Article
Clinical Neurology
Christophe Moderie, Philippe Boudreau, Ari Shechter, Paul Lesperance, Diane B. Boivin
Summary: The study found that intervention with exogenous melatonin increased urinary aMt6, reduced sleep onset latency, decreased slow-wave sleep, increased Stage 2 sleep, and improved symptoms in PMDD patients. Circadian parameters derived from 24-hour plasma melatonin and CBT did not differ significantly between intervention and baseline conditions, except for an increased melatonin mesor in the intervention condition. Ovarian hormones remained comparable between the two conditions.
Article
Clinical Neurology
Christophe Moderie, Philippe Boudreau, Ari Shechter, Paul Lesperance, Diane B. Boivin
Summary: The study suggests that exogenous melatonin can increase urinary melatonin levels, reduce sleep onset latency, decrease slow-wave sleep, and increase stage 2 sleep in women with premenstrual dysphoric disorder (PMDD). Additionally, melatonin intervention improves mood and symptoms in these patients.
Review
Endocrinology & Metabolism
Jordan C. Barone, Mitchell P. Butler, Ashley Ross, Anna Patterson, Melissa Wagner-Schuman, Tory A. Eisenlohr-Moul
Summary: Cyclic hormonal variations during the menstrual cycle contribute to multiple central nervous system disorders, such as premenstrual mood disorder, menstrual migraine, and catamenial epilepsy. However, these fields have operated independently without systematic communication. This scoping review examines existing research studies in these disorders to outline hormonal manipulation trials and identify gaps in the literature. Despite the heterogeneity of treatments and study designs, there is significant overlap in the neuroendocrine-based hormone sensitivity among these menstrual cycle-related disorders.
FRONTIERS IN NEUROENDOCRINOLOGY
(2023)
Article
Psychology, Clinical
Sibel Nayman, Theresa Beddig, Iris Reinhard, Christine Kuehner
Summary: In women with premenstrual dysphoric disorder (PMDD), habitual mindfulness and reappraisal have a positive effect on momentary mood, but do not protect against premenstrual mood deterioration. Additionally, habitual mindfulness seems to buffer blunted cortisol activity in women with PMDD, especially during the menstrual phase.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Tory Eisenlohr-Moul, Madeline Divine, Katja Schmalenberger, Laura Murphy, Brett Buchert, Melissa Wagner-Schuman, Alyssa Kania, Sabina Raja, Adam Bryant Miller, Jordan Barone, Jaclyn Ross
Summary: This study found high rates of self-injurious thoughts and behaviors in individuals reporting a diagnosis of PMDD, emphasizing the need for further research on understanding and preventing STBs in PMDD. Clinical practice guidelines for PMDD should address comorbidities and include frequent screenings for suicide risk. STBs should be considered for inclusion in future updates of the DSM PMDD diagnostic criteria.
Article
Psychiatry
Liisa Hantsoo, Shivani Rangaswamy, Kristin Voegtline, Rodion Salimgaraev, Liudmila Zhaunova, Jennifer L. Payne
Summary: Premenstrual symptoms, including food cravings, mood swings, and fatigue, affect a large proportion of women worldwide. Age is associated with an increase in certain symptoms, but mood symptoms remain consistent across age groups. Premenstrual symptoms can significantly impact the everyday lives of some women.
ARCHIVES OF WOMENS MENTAL HEALTH
(2022)
Article
Psychiatry
Yola El Dahr, Taiane de Azevedo Cardoso, Sabrina K. Syan, Luisa Caropreso, Luciano Minuzzi, Mara Smith, Olivia R. Allega, Maha El-Tayebani, Jeronimo Mendes-Ribeiro, Luciano Dias de Mattos Souza, Ricardo Azevedo da Silva, Thaise Campos Mondin, Fernanda Pedrotti Moreira, Flavio Kapczinski, Karen Jansen, Benicio N. Frey
Summary: We investigated whether women diagnosed with comorbid bipolar disorder and premenstrual dysphoric disorder experience higher disruptions in biological rhythms. Two independent study samples were used. The results showed that all diagnostic groups had greater disruptions in biological rhythms compared to controls. Women with bipolar disorder experienced greater disruption in overall biological rhythms and in sleep, activity, and eating patterns compared to those with premenstrual dysphoric disorder. These findings suggest that the comorbidity between bipolar disorder and premenstrual dysphoric disorder may have a significant impact on biological rhythms.
ARCHIVES OF WOMENS MENTAL HEALTH
(2022)
Article
Neurosciences
Inbal Reuveni, Rotem Dan, Laura Canetti, Atira S. Bick, Ronen Segman, Moria Azoulay, Carmel Kalla, Omer Bonne, Gadi Goelman
Summary: Premenstrual dysphoric disorder (PMDD) in women is associated with abnormal brain network connectivity, specifically decreased default mode network connectivity, increased salience network connectivity, and decreased central executive network connectivity.
