Article
Chemistry, Medicinal
Yin-Ying Mak, Bi-Juin Loong, Paul Millns, Claudia C. Bauer, Robin S. Bon, Yvonne Mbaki, Fong-Kai Lee, Kuan-Hon Lim, Cin Kong, Sue-Mian Then, Kang-Nee Ting
Summary: This study investigated the vasorelaxant effects of schwarzinicine A, a newly reported alkaloid from Ficus schwarzii Koord. The results showed that schwarzinicine A exerts its significant vasorelaxant effect by blocking multiple TRPC channels and L-type VGCC.
PHYTOTHERAPY RESEARCH
(2022)
Review
Cell Biology
Bethan A. Cole, Esther B. E. Becker
Summary: The TRPC3 channel is a crucial player in calcium signaling and is regulated by various endogenous and exogenous factors. Recent studies have advanced our understanding of the regulatory mechanisms of TRPC3, which has implications for the development of therapeutic interventions for diseases associated with this channel.
Article
Oncology
Li-ping Bai, Ya-li Chen, Ai Zheng
Summary: This study found that the high expression of TRPC6 protein in cervical cancer cell lines HeLa and SiHa may be related to the malignant behavior of the cells. SKF-96365 inhibits cell proliferation and DNA synthesis, while OAG promotes cell proliferation and DNA synthesis.
CANCER CELL INTERNATIONAL
(2022)
Article
Cell Biology
Christine Haewon Park, Jinsung Kim, Jung Eun Lee, Misun Kwak, Insuk So
Summary: This study focuses on the pore region of TRPC1 and TRPC4 as a determinant of the characteristics of a heteromeric TRPC1/4 channel. Mutants and chimeras were used to investigate the effects of changes in the pore region on calcium permeability and current-voltage curve.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Medicine, Research & Experimental
Jingzhen Zhu, Yi Fan, Qudong Lu, Yang Yang, Hui Li, Xin Liu, Hengshuai Zhang, Bishao Sun, Qian Liu, Jiang Zhao, Zhenxing Yang, Longkun Li, Huan Feng, Jie Xu
Summary: The expression and functional levels of TRPC3, a nonselective cation channel, and NCX1, a Na+/Ca2(+) exchanger, are increased in the bladders of rats with partial bladder outlet obstruction-induced detrusor overactivity. The synergistic effects of TRPC3 and NCX1 significantly increase the concentration of Ca-i(2+) in smooth muscle cells, which induces bladder hyperactivity in this animal model of overactive bladder. TRPC3 and NCX1 may be new therapeutic targets for detrusor overactivity.
LABORATORY INVESTIGATION
(2022)
Article
Cell Biology
Katelyn E. Sadler, Francie Moehring, Stephanie Shiers, Lauren J. Laskowski, Alexander R. Mikesell, Zakary R. Plautz, Allison N. Brezinski, Christina M. Mecca, Gregory Dussor, Theodore J. Price, John D. McCorvy, Cheryl L. Stucky
Summary: The study identified TRPC5 as a key contributor to tactile and spontaneous pain in multiple rodent pain models, particularly in conditions characterized by elevated LPC concentrations. 75% of human sensory neurons express TRPC5, and its activity is directly modulated by LPC.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Xiao-Yu Cheng, Shu-Fang Li, Yong Chen, Ying-Jie Zhao, Wei Hu, Chao Lu, Ren-Peng Zhou
Summary: TRPM7 is a channel protein located on the cell membrane that regulates the balance of intracellular Mg2+. It plays an important role in cell proliferation, adhesion, migration, and is directly related to disease occurrence and development.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Chemistry, Medicinal
Yuan-Yuan Gao, Wen Tian, Hui-Nan Zhang, Yang Sun, Jing-Ru Meng, Wei Cao, Xiao-Qiang Li
Summary: TRPCs channels play crucial roles in human physiological and pathological processes, but finding selective TRPCs modulators remains challenging. Further exploration for more effective and selective TRPCs modulators is needed.
