Article
Microbiology
Lifei Shen, Jiaxue Zhang, Jian Xue, Ling Du, Lingyue Yuan, Hao Nie, Sue Dai, Qian Yu, Yingli Li
Summary: This study discovered that RcsAB positively regulates the expression of ECP fimbriae-related gene clusters by directly binding to the promoter region of the ykgK gene, thereby positively affecting biofilm formation.
JOURNAL OF BASIC MICROBIOLOGY
(2022)
Article
Microbiology
Beibei Wu, Yao Wang, Zhuoren Ling, Zhuoling Yu, Zhangqi Shen, Suxia Zhang, Xiaoming Wang
Summary: The study found that 9.83% of chicken-origin K. pneumoniae isolates carried the mcr-8 gene on a plasmid, with diverse genetic contexts. The synergistic effect of mcr-8 and chromosomal mechanisms contribute to high-level colistin resistance in strains.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Infectious Diseases
Nan-Yao Lee, Ching-Lung Lo, Po-Lin Chen, Ling-Shan Syue, Chia-Wen Li, Ming-Chi Li, Wen-Chien Ko
Summary: This study examined adult cases of monomicrobial bloodstream infection caused by cefepime-susceptible Klebsiella pneumoniae isolates with carbapenem resistance between 2010 and 2015. The results showed that cefepime therapy and combination therapy were protective against fatal outcomes, but clinicians should be aware of the possibility of treatment failure for isolates classified as cefepime susceptible dose-dependent.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2021)
Article
Microbiology
Yuchen Wu, Xuemei Yang, Congcong Liu, Yanyan Zhang, Yan Chu Cheung, Edward Wai Chi Chan, Sheng Chen, Rong Zhang
Summary: A new variant of Klebsiella pneumoniae carbapenemase (KPC-93) was identified in clinical isolates, causing resistance to ceftazidime-avibactam. The study highlights the potential risk of bla(KPC) gene mutations associated with ceftazidime-avibactam exposure over a short period of time.
MICROBIOLOGY SPECTRUM
(2022)
Article
Microbiology
M. Ortiz-Padilla, I Portillo-Calderon, B. de Gregorio-Iaria, J. Blazquez, J. Rodriguez-Bano, A. Pascual, J. M. Rodriguez-Martinez, F. Docobo-Perez
Summary: This study aimed to characterize the role of specific genes in fosfomycin resistance in Klebsiella pneumoniae and assess the potential synergistic effect of combining fosfomycin with sodium phosphonoformate. The results showed that inactivation of the fosA gene led to decreased fosfomycin resistance, while the addition of PPF had limited effects and showed decreased activity in the presence of fosfomycin-resistant mutations.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Microbiology
Lifeng Li, Jiayue Ma, Ping Cheng, Mingchao Li, Zengyuan Yu, Xiaorui Song, Zhidan Yu, Huiqing Sun, Wancun Zhang, Zhaobao Wang
Summary: In this review, the composition and regulation mechanisms of two-component regulatory systems (TCSs) in Klebsiella pneumoniae were analyzed. The important roles of TCSs in the regulation of virulence, antibiotic resistance, and stress responses were summarized. However, further studies are required to understand the function and regulation mechanism of some TCSs in K. pneumoniae.
MICROBIOLOGICAL RESEARCH
(2023)
Article
Chemistry, Analytical
Fatma Uysal Ciloglu, Mehmet Hora, Aycan Gundogdu, Mehmet Kahraman, Mahmut Tokmakci, Omer Aydin
Summary: Colistin-resistant Klebsiella pneumoniae (ColR-Kp) causes high mortality rates. This study developed a label-free SERS-based sensor with machine learning algorithms to discriminate colistin-resistant and susceptible strains of K. pneumoniae. The results demonstrate that non-linear features can provide better discrimination of antibiotic-resistant and susceptible bacteria in SERS spectral data.
ANALYTICA CHIMICA ACTA
(2022)
Article
Immunology
Chawalit Chatupheeraphat, Jiratchaya Peamchai, Sirirat Luk-in, Warawan Eiamphungporn
Summary: This study found that K11 is a promising candidate with potent antibacterial and antibiofilm activities against drug-resistant Klebsiella pneumoniae. It acts synergistically with conventional antibiotics without inducing resistance. These findings suggest that K11 could be a potential treatment option for infections caused by drug-resistant K. pneumoniae.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Microbiology
Alessandra Carattoli, Gabriele Arcari, Giulia Bibbolino, Federica Sacco, Dario Tomolillo, Federica Maria Di Lella, Maria Trancassini, Luigi Faino, Mario Venditti, Guido Antonelli, Giammarco Raponi
Summary: A study conducted in a university hospital in Rome, Italy identified multiple CZA-resistant KPC-3 protein variants, including novel variants that had not been reported before. These variants showed different sensitivities and activities to antibiotics, possibly due to mutations caused by amino acid substitutions, insertions, and deletions.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Infectious Diseases
Sharmi Naha, Kirsty Sands, Suchandra Mukherjee, Shanta Dutta, Sulagna Basu
Summary: This study aimed to understand the susceptibility trend and molecular mechanisms of colistin resistance in neonatal isolates over a 12 year period. The results showed that colistin-resistant Klebsiella pneumoniae had multiple mechanisms of resistance, including overexpression of two-component systems and AcrAB-TolC pump and its regulators. The presence of strains with dual carbapenemases causing sepsis in neonates is alarming.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Joseph Meletiadis, Paschalis Paranos, Panagiota-Christina Georgiou, Sofia Vourli, Stavroula Antonopoulou, Aikaterini Michelaki, Eleni Vagiakou, Spyros Pournaras
Summary: Metallo-beta-lactamase (MBL)-producing Gram-negative bacteria are increasing globally, with few effective agents against them. Taniborbactam is a newly developed bicyclic boronate beta-lactamase inhibitor that shows promising activity against MBL-producing isolates when used in combination with cefepime or meropenem.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2021)
Article
Immunology
Zhiyuan Liu, Jiahao Guan, Zhaoyan Chen, Cui Tai, Zixin Deng, Yanjie Chao, Hong-Yu Ou
Summary: This study demonstrates that the cpxR gene in Klebsiella pneumoniae regulates carbapenem resistance by directly binding to the promoter DNA of bla KPC, and also promotes the transfer of the bla KPC-carrying IncFII plasmid between different strains.