BIOLOGICAL PSYCHIATRY
(2023)
Review
Cell Biology
Yihao Tian, Jian Ming
Summary: Osteoporosis is a common and impactful disease with no known treatments. Recent studies have shown that melatonin can be used to treat osteoporosis by regulating biological rhythms in bone tissue, promoting bone formation and inhibiting bone resorption. This review provides an overview of these processes and offers treatment and management strategies for individuals with osteoporosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Soyhan Bagci, Astrid Wieduwilt, Ebru Aileen Alsat, Jana Blickwedel, Brigitte Strizek, Christian Di Battista, Agnes Lachner, Herbert Plischke, Tamene Melaku, Andreas Mueller
Summary: This study aims to evaluate the effect of environmental lighting conditions on melatonin production in pregnant women with reduced mobility during hospitalization. The results show that installing biodynamic lighting systems in patient rooms can maintain nocturnal melatonin production in pregnant women.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Mingzhou Gao, Dongmei Gao, Hui Sun, Xunshu Cheng, Li An, Mingqi Qiao
Summary: The global scientific output of research on PMS and PMDD has been increasing from 1945 to 2018, with menstrual cycle, depression, and ovarian hormones identified as research hotspots, while prevalence, systematic review, anxiety and depression, and young women are considered the research frontiers.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Psychiatry
Aysenur Turan, Iffet Guler Kaya, Hilal Basak Cakir, Secil Topaloglu
Summary: This study investigated the prevalence and correlates of PMS and PMDD in 1125 female college students aged 18-25. The findings showed that approximately 49.2% of participants had PMS and 48.0% had PMDD. Blood type B, lack of physical activity, longer menstrual cycle duration, and higher caffeine intake were associated with PMS and PMDD.
INTERNATIONAL JOURNAL OF PSYCHIATRY IN MEDICINE
(2023)
Article
Genetics & Heredity
Christos M. Polymeropoulos, Justin Brooks, Emily L. Czeisler, Michaela A. Fisher, Mary M. Gibson, Kailey Kite, Sandra P. Smieszek, Changfu Xiao, Sarah H. Elsea, Gunther Birznieks, Mihael H. Polymeropoulos
Summary: The study confirmed that tasimelteon significantly improved sleep quality and total sleep time in patients with Smith-Magenis syndrome.
GENETICS IN MEDICINE
(2021)
Review
Nutrition & Dietetics
Asuka Ishihara, Amber B. Courville, Kong Y. Chen
Summary: Light is crucial for many life forms and the natural light-dark cycle has been a dominant factor for circadian rhythms throughout human evolution. Artificial light has altered human activity patterns and allowed for extended periods of wakefulness outside of natural day-night cycles. However, increased exposure to light at inappropriate times or a reduced range of light between day and night can have negative effects on human health.
Review
Neurosciences
Mayuri Shukla, Bruno Vincent
Summary: The synthesis and release of melatonin in the brain regulate various physiological functions. The decline in melatonin levels with aging leads to alterations in circadian rhythm components and increases susceptibility to develop neurodegenerative diseases. Circadian rhythm disturbances impact memory formation and recall. The molecular machinery of the cell cycle has a regulatory role in neurodegenerative disorders such as Alzheimer's disease. Understanding the mechanisms of action of melatonin in regulating circadian rhythm, cell cycle components, and neurogenesis may provide new therapeutic targets for Alzheimer's disease.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Behavioral Sciences
Talea Cornelius, Jeffrey L. Birk, Ari Shechter
Summary: Patients and their partners both experience adverse mental and physical health outcomes after hospital discharge, and these outcomes may be explained by hospital stressors. This study found that greater times and nights of patient hospitalization were associated with increased partner depression, but not with changes in partner self-reported health.
