Alpha-synuclein supports type 1 interferon signalling in neurons and brain tissue

Alpha synuclein, the culprit in Parkinson disease, is required for normal immune function

(2022) Md Masud Alam et al.   Cell Reports

α-Synuclein A53T Binds to Transcriptional Adapter 2-Alpha and Blocks Histone H3 Acetylation

(2021) Ji-Yeong Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Toll-Like Receptor 2 Signaling and Current Approaches for Therapeutic Modulation in Synucleinopathies

(2018) Ian F. Caplan et al.   Frontiers in Pharmacology

Immunology of West Nile Virus Infection and the Role of Alpha-Synuclein as a Viral Restriction Factor

(2018) Kelsey E. Lesteberg et al.   VIRAL IMMUNOLOGY

Engineering synucleinopathy-resistant human dopaminergic neurons by CRISPR-mediated deletion of the SNCA gene

(2018) Yixi Chen et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

A Role for Neuronal Alpha-Synuclein in Gastrointestinal Immunity

(2017) Ethan Stolzenberg et al.   Journal of Innate Immunity

Holocranohistochemistry enables the visualization of α-synuclein expression in the murine olfactory system and discovery of its systemic anti-microbial effects

(2017) Julianna J. Tomlinson et al.   JOURNAL OF NEURAL TRANSMISSION

Lack of Neuronal IFN-β-IFNAR Causes Lewy Body- and Parkinson’s Disease-like Dementia

(2015) Patrick Ejlerskov et al.   CELL

Alpha-Synuclein Expression Restricts RNA Viral Infections in the Brain

(2015) Erica L. Beatman et al.   JOURNAL OF VIROLOGY

The relation between α-synuclein and microglia in Parkinson’s disease: Recent developments

(2015) V. Sanchez-Guajardo et al.   NEUROSCIENCE

The complex relationships between microglia, alpha-synuclein, and LRRK2 in Parkinson’s disease

(2015) J. Schapansky et al.   NEUROSCIENCE

IFIT1 Differentially Interferes with Translation and Replication of Alphavirus Genomes and Promotes Induction of Type I Interferon

(2015) Josephine M. Reynaud et al.   PLoS Pathogens

West Nile Virus Population Structure, Injury, and Interferon-Stimulated Gene Expression in the Brain From a Fatal Case of Encephalitis

(2015) Nathan D. Grubaugh et al.   Open Forum Infectious Diseases

A Viral RNA Structural Element Alters Host Recognition of Nonself RNA

(2014) J. L. Hyde et al.   SCIENCE

MHCII Is Required for  -Synuclein-Induced Activation of Microglia, CD4 T Cell Proliferation, and Dopaminergic Neurodegeneration

(2013) A. S. Harms et al.   JOURNAL OF NEUROSCIENCE

Preconditioning of Microglia by α-Synuclein Strongly Affects the Response Induced by Toll-like Receptor (TLR) Stimulation

(2013) Cintia Roodveldt et al.   PLoS One

Microglial Activation and Antioxidant Responses Induced by the Parkinson’s Disease Protein α-Synuclein

(2012) Dawn Béraud et al.   Journal of Neuroimmune Pharmacology

Quality assurance for polychromatic flow cytometry using a suite of calibration beads

(2012) Stephen P Perfetto et al.   Nature Protocols

Directed differentiation of human pluripotent stem cells to cerebral cortex neurons and neural networks

(2012) Yichen Shi et al.   Nature Protocols

West Nile virus growth is independent of autophagy activation

(2012) Erica Beatman et al.   VIROLOGY

Immune Responses to West Nile Virus Infection in the Central Nervous System

(2012) Hyelim Cho et al.   Viruses-Basel

Host Genetic Risk Factors for West Nile Virus Infection and Disease Progression

(2011) Abigail W. Bigham et al.   PLoS One

Glial Innate Immunity Generated by Non-Aggregated Alpha-Synuclein in Mouse: Differences between Wild-type and Parkinson's Disease-Linked Mutants

(2010) Cintia Roodveldt et al.   PLoS One

 -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro

(2010) J. Burre et al.   SCIENCE

Genetic Variation in OAS1 Is a Risk Factor for Initial Infection with West Nile Virus in Man

(2009) Jean K. Lim et al.   PLoS Pathogens

Dysregulation of TLR3 Impairs the Innate Immune Response to West Nile Virus in the Elderly

(2008) K.-F. Kong et al.   JOURNAL OF VIROLOGY

Red Blood Cells Are the Major Source of Alpha-Synuclein in Blood

(2008) Robin Barbour et al.   Neurodegenerative Diseases