Article
Immunology
Jiabin Yang, Liangtang Zeng, Ruiwan Chen, Shangyou Zheng, Yu Zhou, Rufu Chen
Summary: By integrating genomic, transcriptomic, and clinical data from HCC patients, four metabolic subtypes were identified with distinct differences in mutation profiles, metabolic pathway activities, prognostic metabolism genes, and immune features. The study also identified palmitoyl-protein thioesterase 1 (PPT1) as a specific prognostic gene and therapeutic target for the poorest outcome subtype, mHCC1. The findings highlight the importance of understanding metabolic heterogeneity and developing subtype-specific treatment strategies for HCC.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Juan Bayo, Esteban J. Fiore, Luciana Maria Dominguez, Maria Jose Cantero, Matias S. Ciarlantini, Mariana Malvicini, Catalina Atorrasagasti, Mariana Gabriela Garcia, Mario Rossi, Claudio Cavasotto, Elisabeth Martinez, Julieta Comin, Guillermo D. Mazzolini
Summary: The study identified RAC1 as a potential therapeutic target for HCC and demonstrated the potent antitumor effect of the RAC1 inhibitor 1D-142 in highly proliferative HCC. The inhibition of RAC1 by 1D-142 resulted in apoptosis and cell cycle arrest in HCC cells, as well as a decrease in tumor growth and metastasis in HCC mouse models. Additionally, 1D-142 showed an anti-fibrotic effect by decreasing hepatic stellate cell activation in vivo.
Article
Cell Biology
Qing-hua Chang, Ting Mao, Yan Tao, Tao Dong, Xuan-xuan Tang, Guo-hong Ge, Zi-jun Xu
Summary: The study comprehensively analyzed the expression patterns and clinical significance of ITIHs in various cancers, showing primarily down-regulated expression. ITIH1 was found to be significantly decreased in liver hepatocellular carcinoma (LIHC) and its down-regulation adversely impacted patient outcome, possibly involving cellular metabolic processes. The findings established ITIH1 as a potential diagnostic and prognostic biomarker for LIHC.
Article
Cell Biology
Yinjiang Zhang, Hongyun Wei, Lu Fan, Mingyan Fang, Xu He, Binan Lu, Zongran Pang
Summary: The study found that CLEC4A and CLEC4L mRNA levels were significantly higher in HCC tissues compared to normal liver tissues, while CLEC4G/H1/H2/M expression levels were significantly lower. The expression of CLEC4H1 and CLEC4H2 was significantly associated with clinical stages, and the expression of other CLEC4s decreased with tumor progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Junyi Li, Tao Pan, Liuxin Chen, Qi Wang, Zhenghong Chang, Weiwei Zhou, Xinhui Li, Gang Xu, Xia Li, Yongsheng Li, Yunpeng Zhang
Summary: The study showed that AS alterations are prevalent in cancer and involve cancer-related pathways. The extent of AS perturbation is associated with disease severity, and a computational pipeline was proposed to identify RBP regulators.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Health Care Sciences & Services
Szu-Jen Wang, Pei-Ming Yang
Summary: This study identified STMN1 as a prognosis biomarker and therapeutic target for HCC, and demonstrated that MST-312 has significant anticancer activity against HCC cells with high STMN1 expression.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Genetics & Heredity
Jun Liu, Jianjun Lu, Wenli Li, Wenjie Mao, Yamin Lu
Summary: This study establishes a five-gene signature associated with proliferation in hepatocellular carcinoma (HCC), which can be used for survival prediction and risk stratification of patients. Additionally, potential drugs targeting this gene signature are identified, providing new prospects for the treatment of HCC.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Qiangan Jing, Chen Yuan, Chaoting Zhou, Weidong Jin, Aiwei Wang, Yanfang Wu, Wenzhong Shang, Guibing Zhang, Xia Ke, Jing Du, Yanchun Li, Fangchun Shao
Summary: CLEC1B, encoding the CLEC-2 protein, is involved in platelet activation, angiogenesis, and immune and inflammatory responses. This study found that CLEC1B is downregulated in hepatocellular carcinoma (HCC) and has a good clinical prognostic value. CLEC1B expression is closely associated with immune cell infiltration and correlates with a variety of immunomodulators in the HCC tumor microenvironment. Furthermore, CLEC1B and its related genes or interacting proteins are implicated in multiple immune-related processes and signaling pathways. Overexpression of CLEC1B significantly influences the treatment effects of sorafenib on HCC cells.
