Article
Microbiology
Shengru Wu, Lalle Hammarstedt-Nordenvall, Mattias Jangard, Liqin Cheng, Sebastian Alexandru Radu, Pia Angelidou, Yinghua Zha, Marica Hamsten, Lars Engstrand, Juan Du, Anders Ternhag
Summary: The study aimed to identify the tonsillar microbiota in chronic tonsillitis (CT) and tonsillar hypertrophy (TH) patients. Different microbiotas were found in CT versus TH patients and surface versus core tissues. Certain bacteria, such as Haemophilus, Neisseria, Dialister, and Parvimonas, may serve as microbial biomarkers to discriminate CT patients from TH patients, with distinct microbial types detected in each group. This research contributes important microbiota data for researchers in the oral microbiome and clinical fields.
Article
Microbiology
James Johnston, Brett Wagner Mackenzie, Kristi Biswas, Sharon Waldvogel-Thurlow, Sita Tarini Clark, Fiona Radcliff, Murali Mahadevan, Richard G. Douglas
Summary: This study aimed to investigate the effects of amoxicillin with clavulanate on the composition and quantity of bacteria in the tonsils of children with recurrent tonsillitis. The results showed that the antibiotic group had significantly different relative abundances of certain bacteria compared to the control group, with a higher abundance of bacteria from the genera Fusobacterium and Treponema in the antibiotic group. Microscopic examination also revealed a lower quantity of bacterial microcolonies in the tonsils of the antibiotic group.
MICROBIOLOGY SPECTRUM
(2022)
Article
Cell Biology
Paolo Manghi, Aitor Blanco-Miguez, Serena Manara, Amir NabiNejad, Fabio Cumbo, Francesco Beghini, Federica Armanini, Davide Golzato, Kun D. Huang, Andrew M. Thomas, Gianmarco Piccinno, Michal Puncochar, Moreno Zolfo, Till R. Lesker, Marius Bredon, Julien Planchais, Jeremy Glodt, Mireia Valles-Colomer, Omry Koren, Edoardo Pasolli, Francesco Asnicar, Till Strowig, Harry Sokol, Nicola Segata
Summary: In this study, the researchers used MetaPhlAn 4, a metagenomic profiling method, to improve the analysis of the mouse gut microbiome. By combining multiple datasets and additional samples, they were able to identify several diet-related microbial biomarkers, including previously unknown ones.
Article
Pharmacology & Pharmacy
B. Sizer, E. Deveci, S. Demir, A. E. Yorgancilar
Summary: This study compared the histopathological and immunohistochemical examination of Weber's glands in pediatric patients with recurrent tonsillitis and obstructive tonsillar hypertrophy, revealing inflammatory changes.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Biochemical Research Methods
Kristen D. Curry, Qi Wang, Michael G. Nute, Alona Tyshaieva, Elizabeth Reeves, Sirena Soriano, Qinglong Wu, Enid Graeber, Patrick Finzer, Werner Mendling, Tor Savidge, Sonia Villapol, Alexander Dilthey, Todd J. Treangen
Summary: 16S ribosomal RNA-based analysis is the standard method for studying microbial community composition. Full-length 16S rRNA gene sequences have the potential to provide species-level accuracy. Emu is an approach that can generate taxonomic abundance profiles from full-length 16S rRNA reads, accurately estimating microbial abundance.
Article
Microbiology
Jordan G. Kueneman, Ernesto Bonadies, Devin Thomas, David W. Roubik, William T. Wcislo
Summary: The composition of gut microbiomes varies among different types of bees, with eusocial bees showing a more conserved microbiome. The behavior and foraging habits of bees are associated with the diversity and distribution of their gut microbiomes. The presence of certain bacterial taxa in bees challenges the traditional view of their association with eusociality.
Review
Cell Biology
Xiaoqiang Qi, Yajun Liu, Samira Hussein, Grace Choi, Eric T. Kimchi, Kevin F. Staveley-O'Carroll, Guangfu Li
Summary: Modulation of gut microbiota is a promising strategy for enhancing antitumor immune responses and reducing resistance to immunotherapy in cancer. However, identifying gut bacteria species that are favorable or unfavorable for cancer therapy remains a major challenge.
Article
Medicine, Research & Experimental
Aleksi Laajala, Paulus Tokola, Timo J. Autio, Timo Koskenkorva, Mikko Tastula, Pasi Ohtonen, Esa Laara, Olli-Pekka Alho
Summary: This study aims to compare the effectiveness of total tonsillectomy and partial tonsillotomy surgeries for adults with chronic or recurrent tonsillitis, in terms of impact on quality of life and potential harms.
