HIV Protease Inhibitors Disrupt Lipid Metabolism by Activating Endoplasmic Reticulum Stress and Inhibiting Autophagy Activity in Adipocytes

The protease inhibitor atazanavir triggers autophagy and mitophagy in human preadipocytes

(2012) Lara Gibellini et al.   AIDS

The Cellular Pharmacokinetics of HIV Protease Inhibitors: Current Knowledge and Future Perspectives

(2012) Weibin Zha et al.   CURRENT DRUG METABOLISM

Effects of ritonavir-boosted darunavir, atazanavir and lopinavir on adipose functions and insulin sensitivity in murine and human adipocytes

(2011) Emilie Capel et al.   ANTIVIRAL THERAPY

Adipose tissue biology and HIV-infection

(2011) Marta Giralt et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Cell disposition of raltegravir and newer antiretrovirals in HIV-infected patients: high inter-individual variability in raltegravir cellular penetration

(2011) A. Fayet Mello et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Adipose Tissue, Inflammation and Atherosclerosis

(2011) Birgit Gustafson   Journal of Atherosclerosis and Thrombosis

Distinct Autophagosomal-Lysosomal Fusion Mechanism Revealed by Thapsigargin-Induced Autophagy Arrest

(2011) Ian G. Ganley et al.   MOLECULAR CELL

Regulation of lipid droplets by autophagy

(2011) Hanqing Dong et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Macroautophagy Is Regulated by the UPR–Mediator CHOP and Accentuates the Phenotype of SBMA Mice

(2011) Zhigang Yu et al.   PLoS Genetics

Autophagy in health and disease. 2. Regulation of lipid metabolism and storage by autophagy: pathophysiological implications

(2010) Mark J. Czaja   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Pharmacokinetics and safety of twice-daily atazanavir 300 mg and raltegravir 400 mg in healthy individuals

(2010) Li Zhu et al.   ANTIVIRAL THERAPY

Autophagy

(2010) Lijun Zhou et al.   Autophagy

Free fatty acids stimulate autophagy in pancreatic β-cells via JNK pathway

(2010) Koji Komiya et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome — An allostatic perspective

(2010) Sam Virtue et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Differential Effects of Efavirenz and Lopinavir/Ritonavir on Human Adipocyte Differentiation, Gene Expression and Release of Adipokines and Pro-Inflammatory Cytokines.

(2010) Jose M. Gallego-Escuredo et al.   CURRENT HIV RESEARCH

Pharmacokinetics of plasma lopinavir/ritonavir following the administration of 400/100 mg, 200/150 mg and 200/50 mg twice daily in HIV-negative volunteers

(2010) A. Jackson et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Fenofibrate Reduces Systemic Inflammation Markers Independent of Its Effects on Lipid and Glucose Metabolism in Patients with the Metabolic Syndrome

(2010) Renata Belfort et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Relationship Between Plasma Protease Inhibitor Concentrations and Lipid Elevations in HIV Patients on a Double-Boosted Protease Inhibitor Regimen (Saquinavir/Lopinavir/Ritonavir)

(2010) Martin S. Rhee et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Lipodystrophy: pathophysiology and advances in treatment

(2010) Christina G. Fiorenza et al.   Nature Reviews Endocrinology

Prion Protein Misfolding Affects Calcium Homeostasis and Sensitizes Cells to Endoplasmic Reticulum Stress

(2010) Mauricio Torres et al.   PLoS One

Quantitative Monitoring of Lipid Accumulation Over Time in Cultured Adipocytes as Function of Culture Conditions: Toward Controlled Adipose Tissue Engineering

(2010) Shira Or-Tzadikario et al.   TISSUE ENGINEERING PART C-METHODS

Differential gene expression indicates that ‘buffalo hump’ is a distinct adipose tissue disturbance in HIV-1-associated lipodystrophy

(2009) Jordi P Guallar et al.   AIDS

Effect of atazanavir and ritonavir on the differentiation and adipokine secretion of human subcutaneous and omental preadipocytes

(2009) Simon P Jones et al.   AIDS

Lopinavir co-induces insulin resistance and ER stress in human adipocytes

(2009) Mansour Djedaini et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Acute hyperinsulinaemia and hyperlipidaemia modify circulating adiponectin and its oligomers

(2009) Thomas Bobbert et al.   CLINICAL ENDOCRINOLOGY

HIV Protease Inhibitors Induce Endoplasmic Reticulum Stress and Disrupt Barrier Integrity in Intestinal Epithelial Cells

(2009) Xudong Wu et al.   GASTROENTEROLOGY

The HIV protease inhibitor saquinavir induces endoplasmic reticulum stress, autophagy, and apoptosis in ovarian cancer cells

(2009) Karen McLean et al.   GYNECOLOGIC ONCOLOGY

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

From chronic overnutrition to insulin resistance: The role of fat-storing capacity and inflammation

(2009) L. Lionetti et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Association betweenABCC2polymorphism and lopinavir accumulation in peripheral blood mononuclear cells of HIV-infected patients

(2009) Laure Elens et al.   PHARMACOGENOMICS

The Role of Protease Inhibitors in the Pathogenesis of HIV-Associated Lipodystrophy: Cellular Mechanisms and Clinical Implications

(2009) Oliver P. Flint et al.   TOXICOLOGIC PATHOLOGY

The life of lipid droplets

(2008) Tobias C. Walther et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Is adiposopathy (sick fat) an endocrine disease?

(2008) H. E. Bays et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

Efficacy and tolerability of a fosamprenavir-ritonavir-based versus a lopinavir-ritonavir-based antiretroviral treatment in 82 therapy-naïve patients with HIV-1 infection

(2008) L Calza et al.   INTERNATIONAL JOURNAL OF STD & AIDS

Adipocytokines and the Metabolic Complications of Obesity

(2008) Neda Rasouli et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM