Review
Biochemistry & Molecular Biology
Chen-Chen Jiang, Li-Shan Lin, Sen Long, Xiao-Yan Ke, Kohji Fukunaga, Ying-Mei Lu, Feng Han
Summary: Autism spectrum disorder (ASD) is a common and complex neurodevelopmental disorder with a strong genetic basis. Despite the limited understanding of its etiology, risk factors, and disease progression, significant progress has been made in genetics, identifying hundreds of genes associated with a high risk for autism. The involvement of signal transduction molecular events in pathological processes has important implications for precise molecular targeting in autism. This review provides insights into the mechanisms and clinical implications of signal transduction in autism, as well as future challenges and perspectives.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Article
Clinical Neurology
Brendan Monogue, Yixi Chen, Hadrian Sparks, Ranya Behbehani, Andrew Chai, Alexander J. Rajic, Aaron Massey, B. K. Kleinschmidt-Demasters, Matthieu Vermeren, Tilo Kunath, J. David Beckham
Summary: The normal function of alpha-synuclein in neurons is not clearly defined. This study found that alpha-synuclein functions in neurons to support immune signaling by co-localizing to the nucleus with interferon signaling proteins following interferon stimulation.
Review
Pharmacology & Pharmacy
Xiaoqin Zeng, Jingda Li, Fuyuan Yang, Rui Xia
Summary: Ferroptosis is a novel form of programmed cell death characterized by iron-mediated lipid peroxidation induced by reactive oxygen species, distinct from apoptosis, necroptosis, and other forms of cell death. There is limited research on the effects of anesthetics on ferroptosis, making it important to understand the mechanisms for potential clinical applications and disease treatments.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Xue Bai, Ping Nie, Yan Lou, Yuexin Zhu, Shan Jiang, Bing Li, Ping Luo
Summary: Renal fibrosis, a characteristic of all chronic kidney diseases, currently lacks effective therapeutic drugs. Pirfenidone (PFD), widely used in idiopathic pulmonary fibrosis, exerts anti-fibrotic, anti-inflammatory, antioxidant, and anti-apoptotic effects attributed to the suppression of cell growth factors and other pathways. With similar anti-fibrotic pathways in lung and kidney diseases, PFD has shown promising results in improving the treatment of renal fibrotic disease.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Devaraj Basavarajappa, Caridad Galindo-Romero, Vivek Gupta, Marta Agudo-Barriuso, Veer B. Gupta, Stuart L. Graham, Nitin Chitranshi
Summary: In this review, the recent research progress on the degenerative mechanisms of retinal ganglion cells (RGCs) in glaucoma is discussed. High intraocular pressure is not the sole factor contributing to glaucoma pathogenesis. The balance of pro-survival and pro-death signaling pathways in the retina strongly influences RGC function and survival. Various molecules and regulated cell death pathways are involved in the development of glaucoma.
MOLECULAR ASPECTS OF MEDICINE
(2023)
Review
Cell Biology
Xinxin Li, Rongfang Xie, Yilin Luo, Runlu Shi, Yuanqiang Ling, Xiaojing Zhao, Xuejuan Xu, Weiwei Chu, Xusheng Wang
Summary: The skin is a complex multi-layered structure, and understanding the mechanisms of its development is important for clinical applications. The review discusses the regulatory roles of TGF-beta and FGF signalling pathways in the development of different skin layers, particularly the dermis. It also explores the potential of these pathways for skin regeneration and suggests new perspectives for future research.
CELL PROLIFERATION
(2023)
Article
Fisheries
Rodrigo Guabiraba, Damaris Ribeiro Rodrigues, Paul T. Manna, Melanie Chollot, Vincent Saint-Martin, Sascha Trapp, Marisa Oliveira, Clare E. Bryant, Brian J. Ferguson
Summary: The innate immune response relies on the ability of host cells to detect and respond to microbial nucleic acids. Toll-like receptors (TLRs) play a crucial role in this process by distinguishing self from non-self. This study focused on TLR21, an avian TLR that recognizes bacterial DNA motifs. The findings suggest that avian TLR21 shares similar activation mechanisms to mammalian TLR9, highlighting the conservation of nucleic acid sensing mechanisms across species.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Roua Hassoun, Heidi Budde, Saltanat Zhazykbayeva, Melissa Herwig, Marcel Sieme, Simin Delalat, Nusratul Mostafi, Kamilla Goemoeri, Melina Tangos, Muhammad Jarkas, Steffen Pabel, Stefanie Bruckmueller, Marina Skrygan, Maria Lodi, Kornelia Jaquet, Vasco Sequeira, Thilo Gambichler, Cris Dos Remedios, Arpad Kovacs, Hans Georg Mannherz, Andreas Muegge, Samuel Sossalla, Nazha Hamdani
Summary: Hypertrophic cardiomyopathy is a complex myocardial disorder with characteristics of increased stiffness in cardiomyocytes from patients, with titin abnormalities and oxidative stress playing significant roles. The study suggests that reducing oxidative stress may be a viable therapeutic approach to attenuating cardiac dysfunction in heart failure and HCM.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Veterinary Sciences
Yaxin Liang, Rongrong Liu, Jiahui Zhang, Yixin Chen, Shijuan Shan, Yaoyao Zhu, Guiwen Yang, Hua Li
Summary: This study cloned the CcIRF6 gene from common carp and investigated its role in the immune response of fish. The results showed that CcIRF6 is involved in the antiviral and antibacterial immune response and negatively regulates the expression of IFN and NF-kappa B signaling pathways. This study provides a theoretical basis for the study and prevention of fish disease pathogenesis.