CANCER CELL INTERNATIONAL
(2023)
Article
Biology
Muhammad Sufyan, Usman Ali Ashfaq, Sajjad Ahmad, Fatima Noor, Muhammad Hamzah Saleem, Muhammad Farhan Aslam, Hamed A. El-Serehy, Sidra Aslam
Summary: This study aims to uncover the molecular mechanisms of T2DM and HCV-related HCC through integrated bioinformatics analysis. The identification of hub genes and therapeutic drugs may provide new insights for personalized detection and therapies for both diseases in the future.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Oncology
Raunak Shrestha, Marta Llaurado Fernandez, Amy Dawson, Joshua Hoenisch, Stanislav Volik, Yen-Yi Lin, Shawn Anderson, Hannah Kim, Anne M. Haegert, Shane Colborne, Nelson K. Y. Wong, Brian McConeghy, Robert H. Bell, Sonal Brahmbhatt, Cheng-Han Lee, Gabriel E. DiMattia, Stephane Le Bihan, Gregg B. Morin, Colin C. Collins, Mark S. Carey
Summary: In this study, multiomics integration was used to analyze LGSOC cell lines, identifying predictive biomarkers of MEK inhibitor efficacy and potential driver events of CDKN2A/B and MTAP deficiencies. Proteomic data provided better discrimination for predicting in vitro MEKi efficacy, highlighting potential treatment targets in MEKi-resistant cell lines.
Article
Cell Biology
Zhu Shen, Wenfei Du, Cecelia Perkins, Lenn Fechter, Vanita Natu, Holden Maecker, Jesse Rowley, Jason Gotlib, James Zehnder, Anandi Krishnan
Summary: This study explores the use of blood platelet transcriptome profiling as a proxy strategy for highly sensitive progression biomarkers in myeloproliferative neoplasms (MPNs), enabling prediction of disease progression and advanced stages. Subtype-specific markers offer insights into disease mechanisms and therapeutic strategies, highlighting the importance of proteostasis and stress response pathways.
CELL REPORTS MEDICINE
(2021)
Article
Cell Biology
Zijin Zhao, Miaomiao Liu, Zhijie Xu, Yuan Cai, Bi Peng, Qiuju Liang, Yuanliang Yan, Wei Liu, Fanhua Kang, Qingchun He, Qianhui Hong, Wenqin Zhang, Jianbo Li, Jinwu Peng, Shuangshuang Zeng
Summary: This study demonstrates for the first time that the acyl-CoA synthesis gene family, particularly AACS, may be associated with the immune microenvironment, thereby influencing the development and prognosis of patients with hepatocellular carcinoma (HCC).
Review
Oncology
Hu Li, Pengbo Hu, Yajun Zou, Lijuan Yuan, Yucheng Xu, Xiaohui Zhang, Xiaoyan Luo, Zhiqiang Zhang
Summary: Due to its strong biological activity, Tanshinone IIA (TsIIA) extracted from Salvia miltiorrhiza is widely used in Asia to treat cardiovascular and liver diseases. This review explores TsIIA's anti-HCC effects, its liver-protective effect, and its impact on liver fibrosis, NAFLD, and other risk factors for liver cancer. Network pharmacological analysis is also conducted to screen and explore possible targets of TsIIA against hepatocellular carcinoma, providing a theoretical basis for the development of anti-HCC drugs based on TsIIA.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Zehua He, Qingfeng Chen, Wanrong He, Junyue Cao, Shunhan Yao, Qingqiang Huang, Yu Zheng
Summary: This study analyzed the metabolic heterogeneity of epithelial cells in hepatocellular carcinoma (HCC) and identified potential biomarkers. It found that the glycolytic subtype of HCC cells with high ALDOA expression is associated with an immunosuppressive tumor microenvironment and predicts worse clinical outcomes.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, General & Internal
Jiyan Zhang, Jie Xi, Ping Huang, Saitian Zeng
Summary: This study identified two molecular subtypes (C1 and C2) based on the ferroptosis mRNA expression profile, showing distinct clinical outcomes. The C1 subtype exhibited higher stromal score, immune cell score, immune function, and mRNA expression levels of immune checkpoints compared to C2. Potential small molecular drugs and chemotherapy drug sensitivity were also identified. Furthermore, a 15-ferroptosis-related mRNA signature and a nomogram model were developed for predicting outcomes and overall survival probability in ovarian cancer patients.
FRONTIERS IN MEDICINE
(2021)
Article
Oncology
Wai Kit Ma, Dillon M. Voss, Juergen Scharner, Ana S. H. Costa, Kuan-Ting Lin, Hyun Yong Jeon, John E. Wilkinson, Michaela Jackson, Frank Rigo, C. Frank Bennett, Adrian R. Krainer
Summary: The upregulation of the M2 pyruvate kinase (PKM2) isoform in most cancers, which is involved in the Warburg effect, can be inhibited by antisense oligonucleotides (ASO), leading to apoptosis in liver cancer cells. This ASO-based splicing therapy shows potential as a targeted treatment for hepatocellular carcinoma (HCC) by altering glucose metabolism and inhibiting tumor growth.
