Article
Multidisciplinary Sciences
Yufei Lan, Tao Yang, Qu Yue, Zhao Wang, Xiangyang Zhong, Xin Luo, Boming Zuo, Manqing Zhang, Tianci Zeng, Boyang Liu, Hongbo Guo
Summary: This study demonstrated, for the first time, that amplifying IRP1 signals can reverse TMZ resistance and suppress tumor growth in vivo by inhibiting NFKB2 in the noncanonical NF-kappa B signaling pathway. Additionally, we identified that NFKB2 affects the TMZ sensitivity of GBM by modulating the expression of LCN2 and FPN1. In conclusion, this study reveals the role of the IRP1/NFKB2 pathway in regulating the LCN2/FPN1 signaling axis during the progression of TMZ resistance, suggesting a potential innovative therapeutic strategy for GBM.
Article
Oncology
Charlotte Roy, Sylvie Avril, Claire Legendre, Benedicte Lelievre, Honorine Vellenriter, Sebastien Boni, Jerome Cayon, Catherine Guillet, Yannick Guilloux, Michel Cherel, Francois Hindre, Emmanuel Garcion
Summary: GB cells depend on iron metabolism and pathways related to it, and iron is related to the sensitivity of GB cells to radiation therapy. The study found that ceruloplasmin (CP) has functional effects on GB cell response to beam radiation, and its overexpression increases the effectiveness of radiation therapy.
Article
Biology
Luca Tirinato, Maria Grazia Marafioti, Francesca Pagliari, Jeannette Jansen, Ilenia Aversa, Rachel Hanley, Clelia Nistico, Daniel Garcia-Calderon, Geraldine Genard, Joana Filipa Guerreiro, Francesco Saverio Costanzo, Joao Seco
Summary: The study identified that radioresistant cancer cells in breast, bladder, lung, neuroglioma, and prostate showed an increase in lipid droplet (LD) number, with cells containing higher LDs exhibiting greater clonogenic potential after irradiation. The researchers found a close connection between LD content and iron metabolism, particularly with the presence of the ferritin heavy chain (FTH1). Silencing the FTH1 gene in breast and lung cancer cells reduced LD numbers and increased radiosensitivity, while FTH1 overexpression and iron-chelating treatment restored LD levels and radioresistance.
Article
Biology
Sang Hoon Kim, Sun Young Kim, Jaihyunk Ryu, Yeong Deuk Jo, Hong-Il Choi, Jin-Baek Kim, Si-Yong Kang
Summary: The study found that some plant species exhibit resistance to proton ions and gamma-rays, while others are susceptible, with differences in radiosensitivity observed among different plant families and genome sizes. The biological effectiveness of proton ions was greater than that of gamma-rays in inducing mutations in 16 plant species.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2021)
Article
Hematology
Nunziata Maio, De-Liang Zhang, Manik C. Ghosh, Anshika Jain, Anna M. SantaMaria, Tracey A. Rouault
Summary: Humans and other vertebrates have evolved effective mechanisms to maintain iron balance through the regulation of iron concentration and utilization at the cellular and systemic levels, involving iron-regulatory hormone hepcidin and iron regulatory proteins.
SEMINARS IN HEMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yunjia Li, Mengchen Qin, Weichao Zhong, Chang Liu, Guanghui Deng, Menghan Yang, Junjie Li, Haixin Ye, Hao Shi, Chaofeng Wu, Haiyan Lin, Yuyao Chen, Shaohui Huang, Chuying Zhou, Zhiping Lv, Lei Gao
Summary: The study indicates the important role of RAGE in alcoholic liver disease (ALD). Deficiency or inhibition of RAGE can alleviate hepatic inflammation and oxidative stress, as well as affect iron metabolism pathways, thereby improving liver injury.
Article
Immunology
Vanesa Garrido-Rodriguez, Ana Isabel Alvarez-Rios, Israel Olivas-Martinez, Maria del Mar Pozo-Balado, Angel Bulnes-Ramos, Manuel Leal, Yolanda Maria Pacheco
Summary: Virologically suppressed chronic HIV-infected patients under successful antiretroviral treatment exhibit altered levels of iron metabolism modulators, suggesting a complex functional iron deficiency.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Meghan May, Deborah Barlow, Radwa Ibrahim, Karen L. Houseknecht
Summary: Atypical antipsychotic (AA) medications are associated with an increased incidence of non-alcoholic fatty liver disease (NAFLD), but the underlying mechanisms are not fully understood. This study used multi-omic datasets from preclinical murine models and clinical patients to identify differentially expressed traits related to iron homeostasis and NAFLD pathways, providing mechanisms for the development of AA-associated NAFLD and dysregulated iron homeostasis.