ARCHIVES OF PHARMACAL RESEARCH
(2021)
Review
Cell Biology
Uzma Saqib, Sreepadaarchana Munjuluri, Sutripta Sarkar, Subir Biswas, Oyshi Mukherjee, Hargopal Satsangi, Mirza S. S. Baig, Alexander G. G. Obukhov, Krishnan Hajela
Summary: The TRPC subfamily of mammalian Transient Receptor Potential Canonical channels consists of seven transmembrane proteins that form cation channels in mammalian cell plasma membranes. TRPC channels mediate the influx of Ca2+ and Na+ into cells. Deficiency or increased activity of TRPC6 has been linked to various diseases, including kidney disease, pulmonary disease, and neurological disease. This review summarizes the progress made in investigating the physiological roles of TRPC6 and the development of pharmacological tools to modulate its activity.
Review
Anesthesiology
Brian M. Ilfeld, James C. Eisenach, Rodney A. Gabriel
Summary: The study demonstrates that overexpressing a nonconducting TRPC6 channel can partially ameliorate the imbalance of calcium and sodium in muscle caused by RYR1 variants, prolonging survival time during halothane exposure, but is not sufficient to prevent the lethal effects of exposure to volatile anesthetic malignant hyperthermia-triggering agents.
Article
Cardiac & Cardiovascular Systems
Xin Wen, Yidi Peng, Mengru Gao, Yuzhong Zhu, Yifei Zhu, Fan Yu, Tingting Zhou, Jing Shao, Lei Feng, Xin Ma
Summary: This study demonstrates that TRPC1 improves cardiac function after myocardial infarction by promoting angiogenesis. The study explores the regulatory mechanisms of HIF-1 alpha and MEK/ERK, and finds that treatment with dimethyloxaloylglycine has a protective effect on myocardial infarction.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Agriculture, Dairy & Animal Science
Estibaliz Lacalle, Cesar Consuegra, Cristina A. Martinez, Manuel Hidalgo, Jesus Dorado, Felipe Martinez-Pastor, Manuel Alvarez-Rodriguez, Heriberto Rodriguez-Martinez
Summary: The detection of sub-fertile boars is challenging, with economic impacts on AI centers and farms due to difficulties in routine analysis of important reproductive processes like sperm capacitation needed for fertilization. In vitro capacitation using bicarbonate results in increased mRNA transcripts of most Ca2+ channels in pig spermatozoa, providing insights for future research on the specific roles of these channels and the physiological implications of changes in sperm mRNA cargo during capacitation.
Review
Biochemistry & Molecular Biology
Omar Mahmoud, Georgia Biazus Soares, Gil Yosipovitch
Summary: Transient Receptor Potential (TRP) channels, found abundantly in the skin, play a crucial role in the sensory pathways of itch, pain, and inflammation. This review article explores the complex physiology of different TRP channels and their involvement in modulating itch sensation and the pathophysiology of acute and chronic itch conditions. The article also highlights emerging small molecule and topical TRP channel agents as potential anti-pruritic treatments, with some advancing into clinical trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, Research & Experimental
Fangyan Hu, Xiaohua Song, Dingxin Long
Summary: Calcium is a crucial signaling molecule in all cells, with TRPA1 being a potential target for treating sensory disorders such as pain and pruritus. TRPA1 is the only identified member of the ankyrin subfamily in mammals and has high permeability to calcium ions.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Charlotte Van den Eynde, Joris Vriens, Katrien De Clercq
Summary: Calcium ions play a critical role in cell function, with transient receptor potential (TRP) channels serving as a type of ion channel that can convey various stimuli and potentially participate in cellular responses to changing environments.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2021)
Review
Transplantation
Christoffer Juul-Nielsen, Jianlin Shen, Peter Stenvinkel, Alexandra Scholze
Summary: "In patients with CKD, NRF2 expression was downregulated, while NQO1 and HO-1 showed varying alterations related to inflammation, comorbidities, and severity of kidney damage."
