Article
Biochemistry & Molecular Biology
Wenting Dai, Zhichao Wang, Qiong A. Wang, David Chan, Lei Jiang
Summary: This study explored the role of OPA1 in cell fitness and metabolic regulation. When cellular mitochondrial fission is unbalanced, OPA1 deficiency activates glutamine-dependent reductive carboxylation to reprogram cellular metabolism in order to support lipid synthesis and cell proliferation.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Microbiology
A. MacLean, F. Legendre, S. Tharmalingam, V. D. Appanna
Summary: By culturing the soil microbe Pseudomonas fluorescens in a phosphate-limited mineral medium, the by-product glycerol from the biofuel industry can be effectively transformed into valuable L-carnitine. The metabolic reconfiguration of the microbe under phosphate stress in the limited medium leads to the enhanced production of L-carnitine and other metabolites.
MICROBIOLOGICAL RESEARCH
(2021)
Article
Oncology
Duc-Vinh Pham, Pil-Hoon Park
Summary: This study elucidates the multifaceted role of adiponectin in tumor fatty acid metabolic reprogramming and provides evidence for the connection between its metabolic actions and suppression of breast cancer.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Xin Cheng, Bowen Yang, Jinfang Zheng, Hongyu Wei, Xuehuan Feng, Yanbin Yin
Summary: The isolation of a Cd-resistant strain CX 2-6 from contaminated farmland sheds light on the genetic response of Enterococcus faecium to heavy metal stress, providing insights into the metabolic reprogramming under Cd stress.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)
Review
Medicine, General & Internal
Xuqing Shen, Ningning Niu, Jing Xue
Summary: KRAS activation is a key driver of PDAC initiation and progression, and PDAC cells undergo extensive metabolic reprogramming to meet their extreme energy and biomass demands.
JOURNAL OF TRANSLATIONAL INTERNAL MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Marilise Nogueira, Eugenia M. A. Enfissi, Elliott J. Price, Guillaume N. Menard, Eudri Venter, Peter J. Eastmond, Einat Bar, Efraim Lewinsohn, Paul D. Fraser
Summary: Plant cells have a remarkable capacity to adapt to the synthesis and response of non-endogenous substances, involving changes in plastidial membrane, core metabolic pathways, and redox control.
PLANT BIOTECHNOLOGY JOURNAL
(2023)
Article
Agricultural Engineering
Yuwen Luo, Luo Luo, Xuejiao Huang, Daihua Jiang, Xiaogang Wu, Zhenlun Li
Summary: The ammonium and nitrate removal performance and metabolic pathways of Pseudomonas fluorescens 2P24 were investigated. Strain 2P24 was able to completely remove 100 mg/L of ammonium and nitrate with removal rates of 8.27 mg/L/h and 4.29 mg/L/h, respectively. The study revealed that most of the ammonium and nitrate were converted to biological nitrogen via assimilation, and only small amounts of nitrous oxide were released.
BIORESOURCE TECHNOLOGY
(2023)
Article
Endocrinology & Metabolism
Hongji Zhang, Tianmeng Chen, Jinghua Ren, Yujia Xia, Amblessed Onuma, Yu Wang, Jiayi He, Junru Wu, Han Wang, Ahmad Hamad, Chengli Shen, Jinxiang Zhang, John M. Asara, Gregory K. Behbehani, Haitao Wen, Meihong Deng, Allan Tsung, Hai Huang
Summary: The research demonstrates that pre-operative exercise protects against liver injury by driving Kupffer cells towards an anti-inflammatory phenotype through itaconate metabolism.
Article
Microbiology
Gemini Gajera, Nidhi Thakkar, Chhaya Godse, Anselm DeSouza, Dilip Mehta, Vijay Kothari
Summary: This study reveals the antibacterial effects of Silversol (R), a colloidal nano-silver formulation, against a multidrug resistant strain of P. aeruginosa. Silversol (R) was found to inhibit the growth and pathogenicity of P. aeruginosa by affecting various cellular processes and metabolic pathways. The study also identifies potential molecular targets associated with the antibacterial activity of Silversol (R).
Article
Microbiology
Linde F. C. Kampers, Jasper J. Koehorst, Ruben J. A. van Heck, Maria Suarez-Diez, Alfons J. M. Stams, Peter J. Schaap
Summary: A rational design for a P. putida KT2440 derivative strain capable of anaerobic respiration was developed using a data-driven approach, requiring the addition of at least 49 known genes, 8 genes encoding proteins of unknown function, and 3 externally added vitamins.
Article
Microbiology
Grace P. Carreno-Florez, Brian R. Kocak, Matthew R. Hendricks, Jeffrey A. Melvin, Katrina B. Mar, Jessica Kosanovich, Rachel L. Cumberland, Greg M. Delgoffe, Sruti Shiva, Kerry M. Empey, John W. Schoggins, Jennifer M. Bomberger
Summary: Viral infections can make the host susceptible to secondary bacterial infections, and this study identified specific interferon-stimulated genes (ISGs) that promote Pseudomonas aeruginosa infection. The mechanism of action was also investigated, revealing the role of hexokinase 2 (HK2) in mediating metabolic changes and lactate secretion to enhance bacterial infection. These findings improve our understanding of how the host immune response can lead to viral-bacterial co-infection.