EMERGING MICROBES & INFECTIONS
(2023)
Article
Biochemistry & Molecular Biology
Fuqiang Kang, Zili Chai, Beiping Li, Mingda Hu, Zilong Yang, Xia Wang, Wenting Liu, Hongguang Ren, Yuan Jin, Junjie Yue
Summary: This study identified 15,946 prophages from 1437 fully assembled K. pneumoniae genomes deposited in the NCBI database, with 9755 prophages on chromosomes and 6191 prophages on plasmids. The results showed that prophages in the K. pneumoniae genomes are diverse and widely distributed. The prophages encoded multiple putative virulence factors and antibiotic resistance genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Kan Zhang, Lei Liu, Min Yang, Chunmei Chen, Xianping Li, Jingjing Tian, Can Luo, Xiaofan Wang, Min Wang
Summary: This study used proteomic profiling and bioinformatics approaches to explore the mechanisms of carbapenem resistance in Klebsiella pneumoniae, a pathogen that poses an urgent threat to human health. The study confirmed the involvement of outer membrane, beta-lactam resistance pathway, and two-component systems in carbapenem resistance, and identified the downregulation of certain genes and reduction of porins. These findings reaffirmed the significance of the beta-lactam resistance pathway and shed light on the mechanisms of carbapenem resistance in Klebsiella pneumoniae.
MICROBIAL PATHOGENESIS
(2022)
Article
Infectious Diseases
Einas A. A. Osman, Maho Yokoyama, Hisham N. N. Altayb, Daire Cantillon, Julia Wille, Harald Seifert, Paul G. Higgins, Leena Al-Hassan
Summary: This study sequenced the whole genomes of 86 Klebsiella pneumoniae isolates from hospitals in Khartoum, Sudan, and revealed their molecular epidemiology, virulence, and resistance profiles. The findings showed the presence of multiple resistance genes, including genes coding for ESBLs, carbapenemases, and aminoglycoside-modifying enzymes.
Article
Genetics & Heredity
Vijaya Bharathi Srinivasan, Mahavinod Angrasan, Neha Chandel, Govindan Rajamohan
FUNCTIONAL & INTEGRATIVE GENOMICS
(2018)
Article
Biotechnology & Applied Microbiology
Vijaya Bharathi Srinivasan, Govindan Rajamohan
Article
Microbiology
Vijaya Bharathi Srinivasan, Govindan Rajamohan
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2013)
Article
Microbiology
Vijaya Bharathi Srinivasan, Vasanth Vaidyanathan, Govindan Rajamohan
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2015)
Article
Biochemistry & Molecular Biology
Monika Dahiya, Satish Singh, Govindan Rajamohan, Deepti Sethi, Ashish, Kanak L. Dikshit
Article
Biochemistry & Molecular Biology
Vijaya Bharathi Srinivasan, Vasanth Vaidyanathan, Amitabha Mondal, Manjunath Venkataramaiah, Govindan Rajamohan
Article
Infectious Diseases
Govindan Rajamohan, Vijaya Bharathi Srinivasan, Wondwossen A. Gebreyes
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2010)
Article
Infectious Diseases
Govindan Rajamohan, Vijaya Bharathi Srinivasan, Wondwossen A. Gebreyes
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2010)
Article
Infectious Diseases
Vijaya Bharathi Srinivasan, Govindan Rajamohan, Preeti Pancholi, Mario Marcon, Wondwossen A. Gebreyes
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2011)
Article
Microbiology
Vijaya Bharathi Srinivasan, Amitabha Mondal, Manjunath Venkataramaiah, Neeraj Kumar Chauhan, Govindan Rajamohan
Article
Multidisciplinary Sciences
Vijaya Bharathi Srinivasan, Manjunath Venkataramaiah, Amitabha Mondal, Vasanth Vaidyanathan, Tanvi Govil, Govindan Rajamohan
Article
Multidisciplinary Sciences
Vijaya Bharathi Srinivasan, Bharat Bhushan Singh, Nitesh Priyadarshi, Neeraj Kumar Chauhan, Govindan Rajamohan
Article
Multidisciplinary Sciences
Vijaya Bharathi Srinivasan, Manjunath Venkataramaiah, Amitabha Mondal, Govindan Rajamohan
Article
Multidisciplinary Sciences
Amitabha Mondal, Manjunath Venkataramaiah, Govindan Rajamohan, Vijaya Bharathi Srinivasan