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Transplantation
Chang Chu, Xin Chen, Ahmed A. Hasan, Angelika Szakallova, Bernhard K. Kramer, Martin Tepel, Berthold Hocher
Summary: This study indicates that baseline serum Ang-2 concentrations are independently associated with all-cause mortality in male ESRD patients on hemodialysis.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Medicine, Research & Experimental
Chengkang He, Qiang Li, Yuanting Cui, Peng Gao, Wentao Shu, Qing Zhou, Lijuan Wang, Li Li, Zongshi Lu, Yu Zhao, Huan Ma, Xiaowei Chen, Hongbo Jia, Hongting Zheng, Gangyi Yang, Daoyan Liu, Martin Tepel, Zhiming Zhu
Summary: This research found that recurrent moderate hypoglycemia (RH) accelerates the progression of cognitive deficits in patients with diabetes and leads to neuronal hyperactivity and mitochondrial dysfunction. The study also found that enhancing glucose uptake mediated by glucose transporter 3 (GLUT3) and activating the transient receptor potential channel 6 (TRPC6) can improve cognitive deficits.
Review
Biochemistry & Molecular Biology
Ana Karina Aranda-Rivera, Anjali Srivastava, Alfredo Cruz-Gregorio, Jose Pedraza-Chaverri, Shrikant R. Mulay, Alexandra Scholze
Summary: Inflammasomes play an important role in the innate immune response. Animal models of kidney diseases have shown their involvement in inflammation, pyroptosis, and fibrosis. Besides the commonly studied NLRP3, other inflammasome components are also important in kidney disease. The interaction of inflammasome components with redox signaling, endoplasmic reticulum stress, and mitochondrial function is a research focus.
Article
Multidisciplinary Sciences
Martin Tepel, Firas F. Alkaff, Daan Kremer, Stephan J. L. Bakker, Olivier Thaunat, Subagini Nagarajah, Qais Saleh, Stefan P. Berger, Jacob van den Born, Nicoline Krogstrup, Marie B. Nielsen, Rikke Norregaard, Bente Jespersen, Nadja Sparding, Federica Genovese, Morten A. Karsdal, Daniel G. K. Rasmussen
Summary: Pretransplant plasma endotrophin is associated with the risk of delayed graft function after kidney transplantation, suggesting it as a potential target for therapeutic interventions.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Ana Karina Aranda-Rivera, Alfredo Cruz-Gregorio, Jose Pedraza-Chaverri, Alexandra Scholze
Summary: The nuclear factor erythroid 2-related factor 2 (Nrf2) plays a role in protecting cells against oxidative damage and is linked to the progression of chronic kidney disease (CKD) and CKD-related morbidity. The activity of the Nrf2 system is influenced by factors such as inflammation, kidney fibrosis, mitochondrial and metabolic effects, and the accumulation of uremic toxins and inflammation. The activation or repression of Nrf2 varies depending on the stage and cause of kidney disease.
Review
Immunology
Martin Tepel, Subagini Nagarajah, Qais Saleh, Olivier Thaunat, Stephan J. L. Bakker, Jacob van den Born, Morten A. Karsdal, Federica Genovese, Daniel G. K. Rasmussen
Summary: The characterization of potential kidney transplant recipients using novel biomarkers can lead to improved outcomes after transplantation. This mini-review focuses on the current understanding of pretransplant recipients' characteristics, biomarkers, and immunology. Clinical characteristics and immunological risk assessment, such as histocompatibility leukocyte antigens (HLAs) and non-HLA antibodies, have been used to predict recipient and allograft survival. Recent studies have shown that pretransplant markers, such as plasma endotrophin levels and non-synonymous single-nucleotide polymorphism mismatch, are associated with posttransplant complications and allograft loss. Integrating clinical characteristics and novel markers is important for making better diagnostic decisions tailored to individual patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jiao Zuo, Lyubov Chaykovska, Chang Chu, Xin Chen, Ahmed A. Hasan, Bernhard K. Kraemer, Martin Tepel, Berthold Hocher
Summary: This study compares the predictive value of different oxidative markers for all-cause mortality in hemodialysis patients. The study found that carbonyl proteins and myeloperoxidase are independent predictors of all-cause mortality in hemodialysis patients, while advanced oxidation protein products and oxidized low-density lipoprotein are not significantly associated with all-cause mortality in hemodialysis patients.