Article
Agriculture, Dairy & Animal Science
Rebecca Di Pietro, Luis G. Arroyo, Mathilde Leclere, Marcio Carvalho Costa
Summary: This study compared the gut microbiota of horses using different sequencing technologies, PacBio failed to classify the equine intestinal microbiota at the species level but detected greater richness and fewer unclassified bacteria compared to Illumina sequencing.
Article
Multidisciplinary Sciences
Sandra Alvarez-Carretero, Asif U. Tamuri, Matteo Battini, Fabricia F. Nascimento, Emily Carlisle, Robert J. Asher, Ziheng Yang, Philip C. J. Donoghue, Mario dos Reis
Summary: A Bayesian molecular-clock dating approach was developed to estimate a timetree of 4,705 mammal species using information from 72 mammal genomes. Larger phylogenomic datasets produced diversification time estimates with smaller uncertainties, allowing for precise tests of macroevolutionary hypotheses. This approach facilitates the analysis of complete genomes and thousands of species within an integrated framework to address previously intractable research questions on species diversifications.
Article
Immunology
Tulia Mateus, Elke J. Seppanen, Camilla de Gier, Sharon Clark, Harvey Coates, Shyan Vijayasekaran, Karen Prosser, Selma P. Wiertsema, Angela Fuery, Lea-Ann S. Kirkham, Peter C. Richmond, Ruth B. Thornton
Summary: This study investigated the bacterial load and species-specific densities in nasopharyngeal and oropharyngeal samples of children with pediatric obstructive sleep disordered breathing (SDB) and recurrent tonsillitis (RT). The presence of certain bacterial species was found to be associated with these conditions, suggesting that antimicrobials, especially anti-biofilm therapies, may be a strategy for managing these children.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Ashomathi Mollin, Mounika Katta, Jack D. Sobel, Robert A. Akins
Summary: Bacterial vaginosis (BV) is associated with vaginal dysbiosis and high recurrence rates. This study found that different bacterial species and their abundance are correlated with treatment outcomes, suggesting potential prognostic and therapeutic significance.
Article
Chemistry, Applied
Ting Qiang, Jinyu Wang, Lan Jiang, Ke Xiong
Summary: Previous studies have shown that sodium alginates of different molecular weights have different effects on reducing postprandial glucose levels. In this study, it was found that high molecular weight sodium alginate more significantly reduced fasting blood glucose levels and enriched specific serum metabolites, and these effects were correlated with differential modulation of gut microbiota.
CARBOHYDRATE POLYMERS
(2022)
Article
Multidisciplinary Sciences
Louise Grahnemo, Maria Nethander, Eivind Coward, Maiken Elvestad Gabrielsen, Satya Sree, Jean-Marc Billod, Klara Sjogren, Lars Engstrand, Koen F. Dekkers, Tove Fall, Arnulf Langhammer, Kristian Hveem, Claes Ohlsson
Summary: In this study, the authors use data from the Norwegian HUNT cohort to investigate the association between gut microbial species and lean mass. They find that the presence of three bacterial species - Coprococcus comes, Dorea longicatena, and Eubacterium ventriosum - is associated with higher lean mass.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Essence Turner, Jack D. Sobel, Robert A. Akins
Summary: The study found that persistently high levels of Gardnerella Gsp07 were associated with poor clinical outcomes in refractory bacterial vaginosis patients, while persistently low levels of Gardnerella Gsp07 and G. swidsinskii / G. leopoldii were associated with remission. In most recurrent and remission patients, Lactobacillus species abundance increased 4-14 days after treatment initiation, with more sustained increases in remission patients. The findings suggest that targeting specific strains of Gardnerella may improve patient outcomes.