Review
Multidisciplinary Sciences
Waheed Miran, Divya Naradasu, Akihiro Okamoto
Summary: The article discusses the role of electron transfer in the metabolic activity of biofilms, as well as the new method of using electrical currents produced by biofilm cells to evaluate the effects of antimicrobial agents. It also explores the mechanisms of EET in pathogens and environmental bacteria, along with addressing the current limitations and future research directions in the assessment of biofilm metabolic activity.
Review
Chemistry, Multidisciplinary
Qiong Wu, Bo Zhao, Guangchao Sui, Jinming Shi
Summary: This article summarizes the activities of natural small molecules in inhibiting key enzymes of metabolic pathways in cancer cells, focusing on their role in modulating metabolic pathways and cancer cell fate.
APPLIED SCIENCES-BASEL
(2021)
Article
Ecology
Leonardo Ona, Samir Giri, Neele Avermann, Maximilian Kreienbaum, Kai M. Thormann, Christian Kost
Summary: The study shows that obligate cross-feeding among bacteria can expand their metabolic niche space, especially between specialist taxa, and is positively correlated with the phylogenetic distance between interaction partners.
NATURE ECOLOGY & EVOLUTION
(2021)
Article
Microbiology
Kensuke Shima, Inga Kaufhold, Thomas Eder, Nadja Kaeding, Nis Schmidt, Iretiolu M. Ogunsulire, Rene Deenen, Karl Koehrer, Dirk Friedrich, Sophie E. Isay, Florian Grebien, Matthias Klinger, Barbara C. Richer, Ulrich L. Guenther, George S. Deepe, Thomas Rattei, Jan Rupp
Summary: Chlamydia trachomatis infection is the most common bacterial sexually transmitted disease globally, with no vaccine available. Changes in chlamydial replicative activity and the occurrence of chlamydial persistence affect treatment effectiveness. This study highlights the importance of mitochondrion-fatty acid interplay for the metabolic reprogramming of C. trachomatis during treatment with beta-lactam antimicrobials.
Article
Biochemistry & Molecular Biology
Christopher Auger, Vasu D. Appanna
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2015)
Article
Pharmacology & Pharmacy
Anita A. Mehta, Ashok D. Agrawal, Vasu Appanna, Kiranj K. Chaudagar
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2015)
Article
Biotechnology & Applied Microbiology
Azhar Alhasawi, Jacob Costanzi, Christopher Auger, Nishma D. Appanna, Vasu D. Appanna
JOURNAL OF BIOTECHNOLOGY
(2015)
Article
Geriatrics & Gerontology
S. C. Thomas, A. Alhasawi, V. P. Appanna, C. Auger, V. D. Appanna
JOURNAL OF NUTRITION HEALTH & AGING
(2015)
Article
Microbiology
Azhar Alhasawi, Zachary Castonguay, Nishma D. Appanna, Christopher Auger, Vasu D. Appanna
MICROBIOLOGICAL RESEARCH
(2015)
Review
Biochemical Research Methods
Sungwon Han, Christopher Auger, Zachary Castonguay, Varun P. Appanna, Sean C. Thomas, Vasu D. Appanna
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2013)
Article
Microbiology
Varun P. Appanna, Christopher Auger, Sean C. Thomas, Abdelwahab Omri
ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY
(2014)
Article
Biochemistry & Molecular Biology
Zachary Castonguay, Christopher Auger, Sean C. Thomas, M'hamed Chahma, Vasu D. Appanna
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2014)
Review
Biotechnology & Applied Microbiology
Christopher Auger, Sungwon Han, Varun P. Appanna, Sean C. Thomas, Gerardo Ulibarri, Vasu D. Appanna
BIOTECHNOLOGY ADVANCES
(2013)
Review
Cell Biology
Sungwon Han, Joseph Lemire, Varun P. Appanna, Christopher Auger, Zachary Castonguay, Vasu D. Appanna
CELL BIOLOGY AND TOXICOLOGY
(2013)
Article
Cell & Tissue Engineering
Sungwon Han, Christopher Auger, Sean C. Thomas, Crestina L. Beites, Vasu D. Appanna
CELLULAR REPROGRAMMING
(2014)
Article
Biotechnology & Applied Microbiology
A. Alhasawi, C. Auger, V. P. Appanna, M. Chahma, V. D. Appanna
JOURNAL OF APPLIED MICROBIOLOGY
(2014)
Article
Neurosciences
Joseph Lemire, Christopher Auger, Ryan Mailloux, Vasu D. Appanna
JOURNAL OF NEUROSCIENCE RESEARCH
(2014)
Review
Biotechnology & Applied Microbiology
F. Legendre, A. MacLean, V. P. Appanna, V. D. Appanna
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
(2020)
Article
Cell Biology
Vasu D. Appanna, Christopher Auger, Joseph Lemire
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2014)