Energy Landscapes as a Tool to Integrate GPCR Structure, Dynamics, and Function

Tracking G-protein-coupled receptor activation using genetically encoded infrared probes

(2010) Shixin Ye et al.   NATURE

Retinal dynamics during light activation of rhodopsin revealed by solid-state NMR spectroscopy

(2009) Michael F. Brown et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Engineering G protein-coupled receptors to facilitate their structure determination

(2009) Christopher G Tate et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Exploring the Mechanism of Agonist Efficacy: A Relationship between Efficacy and Agonist Dissociation Rate at the Muscarinic M3 Receptor

(2009) D. A. Sykes et al.   MOLECULAR PHARMACOLOGY

Rhodopsin Activation Switches in a Native Membrane Environment

(2009) Steffen Lüdeke et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Conserved waters mediate structural and functional activation of family A (rhodopsin-like) G protein-coupled receptors

(2009) T. E. Angel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A G protein-coupled receptor at work: the rhodopsin model

(2009) Klaus Peter Hofmann et al.   TRENDS IN BIOCHEMICAL SCIENCES

‘7TM Receptor Allostery: Putting Numbers to Shapeshifting Proteins

(2009) Terry P. Kenakin   TRENDS IN PHARMACOLOGICAL SCIENCES

Using relaxation dispersion NMR spectroscopy to determine structures of excited, invisible protein states

(2008) D. Flemming Hansen et al.   JOURNAL OF BIOMOLECULAR NMR

Functional Role of the “Ionic Lock”—An Interhelical Hydrogen-Bond Network in Family A Heptahelical Receptors

(2008) Reiner Vogel et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of a β1-adrenergic G-protein-coupled receptor

(2008) Tony Warne et al.   NATURE

Crystal structure of opsin in its G-protein-interacting conformation

(2008) Patrick Scheerer et al.   NATURE

Two protonation switches control rhodopsin activation in membranes

(2008) M. Mahalingam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct conformational changes in  -arrestin report biased agonism at seven-transmembrane receptors

(2008) A. K. Shukla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A role for membrane potential in regulating GPCRs?

(2008) Martyn P. Mahaut-Smith et al.   TRENDS IN PHARMACOLOGICAL SCIENCES