Article
Medicine, Research & Experimental
Tolani F. Olonisakin, Tomeka Suber, Shekina Gonzalez-Ferrer, Zeyu Xiong, Hernan F. Penaloza, Rick van der Geest, Yuting Xiong, David O. Osei-Hwedieh, Jesus Tejero, Matthew R. Rosengart, Wendy M. Mars, Daria Van Tyne, Andreas Perlegas, Samuel Brashears, Daniel B. Kim-Shapiro, Mark T. Gladwin, Michael A. Bachman, Eldad A. Hod, Claudette St Croix, Yulia Y. Tyurina, Valerian E. Kagan, Rama K. Mallampalli, Anuradha Ray, Prabir Ray, Janet S. Lee
Summary: Macrophages play a crucial role in heme metabolism and immune defense, but excessive heme can lead to immunosuppression. The clearance of senescent RBCs by macrophages impairs immunity and is independent of bacterial iron acquisition.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Biochemistry & Molecular Biology
Tatiana A. A. Pavlenko, Andrei Y. Y. Roman, Olga A. A. Lytkina, Nadezhda E. E. Pukaeva, Martha W. W. Everett, Iuliia S. S. Sukhanova, Vladislav O. O. Soldatov, Nina G. G. Davidova, Natalia B. B. Chesnokova, Ruslan K. K. Ovchinnikov, Michail S. S. Kukharsky
Summary: Dysfunction of gamma-synuclein is involved in glaucoma-related pathophysiological changes, including dysregulation of intraocular pressure. Autoantibodies to gamma-synuclein were detected in the blood serum of some patients with primary open-angle glaucoma (POAG), suggesting a possible link between gamma-synuclein dysfunction and glaucoma. Knockout mice studies further support this association, as they showed decreased intraocular pressure and altered protein concentrations in tear fluid.
Article
Gastroenterology & Hepatology
Qifeng Deng, Sidi Yang, Lanqing Sun, Kedi Dong, Yuanyuan Li, Shuyan Wu, Rui Huang
Summary: SpvB facilitates Salmonella to scavenge iron from the host by modulating the hepcidin-ferroportin axis, while also promoting the production of proinflammatory molecules via highly upregulating TREM-1 signaling. Targeting TREM-1 might provide a potential therapeutic strategy to prevent or alleviate Salmonella pathogenesis.
Article
Medicine, Research & Experimental
Jordan Kho, Urszula Polak, Ming-Ming Jiang, John D. Odom, Jill V. Hunter, Saima M. Ali, Lindsay C. Burrage, Sandesh C. S. Nagamani, Robia G. Pautler, Hannah P. Thompson, Akihiko Urayama, Zixue Jin, Brendan Lee
Summary: Nitric oxide (NO) is a critical signaling molecule implicated in neurocognitive diseases. Excessive and insufficient NO production have both been linked to pathology. This study investigates the effects of NO on brain endothelial cells and the blood-brain barrier using a model of NO deficiency. The results suggest that ASL-mediated NO synthesis is necessary for maintaining brain microvascular endothelial cell functions and BBB integrity.
Article
Physiology
James A. Votava, Shannon R. Reese, Kathryn M. Deck, Christopher P. Nizzi, Sheila A. Anderson, Arjang Djamali, Richard S. Eisenstein
Summary: This study reveals the dysregulation of iron metabolism and hypoxia signaling in unilateral obstructive nephropathy. The expression of iron regulatory proteins (IRPs), key regulators of cellular iron metabolism, and their target proteins, including the iron uptake protein transferrin receptor 1 and iron storage proteins ferritins, is significantly altered. This suggests the involvement of IRPs in previously observed changes in iron metabolism in progressive kidney disease. Hypoxia signaling is disrupted and appears to dominate the function of IRP1 in regulating erythropoietin expression.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2022)
Article
Hematology
Marta Lopes, Tiago L. Duarte, Maria J. Teles, Laura Mosteo, Sergio Chacim, Eliana Aguiar, Joana Pereira-Reis, Monica Oliveira, Andre M. N. Silva, Nuno Goncalves, Gabriela Martins, Isabella Y. Kong, Magnus Zethoven, Stephin Vervoort, Sandra Martins, Miguel Quintela, Edwin D. Hawkins, Fernanda Trigo, Joao T. Guimaraes, Jose M. Mariz, Graca Porto, Delfim Duarte
Summary: Research indicates that AML patients have a unique iron profile, with high TSAT differing from other cancer types and anemia of inflammation. The loss of erythroblasts induced by AML leads to iron redistribution and increased TSAT. TSAT may be a significant prognostic marker in AML.
Article
Environmental Sciences
Biao He, Zhihao Liu, Yuedi Wang, Lanchun Cheng, Qiqian Qing, Jiaxin Duan, Jinshan Xu, Xiaoqun Dang, Zeyang Zhou, Zhi Li
Summary: Imidacloprid, a neonicotinoid pesticide, was found to increase reactive oxygen species (ROS) and Fe2+ levels in bees, leading to higher mortality. Additionally, the upregulation of ferritin gene induced by imidacloprid exacerbates iron overload, ultimately resulting in elevated ROS activation and mortality in bees.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)