Article
Biochemistry & Molecular Biology
Hazel Dunbar, Ian J. Hawthorne, Courteney Tunstead, Michelle E. Armstrong, Seamas C. Donnelly, Karen English
Summary: Macrophage migration inhibitory factor (MIF) expression is affected by a functional promoter polymorphism, with the number of CATT repeats correlating to MIF expression level. In a pre-clinical model of allergic asthma, mice with increasing CATT repeats (CATT(5) and CATT(7)) showed varying degrees of airway inflammation. The potent MIF inhibitor SCD-19 was able to mitigate the pathophysiology observed in CATT(7) mice, indicating the important role of endogenous human MIF expression in airway inflammation severity.
Article
Biochemistry & Molecular Biology
Hazel Dunbar, Ian J. Hawthorne, Courteney Tunstead, Michelle E. Armstrong, Seamas C. Donnelly, Karen English
Summary: The expression of macrophage migration inhibitory factor (MIF) is controlled by a functional promoter polymorphism, where the number of tetranucleotide repeats (CATTn) corresponds to the level of MIF expression. Using a pre-clinical model of allergic asthma, novel humanized MIF mice with increasing CATT repeats (CATT5 and CATT7) were employed to study airway inflammation. The results showed that high expression of human MIF in CATT7 mice led to a severe asthma phenotype, which could be mitigated by the MIF inhibitor SCD-19. This study provides a reproducible model for studying asthma airway remodeling and suggests a potential role of MIF in driving this process.
Article
Pediatrics
A. Brzozowska, K. Woicka-Kolejwa, J. Jerzynska, P. Majak, I Stelmach
Summary: The objective of this study was to identify the clinical and immunological parameters associated with the development or regression of persistent asthma. The results showed that allergic rhinitis and sensitization to house dust mite were closely related to the persistence of childhood asthma.
INDIAN JOURNAL OF PEDIATRICS
(2022)
Article
Immunology
Akira Hasegawa, Daichi Utsumi, Kaare Lund, Mitsuhiro Okano, Katsuyo Ohashi-Doi, Kimihiro Okubo
Summary: In Japanese HDM allergic rhinitis patients without asthma, there is a high prevalence of allergic sensitization to the HDM major allergens Der p 1, Der p 2, and Der p 23, with a significantly higher prevalence of Der p 23 sensitization in the younger age group. However, there was no significant correlation found between AR symptom scores and concentration of s-IgE towards Der p extract and any of the three HDM major allergens in this population.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Allergy
Saliha Ait Yahia, Camille Audousset, Daniel Alvarez-Simon, Han Vorng, Dieudonnee Togbe, Philippe Marquillies, Myriam Delacre, Stephanie Rose, Helene Bouscayrol, Aline Rifflet, Valerie Quesniaux, Ivo Gomperts Boneca, Mathias Chamaillard, Anne Tsicopoulos
Summary: The study found that NOD1-dependent sensing of gram-negative bacteria associated with HDM exacerbates the severity of experimental asthma, suggesting that inhibiting the NOD1 signaling pathway may be a therapeutic approach to treating asthma.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Immunology
Matheus Fonseca Aarestrup, Paula Fonseca Aarestrup, Mariana Senff de Andrade, Beatriz Juliao Aarestrup, Akinori Cardozo Nagato, Fernando Monteiro Aarestrup
Summary: Research has shown that allergic patients undergoing house dust mite SLIT generally have a high perception of satisfaction regarding treatment effectiveness, improvement in daily activities, cost-benefit balance, and overall satisfaction.
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
(2021)
Article
Environmental Sciences
Reiji Kojima, Ryoji Shinohara, Megumi Kushima, Sayaka Horiuchi, Sanae Otawa, Kunio Miyake, Hiroshi Yokomichi, Yuka Akiyama, Tadao Ooka, Zentaro Yamagata
Summary: The association between endotoxin and allergic rhinitis is inconclusive. This study found that in a non-farming setting, both endotoxin and house dust mite allergens in dust were associated with an increased risk of house dust mite sensitization, but not with allergic rhinitis.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Allergy
Mariana Farraia, Ines Paciencia, Francisca Castro Mendes, Joao Cavaleiro Rufo, Mohamed H. Shamji, Ioana Agache, Andre Moreira
Summary: This study compared the cost-effectiveness of allergen immunotherapy (AIT) to standard treatment in children with allergic asthma. The results showed that AIT, especially when administered subcutaneously, was cost effective in reducing asthma exacerbations and medication use.