Article
Microbiology
Helena Fago-Olsen, Laura Marie Dines, Christian Hjort Sorensen, Anders Jensen
Article
Hematology
Lise M. Lindahl, Andreas Willerslev-Olsen, Lise M. R. Gjerdrum, Pia R. Nielsen, Edda Blumel, Anne H. Rittig, Pamela Celis, Bjorn Herpers, Juergen C. Becker, Birgitte Stausbol-Gron, Mariusz A. Wasik, Maria Gluud, Simon Fredholm, Terkild B. Buus, Claus Johansen, Claudia Nastasi, Lukas Peiffer, Linda Kubat, Michael Bzorek, Jens O. Eriksen, Thorbjorn Krejsgaard, Charlotte M. Bonefeld, Carsten Geisler, Tomas Mustelin, Erik Langhoff, Michael Givskov, Anders Woetmann, Mogens Kilian, Thomas Litman, Lars Iversen, Niels Odum
Article
Ecology
Szymon P. Szafranski, Mogens Kilian, Ines Yang, Gesa Bei Der Wieden, Andreas Winkel, Jan Hegermann, Meike Stiesch
Article
Immunology
Moon H. Nahm, Terry Brissac, Mogens Kilian, Jiri Vlach, Carlos J. Orihuela, Jamil S. Saad, Feroze Ganaie
JOURNAL OF INFECTIOUS DISEASES
(2020)
Article
Microbiology
Mogens Kilian, Herve Tettelin
Correction
Microbiology
Mogens Kilian, Herve Tettelin
Article
Chemistry, Multidisciplinary
Helina Marshall, Sebastian Aguayo, Mogens Kilian, Fernanda Petersen, Laurent Bozec, Jeremy Brown
Letter
Dermatology
Lise M. Lindahl, Lars Iversen, Niels Odum, Mogens Kilian
Article
Microbiology
Helina Marshall, Ricardo J. Jose, Mogens Kilian, Fernanda C. Petersen, Jeremy S. Brown
Summary: Streptococcus pneumoniae and Streptococcus mitis are closely related genetically, but the former can resist complement attack while the latter cannot, leading to differences in their pathogenicity.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Medicine, Research & Experimental
Anders Kirkegaard Jensen, Katerina Chatzidionysiou, Christopher Kirkegaard Torp, Anne Sofie Sorensen, Helene Broch Tenstad, Valentin S. Schafer, Marie Kostine, Soren Jacobsen, Jan Leipe, Tue Wenzel Kragstrup
Summary: This literature review compares the pharmacological management of immune checkpoint inhibitor-induced inflammatory arthritis (ICI-IA) and reactive arthritis (ReA). The studies suggest that non-steroidal anti-inflammatory drugs (NSAIDs), glucocorticoids (GC), methotrexate (MTX), sulfasalazine (SSZ), and tumor necrosis factor alpha inhibition (TNFi) have shown effectiveness in both diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Microbiology
Mogens Kilian, Steffen Husby, Jesper Andersen, Zina Moldoveanu, Uffe B. Skov Sorensen, Jesper Reinholdt, Herve Tettelin
Summary: Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae type b are the main bacteria causing bacterial meningitis. This study suggests that patients may be primed for infection by acquiring different bacteria, an immunogenic commensal followed by the pathogen, both expressing the same capsular polysaccharide. The IgA1 protease common to the three pathogens cleaves preexisting IgA1 antibodies induced by the commensal, releasing capsule-binding monomeric Fab fragments that enhance bacterial adherence and block other isotypes of antibody molecules.
Article
Infectious Diseases
Florens Lohrmann, Markus Hufnagel, Mirjam Kunze, Baharak Afshar, Roberta Creti, Antoaneta Detcheva, Jana Kozakova, Javier Rodriguez-Granger, Uffe B. Skov Sorensen, Immaculada Margarit, Domenico Maione, Daniela Rinaudo, Graziella Orefici, John Telford, Manuel de la Rosa Fraile, Mogens Kilian, Androulla Efstratiou, Reinhard Berner, Pierrette Melin
Summary: This study describes the clinical and microbiological characteristics of neonatal Group B streptococcus (GBS) diseases. It found that respiratory distress is the most frequent clinical sign in early-onset GBS, while meningitis is found in more than 30% of late-onset GBS cases. The study also revealed that a significant number of mothers of early-onset GBS cases had not received antenatal screening.
Article
Hematology
Christian Damgaard, Susanne G. Saekmose, Martin Nilsson, Mogens Kilian, Claus H. Nielsen, Palle Holmstrup
Summary: Periodontitis correlates with viable bacteria in standard blood donations, with a higher risk of bacterial contamination in blood products from donors with periodontitis compared to periodontally healthy donors. Various bacterial species were detected in donations from periodontitis donors, predominantly in the RBC-fraction, indicating a potential limitation in routine screening methods for viable bacteria.
Meeting Abstract
Oncology
Lise M. Lindahl, Andreas Willerslev-Olsen, Lise M. R. Gjerdrum, Pia R. Nielsen, Edda Blumel, Anne H. Rittig, Pamela Celis, Bjorn Herpers, Juergen C. Becker, Birgitte Stausbol-Gron, Mariusz A. Wasik, Maria Gluud, Simon Fredholm, Terkild B. Buus, Claus Johansen, Claudia Nastasi, Lukas Peiff Er, Linda Kubat, Michael Bzorek, Jens O. Eriksen, Thorbjorn Krejsgaard, Charlotte M. Bonefeld, Carsten Geisler, Tomas Mustelin, Erik Langhoff, Michael Givskov, Anders Woetmann, Mogens Kilian, Thomas Litman, Lars Iversen, Niels Odum
EUROPEAN JOURNAL OF CANCER
(2019)
Article
Multidisciplinary Sciences
Tilde Andersson, Gizem Erturk Bergdahl, Karim Saleh, Helga Magnusdottir, Kristian Stodkilde, Christian Brix Folsted Andersen, Katarina Lundqvist, Anders Jensen, Holger Bruggemann, Rolf Lood
SCIENTIFIC REPORTS
(2019)