BEHAVIORAL MEDICINE
(2022)
Article
Clinical Neurology
Franchesca Diaz, Talea Cornelius, Sean Bramley, Hadiah Venner, Kaitlin Shaw, Melissa Dong, Patrick Pham, Cara L. McMurry, Diane E. Cannone, Alexandra M. Sullivan, Sung A. J. Lee, Joseph E. Schwartz, Ari Shechter, Marwah Abdalla
Summary: During the COVID-19 pandemic in New York City, a significant number of healthcare workers experienced symptoms of disturbed sleep and psychological distress, with insomnia and short sleep duration being associated with higher levels of acute stress, depression, and anxiety symptoms. Sleep interventions may be important for reducing psychological distress among healthcare workers.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Environmental Sciences
Ari Shechter, Codruta Chiuzan, Yimeng Shang, Gavin Ko, Franchesca Diaz, Hadiah K. Venner, Kaitlin Shaw, Diane E. Cannone, Cara L. McMurry, Alexandra M. Sullivan, Reynaldo R. Rivera, Courtney Vose, Peter A. Shapiro, Marwah Abdalla
Summary: This study investigated the incidence, prevalence, and factors associated with posttraumatic stress disorder (PTSD) symptoms among healthcare workers in New York City after the first wave of the COVID-19 pandemic. The results showed that PTSD symptoms improved over a 3-month period, but one-fourth of the healthcare workers still had an increased risk for PTSD at 10 weeks. Being female, working as a nurse, and working in a COVID-19-focused setting were associated with increased odds of PTSD symptoms at 10 weeks.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Clinical Neurology
Michael W. Otto, Rebecca E. Lubin, David Rosenfield, Daniel J. Taylor, Jeffrey L. Birk, Colin A. Espie, Ari Shechter, Donald Edmondson, Justin M. Shepherd, Michael J. Zvolensky
Summary: This study examined the association between psychosocial factors and self-reported sleep duration and quality in a diverse sample of adults. The findings suggest that rumination amplifies the negative sleep consequences of race- and ethnicity-related stressors, highlighting the importance of addressing rumination as a potential treatment target for sleep disparities.
Review
Cardiac & Cardiovascular Systems
Joseph Belloir, Nour Makarem, Ari Shechter
Summary: There is a relationship between sleep and circadian factors with cardiovascular disease risk. Sleep duration, insomnia, sleep regularity, multidimensional sleep health, and circadian factors like chronotype and social jetlag are all related to cardiovascular disease risk. Interventions focusing on sleep can help reduce cardiovascular disease risk and burden. Sleep is recognized as an integral component of cardiovascular health.
CURRENT CARDIOLOGY REPORTS
(2022)
Editorial Material
Medicine, General & Internal
Ari Shechter, Allison A. Norful
Review
Clinical Neurology
Evan Hale, Elie Gottlieb, John Usseglio, Ari Shechter
Summary: Despite improvements in survival rates, the risk of recurrent events after stroke remains high. Sleep disturbances are both a contributor to and a consequence of stroke, making the relationship complex. This study aimed to examine the association between sleep disturbance and recurrent major acute coronary events or all-cause mortality in stroke survivors. The analysis of 32 studies found a positive relationship between obstructive sleep apnea (OSA) and recurrent events/mortality, while the findings on positive airway pressure (PAP) treatment for OSA were mixed.
Article
Health Care Sciences & Services
Mark Butler, Stefani D'Angelo, Alexandra Perrin, Jordyn Rodillas, Danielle Miller, Lindsay Arader, Thevaa Chandereng, Ying Kuen Cheung, Ari Shechter, Karina W. Davidson
Summary: This study aims to evaluate the feasibility, acceptability, and effectiveness of personalized interventions for improving sleep quality. Participants will receive different interventions of 3 mg melatonin, 0.5 mg melatonin, and placebo based on random allocation. The effectiveness of the intervention will be assessed through self-reported sleep quality and duration, as well as Fitbit tracker-measured sleep duration and efficiency. The trial is currently ongoing.
JMIR RESEARCH PROTOCOLS
(2023)
Meeting Abstract
Clinical Neurology
Joseph Belloir, Tsion Firew, Maody Miranda, Kaitlin Shaw, Joseph Schwartz, Nour Makarem, Kathryn Marcon, Katharina Schultebraucks, Alexandra Sullivan, Bernard Chang, Ari Shechter
Meeting Abstract
Clinical Neurology
Nour Makarem, Charles German, Zhanhao Zhang, Keith Diaz, Priya Palta, Dustin Duncan, Cecilia Castro-Diehl, Ari Shechter
Meeting Abstract
Clinical Neurology
Allison Norful, Joseph Belloir, Tsion Firew, Maody Miranda, Kaitlin Shaw, Joseph Schwartz, Kathryn Macron, Katharina Schultebraucks, Alexandra Sullivan, Bernard Chang, Ari Shechter
Meeting Abstract
Psychiatry
Alison Trainor, Margaret E. Murdock, Cara L. McMurry, Ian M. Kronish, Ari Shechter
PSYCHOSOMATIC MEDICINE
(2022)
Meeting Abstract
Clinical Neurology
Franchesca Diaz, Sean Bramley, Hadiah Venner, Kaitlin Shaw, Cara McMurry, Talea Cornelius, Joseph Schwartz, Ari Shechter, Marwah Abdalla
Meeting Abstract
Clinical Neurology
Christophe Moderie, Ari Shechter, Paul Lesperance, Diane Boivin
Meeting Abstract
Clinical Neurology
Ari Shechter, Adam Rosenfeld, Bernard Chang, Allison Norful