Article
Respiratory System
Laura Tamasauskiene, Vilte Marija Gintauskiene, Daina Bastyte, Brigita Sitkauskiene
Summary: This study suggests that IL-22 may have an anti-inflammatory effect in patients with persistent allergic airway diseases caused by house dust mite. The levels of IL-22 were found to be higher in patients compared to healthy individuals, with positive correlations between IL-22 and IL-10 as well as IL-13. Additionally, IL-22 in nasal lavage showed a significant positive correlation with IL-10 in the lavage fluid.
BMC PULMONARY MEDICINE
(2021)
Article
Immunology
Verena M. Merk, Truong San Phan, Alice Wiedmann, Rowan S. Hardy, Gareth G. Lavery, Thomas Brunner
Summary: The local synthesis of glucocorticoids in the lung plays an important role in the regulation of allergic airway inflammation, particularly in HDM-induced airway hypersensitivity, by controlling Toll-like receptor 4 signaling and cytokine/chemokine secretion to influence Th17-type immune response.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Amena Aktar, Lianyu Shan, Latifa Koussih, Mohamed S. Almiski, Sujata Basu, Andrew Halayko, Ifeoma Okwor, Jude E. Uzonna, Abdelilah S. Gounni
Summary: The Sema3E/plexinD1 signaling pathway in interstitial macrophages regulates airway inflammation, airway resistance, and tissue remodeling in house dust mite-induced allergic asthma. Reduced IL-10 expression by plexinD1-deficient macrophages may contribute to the exacerbation of these allergic asthma features.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Immunology
Jingyu Ma, Miaomiao Han, Di Yang, Tingting Zheng, Ran Hu, Bin Wang, Youqiong Ye, Junling Liu, Gonghua Huang
Summary: This study shows that the absence of Vps33B in DCs exacerbates Th2-mediated allergic lung inflammation, revealing the regulatory role of cross-talk between DCs and CD4(+) T cells in the pathogenesis of allergic asthma.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Respiratory System
Tsutomu Saito, Tomohiro Ichikawa, Tadahisa Numakura, Mitsuhiro Yamada, Akira Koarai, Naoya Fujino, Koji Murakami, Shun Yamanaka, Yusaku Sasaki, Yorihiko Kyogoku, Koji Itakura, Hirohito Sano, Katsuya Takita, Rie Tanaka, Tsutomu Tamada, Masakazu Ichinose, Hisatoshi Sugiura
Summary: This study found that PGC-1 alpha is involved in the disruption of airway barrier function induced by aeroallergens through the PAR2/TLR4 pathway. Modulation of this pathway could be a novel approach for asthma treatment.
RESPIRATORY RESEARCH
(2021)
Article
Otorhinolaryngology
Anna S. Englhard, Martin Holzer, Katharina Eder, Donata Gellrich, Moritz Groeger
Summary: Nasal provocation testing remains the gold standard for assessing clinical relevance in patients sensitized to Dermatophagoides species, as clinical data are not sufficient to distinguish between silent sensitization and clinically relevant allergic rhinitis.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Respiratory System
Laura Tamasauskiene, Brigita Sitkauskiene
Summary: The study evaluated the cytokine profile, vitamin D status, symptom score, and quality of life in patients with persistent allergic airway diseases sensitized to house dust mites. Novel cytokines such as IL-22, IL-17, and IL-33, as well as vitamin D, may play a role in the pathogenesis of airway inflammation in patients sensitized to HDM.