BMC VETERINARY RESEARCH
(2022)
Article
Cell Biology
Li Yang, Xin Wang, Xin-Xin Yu, Lu Yang, Bi-Chen Zhou, Jing Yang, Cheng-Ran Xu
Summary: The study reveals that promoter-associated histone modifications and chromatin accessibility dynamics effectively distinguish the default and directed processes of hepatoblast differentiation. The presence of H3K27me3 on bivalent promoters is associated with asymmetric differentiation strategy. The research also highlights the role of enhancer-associated modifications in the progressive development of hepatobiliary lineages.
DEVELOPMENTAL CELL
(2023)
Article
Genetics & Heredity
Xiaoyong Chen, Tongling Shan, Dage Sun, Huanjie Zhai, Sujie Dong, Ning Kong, Hao Zheng, Wu Tong, Guangzhi Tong
Summary: Porcine ZCCHC3 plays an inhibitory role in the proliferation of pseudorabies virus (PRV) by regulating cellular innate immune responses. Overexpression of ZCCHC3 inhibits viral titers and protein levels, while knockdown of ZCCHC3 promotes viral growth. ZCCHC3 overexpression upregulates IFN-beta expression to suppress viral replication. PRV infection reduces endogenous expression of ZCCHC3, and PRV-encoded UL13 and UL24 proteins inhibit ZCCHC3 expression, antagonizing its antiviral effect.
Article
Endocrinology & Metabolism
Maaike E. Straat, Borja Martinez-Tellez, Huub J. van Eyk, Maurice B. Bizino, Suzanne van Veen, Eleonora Vianello, Rinke Stienstra, Tom H. M. Ottenhoff, Hildo J. Lamb, Johannes W. A. Smit, Ingrid M. Jazet, Patrick C. N. Rensen, Mariette R. Boon
Summary: There are differences in immune gene expression between South Asian and Europid individuals with T2D, with a more activated IFN-signaling pathway in South Asians, particularly in women.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Physics, Multidisciplinary
Nayyere Nasiri, Sodeif Ahadpour, Pejman Bordbar
Summary: This work studies type-V intermittency from the perspective of Markov binary block visibility graphs. A piecewise quadratic Poincare map is considered as a simple model for exhibiting this type of intermittency. The behavior of a dynamical system near the points of discontinuity or non-differentiability is studied using networks language, and their properties are described based on statistical tools.
PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS
(2022)
Article
Agricultural Engineering
Rajani Singh, Amarendra Narayan Misra, Pallavi Sharma
Summary: In this study, RNA sequencing was performed to identify differentially expressed genes in As-tolerant and As sensitive castor genotypes in response to As(V) treatment. The results showed distinct expression patterns of stress-related genes and genes associated with metal transport and photosynthesis between the two genotypes. The findings provide insights into the mechanisms of As toxicity and tolerance in castor plants.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Allergy
Lukas Wisgrill, Nanna Fyhrquist, Joseph Ndika, Laura Paalanen, Angelika Berger, Tiina Laatikainen, Piia Karisola, Tari Haahtela, Harri Alenius
Summary: In patients allergic to birch pollen, stimulation by Bet v 1 activates innate immune and antiviral signalling networks, suggesting a tendency of the immune system to interpret pollens as viruses.
