d complex plays a crucial role in metastasis, EMT, and tumor directed angiogenesis by selectively translating mRNAs encoding EMT transcription factors, cell migration integrins, metalloproteinases, and cell survival and angiogenesis factors. These findings reveal a surprising level of plasticity in mRNA translation during cancer progression and metastasis.
Article
Oncology
Camiled Quirindongo-Rivera, Valeria Rullan-Varela, Zoe Underill, Mayra Rivera, Karen J. Ortiz-Ortiz, Michelle M. Martinez-Montemayor
Summary: This study characterizes the population of Hispanic women with inflammatory breast cancer (IBC) in Puerto Rico and estimates the survival rate of IBC. The results suggest that Puerto Rican IBC patients have unique characteristics, and patients with stage IV disease and ER-/PR- tumor subtype have a higher risk of dying.
Article
Oncology
Ivette J. Suarez-Arroyo, Ariana Acevedo-Diaz, Tiffany J. Rios-Fuller, Gabriela Ortiz-Soto, Ricardo Vallejo-Calzada, Jael Reyes-Chea, Geronimo Maldonado-Martinez, Robert J. Schneider, Michelle M. Martinez-Montemayor
Summary: This study investigates the therapeutic potential of using medicinal mushroom Ganoderma lucidum (GLE) in combination with carboplatin for the treatment of Inflammatory Breast Cancer (IBC). The results show that the GLE/carboplatin combination reduces cell viability, induces cell death through two different mechanisms, and delays the response to DNA damage. In addition, the combination treatment suppresses mammosphere formation and the expression of cancer stemness proteins. In animal models, the combination treatment exhibits significant tumor growth inhibitory effects without systemic toxicity.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)