Review
Chemistry, Physical
Ming-Hsien Chan, Zhi-Xuan Chang, Chi-Ying F. Huang, L. James Lee, Ru-Shi Liu, Michael Hsiao
Summary: This review article focuses on the potential of using biomimetic nanoparticles derived from exosomes as drug carriers in cancer therapy, highlighting their targeting capabilities and biocompatibility. Challenges in exosome research include inefficient separation methods, difficulties in characterization/tracking, and a lack of specific biomarkers.
NANOSCALE HORIZONS
(2022)
Review
Pharmacology & Pharmacy
Jing-Xing Yang, Jen-Chih Tseng, Guann-Yi Yu, Yunping Luo, Chi-Ying F. Huang, Yi-Ren Hong, Tsung-Hsien Chuang
Summary: Vaccines are important for controlling microbial infections and preventing epidemic diseases. The development of adjuvants, specifically Toll-like receptor (TLR) agonists, has seen significant progress in recent years for human vaccines. The COVID-19 pandemic has also accelerated the clinical research of TLR agonist-based adjuvants. This paper reviews the agonists for TLR activation and their molecular mechanisms, with a focus on recent advances in TLR agonist-based vaccine adjuvants for infectious diseases.
Review
Chemistry, Multidisciplinary
Zhi-Xuan Chang, Chien-Hsiu Li, Yu-Chan Chang, Chi-Ying F. Huang, Ming-Hsien Chan, Michael Hsiao
Summary: With the high incidence and mortality rates of cancer, current research focuses on developing efficient diagnostic methods. MRI stands out as a powerful diagnostic tool due to its non-invasive nature, high spatial resolution, and good soft-tissue contrast. By using magnetic resonance contrast agents, the sensitivity of MRI-based diagnoses can be improved, leading to a reduced tumor recurrence rate.
NANOSCALE ADVANCES
(2022)
Review
Biochemistry & Molecular Biology
Hsiu-Jung Liao, Chih-Hung Chang, Chi-Ying F. Huang, Hui-Ting Chen
Summary: Infrapatellar fat pad-derived mesenchymal stem cells (IPFP-MSCs) have the potential to contribute to cartilage regeneration and modulation of the immune microenvironment in osteoarthritis patients. They have been found to have greater chondrogenic capacity compared to other MSCs, and are less affected by age and inflammation. Transcription-regulatory factors play an important role in the cartilage differentiation of MSCs, and extracellular vesicles, particularly exosomes, are considered the main therapeutic agents responsible for the regenerative and immunomodulatory functions of MSCs in cartilage repair. This study provides an overview of enhancement strategies for IPFP-MSC chondrogenic differentiation, including the effects of transcriptional factors, modulation of released exosomes, delivery mechanisms, and ethical and regulatory considerations.
Article
Mathematics, Applied
Min-Jen Chen, Kun-Mao Chao
Summary: In this paper, we prove the conjecture that a graph with a star spanning tree, where one vertex is adjacent to all other vertices, has the minimum tree intersection number.
DISCRETE APPLIED MATHEMATICS
(2022)
Article
Cell & Tissue Engineering
Yu-Chen Tsai, Tai-Shan Cheng, Hsiu-Jung Liao, Ming-Hsi Chuang, Hui-Ting Chen, Chun-Hung Chen, Kai-Ling Zhang, Chih-Hung Chang, Po-Cheng Lin, Chi-Ying F. Huang
Summary: This study examined the efficacy and effect of mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) on cell differentiation. The results demonstrated that EVs enhanced chondrogenic differentiation and reduced adipogenic differentiation, suggesting their potential use in future clinical applications for cartilage regeneration.
TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Ju-Fang Liu, Jean-Hong Chen, Shu-Hsien Liao, Kuen-Lin Chen, Wen-Chun Wei, Ting-Yuan Chen, Jen-Jie Chieh, Kai-Wen Huang
Summary: The diagnosis of liquid and solid biopsies poses challenges for clinics due to different instruments. To address this, a versatile magnetic diagnosis platform was proposed using magnetic particles (MPs) and a vibration sample magnetometer (VSM). The platform allowed for low loading in multiple biopsies and analysis of molecular concentration in liquid biopsies using soft Fe3O4 MPs with AFP bioprobe coating. In addition, evaluation of bounded MPs in tissue was achieved using hard cobalt MPs without bio-probes coating. Calibrations for hepatic cell carcinoma stages and microscale images were also obtained.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Amina Jbara, Kuan-Ting Lin, Chani Stossel, Zahava Siegfried, Haya Shqerat, Adi Amar-Schwartz, Ela Elyada, Maxim Mogilevsky, Maria Raitses-Gurevich, Jared L. Johnson, Tomer M. Yaron, Ofek Ovadia, Gun Ho Jang, Miri Danan-Gotthold, Lewis C. Cantley, Erez Y. Levanon, Steven Gallinger, Adrian R. Krainer, Talia Golan, Rotem Karni
Summary: Pancreatic ductal adenocarcinoma (PDA) is a highly lethal cancer characterized by aggressive invasion and metastasis. We identified differentially spliced events correlated with PDA progression through analysis of RNA splicing data. Overexpression of RBFOX2 in a PDA cell line reduced its metastatic potential, while depletion of RBFOX2 in primary pancreatic tumor cell lines increased their metastatic potential.
