Anti-Diabetic Efficacy and Impact on Amino Acid Metabolism of GRA1, a Novel Small-Molecule Glucagon Receptor Antagonist

Hypoglycemia: Still the Limiting Factor in the Glycemic Management of Diabetes

(2013) Philip Cryer   Endocrine Practice

Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover

(2012) Roger H. Unger et al.   JOURNAL OF CLINICAL INVESTIGATION

Polyomic profiling reveals significant hepatic metabolic alterations in glucagon-receptor (GCGR) knockout mice: implications on anti-glucagon therapies for diabetes

(2011) Jianxin Yang et al.   BMC GENOMICS

Glucagonoma and the glucagonoma syndrome - cumulative experience with an elusive endocrine tumour

(2011) Roy Eldor et al.   CLINICAL ENDOCRINOLOGY

Glucagon Receptor Knockout Prevents Insulin-Deficient Type 1 Diabetes in Mice

(2011) Y. Lee et al.   DIABETES

Glucagon antagonism as a potential therapeutic target in type 2 diabetes

(2011) J. I. Bagger et al.   DIABETES OBESITY & METABOLISM

Chronic treatment with a glucagon receptor antagonist lowers glucose and moderately raises circulating glucagon and glucagon-like peptide 1 without severe alpha cell hypertrophy in diet-induced obese mice

(2011) J. Mu et al.   DIABETOLOGIA

A survey of small molecule glucagon receptor antagonists from recent patents (2006 – 2010)

(2011) Dong-Ming Shen et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Discovery of novel, potent, selective, and orally active human glucagon receptor antagonists containing a pyrazole core

(2010) Dong-Ming Shen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Genome-wide Expression Profiling Revealed Peripheral Effects of Cannabinoid Receptor 1 Inverse Agonists in Improving Insulin Sensitivity and Metabolic Parameters

(2010) W. Zhao et al.   MOLECULAR PHARMACOLOGY

Protein and energy metabolism in type 1 diabetes

(2009) Sadie L. Hebert et al.   CLINICAL NUTRITION

Fully Human Monoclonal Antibodies Antagonizing the Glucagon Receptor Improve Glucose Homeostasis in Mice and Monkeys

(2009) H. Yan et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Discovery of potent, orally active benzimidazole glucagon receptor antagonists

(2008) Ronald M. Kim et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS