Article
Cell Biology
Lydia M. M. Parkinson, Sarah L. L. Gillen, Laura M. M. Woods, Lewis Chaytor, Daniel Marcos, Fahad R. R. Ali, Jason S. S. Carroll, Anna Philpott
Summary: ASCL1 plays a role in maintaining proliferation and controlling differentiation in neuroblastoma cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Endocrinology & Metabolism
Irem Altun, Xiaocheng Yan, Siegfried Ussar
Summary: Adipose tissue is important for energy storage and regulating metabolism. Obesity can lead to dysfunction in adipose tissue, affecting the composition and function of stromal cells. Immune cells in adipose tissue play essential roles in regulating adipocyte function. Macrophages, mast cells, innate lymphoid cells, and T cells all have a significant impact on adipocyte progenitor proliferation, differentiation, and lineage commitment.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
M. Kristen Hall, Adam P. Burch, Ruth A. Schwalbe
Summary: The study investigated the impact of different N-glycan populations on neuroblastoma (NB) cell cultures, revealing that changes in N-glycans can affect cell growth, size, and invasiveness. In 2D cultures, NB_1 cells grew faster and were more invasive, while in 3D cultures, mutant cells were smaller with lower invasiveness. This highlights the importance of N-glycosylation pathways and cell culturing methods in influencing aberrant cellular properties in NB.
Article
Cell & Tissue Engineering
Neena Lala-Tabbert, Hamood AlSudais, Francois Marchildon, Dechen Fu, Nadine Wiper-Bergeron
Summary: The study shows that the transcription factor C/EBP beta is necessary to maintain quiescence of satellite cells in uninjured muscle. Loss of C/EBP beta in satellite cells promotes premature exit from quiescence, while forced expression of C/EBP beta inhibits proliferation by upregulating quiescence-associated genes. Additionally, caveolin-1 is identified as a direct transcriptional target of C/EBP beta required for cell cycle exit in muscle satellite cells expressing C/EBP beta.
Review
Cell Biology
Lisa Mueller, Mechthild Hatzfeld, Rene Keil
Summary: Desmosomes are intercellular junctions that preserve tissue integrity by responding to context-dependent signals and transmitting them to change cell behavior. Their composition and size vary depending on tissue specific expression and differentiation state, and their constituent proteins are highly regulated by posttranslational modifications. This review summarizes how signaling pathways control desmosomes to modulate cell behavior.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Yoko Hiyama, Emi Yamaoka, Takahiro Fukazawa, Masato Kojima, Yusuke Sotomaru, Eiso Hiyama
Summary: In this study, we investigated the association between the expression of DHRS3, NROB1, and CYP26A1 genes and the suppression of neuroblastoma cell growth. The overexpression of these genes led to a reduction in cell growth and induced morphological senescence, mainly through pathways related to cellular senescence and cell adhesion. DHRS3 and NROB1 also arrested the cell cycle and induced differentiation and senescence. These findings suggest that the induction of these genes could be a potential therapeutic strategy for suppressing high-risk neuroblastoma growth.
Article
Multidisciplinary Sciences
Shu Shien Chin, Erik Guillen, Laurent Chorro, Sooraj Achar, Karina Ng, Susanne Oberle, Francesca Alfei, Dietmar Zehn, Gregoire Altan-Bonnet, Fabien Delahaye, Gregoire Lauvau
Summary: This study demonstrates that the strength of T cell receptor signaling and interleukin-2 (IL-2) signals control the formation of memory CD8(+) T cells with high functional activity and wide range of genes with open chromatin regions.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Chantana Boonyarat, Panatchakorn Boonput, Nantakorn Tongloh, Rawiwun Kaewamatawong, Suchada Chaiwiwatrakul, Chavi Yenjai, Pornthip Waiwut
Summary: In this study, nordentatin, a coumarin derivative, was found to effectively inhibit the proliferation and migration of neuroblastoma cells through the GSK-3 pathway.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yanqiang Li, Yang Yi, Jie Lv, Xinlei Gao, Yang Yu, Sahana Suresh Babu, Ivone Bruno, Dongyu Zhao, Bo Xia, Weiqun Peng, Jun Zhu, Hong Chen, Lili Zhang, Qi Cao, Kaifu Chen
Summary: Cell identity genes possess unique transcription regulation mechanisms involving super-enhancers and broad H3K4me3 domains, but their mRNA stability has not been well understood. Through transcriptome-wide analysis in nine cell types, we found that unstable transcripts were enriched in pathways related to cell identity, while stable transcripts were enriched in housekeeping pathways. Joint analysis of RNA stability and chromatin state revealed significant enrichment of super-enhancers and broad H3K4me3 domains at the gene loci of unstable transcripts. Interestingly, the RNA m(6)A methyltransferase METTL3 preferentially binds to chromatin at super-enhancers, broad H3K4me3 domains, and their associated genes.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Oncology
Moon Hee Yang, Timothy H. Tran, Bethany Hunt, Rebecca Agnor, Christian W. Johnson, Bing Shui, Timothy J. Waybright, Jonathan A. Nowak, Andrew G. Stephen, Dhirendra K. Simanshu, Kevin M. Haigis
Summary: An allosteric network involving lysine 104 and residues in the switch-II domain is essential for KRAS oncogenicity, which could be utilized in the development of inhibitors targeting the activated oncoprotein.
Article
Oncology
Yagnesh Ladumor, Bo Kyung Alex Seong, Robin Hallett, Ivette Valencia-Sama, Teresa Adderley, Yingying Wang, Lynn Kee, Alexander Gont, David R. Kaplan, Meredith S. Irwin
Summary: The study found that calcipotriol, a vitamin D3 analog, selectively targets cell lines with enhanced metastatic potential in neuroblastoma, leading to reduced proliferation and survival via vitamin D receptor (VDR) signaling. This compound also reduces the levels of YAP and TAZ, the effectors of the Hippo pathway, by increasing the expression of RASSF2, a negative regulator of the pathway.
MOLECULAR CANCER RESEARCH
(2022)
Article
Agriculture, Dairy & Animal Science
Yuefeng Gao, Wei Lu, Luyang Jian, Zoltan Machaty, Hailing Luo
Summary: The effect of Vitamin E on the proliferation of ovine Sertoli cells was investigated. Vitamin E was found to effectively promote cell proliferation by enhancing progression through the cell cycle and affecting the expression of genes that regulate cell division. This indicates a positive effect of Vitamin E on sheep reproductive performance.
ANIMAL BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Rhiannon B. Werder, Tao Liu, Kristine M. Abo, Jonathan Lindstrom-Vautrin, Carlos Villacorta-Martin, Jessie Huang, Anne Hinds, Nathan Boyer, Esther Bullitt, Marc Liesa, Edwin K. Silverman, Darrell N. Kotton, Michael H. Cho, Xiaobo Zhou, Andrew A. Wilson
Summary: This study used CRISPR interference to investigate the function of genes associated with COPD in induced pluripotent stem cell-derived type 2 alveolar epithelial cells. The results showed that these genes affect the differentiation, maturation, and proliferation of cells. Detailed characterization of the DSP gene revealed its role in regulating cell-cell junctions, proliferation, mitochondria function, and response to cigarette smoke-induced injury.
Article
Cell Biology
Isha Kapoor, Juraj Bodo, Brian T. Hill, Alexandru Almasan
Summary: Aberrant microRNA expression, particularly in the 14q32 miRNA cluster region, plays a role in acquired resistance to BTK inhibitors in CLL and DLBCL cells. Overexpression of miRNAs such as miR-494, miR-495, and miR-543 is associated with downregulation of PTEN and further activation of the PI3K/AKT/mTOR pathway in resistant cells, impacting apoptosis regulation. Targeting these miRNAs may have therapeutic value in overcoming acquired BTK resistance.
CELL DEATH & DISEASE
(2021)
Article
Materials Science, Multidisciplinary
Yunsheng Dong, Yufei Liu, Yuehua Chen, Xun Sun, Lin Zhang, Zhiling Zhang, Yanying Wang, Chunxiao Qi, Shufang Wang, Qiang Yang
Summary: The study developed an injectable chitosan/silk fibroin hydrogel system that could spatiotemporally release SDF-1 and KGN, promoting the recruitment and chondrogenic differentiation of MSCs. It showed good cytocompatibility and promoted cartilage regeneration.