Article
Oncology
Ledong Wan, Kuan-Ting Lin, Mohammad Alinoor Rahman, Yuma Ishigami, Zhikai Wang, Mads A. Jensen, John E. Wilkinson, Youngkyu Park, David A. Tuveson, Adrian R. Krainer
Summary: The splicing factor SRSF1 is highly expressed in pancreatitis, precursor lesions, and tumors of pancreatic ductal adenocarcinoma (PDAC). Increased SRSF1 induces pancreatitis and accelerates PDAC development. SRSF1 misregulated alternative splicing may serve as a potential therapeutic target for pancreatitis and PDAC.
Article
Oncology
Chih-Horng Wu, Ming-Chih Ho, Chien-Hung Chen, Ja-Der Liang, Kai-Wen Huang, Mei-Fang Cheng, Chih-Kai Chang, Chia-Hung Chang, Po-Chin Liang
Summary: CT-assessed sarcopenia defined using the psoas muscle (PM) is an independent prognostic factor for the poorer prognosis of unresectable hepatocellular carcinoma (HCC) after radioembolization.
Article
Materials Science, Multidisciplinary
Yu-Chuan Chiu, Kai-Wen Huang, Yong-Heng Lin, Wei-Rong Yin, Yung-Te Hou
Summary: This paper proposes a nanomedicine-based approach to drug delivery that integrates carrier drug therapy with recent advances in liver tissue regeneration. The results show that the proposed drug delivery strategy enhances the regenerative capacity of hepatocytes and improves liver function.
JOURNAL OF MATERIALS SCIENCE
(2023)
Article
Oncology
Chang-Yi Lu, Chih-Yang Hsiao, Pey-Jey Peng, Shao-Chang Huang, Meng-Rong Chuang, Hung-Ju Su, Kai-Wen Huang
Summary: This study explores the potential of using DNA methylation as a new method to assess treatment outcomes in patients with intermediate-stage hepatocellular carcinoma. The findings suggest that DNA methylation markers may be more accurate than serum markers in predicting treatment success and prognosis. Combining DNA methylation and serum markers improves predictive accuracy, indicating the effectiveness of a multi-marker approach in clinical practice. These discoveries have important implications for personalized treatment plans and close monitoring of intermediate-stage HCC patients.
Article
Nutrition & Dietetics
Yu-Tso Liao, Kai-Wen Huang, Wan-Jing Chen, Tzung-Hsien Lai
Summary: This study examined the safety and tolerability of the new drug LEAC-102 in healthy adults. The results showed that LEAC-102 was well tolerated and exhibited potential immunomodulatory function at the recommended dose.
JOURNAL OF THE AMERICAN NUTRITION ASSOCIATION
(2023)
Review
Oncology
Xin Ye, Weijun Fan, Zhongmin Wang, Junjie Wang, Hui Wang, Lizhi Niu, Yong Fang, Shanzhi Gu, Lingxiao Liu, Baodong Liu, Yiping Zhuang, Zhigang Wei, Xiao Li, Xiaoguang Li, Yuliang Li, Chunhai Li, Xia Yang, Wuwei Yang, Po Yang, Zhengyu Lin, Zhiqiang Meng, Kaiwen Hu, Chen Liu, Yong Huang, Guanghui Huang, Kaiwen Huang, Zhongmin Peng, Yue Han, Yong Jin, Guangyan Lei, Bo Zhai, Hailiang Li, Jie Pan, Dimitris Filippiadis, Alexis Kelekis, Uei Pua, Balazs Futacsi, N. Yumchinserchin, Roberto Lezzi, Alex Tang, Shuvro H. Roy
Summary: The Clinical Practice Guidelines on Image-Guided Thermal Ablation (IGTA) of Primary and Metastatic Lung Tumors (2022 Edition) cover the epidemiology, concepts, procedures, outcomes evaluation, complications, limitations, and future development of IGTA for primary and metastatic lung tumors.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2022)