BMC PULMONARY MEDICINE
(2021)
Article
Peripheral Vascular Disease
Lauriane Janssen, Laura Dupont, Mourad Bekhouche, Agnes Noel, Cedric Leduc, Marianne Voz, Bernard Peers, Didier Cataldo, Suneel S. Apte, Johanne Dubail, Alain Colige
Article
Radiology, Nuclear Medicine & Medical Imaging
Nadia Withofs, Philippe Martinive, Jean Vanderick, Noella Bletard, Irene Scagnol, Frederic Mievis, Fabrice Giacomelli, Philippe Coucke, Philippe Delvenne, Didier Cataldo, Sanjiv S. Gambhir, Roland Hustinx
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2016)
Article
Pharmacology & Pharmacy
Gilles Dufour, William Bigazzi, Nelson Wong, Frederic Boschini, Pascal de Tullio, Geraldine Piel, Didier Cataldo, Brigitte Evrard
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2015)
Article
Cardiac & Cardiovascular Systems
Vincent Ninane, Jan Vandevoorde, Didier Cataldo, Eric Derom, Giuseppe Liistro, Evert Munghen, Rudi Peche, Marc Schlesser, Geert Verleden, Walter Vincken
RESPIRATORY MEDICINE
(2015)
Article
Oncology
Oriane Carnet, Julie Lecomte, Anne Masset, Irina Primac, Tania Durre, Ludovic Maertens, Benoit Detry, Silvia Blacher, Christine Gilles, Christel Pequeux, Jenny Paupert, Jean-Michel Foidart, Guy Jerusalem, Didier Cataldo, Agnes Noel
Article
Biochemistry & Molecular Biology
Jonathan Hacha, Kate Tomlinson, Ludovic Maertens, Genevieve Paulissen, Natacha Rocks, Jean-Michel Foidart, Agnes Noel, Roger Palframan, Maud Gueders, Didier D. Cataldo
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2012)
Article
Oncology
Alexandra Paye, Alice Truong, Cassandre Yip, Jonathan Cimino, Silvia Blacher, Carine Munaut, Didier Cataldo, Jean Michel Foidart, Erik Maquoi, Joelle Collignon, Philippe Delvenne, Guy Jerusalem, Agnes Noel, Nor Eddine Sounni
Article
Chemistry, Multidisciplinary
Salome Juliette Koussoroplis, GeneviSve Paulissen, Donatienne Tyteca, Hadi Goldansaz, Julie Todoroff, CLine Barilly, Catherine Uyttenhove, Jacques Van Snick, Didier Cataldo, Rita Vanbever
JOURNAL OF CONTROLLED RELEASE
(2014)
Article
Immunology
Genevieve Paulissen, Mehdi El Hour, Natacha Rocks, Maud M. Gueders, Fabrice Bureau, Jean-Michel Foidart, Carlos Lopez-Otin, Agnes Noel, Didier D. Cataldo
JOURNAL OF IMMUNOLOGY
(2012)
Article
Immunology
M. Toussaint, L. Fievez, P-V Drion, D. Cataldo, F. Bureau, P. Lekeux, C. J. Desmet
MUCOSAL IMMUNOLOGY
(2013)
Article
Immunology
M. Pichavant, G. Remy, S. Bekaert, O. Le Rouzic, G. Kervoaze, E. Vilain, N. Just, I. Tillie-Leblond, F. Trottein, D. Cataldo, P. Gosset
MUCOSAL IMMUNOLOGY
(2014)
Article
Multidisciplinary Sciences
Eleonore Otjacques, Marilene Binsfeld, Natacha Rocks, Silvia Blacher, Karin Vanderkerken, Agnes Noel, Yves Beguin, Didier Cataldo, Jo Caers
Article
Multidisciplinary Sciences
Ludovic Maertens, Charlotte Erpicum, Benoit Detry, Silvia Blacher, Benedicte Lenoir, Oriane Carnet, Christel Pequeux, Didier Cataldo, Julie Lecomte, Jenny Paupert, Agnes Noel
Article
Respiratory System
Marko Topalovic, Eric Derom, Christian R. Osadnik, Thierry Troosters, Marc Decramer, Wim Janssens
RESPIRATORY RESEARCH
(2015)
Article
Ophthalmology
Benoit Detry, Silvia Blacher, Charlotte Erpicum, Jenny Paupert, Ludovic Maertens, Catherine Maillard, Carine Munaut, Nor Eddine Sounni, Vincent Lambert, Jean-Michel Foidart, Jean-Marie Rakic, Didier Cataldo, Agnes Noel
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2013)