CLINICAL AND EXPERIMENTAL ALLERGY
(2022)
Article
Multidisciplinary Sciences
Naif Khalaf Alharbi, Senthil K. Chinnakannan, Sarah C. Gilbert, Simon J. Draper
Meeting Abstract
Gastroenterology & Hepatology
A. Von Delft, T. Donnison, S. Chinnakannan, J. Lourenco, C. Hutchings, A. Brown, P. Klenerman, E. Barnes
JOURNAL OF HEPATOLOGY
(2016)
Article
Immunology
Naif Khalaf Alharbi, Alexandra J. Spencer, Ahmed M. Salman, Claire M. Tully, Senthil K. Chinnakannan, Teresa Lambe, Yuko Yamaguchi, Susan J. Morris, Toritse Orubu, Simon J. Draper, Adrian V. S. Hill, Sarah C. Gilbert
Article
Immunology
Claire M. Tully, Senthil Chinnakannan, Caitlin E. Mullarkey, Marta Ulaszewska, Francesca Ferrara, Nigel Temperton, Sarah C. Gilbert, Teresa Lambe
JOURNAL OF IMMUNOLOGY
(2017)
Meeting Abstract
Gastroenterology & Hepatology
T. Donnison, A. von Delft, S. K. Chinnakannan, J. Lourenco, C. Hutchings, A. Brown, P. Klenerman, E. Barnes
JOURNAL OF HEPATOLOGY
(2018)
Meeting Abstract
Gastroenterology & Hepatology
S. K. Chinnakannan, T. Cargill, T. Donnison, A. Ansari, M. Maini, T. Evans, E. Barnes
JOURNAL OF HEPATOLOGY
(2018)
Article
Immunology
Annette von Delft, Timothy A. Donnison, Jose Lourenco, Claire Hutchings, Caitlin E. Mullarkey, Anthony Brown, Oliver G. Pybus, Paul Klenerman, Senthil Chinnakannan, Eleanor Barnes
Article
Biotechnology & Applied Microbiology
Senthil K. Chinnakannan, Barbara Holzer, Beatriz Sanz Bernardo, Sambit K. Nanda, Michael D. Baron
JOURNAL OF GENERAL VIROLOGY
(2014)
Article
Immunology
Julia M. Colston, Claire Hutchings, Senthil Chinnakannan, Andrew Highton, Christian Perez-Shibayama, Burkhard Ludewig, Paul Klenerman
EUROPEAN JOURNAL OF IMMUNOLOGY
(2019)
Meeting Abstract
Gastroenterology & Hepatology
Tamsin Cargill, Timothy Donnison, Azim Ansari, Mala Maini, Tom Evans, Eleanor Barnes, Senthil Kumar Chinnakannan
JOURNAL OF HEPATOLOGY
(2019)
Article
Gastroenterology & Hepatology
Erwan Atcheson, Wenqin Li, Carly M. Bliss, Senthil Chinnakannan, Kathrin Heim, Hannah Sharpe, Claire Hutchings, Isabelle Dietrich, Dung Nguyen, Amit Kapoor, Michael A. Jarvis, Paul Klenerman, Eleanor Barnes, Peter Simmonds
Article
Immunology
Senthil K. Chinnakannan, Tamsin N. Cargill, Timothy A. Donnison, M. Azim Ansari, Sarah Sebastian, Lian Ni Lee, Claire Hutchings, Paul Klenerman, Mala K. Maini, Tom Evans, Eleanor Barnes
Article
Immunology
Timothy Donnison, Annette von Delft, Anthony Brown, Leo Swadling, Claire Hutchings, Tomas Hanke, Senthil Chinnakannan, Eleanor Barnes
Article
Multidisciplinary Sciences
Nicholas M. Provine, Ali Amini, Lucy C. Garner, Alexandra J. Spencer, Christina Dold, Claire Hutchings, Laura Silva Reyes, Michael E. B. FitzPatrick, Senthil Chinnakannan, Blanche Oguti, Meriel Raymond, Marta Ulaszewska, Fulvia Troise, Hannah Sharpe, Sophie B. Morgan, Timothy S. C. Hinks, Teresa Lambe, Stefania Capone, Antonella Folgori, Eleanor Barnes, Christine S. Rollier, Andrew J. Pollard, Paul Klenerman
Summary: MAIT cells play a crucial role in vaccine immunogenicity, requiring the synergistic activation of IFN, cytokines, and signaling pathways. The study indicates that MAIT cells can enhance vaccine-induced T cell responses, with implications for vaccine design.
Article
Gastroenterology & Hepatology
Timothy Donnison, Joey McGregor, Senthil Chinnakannan, Claire Hutchings, Rob J. Center, Pantelis Poumbourios, Paul Klenerman, Heidi E. Drummer, Eleanor Barnes
Summary: This study aims to develop a vaccine that can generate both viral-specific B-cell and T-cell responses concurrently to target multiple HCV genotypes.