NPG ASIA MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Z. Wang, Y. He, W. Deng, L. Lang, H. Yang, B. Jin, R. Kolhe, H-F Ding, J. Zhang, T. Hai, C. Yan
Article
Oncology
Liqun Yang, Yunhong Zha, Jane Ding, Bingwei Ye, Mengling Liu, Chunhong Yan, Zheng Dong, Hongjuan Cui, Han-Fei Ding
Article
Oncology
Yingfeng Xia, Bingwei Ye, Jane Ding, Yajie Yu, Ahmet Alptekin, Muthusamy Thangaraju, Puttur D. Prasad, Zhi-Chun Ding, Eun Jeong Park, Jeong-Hyeon Choi, Bei Gao, Oliver Fiehn, Chunhong Yan, Zheng Dong, Yunhong Zha, Han-Fei Ding
Article
Biochemistry & Molecular Biology
Liyuan Wang, Yichen Liu, Tingting Du, Heng Yang, Lei Lei, Mengqi Guo, Han-Fei Ding, Junran Zhang, Hongbo Wang, Xiaoguang Chen, Chunhong Yan
CELL DEATH AND DIFFERENTIATION
(2020)
Article
Biochemistry & Molecular Biology
Ahmet Alptekin, Bingwei Ye, Yajie Yu, Candace J. Poole, Jan van Riggelen, Yunhong Zha, Han-Fei Ding
Article
Biochemistry & Molecular Biology
Xingyao Li, Mengqi Guo, Lun Cai, Tingting Du, Ying Liu, Han-Fei Ding, Hongbo Wang, Junran Zhang, Xiaoguang Chen, Chunhong Yan
CELL DEATH AND DIFFERENTIATION
(2020)
Article
Oncology
Zhong-Yan Hua, Jeanne N. Hansen, Miao He, Shang-Kun Dai, Yoonjung Choi, Melody D. Fulton, Sarah M. Lloyd, Marianna Szemes, Ji Sen, Han-Fei Ding, James M. Angelastro, Xiang Fei, Hui-Ping Li, Chao-Ran Wu, Sheng-Yong Yang, Karim Malik, Xiaomin Bao, Y. George Zheng, Chang-Mei Liu, Nina F. Schor, Zhi-Jie Li, Xing-Guo Li
Article
Medicine, Research & Experimental
Zhengwei Ma, Lin Li, N. J. Livingston, Dongshan Zhang, Qingsheng Mi, Ming Zhang, Han-Fei Ding, Yuqing Huo, Changlin Mei, Zheng Dong
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Article
Cell Biology
Yajie Yu, Jane Ding, Shunqin Zhu, Ahmet Alptekin, Zheng Dong, Chunhong Yan, Yunhong Zha, Han-Fei Ding
Summary: Metabolic reprogramming driven by oncogenes like MYC is closely related to growth promotion, but also leads to potential therapeutic metabolic dependencies; MYCN-amplified neuroblastoma promotes pyrimidine nucleotide production by upregulating DHODH and other enzymes, and inhibition of DHODH can effectively suppress proliferation and tumorigenicity of these cancer cells.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Xingyao Li, Daniel Gracilla, Lun Cai, Mingyi Zhang, Xiaolin Yu, Xiaoguang Chen, Junran Zhang, Xiaochun Long, Han-Fei Ding, Chunhong Yan
Summary: ATF3 plays a crucial role in transcriptional activation of the serine synthesis pathway (SSP) under serine deprivation, positively correlates with PHGDH expression, and loss of ATF3 expression impairs cancer cell growth.
Article
Pathology
Zhengwei Ma, Xiaoru Hu, Han-Fei Ding, Ming Zhang, Yuqing Huo, Zheng Dong
Summary: This study is the first to investigate cisplatin-induced nephrotoxicity using snRNA-seq, revealing that RLDC treatment leads to renal dysfunction and pathological changes in mice, as well as transcriptional alterations at the single-cell level in PT cells.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Article
Oncology
Chunwan Lu, Dafeng Yang, John D. Klement, Yolonda L. Colson, Nicholas H. Oberlies, Cedric J. Pearce, Aaron H. Colby, Mark W. Grinstaff, Han-Fei Ding, Huidong Shi, Kebin Liu
Summary: This study reveals the impact of metabolic pathways on the function of tumor-specific CTLs and tumor immune evasion. It identifies the key role of G6PD in CTL activation and discovers the significance of the H3K9me3/G6PD/acetyl-CoA/H3K9ac/Gzmb pathway in epithelioid mesothelioma.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Biochemistry & Molecular Biology
Chunwan Lu, Dafeng Yang, John D. Klement, Yolonda L. Colson, Nicholas H. Oberlies, Cedric J. Pearce, Aaron H. Colby, Mark W. Grinstaff, Zhuoqi Liu, Huidong Shi, Han-Fei Ding, Kebin Liu
Summary: The role of G6PD in human cancer is not fully understood. Inhibition of H3K9 methylation suppresses aerobic glycolysis and enhances PPP, leading to increased tumor cell apoptosis. Activation of G6PD induces tumor cell death, suppresses tumor growth, and increases mouse survival in vivo.
Article
Oncology
Vu N. Bach, Jane Ding, Miranda Yeung, Taylor Conrad, Hussain N. Odeh, Paige Cubberly, Christopher Figy, Han-Fei Ding, Robert Trumbly, Kam C. Yeung
Summary: Breast cancer is the second most common cancer in women worldwide, and the regulation of its metastasis is not well understood. RKIP has been shown to suppress breast cancer metastasis by downregulating elements of the immune system. In addition to its negative regulation of the Raf signaling pathway, RKIP may exert its effects on cancer through modulating various signaling pathways, including those involved in immune response.
Review
Oncology
Mohit Bansal, Anamika Gupta, Han-Fei Ding
Summary: Metabolic reprogramming plays a crucial role in high-risk neuroblastoma and offers potential therapeutic opportunities. This review summarizes the recent progress in understanding neuroblastoma metabolic reprogramming and highlights important areas for future research.