Article
Transplantation
Daan Kremer, Firas F. Alkaff, Adrian Post, Tim J. Knobbe, Martin Tepel, Olivier Thaunat, Stefan P. Berger, Jacob van den Born, Federica Genovese, Morten A. Karsdal, Daniel G. K. Rasmussen, Stephan J. L. Bakker, Behalf Transplant Lines Investigators
Summary: This study found a strong association between plasma endotrophin and graft failure and mortality in kidney transplant recipients. The findings suggest that abnormal extracellular matrix turnover and fibrosis play a key role in the prognosis of kidney transplant recipients and highlight the need for interventional studies targeting the profibrotic state of these patients.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Pediatrics
Stine Hoyer Finsen, Martin Tepel, Mette Neland, Soren Rittig, Helle Charlotte Thiesson
Summary: This case report describes a successful renal transplantation in a pediatric patient with Schimke immuno-osseous dysplasia using a steroid-free, low-dose immunosuppressive protocol. The patient has survived for 7 years with no serious infections, rejections or de novo donor-specific antibodies.
PEDIATRIC TRANSPLANTATION
(2023)
Article
Biochemistry & Molecular Biology
Nadja Sparding, Federica Genovese, Daniel Guldager Kring Rasmussen, Morten A. Karsdal, Nicoline V. Krogstrup, Marie Bodilsen Nielsen, Mads Hornum, Subagini Nagarajah, Henrik Birn, Bente Jespersen, Martin Tepel, Rikke Norregaard
Summary: This study evaluated endotrophin (ETP) as a prognostic marker in kidney transplant recipients. It found that ETP levels in the blood on the first day after transplantation were strongly associated with delayed graft function, while ETP levels in the urine at the third month after transplantation were significantly correlated with kidney graft function at twelve months. The measurement of collagen type VI formation could aid in predicting graft function in kidney transplant recipients.
Article
Biochemistry & Molecular Biology
Marianne Rasmussen, Kristian Horsman Hansen, Alexandra Scholze
Summary: Oxidative stress plays a role in the progression of CKD and related mortality. Nrf2, an important regulator of cellular redox status, is being evaluated for its therapeutic potential in CKD. In this study, Nrf2 protein concentrations were analyzed in CKD patients at different stages and in healthy subjects. The results showed that Nrf2 protein was upregulated in mild to moderate kidney function impairment, but reduced in severe impairment. These findings suggest the need to explore the efficacy of Nrf2 therapies in specific populations of CKD patients.
Article
Immunology
Qais W. Saleh, Afsaneh Mohammadnejad, Martin Tepel
Summary: This study examines the association between levels of FOXP3 gene regulator and inflammatory responses in kidney transplant recipients. The results suggest that lower levels of FOXP3 are associated with prolonged duration of inflammatory responses.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Zhidan Luo, Yihua Zhang, Qais Waleed Saleh, Jie Zhang, Zhiming Zhu, Martin Tepel
Summary: FOXP3 is a crucial protein for the development and function of T cells, and its splicing isoforms have different effects on T cell differentiation and suppressive function. The balance of FOXP3 isoforms is related to various diseases, and the regulation of energy metabolism and signaling pathways can affect FOXP3 transcription and splicing. Therefore, targeting FOXP3 splicing isoforms in Tregs may provide potential approaches for the treatment of certain diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Meeting Abstract
Transplantation
Qais Saleh, Marianne Rasmussen, Subagini Nagarajah, Martin Tepel
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
